Abstract:
BACKGROUND:The first human hand allograft, performed in Lyon, France, on September 23, 1998, was removed during month 29 posttransplantation as the result of rejection because the patient did not comply with the immunosuppressive treatment. METHODS:The patient was regularly examined from the day of transplantation to amputation. Biopsies were taken from the skin of the allograft and examined immunohistologically. After amputation, various tissue specimens obtained from the allograft (including skin, tendons, bone, muscles, and joints) were studied. RESULTS:From month 15 onward, the allografted skin presented lichenoid papules that progressively spread and coalesced into diffuse erythematous-scaly lesions over the allografted hand. Histologically, these showed an aspect of chronic lichenoid cutaneous graft-versus-host disease. At the time of amputation, erosive and necrotic areas over the skin were present. Pathologic examination of the allograft showed that the most severe changes were found in the skin. Mild inflammation was found in muscles and tendons. Bones (including bone marrow) and joints were spared. CONCLUSIONS:The skin is the main target of rejection in human hand allografts. Close clinicopathologic monitoring of the skin is the most reliable way to detect rejection in human composite tissue allografts.
journal_name
Transplantationjournal_title
Transplantationauthors
Kanitakis J,Jullien D,Petruzzo P,Hakim N,Claudy A,Revillard JP,Owen E,Dubernard JMdoi
10.1097/01.TP.0000079458.81970.9Asubject
Has Abstractpub_date
2003-08-27 00:00:00pages
688-93issue
4eissn
0041-1337issn
1534-6080journal_volume
76pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Tolerogenic dendritic cells (Tol-DCs) play a critical role in inducing and maintaining tolerance. Recognizing that both T-cell inactivation and activation are contingent on signals provided by DCs and that graft-specific activated T cells are major mediators of transplant rejection, we aimed to create an env...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182007bbf
更新日期:2010-12-27 00:00:00
abstract::There is substantial evidence that increased cellular calcium may activate processes that lead to cellular injury and death, and calcium entry blockers (CEB) have been shown to protect against renal ischemic injury. This approach has been used experimentally to enhance kidney preservation during both warm and cold isc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198802000-00012
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:This study evaluated the prognostic impact of pretransplant donor-specific anti-human leukocyte antigen antibodies (DSA) detected by single-antigen beads and compared the three generations of crossmatch (XM) tests in kidney transplantation. METHODS:Thirty-seven T-cell complement-dependent cytotoxicity cross...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/tp.0b013e3181e36e08
更新日期:2010-07-27 00:00:00
abstract::DA rats treated with cyclosporine for 2 weeks after being grafted with an RT1-incompatible PVG heart graft did not reject the graft and developed a state of specific unresponsiveness to graft antigens. The cellular mechanisms maintaining this state of unresponsiveness were studied by testing the capacity of lymphocyte...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198406000-00014
更新日期:1984-06-01 00:00:00
abstract::The outcome after liver transplantation when grafts were retrieved from the donor by the classical aortic and portal cooling (APC) method was compared with the outcome when exclusively aortic in situ perfusion (AC) was used. Retrospectively, 163 donor hepatectomies performed over a 20-month period were reviewed to ana...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199405150-00007
更新日期:1994-05-15 00:00:00
abstract::Unilateral, intraorganal injection of parental lymph node cells into thyroid lobes of F1 hybrid rats elicited an intense, local graft-versus-host reaction within the injected lobes containing massive numbers of lymphocytes. Surprisingly, significant mononuclear cell infiltration was also seen within the contralateral ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197805000-00003
更新日期:1978-05-01 00:00:00
abstract:OBJECTIVE:We compared the enzyme release from preserved and ex vivo reperfused livers after acute injury or inflammatory stimulus with organ function. METHODS:Acute injury was induced by carbon tetrachloride and inflammation was induced by turpentine oil treatments. Livers were exsanguinated and preserved for 8 or 24 ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200210270-00004
更新日期:2002-10-27 00:00:00
abstract:BACKGROUND:The objective of the study was to determine surveillance criteria for renal transplant recipients (RTRs) at highest risk for immunosuppressant therapy nonadherence. METHODS:Retrospective analyses were performed on follow-up data in the United States Renal Data System. Those who received transplants between ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000287189.33074.c8
更新日期:2007-11-15 00:00:00
