Matrix metalloproteinases in disease and repair processes in the anterior segment.

Abstract:

:The pathogenesis of many anterior segment disorders and ocular complications following surgery are secondary to the wound healing response. The extent of clinical damage observed is closely related to the amount of scarring and tissue contraction. Matrix metalloproteinases (MMPs) are a family of enzymes that play a vital role in all stages of the wound healing process. They degrade all extracellular matrix components and also have the ability to synthesize collagen and extracellular matrix members, and are therefore important in the remodeling of a wound. Overexpression of MMPs results in excessive extracellular matrix degradation, leading to tissue destruction and loss of organ function. In the case of the anterior segment, this may mean the loss of visual function. This review focuses on the role MMPs have in the development of various anterior segment disorders. The importance of MMPs in the wound healing response and its potential modulation to manipulate the scarring response is being recognized, and current developments will be described.

journal_name

Surv Ophthalmol

journal_title

Survey of ophthalmology

authors

Wong TT,Sethi C,Daniels JT,Limb GA,Murphy G,Khaw PT

doi

10.1016/s0039-6257(02)00287-4

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

239-56

issue

3

eissn

0039-6257

issn

1879-3304

pii

S0039625702002874

journal_volume

47

pub_type

杂志文章,评审
  • Posterior scleritis.

    abstract::Posterior scleritis must be considered in the differential diagnosis of many ocular conditions, including angle closure glaucoma, choroidal folds, optic disk edema, circumscribed fundus mass, choroidal detachment, and exudative retinal detachment. Because it is rare, a high index of suspicion is necessary. Anterior sc...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/0039-6257(88)90093-8

    authors: Benson WE

    更新日期:1988-03-01 00:00:00

  • Normal and pathological mechanisms in retinal vascular development.

    abstract::Angiogenesis is a complex biologic process that occurs normally in development and in turnover and remodeling of mature vascular networks. Pathological angiogenesis and neovascularization occur in association with retinal and ocular ischemic diseases, in retinopathy of prematurity and other developmental disorders, an...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/s0039-6257(96)82014-5

    authors: Gariano RF,Kalina RE,Hendrickson AE

    更新日期:1996-05-01 00:00:00

  • Clinical dose-regimen studies with latanoprost, a new ocular hypotensive PGF2 alpha analogue.

    abstract::This review summarizes recent short-term clinical studies evaluating the ocular hypotensive efficacy of different dose-regimens of latanoprost. When tested in ocular hypertensive and glaucoma patients concomitantly treated with timolol, 0.006% latanoprost given only in the evening, was found to be more effective than ...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/s0039-6257(97)80011-2

    authors: Diestelhorst M,Krieglstein GK,Lusky M,Nagasubramanian S

    更新日期:1997-02-01 00:00:00

  • Neurofibromatosis and neural crest neoplasms: primary acquired melanosis and malignant melanoma of the conjunctiva.

    abstract::With an occurrence of approximately 1 in 3000 births, von Recklinghausen neurofibromatosis (NF) is one of the most common inherited human disorders. NF is considered a neurocristopathy, a disorder of neural crest derived cells. One of the complications of NF is the development of neural crest derived malignancies such...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/0039-6257(89)90014-3

    authors: To KW,Rabinowitz SM,Friedman AH,Merker C,Cavanaugh CP

    更新日期:1989-03-01 00:00:00

  • Advances in the analysis of corneal topography.

    abstract::Recent advances in topographic analysis have provided powerful tools for detecting subtle, but clinically significant, alterations of corneal contour. This article compares keratometry, keratoscopy, and computer-assisted topographic analysis and provides specific examples of the sensitivity of computer-assisted system...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/0039-6257(91)90047-j

    authors: Wilson SE,Klyce SD

    更新日期:1991-01-01 00:00:00

  • Fundus manifestations of orbital disease and treatment of orbital disease.

    abstract::Disorders of the orbit can secondarily involve the eye. Although nonspecific, changes which can be noted on funduscopic examination including abnormalities of the retina, choroid, and optic nerve, can be secondary to an underlying orbital process. Awareness of these findings and their association with orbital disease ...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/s0039-6257(95)80043-3

    authors: De La Paz MA,Boniuk M

    更新日期:1995-07-01 00:00:00

  • Rubeosis iridis in "pseudogliomas".

