Abstract：
PURPOSE:The angiostatic cortisene anecortave acetate was evaluated in three safety and efficacy studies of patients with subfoveal choroidal neovascularization secondary to exudative age-related macular degeneration. METHODS:The Anecortave Acetate Monotherapy Trial enrolled 128 patients randomized to anecortave acetate (3 mg, 15 mg, or 30 mg) or vehicle administered as a sub-Tenon's posterior juxtascleral depot (PJD) at 6-month intervals. The Anecortave Acetate and photodynamic therapy (PDT) with verteporfin Combination Trial enrolled 136 patients randomized to PDT with verteporfin followed by a single depot administration of anecortave acetate (15 mg or 30 mg) or vehicle. The Anecortave Acetate 15 mg versus PDT Comparison Trial enrolled 530 patients to receive either anecortave acetate 15 mg every 6 months + sham PDT every 3 months or PDT with verteporfin every 3 months + sham PJD administration every 6 months. RESULTS:Anecortave acetate 15 mg was statistically superior to vehicle in the monotherapy trial at both 12 and 24 months for maintenance of vision and inhibition of CNV lesion growth. In the combination trial, a trend favored adding either anecortave acetate 15 mg or 30 mg to PDT for these two measures of clinical efficacy, but this short-duration study did not achieve statistical significance. Anecortave acetate 15 mg is comparable to PDT for maintaining vision over the 24-month period in the comparison trial. CONCLUSIONS:Anecortave acetate is safe and effective treatment for exudative age-related macular degeneration.
journal_name
Surv Ophthalmoljournal_title
Survey of ophthalmologyauthors
Russell SR,Hudson HL,Jerdan JA,Anecortave Acetate Clinical Study Group.doi
10.1016/j.survophthal.2006.11.005subject
Has Abstractpub_date
2007-01-01 00:00:00pages
S79-90eissn
0039-6257issn
1879-3304pii
S0039-6257(06)00227-Xjournal_volume
52 Suppl 1pub_type
杂志文章,评审abstract：:Orbital aspergillosis is an uncommon but serious infection that may first present to the ophthalmologist. Usually arising from the paranasal sinuses, it may present in manifold ways within the orbit. Some presentations, such as optic nerve involvement, can respond to systemic corticosteroids, leading to delays in diag...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0039-6257(96)80004-x
更新日期：1996-09-01 00:00:00
abstract：:This review comprises brief discussions of the epidemiology, clinical manifestations, laboratory features, and treatment of the oculogenital diseases as they appear typically in the newborn infant, the child, and the adult. Inclusion conjunctivitis is the most frequently occurring oculogenital infection in all three c...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/0039-6257(76)90223-x
更新日期：1976-01-01 00:00:00
abstract：:The possible applications of biofeedback to the treatment of ophthalmologic disorders is reviewed. Studies have suggested utility in the management of blepharospasms, strabismus, nystagmus, and other eye movement disorders as well as the training of voluntary control of accommodation. Limitations of the current litera...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/0039-6257(83)90195-9
更新日期：1983-05-01 00:00:00
abstract：:The use of intravitreal (IVT) corticosteroids for treatment of posterior segment diseases has increased significantly over the last decade. A commonly recognized complication of IVT steroids is secondary ocular hypertension (OHT) that can occur immediately secondary to direct intraocular volume increase or weeks to mo...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.survophthal.2012.08.003
更新日期：2013-07-01 00:00:00
abstract：:A case is presented of a 16-year-old anticoagulated, immunocompromised male presenting with a blind, proptotic left eye, total ophthalmoplegia, and central retinal artery occlusion. Ophthalmic examination revealed other features of the orbital apex syndrome. Mucormycosis misdiagnosed as a traumatic orbital hemorrhage ...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/0039-6257(87)90106-8
更新日期：1987-09-01 00:00:00
abstract：:Glaucoma is often characterized by decreased pressure-sensitive aqueous outflow through the trabecular meshwork. This defect in pressure-sensitive aqueous outflow is evident from the low tonographic facility of outflow ("C") measured in many patients. The impairment in outflow facility causes the high intraocular pres...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0039-6257(03)00003-1
更新日期：2003-04-01 00:00:00
abstract：:Acanthamoeba species are an important cause of microbial keratitis that may cause severe ocular inflammation and visual loss. The first cases were recognized in 1973, but the disease remained very rare until the 1980s, when an increase in incidence mainly associated with contact lens wear was reported. There is an inc...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0039-6257(98)00004-6
更新日期：1998-05-01 00:00:00
