High-level primary CD8(+) T-cell response to human immunodeficiency virus type 1 gag and env generated by vaccination with recombinant vesicular stomatitis viruses.

abstract：:The structure of a complex between human rhinovirus 2 (HRV2) and the Fab fragment of neutralizing monoclonal antibody (MAb) 3B10 has been determined to 25-A resolution by cryoelectron microscopy and three-dimensional reconstruction techniques. The footprint of 3B10 on HRV2 is very similar to that of neutralizing MAb 8...

journal_title：Journal of virology

authors： Hewat EA,Marlovits TC,Blaas D

更新日期：1998-05-01 00:00:00

abstract：:Epstein-Barr virus (EBV) infection is mediated by several viral envelope glycoproteins. We have assessed gp110's functions during the virus life cycle using a mutant that lacks BALF4 (DeltaBALF4). Exposure of various cell lines and primary cell samples of epithelial or lymphoid lineages to the DeltaBALF4 mutant failed...

journal_title：Journal of virology

authors： Neuhierl B,Feederle R,Adhikary D,Hub B,Geletneky K,Mautner J,Delecluse HJ

更新日期：2009-05-01 00:00:00

abstract：:Nondefective reticuloendotheliosis virus induces chicken bursal lymphoma in a manner similar to that of avian leukosis virus. The provirus integrates in the c-myc locus and uses a promoter insertion mechanism to activate c-myc expression. We cloned a provirus involved in c-myc activation from a B lymphoma. Detailed st...

journal_title：Journal of virology

authors： Swift RA,Boerkoel C,Ridgway A,Fujita DJ,Dodgson JB,Kung HJ

更新日期：1987-07-01 00:00:00

abstract：:The vif gene of human immunodeficiency virus type 1 is absolutely required for productive infection of primary cells derived from human blood and certain immortalized T lymphoid cells, for example, H9. Cells with this restrictive phenotype are termed nonpermissive, whereas cell lines in which vif-deficient virus can r...

journal_title：Journal of virology

authors： Simon JH,Malim MH

更新日期：1996-08-01 00:00:00

abstract：:Human papillomaviruses (HPVs) infect squamous epithelium and establish their genomes as episomes in proliferating basal cells. As infected cells differentiate, the viral DNA is amplified to high copy number and infectious virus is produced. Viral production has not yet been observed in vitro due to the inability of st...

journal_title：Journal of virology

authors： Bedell MA,Hudson JB,Golub TR,Turyk ME,Hosken M,Wilbanks GD,Laimins LA

更新日期：1991-05-01 00:00:00

abstract：:The biological and genetic characteristics of murine leukemia viruses (MuLV) derived from leukemic and normal HRS/J mice were studied. T1-oligonucleotide fingerprinting and mapping of viral RNAs from unpassaged isolates revealed the presence of complex mixtures of viral genomes. MuLV that were purified by endpoint dil...

journal_title：Journal of virology

authors： Thomas CY,Khiroya R,Schwartz RS,Coffin JM

更新日期：1984-05-01 00:00:00

abstract：:Alkylation of T7 bacteriophage by methyl methane sulfonate blocked superinfection exclusion. This blockage could be correlated with a delay in the synthesis of phage-specific proteins. Therefore we conclude that protein synthesis directed by the primary infecting phage is required for efficient exclusion of superinfec...

journal_title：Journal of virology

authors： Karska-Wysocki B,Racine JF,Mamet-Bratley MD

更新日期：1982-11-01 00:00:00

abstract：:In search of an anti-transcriptase, antibody was raised in rabbits to partially purified, soluble NS protein present in cytoplasmic extracts of cells infected with the Indiana serotype of vesicular stomatitis (VSInd) virus. This antiserum gave specific reactions of identity by agar immunodiffusion with both cytoplasmi...

journal_title：Journal of virology

authors： Imblum RL,Wagner RR

更新日期：1975-06-01 00:00:00

abstract：:Nipah virus (NiV) and Hendra virus (HeV) are emerging zoonotic viruses and the causative agents of severe respiratory disease and encephalitis in humans. Little is known about the mechanisms that govern the development of respiratory and neurological disease. Using a hamster model of lethal NiV and HeV infection, we d...

journal_title：Journal of virology

authors： Rockx B,Brining D,Kramer J,Callison J,Ebihara H,Mansfield K,Feldmann H

更新日期：2011-08-01 00:00:00

abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent involved in the disease HTLV-1-associated myelopathy, or tropical spastic paraparesis (HAM/TSP). The pathogenesis of HAM/TSP is poorly understood, but it is probable that viral infection has an indirect, deleterious effect on neural function. In ...

