Beyond the cherry-red spot: Ocular manifestations of sphingolipid-mediated neurodegenerative and inflammatory disorders.

Abstract:

:Sphingolipids are a ubiquitous membrane lipid present in every cell and found most abundantly in neural tissues. Disorders such as Tay-Sachs or Niemann-Pick disease are the most familiar examples of dysfunction in sphingolipid metabolism and are typically associated with neurodegeneration and ocular findings such as blindness. More recently, the role of bioactive sphingolipids has been established in a multitude of cellular events, including cell survival, growth, senescence and apoptosis, inflammation, and neovascularization. We discuss our current knowledge and understanding of sphingolipid metabolism and signaling in the pathogenesis of ocular diseases.

journal_name

Surv Ophthalmol

journal_title

Survey of ophthalmology

authors

Chen H,Chan AY,Stone DU,Mandal NA

doi

10.1016/j.survophthal.2013.02.005

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

64-76

issue

1

eissn

0039-6257

issn

1879-3304

pii

S0039-6257(13)00037-4

journal_volume

59

pub_type

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