Abstract:
:Lamellar keratoplasty procedures have gained momentum in the field of corneal transplantation because of their inherent advantages over full-thickness penetrating keratoplasty. While penetrating keratoplasty is an open sky procedure fraught with sight-threatening intraoperative and postoperative complications, lamellar keratoplasties are relatively closed-system procedures that involve selective removal and replacement of diseased corneal layers and are free from these complications. Anterior lamellar procedures involve partial or lamellar replacement of anterior stroma and reduce the risk of graft rejection, retain structural integrity, and require less stringent donor criteria. Posterior lamellar procedures involve removal of the affected endothelium in eyes with relatively unaffected stroma. These procedures are associated with improved safety profile, accelerated wound healing, structurally stronger globe, and minimal astigmatism, thereby producing faster visual rehabilitation and timely initiation of amblyopia therapy in children. Although the use of lamellar grafts is increasing in adults, their relatively slower adoption in pediatric population is attributable to the steep learning curve and lack of long-term follow-up data. We describe the challenges associated with these procedures and their outcomes in pediatric eyes.
journal_name
Surv Ophthalmoljournal_title
Survey of ophthalmologyauthors
Sharma N,Agarwal R,Jhanji V,Bhaskar S,Kamalakkannan P,Nischal KKdoi
10.1016/j.survophthal.2020.04.002subject
Has Abstractpub_date
2020-01-01 00:00:00pages
675-690issue
6eissn
0039-6257issn
1879-3304pii
S0039-6257(20)30068-0journal_volume
65pub_type
杂志文章,评审abstract::Epidermal growth factor (EGF) is a naturally occurring mitogen which, in its recombinant form, is under intensive investigation for therapeutic use. Receptor activation by EGF induces up-regulation of synthesis of specific proteins as well as proliferation and differentiation of the corneal epithelium, keratocytes, an...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/0039-6257(90)90127-h
更新日期:1990-05-01 00:00:00
abstract::Optic disk imaging is integral to the diagnosis and treatment of patients with glaucoma. We discuss the various forms of imaging the optic nerve, including ophthalmoscopy, photography, and newer imaging modalities, including optical coherence tomography (OCT), confocal scanning laser ophthalmoscopy (HRT), and scanning...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.survophthal.2013.10.004
更新日期:2014-07-01 00:00:00
abstract::Ocular tissues, like those of other organs, exhibit limited morphologic reactions to trauma, i.e., hyperemia, abrupt vasodilation, increased blood flow; increased permeability of blood vessels, edema and increased tissue pressure (disrupted blood-ocular barrier); and later, a cellular inflammatory response. The cystoi...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/0039-6257(84)90236-4
更新日期:1984-05-01 00:00:00
abstract::Pseudoxanthoma elasticum is an autosomally inherited disorder that is associated with the accumulation of mineralized and fragmented elastic fibers in the skin, Bruch's membrane in the retina, and vessel walls. The ophthalmic and dermatologic expression of pseudoxanthoma elasticum and its vascular complications are he...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0039-6257(03)00053-5
更新日期:2003-07-01 00:00:00
abstract::Corneal transplant surgeries have a broad range of indications with outcomes largely dependent on surgeon experience. Traditional manual techniques have certain limitations pertaining to the preparation of donor tissue and the recipient bed that might affect the predictability of visual outcomes. Use of lasers for ker...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.survophthal.2021.01.009
更新日期:2021-01-29 00:00:00
abstract::Drugs across many pharmacologic classes induce corneal epithelial changes. Many of these drugs have cationic amphiphilic structures, with a hydrophobic ring and hydrophilic cationic amine side chain that allow them to cross cell membranes. These drugs lead to intracellular phospholipid accumulation, often manifested i...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2016.11.008
更新日期:2017-01-01 00:00:00
abstract::The presence of retinal vasculopathy in the absence of typical predisposing factors should suggest a possible underlying hematologic abnormality. In such cases, a systemic investigation may reveal a potentially fatal hypercoagulability or hyperviscosity syndrome. Retinal vein occlusion is the most commonly encountered...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2015.10.006
更新日期:2016-03-01 00:00:00
abstract::Based on their mechanism of action, the most frequently used ocular hypertensive agents, the beta-blockers, cannot be assumed to reduce IOP during sleep. The need for drugs that reduce IOP around-the-clock is underscored, however, by the fact that inadequate nocturnal ocular perfusion pressure is considered to be one ...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0039-6257(97)80021-5
更新日期:1997-02-01 00:00:00
abstract::A 32-year-old woman experienced dizziness and headache for 5 months. She also complained of painless, progressive bilateral visual loss for several weeks. Before developing the initial symptoms, she had an uncomplicated pregnancy except for dizziness and systemic hypotension during the first term. Fundus examination d...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.survophthal.2017.03.001
