Neurofibromatosis and neural crest neoplasms: primary acquired melanosis and malignant melanoma of the conjunctiva.

Abstract:

:With an occurrence of approximately 1 in 3000 births, von Recklinghausen neurofibromatosis (NF) is one of the most common inherited human disorders. NF is considered a neurocristopathy, a disorder of neural crest derived cells. One of the complications of NF is the development of neural crest derived malignancies such as malignant schwannoma, pheochromocytoma, and malignant melanoma of the skin and choroid. The case history of a patient with NF and conjunctival malignant melanoma which developed in an eye with primary acquired melanosis is yet another example of a neural crest malignancy developing in a NF patient.

journal_name

Surv Ophthalmol

journal_title

Survey of ophthalmology

authors

To KW,Rabinowitz SM,Friedman AH,Merker C,Cavanaugh CP

doi

10.1016/0039-6257(89)90014-3

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

373-9

issue

5

eissn

0039-6257

issn

1879-3304

pii

0039-6257(89)90014-3

journal_volume

33

pub_type

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