Abstract：
:Adjunctive therapy for the management of glaucoma is commonly used. Unfixed combinations of the prostaglandin analog latanoprost and other glaucoma medications have been demonstrated to effectively lower intraocular pressure (IOP). The range of reported additional reductions in IOP compared to a monotherapy baseline are as follows: latanoprost-timolol (13-37%), latanoprost-pilocarpine 2% (7-14%), latanoprost and carbonic anhydrase inhibitors (15-24.1%), and latanoprost and dipivefrin (15-28%). There is a fixed combination of latanoprost (0.005%) and timolol (0.5%) that has been investigated in Phase III trials in Europe and the United States. In these trials, it was noted that the efficacy of the fixed combination was superior to either of the monotherapy components. After 12 months of follow-up of patients on fixed combination, there was no evidence of long-term drift. The new formulation appears to be safe and does not demonstrate any more side effects than either of the components. The convenience of a fixed combination may enhance patient compliance. Unfixed combination therapy with latanoprost and other antiglaucoma medications and the fixed combination formulation of latanoprost and timolol provide an effective and safe option for lowering IOP in glaucoma patients.
journal_name
Surv Ophthalmoljournal_title
Survey of ophthalmologyauthors
Higginbotham EJ,Diestelhorst M,Pfeiffer N,Rouland JF,Alm Adoi
10.1016/s0039-6257(02)00295-3subject
Has Abstractpub_date
2002-08-01 00:00:00pages
S133-40eissn
0039-6257issn
1879-3304pii
S0039625702002953journal_volume
47 Suppl 1pub_type
杂志文章,评审abstract：:Oxidative stress is one of the main mechanisms of lens opacification, and certain nutritional antioxidants are suspected to have a protective effect. To examine the role of these nutritional antioxidants on cataract prevention, we searched major databases and reviewed current evidence regarding the protective effect o...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,meta分析
doi：10.1016/j.survophthal.2019.03.003
更新日期：2019-01-01 00:00:00
abstract：:Viral conjunctivitis caused by adenovirus is the most common infectious conjunctivitis. Adenoviruses are highly contagious pathogens. The modes of transmission are mainly through hand to eye contact, ocular secretions, respiratory droplets, and contact with ophthalmic care providers and their medical instruments. The ...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.survophthal.2015.04.001
更新日期：2015-09-01 00:00:00
abstract：:Angle-closure glaucoma is a leading cause of irreversible blindness. Diagnosis and treatment are intricately related to angle assessment techniques. This article reviews the literature on angle assessment and provides recommendations about optimal techniques based on the published evidence. Specifically, we review gon...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.survophthal.2007.10.012
更新日期：2008-05-01 00:00:00
abstract：:Orbital aspergillosis is an uncommon but serious infection that may first present to the ophthalmologist. Usually arising from the paranasal sinuses, it may present in manifold ways within the orbit. Some presentations, such as optic nerve involvement, can respond to systemic corticosteroids, leading to delays in diag...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0039-6257(96)80004-x
更新日期：1996-09-01 00:00:00
abstract：:A 74-year-old woman experienced chronic painless progressive binocular horizontal diplopia for 2 years. Initial examination showed a visual acuity of 20/20 OU. External and slit lamp examination was unremarkable. Orthoptic evaluation showed an incomitant esotropia, a small vertical strabismus, and a large degree of ex...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.survophthal.2018.10.006
更新日期：2019-01-01 00:00:00
abstract：:Retinitis pigmentosa is a clinically and genetically heterogeneous group of hereditary disorders in which there is progressive loss of photoreceptor and pigment epithelial function. The prevalence of retinitis pigmentosa is between 1/3000 and 1/5000 making it one of the most common causes of visual impairment in all a...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/0039-6257(88)90085-9
更新日期：1988-11-01 00:00:00
abstract：:Ocular tissues, like those of other organs, exhibit limited morphologic reactions to trauma, i.e., hyperemia, abrupt vasodilation, increased blood flow; increased permeability of blood vessels, edema and increased tissue pressure (disrupted blood-ocular barrier); and later, a cellular inflammatory response. The cystoi...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/0039-6257(84)90236-4
更新日期：1984-05-01 00:00:00
abstract：:The onset of scleral necrosis after ocular surgery may have catastrophic ocular and systemic consequences. The two most frequent surgeries causing surgically-induced scleral necrosis (SISN) are pterygium excision and cataract extraction. Several pathogenic mechanisms are involved in surgically induced scleral necrosis...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.survophthal.2020.12.008
更新日期：2021-01-07 00:00:00