    abstract::A total of 85 eyes (75 patients) with pseudogliomas (i.e., certain conditions which simulate retinoblastoma, were examined histopathologically to determine the incidence of rubeosis iridis. Neovascularization of the anterior surface of the iris was found in 70 eyes (82%). The principal associated changes in these eyes...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0039-6257(80)90151-4

    authors: Moazed K,Albert D,Smith TR

    更新日期:1980-09-01 00:00:00

  • Heavy eye syndrome: Myopia-induced strabismus.

    abstract::Heavy eye syndrome is an important type of myopia-induced strabismus. We provide an overview of heavy eye syndrome, from its history to its most salient features. The theory of the orbital and rectus muscle pulley system as it relates to heavy eye syndrome and the prevailing theories on the pathophysiology of heavy ey...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/j.survophthal.2020.06.001

    authors: Hennein L,Robbins SL

    更新日期:2021-01-01 00:00:00

  • The invention and early manufacture of bifocals.

    abstract::Benjamin Franklin, who died 200 years ago, is generally credited with the invention of bifocals. However, serious historians have from time to time produced evidence to suggest that others may have preceded him in the invention. This historical article includes correspondence from George Whatley, a London philanthropi...

    journal_title:Survey of ophthalmology

    pub_type: 传,历史文章,杂志文章

    doi:10.1016/0039-6257(90)90092-a

    authors: Letocha CE

    更新日期:1990-11-01 00:00:00

  • Corneal lymphangiogenesis in herpetic stromal keratitis.

    abstract::Corneal lymphangiogenesis is the extension of lymphatic vessels into the normally alymphatic cornea, a process that compromises the cornea's immune-privileged state and facilitates herpetic stromal keratitis (HSK). HSK results most commonly from infection by herpes simplex virus-1 (HSV-1) and is characterized by immun...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/j.survophthal.2014.06.001

    authors: Park PJ,Chang M,Garg N,Zhu J,Chang JH,Shukla D

    更新日期:2015-01-01 00:00:00

  • Malignant rhabdoid transformation of a longstanding, aggressive, and recurrent orbital angiomyxoma.

    abstract::A 47-year-old woman presented with a medial orbital tumor initially diagnosed as either a myxoid neurofibroma or myoepithelioma. Over 30 years the tumor recurred seven times and was serially debulked. Careful histopathologic analysis coupled with immunohistochemical studies performed on the last two biopsies establish...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/j.survophthal.2014.12.002

    authors: Jakobiec FA,Callahan AB,Stagner AM,Lee NG,Rashid A,Mendoza P,Grove A,Freitag SK

    更新日期:2015-03-01 00:00:00

  • Retinitis pigmentosa.

    abstract::Retinitis pigmentosa is a clinically and genetically heterogeneous group of hereditary disorders in which there is progressive loss of photoreceptor and pigment epithelial function. The prevalence of retinitis pigmentosa is between 1/3000 and 1/5000 making it one of the most common causes of visual impairment in all a...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/0039-6257(88)90085-9

    authors: Pagon RA

    更新日期:1988-11-01 00:00:00

  • A slippery slope.

    abstract::A 74-year-old woman experienced chronic painless progressive binocular horizontal diplopia for 2 years. Initial examination showed a visual acuity of 20/20 OU. External and slit lamp examination was unremarkable. Orthoptic evaluation showed an incomitant esotropia, a small vertical strabismus, and a large degree of ex...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.survophthal.2018.10.006

    authors: Gross AW,Vickers A,Lee AG,Chen JJ,Bhatti MT

    更新日期:2019-01-01 00:00:00

  • Retinal prosthesis for the blind.

    abstract::Most of current concepts for a visual prosthesis are based on neuronal electrical stimulation at different locations along the visual pathways within the central nervous system. The different designs of visual prostheses are named according to their locations (i.e., cortical, optic nerve, subretinal, and epiretinal). ...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/s0039-6257(02)00311-9

    authors: Margalit E,Maia M,Weiland JD,Greenberg RJ,Fujii GY,Torres G,Piyathaisere DV,O'Hearn TM,Liu W,Lazzi G,Dagnelie G,Scribner DA,de Juan E Jr,Humayun MS

