Abstract:
:Sphingolipids are a ubiquitous membrane lipid present in every cell and found most abundantly in neural tissues. Disorders such as Tay-Sachs or Niemann-Pick disease are the most familiar examples of dysfunction in sphingolipid metabolism and are typically associated with neurodegeneration and ocular findings such as blindness. More recently, the role of bioactive sphingolipids has been established in a multitude of cellular events, including cell survival, growth, senescence and apoptosis, inflammation, and neovascularization. We discuss our current knowledge and understanding of sphingolipid metabolism and signaling in the pathogenesis of ocular diseases.
journal_name
Surv Ophthalmoljournal_title
Survey of ophthalmologyauthors
Chen H,Chan AY,Stone DU,Mandal NAdoi
10.1016/j.survophthal.2013.02.005subject
Has Abstractpub_date
2014-01-01 00:00:00pages
64-76issue
1eissn
0039-6257issn
1879-3304pii
S0039-6257(13)00037-4journal_volume
59pub_type
杂志文章,评审abstract::Leiomyoma of the ciliary body is a rare tumor that often causes a diagnostic dilemma. Sclerouvectomy has been found to be beneficial in the management of iris and ciliary body leiomyoma. We treated a case of leiomyoma of the ciliary body presenting as a fleshy mass in the anterior chamber, removed by partial lamellar ...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0039-6257(99)00114-9
更新日期:2000-01-01 00:00:00
abstract::A melanocytoma (magnocellular nevus) is a benign pigmented tumor that may arise wherever uveal melanocytes are present. The most commonly observed site is on or adjacent to the optic nerve head. In the past this tumor was frequently misdiagnosed as a malignant melanoma and many unnecessary enucleations were carried ou...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/0039-6257(85)90107-9
更新日期:1985-03-01 00:00:00
abstract::The effects of topical adrenergic agents on the tissue circulation of the optic nerve head (ONH) were studied in animal and human eyes with use of a laser speckle tissue circulation analyzer. Drugs studied were nipradilol, a beta1-2-blocker with weak alpha-blocking and nitroglycerinlike activities; bunazosin, a select...
journal_title:Survey of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0039-6257(97)80027-6
更新日期:1997-11-01 00:00:00
abstract::Detachment of the retinal pigment epithelium is a prominent feature of many chorio-retinal disease processes, the most prevalent of which is age-related macular degeneration (AMD). Detachment of the retinal pigment epithelium may or may not be associated with choroidal neovascularization and may be caused by different...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2007.02.008
更新日期:2007-05-01 00:00:00
abstract::With improving surgical technique and equipment, the acceptable age for placing an intraocular lens in infants and children is becoming younger. The tools for predicting intraocular lens power have not necessarily kept up, as current theoretical and regression intraocular lens power prediction formulas are largely bas...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2007.06.010
更新日期:2007-09-01 00:00:00
abstract::Optic nerve hemangioblastoma is a rare tumor that is usually unilateral and most commonly occurs in the context of von Hippel-Lindau disease. Differential diagnosis is based on clinical history and imaging. Magnetic resonance imaging with gadolinium enhancement is the most useful imaging modality as it can reveal flow...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2018.10.002
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:The angiostatic cortisene anecortave acetate was evaluated in three safety and efficacy studies of patients with subfoveal choroidal neovascularization secondary to exudative age-related macular degeneration. METHODS:The Anecortave Acetate Monotherapy Trial enrolled 128 patients randomized to anecortave acetat...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2006.11.005
更新日期:2007-01-01 00:00:00
abstract::Retinoblastoma usually presents in children younger than 5 years. To our knowledge, 20 cases of retinoblastoma in adults (older than 20 years) have been reported in the literature. Of 173 patients with histopathologically proven retinoblastoma seen in our institute, three were adults. All the patients had endophytic t...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0039-6257(99)00132-0
更新日期:2000-03-01 00:00:00
abstract::Medication errors are a frequent cause of medical malpractice claims. Because serious injury often results, medication errors can be costly to defend, indemnify or settle. A review of five closed claims involving glucocorticoids, corticosteroids, antibiotics and silver nitrate offers insight into how ophthalmologists ...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0039-6257(95)80031-x
更新日期:1995-11-01 00:00:00
abstract::Drugs across many pharmacologic classes induce corneal epithelial changes. Many of these drugs have cationic amphiphilic structures, with a hydrophobic ring and hydrophilic cationic amine side chain that allow them to cross cell membranes. These drugs lead to intracellular phospholipid accumulation, often manifested i...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2016.11.008
更新日期:2017-01-01 00:00:00
abstract::William Ellergy Briggs was California's preeminent ophthalmologist for more than fifty years. A student of Ernst Fuchs, he was a clinician, scholar, and innovator who transplanted the best of European ophthalmology to the Western United States. ...
