Methylprednisolone therapy for retinal laser injury.

Abstract:

OBJECTIVE:Laser photocoagulation treatment of the posterior pole of the retina is often complicated by immediate visual impairment, which is caused by the unavoidable laser-induced destruction of the normal tissue adjacent to the lesion. A neuroprotective therapy aimed at salvaging this normal tissue might enhance the benefit obtained from treatment and permit safe perifoveal photocoagulation. To determine whether corticosteroids can provide neuroprotection during photocoagulation, we examined the effect of methylprednisolone on laser-induced retinal injury in a rat model. METHODS:Argon laser lesions were inflicted on the retinas of 36 rats and were followed immediately by intraperitoneal injections of high-dose methylprednisolone or saline. The animals were sacrificed after 3, 20, or 60 days, and their retinal lesions were evaluated histologically and morphometrically. RESULTS:No histopathologic differences were observed between the treated and control animals. Methylprednisolone treatment was demonstrated to posses some neuroprotective effect for a short time after laser exposure, but was ineffective in ameliorating the long-term results of retinal laser injury. CONCLUSIONS:On the basis of our results, we suggest that high-dose methylprednisolone treatment is ineffective in ameliorating laser-induced retinal injury. Other drugs should be investigated for their potential role as neuroprotective agents to prevent the spread of retinal laser damage.

journal_name

Surv Ophthalmol

journal_title

Survey of ophthalmology

authors

Solberg Y,Dubinski G,Tchirkov M,Belkin M,Rosner M

doi

10.1016/s0039-6257(99)00093-4

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

S85-92

eissn

0039-6257

issn

1879-3304

pii

S0039-6257(99)00093-4

journal_volume

44 Suppl 1

pub_type

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