Treatment of patients with recurrent hepatitis C after liver transplantation with peginterferon alfa-2B plus ribavirin.

abstract：BACKGROUND:To define whether immunosuppressive agents that block the interleukin (IL)-2 pathway could prevent activation-induced cell death of activated T cells in the graft, we measured expression of IL-2, IL-2 receptor alpha chain (CD25), IL-15, Fas, and Fas ligand by real time reverse transcription-polymerase chain ...

journal_title：Transplantation

authors： Baan CC,Balk AH,van Riemsdijk IC,Vantrimpont PJ,Maat AP,Niesters HG,Zondervan PE,van Gelder T,Weimar W

更新日期：2003-05-27 00:00:00

abstract：BACKGROUND:Vaccine-preventable viral infections are associated with increased risk of morbidity and mortality in immunocompromised patients. Current guidelines recommend routine screening and vaccination of all patients before solid organ transplantation. We studied rates of immunity against vaccine-preventable viruses...

journal_title：Transplantation

authors： Gardiner A,Liu K,Bonnichsen M,Joshi V,Davis RJ,Strasser SI

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Reconstitution of hematopoiesis after hematopoietic stem cell transplantation (HSCT) occurs through a reservoir of donor CD34+ HSC. CD34+/VEGFR-2+ is a primitive, quiescent subpopulation of HSC known to generate hematopoietic or endothelial progeny in vitro and in vivo. We hypothesized that donor-specific an...

journal_title：Transplantation

authors： Nordlander A,Mattsson J,Sundberg B,Sumitran-Holgersson S

更新日期：2008-09-15 00:00:00

abstract：BACKGROUND:The rate of acute rejection (AR) has decreased significantly, but whether this is associated with improvement in long-term graft survival is controversial. METHODS:We analyzed 1445 consecutive adult deceased donor kidney transplant recipients from 1985 to 2005, over two periods (1985-1995 vs. 1996-2005) to ...

journal_title：Transplantation

authors： Sola E,Gonzalez-Molina M,Cabello M,Burgos D,Ramos J,Gutierrez C,Lopez V,Soler J,de la Vega E,Hernandez D

更新日期：2010-03-27 00:00:00

abstract：:Allogeneic lymphocyte cytotoxicity (ALC) describes the elimination of allogeneic lymphocytes in vivo by an NK-related activity. There is evidence that ALC is demonstrable between donor and recipient when these are incompatible at MHC gene loci alone. Since ALC is a property of T cell-deficient nude rats, the role of t...

journal_title：Transplantation

authors： Ager A,Fajumi J,Sparshott SM,Ford WL,Butcher GW

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Recipients of vascularized composite allografts require aggressive and lifelong immunosuppression, and because the surgery is usually performed in nonlife-threatening situations, the development of strategies to minimize immunosuppression is especially pertinent for this procedure. We investigated how comple...

journal_title：Transplantation

authors： Zhu P,Bailey SR,Lei B,Paulos CM,Atkinson C,Tomlinson S

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Recent advances in the understanding of immunomodulatory properties of phosphodiesterase 4 (PDE4) inhibitors recommend these drugs for immunosuppressive therapy after lung transplantation. The potency of three PDE4 inhibitors was tested using an established model of heterotopic tracheal transplantation in ra...

journal_title：Transplantation

authors： Schade I,Roth-Eichhorn S,Kasper M,Kuss H,Plötze K,Funk RH,Schüler S

更新日期：2002-08-15 00:00:00

abstract：BACKGROUND:Dysregulation of the coagulation system due to inflammatory responses and cross-species molecular incompatibilities represents a major obstacle to successful xenotransplantation. We hypothesized that complement inhibition mediated by transgenic expression of human CD46 in pigs might also regulate the coagula...

journal_title：Transplantation

authors： Bongoni AK,Kiermeir D,Schnider J,Jenni H,Garimella P,Bähr A,Klymiuk N,Wolf E,Ayares D,Voegelin E,Constantinescu MA,Seebach JD,Rieben R

更新日期：2015-10-01 00:00:00

abstract：:This study was undertaken to examine the humoral immune response against endothelial antigens of the donor kidney in human renal allograft recipients. Sera from 61 transplant recipients who received 62 grafts were studied for the presence of circulating endothelial antibodies (CEAb) using an indirect immunofluorescenc...

journal_title：Transplantation

authors： Paul LC,van Es LA,van Rood JJ,van Leeuwen A,de la Rivière GB,de Graeff J

