Growth factors in retinal diseases: proliferative vitreoretinopathy, proliferative diabetic retinopathy, and retinal degeneration.

Abstract:

:The goal of this review is to present the current knowledge on specific growth factor involvement in posterior segment eye disease. Growth factors can be defined as multifunctional signals which modify cell growth or proliferation, alone or in concert, by binding to specific cell surface receptors. Their biological effects on cells include cell adhesion, migration, survival, differentiation, extracellular matrix secretion, protease and protease inhibitor release, production of other growth activities, and angiogenesis. Growth factors couple the cell to the microenvironment. As some growth factors are soluble mediators of wound repair and angiogenesis, it seems possible that proliferative vitreoretinopathy and proliferative diabetic retinopathy are caused or aggravated by these factors. Other factors act as survival factors and can possibly prevent retinal degeneration. The multifunctional nature of growth factors makes it probable that practical uses will be found for these agents in the future.

journal_name

Surv Ophthalmol

journal_title

Survey of ophthalmology

authors

Wiedemann P

doi

10.1016/0039-6257(92)90115-a

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

373-84

issue

5

eissn

0039-6257

issn

1879-3304

pii

0039-6257(92)90115-A

journal_volume

36

pub_type

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