journal_title:Survey of ophthalmology
pub_type: 传,历史文章,杂志文章
doi:10.1016/0039-6257(90)90029-u
更新日期:1990-01-01 00:00:00
abstract::Ocular myasthenia is a localized form of myasthenia clinically involving only the extraocular, levator palpebrae superioris, and/or orbicularis oculi muscles. Ocular manifestations can masquerade as a variety of ocular motility disorders, including cranial nerve and gaze palsies. A history of variable and fatiguable m...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/0039-6257(94)90194-5
更新日期:1994-11-01 00:00:00
abstract::A 55-year-old man with a history of mantle cell lymphoma reported acute blurred vision in the right eye. Although initially diagnosed with acute retrobulbar optic neuritis, 3 weeks later retinal infiltrates and vitritis developed, but vitrectomy resulted negative for vitreoretinal lymphoma. Further investigation revea...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.survophthal.2018.05.006
更新日期:2018-01-01 00:00:00
abstract::Corneal transplant surgeries have a broad range of indications with outcomes largely dependent on surgeon experience. Traditional manual techniques have certain limitations pertaining to the preparation of donor tissue and the recipient bed that might affect the predictability of visual outcomes. Use of lasers for ker...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.survophthal.2021.01.009
更新日期:2021-01-29 00:00:00
abstract::Botulinum toxin has become the initial treatment of choice for the management of essential blepharospasm, hemifacial spasm and other craniocervical dystonias. Numerous studies have confirmed a 90% to 95% response rate. Although a number of common side effects have been reported, the occurrence and incidence of rare lo...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0039-6257(97)81995-9
更新日期:1996-07-01 00:00:00
abstract::Congenital corneal anesthesia is a rare clinical entity that poses a diagnostic dilemma, particularly in the pediatric age group. The sensory deficit may be confined to the cornea, or extend to other divisions of the trigeminal nerve. The sensory deficit may occur as an isolated abnormality, as part of a complex neuro...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2006.10.004
更新日期:2007-01-01 00:00:00
abstract::Lamellar keratoplasty procedures have gained momentum in the field of corneal transplantation because of their inherent advantages over full-thickness penetrating keratoplasty. While penetrating keratoplasty is an open sky procedure fraught with sight-threatening intraoperative and postoperative complications, lamella...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2020.04.002
更新日期:2020-01-01 00:00:00
abstract::Disorders of the orbit can secondarily involve the eye. Although nonspecific, changes which can be noted on funduscopic examination including abnormalities of the retina, choroid, and optic nerve, can be secondary to an underlying orbital process. Awareness of these findings and their association with orbital disease ...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0039-6257(95)80043-3
更新日期:1995-07-01 00:00:00
abstract::Recent advances in topographic analysis have provided powerful tools for detecting subtle, but clinically significant, alterations of corneal contour. This article compares keratometry, keratoscopy, and computer-assisted topographic analysis and provides specific examples of the sensitivity of computer-assisted system...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/0039-6257(91)90047-j
更新日期:1991-01-01 00:00:00
abstract::This review comprises brief discussions of the epidemiology, clinical manifestations, laboratory features, and treatment of the oculogenital diseases as they appear typically in the newborn infant, the child, and the adult. Inclusion conjunctivitis is the most frequently occurring oculogenital infection in all three c...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/0039-6257(76)90223-x
更新日期:1976-01-01 00:00:00