更新日期:2018-01-01 00:00:00
abstract::Autosomal dominant optic atrophy is an inherited optic neuropathy manifesting with variable penetrance and expressivity. Other genetic and environmental factors are postulated to contribute to more marked visual loss in some affected individuals. Optic neuropathy is also a known adverse effect of ethambutol therapy fo...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.survophthal.2009.10.005
更新日期:2010-07-01 00:00:00
abstract::Disorders of the orbit can secondarily involve the eye. Although nonspecific, changes which can be noted on funduscopic examination including abnormalities of the retina, choroid, and optic nerve, can be secondary to an underlying orbital process. Awareness of these findings and their association with orbital disease ...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0039-6257(95)80043-3
更新日期:1995-07-01 00:00:00
abstract::The purpose of this review is to present the recent evidence linking the family of ubiquitous proteases called calpains (EC 3.4.22.17) to neuropathologies of the retina. The hypothesis being tested in such studies is that over-activation of calpains by elevated intracellular calcium contributes to retinal cell death p...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2007.12.006
更新日期:2008-03-01 00:00:00
abstract::A total of 85 eyes (75 patients) with pseudogliomas (i.e., certain conditions which simulate retinoblastoma, were examined histopathologically to determine the incidence of rubeosis iridis. Neovascularization of the anterior surface of the iris was found in 70 eyes (82%). The principal associated changes in these eyes...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/0039-6257(80)90151-4
更新日期:1980-09-01 00:00:00
abstract::Ocular hypertension (intraocular pressure greater than or equal to 21 mm Hg, normal visual fields, normal optic discs, open angles, and the absence of any contributing ocular disease) occurs in 4-10% of the population over age 40. The question of whether to treat ocular hypertensive patients remains controversial. The...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/0039-6257(83)90136-4
更新日期:1983-12-01 00:00:00
abstract::Lymphoma of the eyelid constitutes 5% of ocular adnexal lymphoma. In previously published cases, 56% of lymphomas of the eyelid are of B-cell origin and 44% are of T-cell origin. The most frequent B-cell lymphomas are extranodal marginal zone lymphoma (27 cases-14%) and diffuse large B-cell lymphoma (18 cases-9%). T-c...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2016.11.009
更新日期:2017-01-01 00:00:00
abstract::A 24-year-old man experienced the sudden onset of a painless superior-temporal visual field defect of the left eye. Fundoscopy showed peripapillary pigmentary changes and a few nasal retinal white spots. Automated perimetry demonstrated an enlarged blind spot. The differential diagnosis of the various presumed inflamm...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.survophthal.2004.12.003
更新日期:2005-03-01 00:00:00
abstract::Scleritis is typically a severe painful inflammatory process centered in the sclera that may involve the cornea, adjacent episclera, and underlying uvea; it poses a significant threat to vision. Careful clinical history taking, detailed ocular examination, appropriate investigation for ocular disease with or without u...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2005.04.001
更新日期:2005-07-01 00:00:00
abstract::A 55-year-old man with a history of mantle cell lymphoma reported acute blurred vision in the right eye. Although initially diagnosed with acute retrobulbar optic neuritis, 3 weeks later retinal infiltrates and vitritis developed, but vitrectomy resulted negative for vitreoretinal lymphoma. Further investigation revea...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.survophthal.2018.05.006
更新日期:2018-01-01 00:00:00
abstract::Proliferative vitreoretinopathy (PVR) is still the most common cause of failure of surgery for rhegmatogenous retinal detachment, despite the substantial effort that has been devoted to better understanding and managing this condition during the past 25 years. Basic research has indicated that PVR represents scarring,...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0039-6257(98)00023-x
更新日期:1998-07-01 00:00:00
abstract::The possible applications of biofeedback to the treatment of ophthalmologic disorders is reviewed. Studies have suggested utility in the management of blepharospasms, strabismus, nystagmus, and other eye movement disorders as well as the training of voluntary control of accommodation. Limitations of the current litera...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/0039-6257(83)90195-9
更新日期:1983-05-01 00:00:00
abstract::A case is presented of a 16-year-old anticoagulated, immunocompromised male presenting with a blind, proptotic left eye, total ophthalmoplegia, and central retinal artery occlusion. Ophthalmic examination revealed other features of the orbital apex syndrome. Mucormycosis misdiagnosed as a traumatic orbital hemorrhage ...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/0039-6257(87)90106-8
更新日期:1987-09-01 00:00:00
abstract::In the present study the relationship between intraocular pressure (IOP) and pulsatile ocular blood flow (POBF) in low tension glaucoma (LTG) has been investigated. The POBF was measured using the Ocular Blood Flow system of Langham in undisturbed eyes and repeated at IOP increments of about 5 and 10 mmHg in 20 patien...
