The vascular endothelium as a regulator of the ocular circulation: a new concept in ophthalmology?

Abstract:

:The endothelium influences local vascular tone by releasing endothelium-derived relaxing factors such as nitric oxide, prostacyclin and a putative hyperpolarizing factor. In isolated ophthalmic arteries and the perfused eye, all endothelial factors importantly contribute to vascular regulation. In larger ophthalmic vessels, this is due to their effects on vascular smooth muscle cells; in smaller vessels, pericytes can be influenced as well. Contracting factors formed include peptide endothelin-1 and cyclooxygenase products, such as thromboxane A2 and prostaglandin H2. In the peripheral circulation endothelial dysfunction occurs under pathological conditions, both in conduit arteries and the microcirculation. An imbalance of endothelium-derived relaxing and contracting factors could be important for the development of vascular ophthalmic complications like hypertension, diabetes, arteriolosclerosis and retinal ischemia. Endothelial dysfunction may also contribute to vasospastic events in retinal migraine and some forms of low tension glaucoma associated with Raynaud phenomenon and migraine.

journal_name

Surv Ophthalmol

journal_title

Survey of ophthalmology

authors

Haefliger IO,Meyer P,Flammer J,Lüscher TF

doi

10.1016/0039-6257(94)90157-0

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

123-32

issue

2

eissn

0039-6257

issn

1879-3304

pii

0039-6257(94)90157-0

journal_volume

39

pub_type

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