    更新日期:2002-07-01 00:00:00

  • Black as night.

    abstract::A 30-year-old man presented with painless total visual loss in the right eye. Fundus exam and imaging was consistent with total internal carotid artery occlusion and hemispheric stroke. The presentation and management options of retinal vascular occlusive disease in association with asymptomatic stroke are discussed. ...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.survophthal.2014.06.007

    authors: Kleinberg TT,Uretsky S,Flanders AE,Bilyk JR,Murchison AP

    更新日期:2015-05-01 00:00:00

  • The optics of aphakic and pseudophakic eyes in childhood.

    abstract::The growth of the eye results in a myopic shift in aphakic and pseudophakic eyes during childhood. Cataract surgery after the age of 6 months, with or without lens implantation, appears to have little effect on the rate of refractive growth. Most children with pseudophakia have a large amount of myopic shift. This myo...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.survophthal.2009.07.001

    authors: McClatchey SK,Hofmeister EM

    更新日期:2010-03-01 00:00:00

  • Magnetic resonance images in a case of "divergence paralysis".

    abstract::The clinical syndrome of divergence paralysis has been described since the mid 19th century. Speculation still surrounds the possible existence of an anatomical center for divergence function. Our report explores this possibility and describes the magnetic resonance images of a patient with a unilateral 6th nerve pals...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0039-6257(86)90094-9

    authors: Stern RM,Tomsak RL

    更新日期:1986-05-01 00:00:00

  • Advances in the evaluation and management of cortical/cerebral visual impairment in children.

    abstract::Cortical/cerebral visual impairment (CVI) is the most frequent cause of pediatric visual impairment in developed countries and is increasing in prevalence in developing nations. The most common underlying etiology is hypoxic-ischemic encephalopathy, particularly in premature children. Other causes include seizures, hy...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/j.survophthal.2020.03.001

    authors: Chang MY,Borchert MS

    更新日期:2020-01-01 00:00:00

  • Coats'-type retinitis pigmentosa.

    abstract::Coats'-like changes (i.e., retinal telangiectasia and/or exudative detachment) have been reported in as many as 1.2 to 3.6 percent of patients with retinitis pigmentosa. In severe cases this disorder may progress to total retinal detachment and visual loss in the context of longstanding retinitis pigmentosa. Forty-six...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/0039-6257(88)90094-x

    authors: Khan JA,Ide CH,Strickland MP

    更新日期:1988-03-01 00:00:00

  • Unilateral headache and ptosis in a 30-year-old woman.

    abstract::A 30-year-old woman developed left-sided headaches and ipsilateral oculosympathetic paresis (Horner's syndrome) secondary to carotid dissection. Although she initially denied preceding trauma, further questioning revealed a pattern of physical abuse by her boyfriend, including an attempted strangulation shortly before...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0039-6257(97)00054-4

    authors: Purvin V

    更新日期:1997-09-01 00:00:00

  • Congenital corneal anesthesia.

    abstract::Congenital corneal anesthesia is a rare clinical entity that poses a diagnostic dilemma, particularly in the pediatric age group. The sensory deficit may be confined to the cornea, or extend to other divisions of the trigeminal nerve. The sensory deficit may occur as an isolated abnormality, as part of a complex neuro...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/j.survophthal.2006.10.004

    authors: Ramaesh K,Stokes J,Henry E,Dutton GN,Dhillon B

    更新日期:2007-01-01 00:00:00

  • Validity of pulsatile ocular blood flow measurements.

    abstract::The determination of average net pulsatile ocular blood flow form measurements of the intraocular pressure (IOP) pulse is based upon 1) an accurate measurement of IOP and its time variation; 2) a knowledge of the relation between the volume of the living eye and its IOP; 3) a physical model for the flow of blood throu...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/0039-6257(94)90049-3

    authors: Silver DM,Farrell RA

    更新日期:1994-05-01 00:00:00

  • Visual field responses to a hand vibration stimulus.