journal_title:Survey of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/0039-6257(94)90064-7
更新日期:1994-05-01 00:00:00
abstract::Several Greek and Byzantine sovereigns are known in history by nicknames that are of ophthalmologic origin; the sobriquets derive from characteristics of their eyes or their actions in relation to the eyes. The first was Antigonos I Monophthalmus (the One-eyed), who was the most eminent successor of Alexander the Grea...
journal_title:Survey of ophthalmology
pub_type: 历史文章,杂志文章
doi:10.1016/s0039-6257(99)00039-9
更新日期:1999-07-01 00:00:00
abstract::Advances in immunology, particularly ocular immunology, have been accompanied by the emergence of safer, more specific immunosuppressive drugs, notably, cyclophosphamide, chlorambucil, methotrexate, azathioprine, cyclosporine A, bromocriptine, dapsone, and colchicine. These drugs have become an important, and often es...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/0039-6257(91)90186-j
更新日期:1991-03-01 00:00:00
abstract::A 63-year-old man developed bilateral conjunctival injection and irritation followed by periocular discomfort and diplopia. Within weeks left proptosis and intermittent fever were noted. Orbital CT scan showed bilateral nodular enlargement of multiple extraocular muscles. Fine needle aspiration biopsy of the extraocul...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/0039-6257(88)90087-2
更新日期:1988-11-01 00:00:00
abstract::In the current medical environment, long-standing and appropriate referral patterns among medical care providers may be scrutinized for possible violation of a technical provision of Medicare, the "anti-fraud and abuse statute." The physician can avoid misunderstanding by preparing and implementing a compliance progra...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0039-6257(99)90134-0
更新日期:2000-05-01 00:00:00
abstract::Angle-closure glaucoma is a leading cause of irreversible blindness. Diagnosis and treatment are intricately related to angle assessment techniques. This article reviews the literature on angle assessment and provides recommendations about optimal techniques based on the published evidence. Specifically, we review gon...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2007.10.012
更新日期:2008-05-01 00:00:00
abstract::Bilateral disk swelling and marked peripapillary and macular exudates were found on routine ophthalmologic examination in a 12 1/2-year-old girl. Eleven months later, with persistent findings, her blood pressure was found to be extremely elevated. She had an Ask-Upmark kidney, a rare form of segmental renal hypoplasia...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0039-6257(97)00016-7
更新日期:1997-05-01 00:00:00
abstract::The court decisions included in this article reflect judicial attitudes towards medicolegal cases in most states. The courts have defined and amplified issues of informed consent, the physician's duty to warn patients and protect third parties, the limitations of the "Good Samaritan" statute, the responsibility of the...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/0039-6257(87)90071-3
更新日期:1987-07-01 00:00:00
abstract::Recent literature suggests that the incidence of postoperative endophthalmitis is variable and may be on the rise. This article reviews established perioperative preventative measures, and discusses some possible causes of postoperative endophthalmitis that may be insufficiently addressed by current risk reduction tec...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2004.01.002
更新日期:2004-03-01 00:00:00