abstract：:Primary angle-closure glaucoma is a major cause of blindness worldwide. It is a disease of ocular anatomy that is related to pupillary-block and angle-crowding mechanisms of filtration angle closure. Eyes at increased risk for primary angle-closure are small with decreased axial length, anterior chamber depth, and fil...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.survophthal.2008.12.002
更新日期：2009-03-01 00:00:00
abstract：:Glaucomatous optic neuropathy implies loss of retinal ganglion cells, including their axons, and a major tissue remodeling, especially in the optic nerve head. Although increased intraocular pressure is a major risk factor for glaucomatous optic neuropathy, there is little doubt that other factors such as ocular blood...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.survophthal.2008.06.006
更新日期：2008-09-01 00:00:00
abstract：:An analytical review of the data available in the field of phakic intraocular lens implantation was conducted. Particular attention was paid to the more critical issues of intraocular lens sizing and safety guidelines. A comprehensive, competitive analysis of different implantation sites, intraocular lens model design...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.survophthal.2005.08.011
更新日期：2005-11-01 00:00:00
abstract：:Optic nerve hemangioblastoma is a rare tumor that is usually unilateral and most commonly occurs in the context of von Hippel-Lindau disease. Differential diagnosis is based on clinical history and imaging. Magnetic resonance imaging with gadolinium enhancement is the most useful imaging modality as it can reveal flow...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.survophthal.2018.10.002
更新日期：2019-01-01 00:00:00
abstract：:Optic disk imaging is integral to the diagnosis and treatment of patients with glaucoma. We discuss the various forms of imaging the optic nerve, including ophthalmoscopy, photography, and newer imaging modalities, including optical coherence tomography (OCT), confocal scanning laser ophthalmoscopy (HRT), and scanning...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.survophthal.2013.10.004
更新日期：2014-07-01 00:00:00
abstract：:Invasive mucoepidermoid carcinoma of the conjunctiva of the left lower eyelid was diagnosed in an orbital exenteration specimen of a 57-year-old woman, after a biopsy of the same lesion was originally diagnosed as invasive squamous cell carcinoma. The woman was undergoing mitomycin C injections for ocular cicatricial ...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.survophthal.2006.06.012
更新日期：2006-09-01 00:00:00
abstract：:The Statue of Freedom, which sits on top of the Capitol Dome in Washington, DC, was created by Thomas Crawford. At the peak of his career in 1856, while busy completing multiple commissions for the new Capitol extensions, he developed diplopia and consulted the leading oculists of the time in Paris, Drs. Desmarres and...
journal_title：Survey of ophthalmology
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.survophthal.2014.11.003
更新日期：2015-07-01 00:00:00
abstract：:Disorders of the orbit can secondarily involve the eye. Although nonspecific, changes which can be noted on funduscopic examination including abnormalities of the retina, choroid, and optic nerve, can be secondary to an underlying orbital process. Awareness of these findings and their association with orbital disease ...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0039-6257(95)80043-3
更新日期：1995-07-01 00:00:00
abstract：:Most of current concepts for a visual prosthesis are based on neuronal electrical stimulation at different locations along the visual pathways within the central nervous system. The different designs of visual prostheses are named according to their locations (i.e., cortical, optic nerve, subretinal, and epiretinal). ...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0039-6257(02)00311-9
更新日期：2002-07-01 00:00:00
abstract：:The introduction of the concept of blood-ocular barriers in the ophthalmic literature is briefly reviewed. Two main blood-ocular barriers are proposed: the blood-aqueous barrier and the blood-retinal barrier. The blood-aqueous barrier is formed by an epithelial barrier located in the nonpigmented layer of the ciliary ...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/0039-6257(79)90158-9
更新日期：1979-03-01 00:00:00
abstract：:The practical value of any therapy depends upon a combination of effectiveness of the agent (or procedure) and the extent to which the patient complies in its proper administration. Thus, it might be said that the multiple of effectiveness times compliance equals the "usefulness product." Among the various glaucoma th...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/0039-6257(79)90236-4
更新日期：1979-05-01 00:00:00
abstract：:A 24-year-old woman with acute optic neuritis is presented. Appropriate management and treatment of this case using the Optic Neuritis Treatment Trial guidelines and an evaluation of the cost involved is discussed. ...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0039-6257(97)00117-3
