Normal and pathological mechanisms in retinal vascular development.

Abstract:

:Angiogenesis is a complex biologic process that occurs normally in development and in turnover and remodeling of mature vascular networks. Pathological angiogenesis and neovascularization occur in association with retinal and ocular ischemic diseases, in retinopathy of prematurity and other developmental disorders, and in tumor growth and metastasis. We describe current understanding of cellular and molecular mechanisms of retinal vascular development, highlighting aspects that relate to eye diseases, that provide sites of therapeutic intervention in ophthalmology and that are potential avenues for research.

journal_name

Surv Ophthalmol

journal_title

Survey of ophthalmology

authors

Gariano RF,Kalina RE,Hendrickson AE

doi

10.1016/s0039-6257(96)82014-5

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

481-90

issue

6

eissn

0039-6257

issn

1879-3304

pii

S0039-6257(96)82014-5

journal_volume

40

pub_type

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