abstract::The fate of solid tissue allografts--skin or parathyroid glands--implanted in the interstitial tissue of the testis was investigated using inbred rats. The results affirm that the testis is an immunologically privileged site despite its efficient lymphatic drainage. Skin allografts survived at least several days longe...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198310000-00014
更新日期:1983-10-01 00:00:00
abstract::Monocytes play a crucial role in the response of lymphocytes to phytomitogens. This role is evident during the very early events after exposure to the mitogen. Thus, significant lymphocyte transformation does occur when monocytes are removed from the culture within a few hours after exposure to mitogen, and the presen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197901000-00015
更新日期:1979-01-01 00:00:00
abstract::Longitudinal studies over an eight-month period have been performed to follow the T killer response restoration after allogeneic bone marrow transplantation (BMT). The capacity of the patient's peripheral blood mononuclear cells (PBM) to develop cytotoxic effector cells directed either against allogeneic cells or agai...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198708000-00024
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:Liver transplantation from donation after cardiac death (DCD) donors is an increasingly common approach for expansion of the donor organ supply. However, transplantation with DCD livers results in inferior graft survival. In this study, we examined donor and recipient characteristics that are associated with...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000250936.73034.98
更新日期:2006-12-27 00:00:00
abstract::The fungal metabolite FK506 was discovered because it shared an important property, the ability to inhibit production of IL-2, with another well-known immunosuppressive fungal metabolite, CsA. FK506 has, since its isolation, also been shown to share other immunosuppressive effects with CsA. This study was performed to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199012000-00021
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:The ability to induce tolerance, or at least minimize the need for immunosuppressive therapy, is a high priority in organ transplantation. Accomplishing this goal requires a novel method for determining when a patient has become tolerant to or is rejecting their graft. Here, we sought to develop an efficient...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182696a5b
更新日期:2012-10-27 00:00:00
abstract:BACKGROUND:Recurrent hepatitis C virus (HCV) after liver transplantation (OLT) is a major cause of graft loss in HCV-positive patients. In this study, we evaluated the efficacy and safety of pegylated interferon alfa-2b (peginterferon) and ribavirin treatment for recurrent HCV after OLT and analyzed the influence of an...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000225827.18034.be
更新日期:2006-07-15 00:00:00
abstract::In order to understand in more detail the role of endogenous interleukin 1 receptor antagonist (IL-1ra) during bone marrow transplantation, IL-1ra serum levels of 28 patients undergoing allogeneic (n=25) or autologous (n=3) bone marrow transplantation were measured with a commercially available ELISA. In addition, the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199701150-00010
更新日期:1997-01-15 00:00:00
abstract::To investigate the clinical manifestations of Aspergillus infections in lung transplant recipients, we reviewed the mycology and autopsy reports of all double (DLT=93) and single (SLT=48) lung transplant recipients from November 1983 to May 1993. Positive Aspergillus cultures were identified in 22% of the recipients (...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199603270-00013
更新日期:1996-03-27 00:00:00
abstract:BACKGROUND:Long-term use of immunosuppressants is associated with significant morbidity and mortality in transplant recipients. A simple whole blood assay that has U.S. Food and Drug Administration clearance directly assesses the net state of immune function of allograft recipients for better individualization of thera...
journal_title:Transplantation
pub_type: 杂志文章,meta分析
doi:10.1097/01.tp.0000234837.02126.70
更新日期:2006-09-15 00:00:00
abstract::Living-donor liver transplantation has provided a solution to the severe lack of cadaveric grafts for the replacement of livers afflicted with end-stage cirrhosis, fulminant disease, or inborn errors of metabolism. The pioneering experience in Japan in the early 1990s helped open wide the avenues of a new branch of sc...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.TP.0000046533.93621.C7
更新日期:2003-02-15 00:00:00
abstract::Donation physicians are specialists with expertise in organ and tissue donation and have been recognized internationally as a key contributor to improving organ and tissue donation services. Subsequent to a 2011 Canadian Critical Care Society-Canadian Blood Services consultation, the donation physician role has been g...