更新日期：1998-01-01 00:00:00
abstract：:A 47-year-old woman presented with a medial orbital tumor initially diagnosed as either a myxoid neurofibroma or myoepithelioma. Over 30 years the tumor recurred seven times and was serially debulked. Careful histopathologic analysis coupled with immunohistochemical studies performed on the last two biopsies establish...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.survophthal.2014.12.002
更新日期：2015-03-01 00:00:00
abstract：:There are numerous unresolved issues and controversies regarding the management of open-globe injuries involving the posterior segment. These areas include, but are not limited to, the following issues. Although vitrectomy has been shown to improve visual outcomes and allow retention of the eye in many cases, the exte...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0039-6257(99)00104-6
更新日期：1999-11-01 00:00:00
abstract：:Leiomyoma of the ciliary body is a rare tumor that often causes a diagnostic dilemma. Sclerouvectomy has been found to be beneficial in the management of iris and ciliary body leiomyoma. We treated a case of leiomyoma of the ciliary body presenting as a fleshy mass in the anterior chamber, removed by partial lamellar ...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0039-6257(99)00114-9
更新日期：2000-01-01 00:00:00
abstract：:The optical considerations of intraocular lenses can be understood, using only the formulae and principles taught in a typical basic science course in ophthalmology. Some of the more common optical problems associated with intraocular lenses are presented and the methods for their solutions are illustrated and explain...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/0039-6257(79)90146-2
更新日期：1979-07-01 00:00:00
abstract：:A 47-year-old man presented with sudden visual loss, optic disk edema, retinal ischemia, and limited upgaze in the left eye. Initial MRI revealed thickened, enhancing left optic nerve. Extensive work-up for an inflammatory and infiltrative etiology was positive only for Borrelia burgdorferi IgM by Western blot. Six we...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.survophthal.2013.12.003
更新日期：2014-09-01 00:00:00
abstract：:Despite the improving results that have been noted with penetrating keratoplasty, graft failure remains a significant problem. The causes of graft failure are quite varied. Primary donor failure, surgical complications, intraocular lens complications, persistent epithelial defects, allograft rejection, infection, glau...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/0039-6257(90)90110-h
更新日期：1990-03-01 00:00:00
abstract：:Latent herpes simplex virus (HSV) is known to reside in the trigeminal ganglia. Our studies show that the temporary retrobulbar disruption of trigeminal nerve function in chronically infected animals caused a striking decrease in the number of positive HSV cultures obtained during the 20 weeks immediately following su...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/0039-6257(76)90098-9
更新日期：1976-09-01 00:00:00
abstract：:Medication errors are a frequent cause of medical malpractice claims. Because serious injury often results, medication errors can be costly to defend, indemnify or settle. A review of five closed claims involving glucocorticoids, corticosteroids, antibiotics and silver nitrate offers insight into how ophthalmologists ...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0039-6257(95)80031-x
更新日期：1995-11-01 00:00:00
abstract：:A 37-year-old woman experienced painless, progressive vision loss to no light perception in the left eye over the course of 3 days. The right eye was unaffected. On examination, the only other abnormal finding was a +4 left afferent pupillary defect. She was initially diagnosed with retrobulbar optic neuritis and admi...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.survophthal.2004.02.012
更新日期：2004-05-01 00:00:00
abstract：:Glutamatergic excitotoxicity has been implicated as a mechanism for injury in a variety of central nervous system pathologies, including glaucoma. Memantine, an NMDA-type glutamatergic open-channel blocker, has pharmacologic properties that make its efficacy greater under excitotoxic conditions, but lesser under norma...
journal_title：Survey of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0039-6257(01)00200-4
更新日期：2001-05-01 00:00:00
abstract：:Age-related macular degeneration (AMD) involves a progressive impairment of the outer layers in the center of the retina. Experimental studies have demonstrated that bright light preferentially damages precisely the region that degenerates in AMD. The evidence that solar radiation is responsible for some of the deteri...
journal_title：Survey of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/0039-6257(88)90174-9
更新日期：1988-01-01 00:00:00