abstract：:The practical value of any therapy depends upon a combination of effectiveness of the agent (or procedure) and the extent to which the patient complies in its proper administration. Thus, it might be said that the multiple of effectiveness times compliance equals the "usefulness product." Among the various glaucoma th...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/0039-6257(79)90236-4
更新日期：1979-05-01 00:00:00
abstract：:Pyogenic granulomas are vasoproliferative, inflammatory lesions composed of granulation tissue, which occur on cutaneous or mucosal tissues, often arising secondary to other processes such as trauma or infection. Conjunctival pyogenic granulomas are not rare, but corneal involvement is very unusual and can occasionall...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/0039-6257(84)90204-2
更新日期：1984-11-01 00:00:00
abstract：:Functional magnetic resonance imaging (fMRI) is a powerful, non-invasive technique for mapping human brain function. Because of the robust signal intensity changes associated with visual stimuli, fMRI is particularly useful for studying visual cortex (including both striate and extrastriate cortex). Also, activation o...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0039-6257(02)00356-9
更新日期：2002-11-01 00:00:00
abstract：:To diagnose the cause of chronic unilateral external ocular inflammation, the physician must take into account many factors usually not considered in bilateral cases. We report on the diagnosis and treatment of ten unilateral cases encompassing a variety of ocular and systemic problems. The purpose of this report is t...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/0039-6257(79)90019-5
更新日期：1979-11-01 00:00:00
abstract：:The Polymerase Chain Reaction (PCR) is a highly innovative technique which allows for the generation of large amounts of DNA starting from minute quantities obtained from the blood or tissue of a patient. With the increasing knowledge concerning the structure of the human genome and the potential to amplify specific s...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0039-6257(96)00004-5
更新日期：1997-01-01 00:00:00
abstract：:Congenital corneal anesthesia is a rare clinical entity that poses a diagnostic dilemma, particularly in the pediatric age group. The sensory deficit may be confined to the cornea, or extend to other divisions of the trigeminal nerve. The sensory deficit may occur as an isolated abnormality, as part of a complex neuro...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.survophthal.2006.10.004
更新日期：2007-01-01 00:00:00
abstract：:Selective laser trabeculoplasty (SLT) is a relatively new type of laser used in treating open-angle glaucoma (OAG) and is reported to be equally efficacious to a first-line medication and argon laser trabeculoplasty (ALT). We summarize available evidence for considering SLT as an alternative treatment in OAG through s...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.survophthal.2014.06.006
更新日期：2015-01-01 00:00:00
abstract：:An analytical review of the data available in the field of phakic intraocular lens implantation was conducted. Particular attention was paid to the more critical issues of intraocular lens sizing and safety guidelines. A comprehensive, competitive analysis of different implantation sites, intraocular lens model design...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.survophthal.2005.08.011
更新日期：2005-11-01 00:00:00
abstract：PURPOSE:The angiostatic cortisene anecortave acetate was evaluated in three safety and efficacy studies of patients with subfoveal choroidal neovascularization secondary to exudative age-related macular degeneration. METHODS:The Anecortave Acetate Monotherapy Trial enrolled 128 patients randomized to anecortave acetat...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.survophthal.2006.11.005
更新日期：2007-01-01 00:00:00
abstract：:There are numerous unresolved issues and controversies regarding the management of open-globe injuries involving the posterior segment. These areas include, but are not limited to, the following issues. Although vitrectomy has been shown to improve visual outcomes and allow retention of the eye in many cases, the exte...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0039-6257(99)00104-6
更新日期：1999-11-01 00:00:00
abstract：:The need of blood flow to different organs varies rapidly over time which is why there is sophisticated local regulation of blood flow. The term dysregulation simply means that blood flow is not properly adapted to this need. Dysregulative mechanisms can lead to an over- or underperfusion. A steady overperfusion may b...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.survophthal.2007.08.010
更新日期：2007-11-01 00:00:00
abstract：:The only Confederate president, Jefferson Davis, led a long and eventful life. He was a Mississippi planter, a husband, a father, West Point graduate, war hero, congressman, senator, secretary of war, and finally President of the Confederate States of America. In many ways he was a study of contrast with his northern ...