    abstract::Two short visual field tests were performed on 106 subjects approximately 5 minutes apart with or without a hand vibration stimulus between the field tests. There were 31 eyes in the control group (10 without glaucoma, eight glaucoma suspects, 10 with primary open-angle glaucoma, and three with secondary open-angle gl...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0039-6257(99)00051-x

    authors: Chai E,Goldberg I,Chia A,Chen J

    更新日期:1999-06-01 00:00:00

  • Pars plana lensectomy by ultrasonic fragmentation. I. Versatile and simple technique for cataract removal.

    abstract::A comparison has been made between pars plana lansectomy and intracapsular cataract extraction Pars plana lensectomy has been shown to have many advantages. It is applicable to any age, while intracapsular cataract extraction is restricted to patients over 30 years old. It can be used in any type of cataract, whereas ...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0039-6257(82)90191-6

    authors: Girard LJ

    更新日期:1982-09-01 00:00:00

  • Minor trauma, disastrous results.

    abstract::An 81-year-old-woman developed a right facial palsy and orbital cellulitis following an apparently innocuous puncture injury of the right lower eyelid. Generalized tetanus ensued which proved fatal despite aggressive treatment including use of tetanus immune globulin, wound debridement, and neuromuscular blockade with...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0039-6257(87)90118-4

    authors: Searl SS

    更新日期:1987-03-01 00:00:00

  • Orbital lymphoma associated with acquired immune deficiency syndrome (AIDS).

    abstract::A new case of AIDS-associated, small noncleaved cell (Burkitt's) lymphoma that presented as an orbital mass is described. Extraocular muscle involvement was documented by computed tomography and confirmed by orbital biopsy. Extensive abdominal involvement was subsequently diagnosed and this caused the patient's death ...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/0039-6257(94)90075-2

    authors: Reifler DM,Warzynski MJ,Blount WR,Graham DM,Mills KA

    更新日期:1994-01-01 00:00:00

  • The efficacy and safety of unfixed and fixed combinations of latanoprost and other antiglaucoma medications.

    abstract::Adjunctive therapy for the management of glaucoma is commonly used. Unfixed combinations of the prostaglandin analog latanoprost and other glaucoma medications have been demonstrated to effectively lower intraocular pressure (IOP). The range of reported additional reductions in IOP compared to a monotherapy baseline a...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/s0039-6257(02)00295-3

    authors: Higginbotham EJ,Diestelhorst M,Pfeiffer N,Rouland JF,Alm A

    更新日期:2002-08-01 00:00:00

  • A woman with unilateral visual loss and bilateral disk edema.

    abstract::A 38-year-old woman presented with bilateral optic neuropathy, leg weakness, and urinary symptoms. Despite her spinal MR being normal, her serum was positive for NMO-IgG. This indicated that she likely had Devic disease. ...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.survophthal.2007.10.002

    authors: Gilbert ME,Vaphiades M

    更新日期:2008-01-01 00:00:00

  • Corneal nerves in diabetes-The role of the in vivo corneal confocal microscopy of the subbasal nerve plexus in the assessment of peripheral small fiber neuropathy.

    abstract::The cornea's intense innervation is responsible for corneal trophism and ocular surface hemostasis maintenance. Corneal diabetic neuropathy affects subbasal nerve plexus, with progressive alteration of nerves' morphology and density. The quantitative analysis of nerve fibers can be performed with in vivo corneal confo...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/j.survophthal.2020.09.003

    authors: Roszkowska AM,Licitra C,Tumminello G,Postorino EI,Colonna MR,Aragona P

    更新日期:2020-09-19 00:00:00

  • Solar radiation and age-related macular degeneration.

    abstract::Age-related macular degeneration (AMD) involves a progressive impairment of the outer layers in the center of the retina. Experimental studies have demonstrated that bright light preferentially damages precisely the region that degenerates in AMD. The evidence that solar radiation is responsible for some of the deteri...

    journal_title:Survey of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/0039-6257(88)90174-9

    authors: Young RW

    更新日期:1988-01-01 00:00:00