abstract::The optical considerations of intraocular lenses can be understood, using only the formulae and principles taught in a typical basic science course in ophthalmology. Some of the more common optical problems associated with intraocular lenses are presented and the methods for their solutions are illustrated and explain...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/0039-6257(79)90146-2
更新日期:1979-07-01 00:00:00
abstract::Although airbags measurably reduce the overall risk of injury to adults (including eye injury), and death from motor vehicle accidents, injuries attributed to airbag deployment have been reported. To identify reported cases of ocular trauma related to airbag deployment, a MEDLINE search from 1991 to 2000 was performed...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0039-6257(01)00256-9
更新日期:2001-11-01 00:00:00
abstract::A 20-year-old Hispanic man with Down syndrome presented with progressively worsening headache, fluctuating decreased vision, and bilateral optic disk edema. Magnetic resonance imaging of the head showed an empty sella, and magnetic resonance venography showed thrombosis of left transverse and sigmoid sinuses. Catheter...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.survophthal.2012.10.005
更新日期:2013-11-01 00:00:00
abstract::Viral conjunctivitis caused by adenovirus is the most common infectious conjunctivitis. Adenoviruses are highly contagious pathogens. The modes of transmission are mainly through hand to eye contact, ocular secretions, respiratory droplets, and contact with ophthalmic care providers and their medical instruments. The ...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2015.04.001
更新日期:2015-09-01 00:00:00
abstract::In the present study the relationship between intraocular pressure (IOP) and pulsatile ocular blood flow (POBF) in low tension glaucoma (LTG) has been investigated. The POBF was measured using the Ocular Blood Flow system of Langham in undisturbed eyes and repeated at IOP increments of about 5 and 10 mmHg in 20 patien...
journal_title:Survey of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/0039-6257(94)90064-7
更新日期:1994-05-01 00:00:00
abstract::Intraocular lens (IOL) confusions and errors are among the most common postoperative adverse events. Errors may occur at any stage from the decision to operate to the insertion of the IOL. The most common errors occur during IOL selection pre-operative preparation (anaesthesia given before recognition that the intende...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2011.12.003
更新日期:2012-09-01 00:00:00
abstract::Testicular lymphoma is a rare neoplasm of the testis that is most commonly seen in older patients. It metastasizes preferentially to extranodal sites, including the skin, central nervous system, Waldeyer ring, contralateral testis, and lung. Two case reports of patients with a history of testicular lymphoma who develo...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.survophthal.2005.11.002
更新日期:2006-01-01 00:00:00
abstract::The use of intravitreal (IVT) corticosteroids for treatment of posterior segment diseases has increased significantly over the last decade. A commonly recognized complication of IVT steroids is secondary ocular hypertension (OHT) that can occur immediately secondary to direct intraocular volume increase or weeks to mo...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.survophthal.2012.08.003
更新日期:2013-07-01 00:00:00
abstract::A macular hole is a full-thickness defect of retinal tissue involving the anatomic fovea, thereby affecting central visual acuity. Macular holes have been associated with myriad ocular conditions and originally were described in the setting of trauma. The pathogenesis of idiopathic, age-related macular holes remains u...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0039-6257(97)00132-x
更新日期:1998-03-01 00:00:00
abstract::Electrophysiological research on acquired retinal disorders, both common and rare, is reviewed. Age is a major factor influencing electroretinogram (ERG) and electro-oculogram (EOG) findings. Bipolar or Müller cell death in the aging retina could account for much of the amplitude decline that is observed with age. In ...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0039-6257(00)00125-9
更新日期:2000-07-01 00:00:00