journal_title：Survey of ophthalmology
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.survophthal.2006.08.007
更新日期：2006-11-01 00:00:00
abstract：:Proliferative vitreoretinopathy (PVR) is still the most common cause of failure of surgery for rhegmatogenous retinal detachment, despite the substantial effort that has been devoted to better understanding and managing this condition during the past 25 years. Basic research has indicated that PVR represents scarring,...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0039-6257(98)00023-x
更新日期：1998-07-01 00:00:00
abstract：:Detachment of the retinal pigment epithelium is a prominent feature of many chorio-retinal disease processes, the most prevalent of which is age-related macular degeneration (AMD). Detachment of the retinal pigment epithelium may or may not be associated with choroidal neovascularization and may be caused by different...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.survophthal.2007.02.008
更新日期：2007-05-01 00:00:00
abstract：:Ocular hypertension (intraocular pressure greater than or equal to 21 mm Hg, normal visual fields, normal optic discs, open angles, and the absence of any contributing ocular disease) occurs in 4-10% of the population over age 40. The question of whether to treat ocular hypertensive patients remains controversial. The...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/0039-6257(83)90136-4
更新日期：1983-12-01 00:00:00
abstract：:Jules Gonin's former student presents a personal and historical biography of the Swiss ophthalmologist, who, between 1902 and 1921, explored and illustrated the many unknown aspects of retinal detachment, defined its pathogenesis, and developed the method of reattachment by ignipuncture and thermocautery. ...
journal_title：Survey of ophthalmology
pub_type： 传,历史文章,杂志文章
doi：10.1016/0039-6257(76)90125-9
更新日期：1976-11-01 00:00:00
abstract：:Several Greek and Byzantine sovereigns are known in history by nicknames that are of ophthalmologic origin; the sobriquets derive from characteristics of their eyes or their actions in relation to the eyes. The first was Antigonos I Monophthalmus (the One-eyed), who was the most eminent successor of Alexander the Grea...
journal_title：Survey of ophthalmology
pub_type： 历史文章,杂志文章
doi：10.1016/s0039-6257(99)00039-9
更新日期：1999-07-01 00:00:00
abstract：:The goal of this review is to present the current knowledge on specific growth factor involvement in posterior segment eye disease. Growth factors can be defined as multifunctional signals which modify cell growth or proliferation, alone or in concert, by binding to specific cell surface receptors. Their biological ef...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/0039-6257(92)90115-a
更新日期：1992-03-01 00:00:00
abstract：:Suprachoroidal hemorrhage is a feared complication of all types of intraocular surgery. Although rare, it is typically associated with severe visual disability, and this has prompted efforts to better understand the pathogenesis of this condition, to identify the patients at risk for this event, and to improve treatme...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0039-6257(99)00037-5
更新日期：1999-05-01 00:00:00
abstract：:A 32-year-old woman experienced dizziness and headache for 5 months. She also complained of painless, progressive bilateral visual loss for several weeks. Before developing the initial symptoms, she had an uncomplicated pregnancy except for dizziness and systemic hypotension during the first term. Fundus examination d...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.survophthal.2017.03.001
更新日期：2018-01-01 00:00:00
abstract：:Based on their mechanism of action, the most frequently used ocular hypertensive agents, the beta-blockers, cannot be assumed to reduce IOP during sleep. The need for drugs that reduce IOP around-the-clock is underscored, however, by the fact that inadequate nocturnal ocular perfusion pressure is considered to be one ...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0039-6257(97)80021-5
更新日期：1997-02-01 00:00:00
abstract：:There are few records detailing the techniques and tribulations of early American surgeons who dared venture into the treacherous recess of the human orbit. The authors present a recently discovered letter written by a young woman who in 1841 underwent an orbital operation performed by the prominent New York City surg...
journal_title：Survey of ophthalmology
pub_type： 传,历史文章,杂志文章
doi：10.1016/0039-6257(88)90163-4
更新日期：1988-09-01 00:00:00