journal_title：Journal of virology

authors： Akaoka H,Hardin-Pouzet H,Bernard A,Verrier B,Belin MF,Giraudon P

更新日期：1996-12-01 00:00:00

abstract：:Herpes simplex virus 2 (HSV-2) infection is still one of the common causes of sexually transmitted diseases worldwide. The prevalence of HSV strains resistant to traditional nucleoside antiviral agents has led to the development of novel antiviral drugs. Human alpha-defensin 5 (HD5), a kind of endogenous antimicrobial...

journal_title：Journal of virology

authors： Wang A,Chen F,Wang Y,Shen M,Xu Y,Hu J,Wang S,Geng F,Wang C,Ran X,Su Y,Cheng T,Wang J

更新日期：2013-03-01 00:00:00

abstract：:Electron micrographic studies of neuronal axons have produced contradictory conclusions on how alphaherpesviruses are transported from neuron cell bodies to axon termini. Some reports have described unenveloped capsids transported on axonal microtubules with separate transport of viral glycoproteins within membrane ve...

journal_title：Journal of virology

authors： Snyder A,Wisner TW,Johnson DC

更新日期：2006-11-01 00:00:00

abstract：:The relative contribution of measles virus hemagglutinin (H)- or fusion protein (F)-specific antibodies to virus neutralization (VN) has not been demonstrated. We have depleted these specific antibodies from sera collected from young adults, who had been vaccinated during childhood, by prolonged incubation with viable...

journal_title：Journal of virology

authors： de Swart RL,Yüksel S,Osterhaus AD

更新日期：2005-09-01 00:00:00

abstract：:Tomato bushy stunt virus (TBSV), a tombusvirus with a nonsegmented, plus-stranded RNA genome, codes for two essential replicase proteins. The sequence of one of the replicase proteins, namely p33, overlaps with the N-terminal domain of p92, which contains the signature motifs of RNA-dependent RNA polymerases (RdRps) i...

journal_title：Journal of virology

authors： Rajendran KS,Nagy PD

更新日期：2003-09-01 00:00:00

abstract：:The flavivirus dengue virus (DV) infects cells through a low-pH-triggered membrane fusion reaction mediated by the viral envelope protein E. E is an elongated transmembrane protein with three domains and is organized as a homodimer on the mature virus particle. During fusion, the E protein homodimer dissociates, inser...

journal_title：Journal of virology

authors： Liao M,Sánchez-San Martín C,Zheng A,Kielian M

更新日期：2010-06-01 00:00:00

abstract：:A mutation (asparagine 815 to serine 815) was introduced into the herpes simplex virus type 1 (HSV-1) DNA polymerase (pol). The HSV-1 pol enzyme in lysates of Saccharomyces cerevisiae cells expressing the mutant protein showed increased resistance to acyclovir triphosphate and increased sensitivity to phosphonoacetate...

journal_title：Journal of virology

authors： Matthews JT,Carroll RD,Stevens JT,Haffey ML

更新日期：1989-11-01 00:00:00

abstract：:We have studied the fate of CD4 in CEM T cells expressing a human immunodeficiency virus type 1 HIV-1 Nef protein. Nef triggered a rapid endocytosis and a degradation of CD4, while most of the p56lck was upheld at the cell membrane. In the presence of Nef, CD4 accumulated in acidic intracellular vesicles that were not...

journal_title：Journal of virology

authors： Schwartz O,Dautry-Varsat A,Goud B,Maréchal V,Subtil A,Heard JM,Danos O

更新日期：1995-01-01 00:00:00

abstract：:We report a Sendai virus (SeV) vector system for expression of major histocompatibility complex (MHC) class I/peptide complexes. We cloned the extracellular domain of a human MHC class I heavy chain, HLA-A*2402, and human beta-2 microglobulin (beta2m) fused with HLA-A*2402-restricted human immunodeficiency virus type ...

journal_title：Journal of virology

authors： Kawana-Tachikawa A,Tomizawa M,Nunoya J,Shioda T,Kato A,Nakayama EE,Nakamura T,Nagai Y,Iwamoto A

更新日期：2002-12-01 00:00:00

abstract：:The vast majority of people already have preexisting immune responses to influenza viruses from one or more subtypes. However, almost all preclinical studies evaluate new influenza vaccine candidates in immunologically naive animals. Recently, our group demonstrated that priming naive ferrets with broadly reactive H1 ...

journal_title：Journal of virology

authors： Allen JD,Jang H,DiNapoli J,Kleanthous H,Ross TM

更新日期：2019-01-17 00:00:00

abstract：:Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid. Moreover, PEDV infects cells from pig, human,...

