Orbital lymphoma associated with acquired immune deficiency syndrome (AIDS).

Abstract:

:A new case of AIDS-associated, small noncleaved cell (Burkitt's) lymphoma that presented as an orbital mass is described. Extraocular muscle involvement was documented by computed tomography and confirmed by orbital biopsy. Extensive abdominal involvement was subsequently diagnosed and this caused the patient's death only 15 days after the initial consultation and orbital biopsy. A literature review discloses only eight previous case reports of AIDS-associated non-Hodgkin's lymphoma (NHL) involving the orbit: two cases of Burkitt's type and six cases of large cell immunoblastic type. Three additional cases of orbital NHL can be found among larger series of AIDS cases. Affected patients are uniformly young adult males with a history of homosexuality and/or IV drug abuse. Variations in clinical presentation are discussed. Although the morphology of the histopathologic specimen in our case was consistent with a high-grade, small noncleaved cell NHL, flow cytometry revealed an atypical immunophenotype for Burkitt's lymphoma in that CD20 and immunoglobulin light chain antigens were not expressed. Morphologic classification and immunophenotypic characteristics of AIDS-associated NHLs are discussed.

journal_name

Surv Ophthalmol

journal_title

Survey of ophthalmology

authors

Reifler DM,Warzynski MJ,Blount WR,Graham DM,Mills KA

doi

10.1016/0039-6257(94)90075-2

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

371-80

issue

4

eissn

0039-6257

issn

1879-3304

pii

0039-6257(94)90075-2

journal_volume

38

pub_type

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