Corneal cross-linking.

Abstract:

:Since its inception in the late 1990s, corneal cross-linking has grown from an interesting concept to a primary treatment for corneal ectatic disease worldwide. Using a combination of ultraviolet-A light and a chromophore (vitamin B2, riboflavin), the cornea can be stiffened, usually with a single application, and progressive thinning diseases such as keratoconus arrested. Despite being in clinical use for many years, some of the underlying processes, such as the role of oxygen and the optimal treatment times, are still being worked out. More than a treatment technique, corneal cross-links represent a physiological principle of connective tissue, which may explain the enormous versatility of the method. We highlight the history of corneal cross-linking, the scientific underpinnings of current techniques, evolving clinical treatment parameters, and the use of cross-linking in combination with refractive surgery and for the treatment of infectious keratitis.

journal_name

Surv Ophthalmol

journal_title

Survey of ophthalmology

authors

Randleman JB,Khandelwal SS,Hafezi F

doi

10.1016/j.survophthal.2015.04.002

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

509-23

issue

6

eissn

0039-6257

issn

1879-3304

pii

S0039-6257(15)00069-7

journal_volume

60

pub_type

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