journal_title：Journal of virology

authors： Liu C,Tang J,Ma Y,Liang X,Yang Y,Peng G,Qi Q,Jiang S,Li J,Du L,Li F

更新日期：2015-06-01 00:00:00

abstract：:Although in vitro replication of the hepatitis C virus (HCV) JFH1 clone of genotype 2a (HCVcc) has been developed, a robust cell culture system for the 1a and 1b genotypes, which are the most prevalent viruses in the world and resistant to interferon therapy, has not yet been established. As a surrogate virus system, ...

journal_title：Journal of virology

authors： Tani H,Komoda Y,Matsuo E,Suzuki K,Hamamoto I,Yamashita T,Moriishi K,Fujiyama K,Kanto T,Hayashi N,Owsianka A,Patel AH,Whitt MA,Matsuura Y

更新日期：2007-08-01 00:00:00

abstract：:The matrix domain of human immunodeficiency virus type 1 Gag polyprotein was studied for its role in virus assembly. Deletion and substitution mutations caused a dramatic reduction in virus production. Mutant Gag polyproteins were myristoylated and had a high affinity for membrane association. Immunofluorescence stain...

journal_title：Journal of virology

authors： Yuan X,Yu X,Lee TH,Essex M

更新日期：1993-11-01 00:00:00

abstract：:Vaccines preventing HIV-1 infection will likely elicit antibodies that neutralize diverse strains. However, the capacity for lentiviruses to escape broadly neutralizing antibodies (NAbs) is not completely understood, nor is it known whether NAbs alone can control heterologous infection. Here, we determined that conval...

journal_title：Journal of virology

authors： Taylor SD,Leib SR,Carpenter S,Mealey RH

更新日期：2010-07-01 00:00:00

abstract：:Two defective RNAs (designated D RNA 3 alpha and D RNA 3 beta) were found to be associated with the Fny strain of cucumber mosaic cucumovirus but not with the Sny strain after serial passages in a tobacco host. The D RNAs were derived from RNA 3 by single, in-frame deletions within the 3a open reading frame. A full-le...

journal_title：Journal of virology

authors： Graves MV,Roossinck MJ

更新日期：1995-08-01 00:00:00

abstract：:Aichi virus, a member of the family Picornaviridae, encodes a leader (L) protein of 170 amino acids (aa). The Aichi virus L protein exhibits no significant sequence homology to those of other picornaviruses. In this study, we investigated the function of the Aichi virus L protein in virus growth. In vitro translation ...

journal_title：Journal of virology

authors： Sasaki J,Nagashima S,Taniguchi K

更新日期：2003-10-01 00:00:00

abstract：:The human T-cell leukemia virus type I (HTLV-I) envelope protein is synthesized as a gp61 precursor product cleaved into two mature proteins, a gp45 exterior protein and a gp20 anchoring the envelope at the cell membrane. Using N-glycosylation inhibitors and site-directed mutagenesis of the potential glycosylation sit...

journal_title：Journal of virology

authors： Pique C,Pham D,Tursz T,Dokhélar MC

更新日期：1992-02-01 00:00:00

abstract：:The V20 cultivar of Nicotiana tabacum was shown previously to exhibit a strain-specific restriction of long-distance movement of tobacco etch potyvirus (TEV). In V20, both TEV-HAT and TEV-Oxnard strains are capable of genome amplification and cell-to-cell movement, but only TEV-Oxnard is capable of systemic infection ...

journal_title：Journal of virology

authors： Schaad MC,Lellis AD,Carrington JC

更新日期：1997-11-01 00:00:00

abstract：:Infection with human T-cell leukemia virus type 1 (HTLV-1) can result in the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a chronic inflammatory disease of the central nervous system (CNS). HTLV-2 is highly related to HTLV-1 at the genetic level and shares a high degree of sequen...

journal_title：Journal of virology

authors： Banerjee P,Rochford R,Antel J,Canute G,Wrzesinski S,Sieburg M,Feuer G

更新日期：2007-02-01 00:00:00

abstract：:The steady-state level and metabolic half-life of retinoblastoma tumor suppressor protein pRB are decreased in cells that express high-risk human papillomavirus (HPV) E7 proteins. Here we show that pRB degradation is a direct activity of E7 and does not reflect a property of cell lines acquired during the selection pr...

journal_title：Journal of virology

authors： Gonzalez SL,Stremlau M,He X,Basile JR,Münger K

更新日期：2001-08-01 00:00:00

abstract：:The therapeutic efficacy of direct drug infusion into the brain, the target organ of transmissible spongiform encephalopathies, was assessed in transgenic mice intracerebrally infected with 263K scrapie agent. Pentosan polysulfate (PPS) gave the most dramatic prolongation of the incubation period, and amphotericin B h...

journal_title：Journal of virology

authors： Doh-ura K,Ishikawa K,Murakami-Kubo I,Sasaki K,Mohri S,Race R,Iwaki T

更新日期：2004-05-01 00:00:00