journal_title:Transplantation
pub_type: 杂志文章,实务指引
doi:10.1097/TP.0000000000001694
更新日期:2017-05-01 00:00:00
abstract::Platelet activating factor (PAF, 1-alkyl-2(R)-acetyl-glycero-3- phosphorylcholine) is a phospholipid that is released by a variety of cells. The similarity between the pathophysiological effects of PAF and posttransplant pulmonary dysfunction led to an evaluation of a PAF antagonist as an adjunct to lung preservation....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199106000-00002
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:In patients with acute liver failure (ALF) of unknown cause, viral infections are believed to be involved. This study investigates the involvement of human herpesvirus-6 (HHV-6). METHODS:Thirty-two patients with ALF who underwent transplantations during a 6-year period were studied for viruses in biopsies f...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000069233.13409.DF
更新日期:2003-08-15 00:00:00
abstract:BACKGROUND:The role of human herpesvirus (HHV)-8 in the pathogenesis of multiple myeloma and its pre-malignant state of monoclonal gammopathy is unclear. HHV-8 is transmitted by organ transplantation, representing a unique model with which to investigate primary HHV-8 infection. METHODS:The authors studied the inciden...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000129065.31427.96
更新日期:2004-05-27 00:00:00
abstract:BACKGROUND:Delayed graft function (DGF) after renal transplantation can be diagnosed according to several different definitions, complicating comparison between studies that use DGF as an endpoint. This is a particular problem after transplantation with kidneys from donation after circulatory death (DCD) kidneys, becau...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182a19348
更新日期:2013-11-27 00:00:00
abstract::H-1-incompatible rat renal allograft survival rates are strongly influenced by the non-major histocompatibility system (MHS) genes. The same H-1 (MHS) incompatibility tested on four different non-MHS backgrounds gave widely differing results ranging from 11 to 60% fractional survival between the best and the poorest (...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197805000-00006
更新日期:1978-05-01 00:00:00
abstract::In adult recipients of allogeneic hematopoietic cell transplants (HCT) studied at 1 year after grafting, there was a significant correlation between the counts of T cell receptor excision circle (TREC)-containing CD4 T cells (presumed recent thymic emigrants) and the counts of total T cells (r=0.65, P<0.001). Thus, th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200204150-00026
更新日期:2002-04-15 00:00:00
abstract::CD18 antibodies react with the common beta chain of the human leukocyte function antigen (LFA1)* and thus block the functions mediated by the three identified molecules in humans. A murine CD18 monoclonal antibody was infused in 8 leukemic patients receiving allogeneic T-depleted bone marrow transplantation in order t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198903000-00014
更新日期:1989-03-01 00:00:00
abstract::We studied the reactivity of cardiac graft-infiltrating cells, cultured from endomyocardial biopsy specimens, toward heart endothelial cells (Hec). In two cases, Hec derived from the specific donor heart or Hec compatible with the donor were lysed, but not the syngeneic B cell line. A vessel-derived endothelial cell l...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199608150-00017
更新日期:1996-08-15 00:00:00
abstract::We have previously shown that trophic factor supplementation (TFS) of University of Wisconsin (UW) solution enhanced kidney viability after cold storage. Here, we use an in vitro model to study the effect of TFS on early apoptotic changes after cold ischemic storage. Mitochondrial membrane potential was determined by ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000242524.35562.4b
更新日期:2007-01-15 00:00:00
abstract:BACKGROUND:We previously reported the novel activity of alloprimed CD8 T cells that suppress posttransplant alloantibody production. The purpose of the study is to investigate the expression and role of CXCR5 on antibody-suppressor CD8 T-cell function. METHODS:C57BL/6 mice were transplanted with FVB/N hepatocytes. All...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002683
更新日期:2019-09-01 00:00:00