更新日期：1979-03-01 00:00:00

abstract：:Temperature is a key parameter in organ preservation that has been consistently linked to primary nonfunction (PNF). In this communication, and for the first time anywhere, continued and direct measurements of human liver intraparenchymal temperatures are reported in six clinical cases of orthotopic liver transplantat...

journal_title：Transplantation

authors： Villa R,Fondevila C,Erill I,Guimerà A,Bombuy E,Gómez-Suárez C,Sacristán JC,García-Valdecasas JC

更新日期：2006-02-15 00:00:00

abstract：:The possible ability of the mixed-epidermal-cell-lymphocyte reaction (MECLR) to detect alloreactivities in HLA-identical MLR negative siblings has been investigated before grafting in 30 donor-recipients pairs and their families. Results indicate that recipients' epidermal cells (EC) can induce proliferative responses...

journal_title：Transplantation

authors： Bagot M,Cordonnier C,Tilkin AF,Heslan M,Vernant JP,Dubertret L,Levy JP

更新日期：1986-03-01 00:00:00

abstract：:A study was designed to determine if cold preservation induces an increase in lymphocyte adherence to liver sinusoids on reperfusion. Rat livers were stored at 1 degree C in University of Wisconsin solution for 45 min, 8 hr, or 30 hr, and then reperfused for 90 min at 37 degrees C in an isolated perfused rat liver app...

journal_title：Transplantation

authors： Clavien PA,Morgan GR,Sanabria JR,Petrunka C,Levy GA,Robert P,Harvey C,Strasberg SM

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:De novo donor HLA-specific (dnDSA) and non-HLA antibodies including antiangiotensin type 1 receptor antibodies (AT1R-abs) have been associated with antibody-mediated rejection (AMR) and decreased graft survival as well as cellular-mediated rejection (CMR) and early onset of microvasculopathy in heart transpl...

journal_title：Transplantation

authors： Reinsmoen NL,Lai CH,Mirocha J,Cao K,Ong G,Naim M,Wang Q,Haas M,Rafiei M,Czer L,Patel J,Kobashigawa J

更新日期：2014-03-15 00:00:00

abstract：BACKGROUND:Malnutrition is common in patients with end-stage liver disease considered for transplantation, but it is unclear whether this affects the outcome after transplantation. AIM.: To determine whether the severity of malnutrition in liver transplant candidates affects outcome after transplantation. METHODS:We d...

journal_title：Transplantation

authors： Shahid M,Johnson J,Nightingale P,Neuberger J

更新日期：2005-02-15 00:00:00

abstract：:For many individuals suffering from end-stage liver disease (ESLD), the only treatment option is liver transplantation. However, liver transplant rejection is observed in 24-80% of transplant patients and lifelong drug regimens that follow the transplant procedure lead to serious side effects. Furthermore, the pool of...

journal_title：Transplantation

authors： Wang X,MacParland SA,Perciani CT

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Endomyocardial biopsy (EMB) remains the gold standard for acute cellular rejection (ACR) diagnosis in cardiac transplantation yet is subject to interobserver variability. A method that could avoid discordant EMB analysis would be desirable. The apoptosis rate in EMB correlates with ACR severity. Apollon inhi...

journal_title：Transplantation

authors： Aharinejad S,Andrukhova O,Gmeiner M,Thomas A,Krenn K,Zuckermann A,Grimm M

更新日期：2010-01-27 00:00:00

abstract：:Adult bone marrow-derived mesenchymal stem cells (MSCs) are multipotential cells capable of regenerating injured tissues. In addition to their multipotency, MSCs inhibit natural killer cell cytotoxicity and T-lymphocyte alloproliferation. Several immunosuppressive mechanisms have been described, including indoleamine ...

journal_title：Transplantation

authors： Selmani Z,Naji A,Gaiffe E,Obert L,Tiberghien P,Rouas-Freiss N,Carosella ED,Deschaseaux F

更新日期：2009-05-15 00:00:00

abstract：:The majority of skin tumors induced in mice by ultraviolet (UV) light are rejected when implanted into normal syngeneic recipients. Subcarcinogenic levels of UV light exposure render the normally resistant mice susceptible to tumor challenge. The immunoregulatory effect of UV light appears to be additive, since the gr...

journal_title：Transplantation

authors： Daynes RA,Spellman CW,Woodward JG,Stewart DA

更新日期：1977-04-01 00:00:00

abstract：:We investigated the preventive effect of the immunosuppressive agent FK506 on autoimmune insulitis in nonobese diabetic mice. The mice were given FK506 in a dose of 1.0 mg/kg, every other day, from age 2 to 12, 2 to 6, and 4 to 12 weeks, respectively; after which, the incidence of insulitis and overt diabetes was moni...

journal_title：Transplantation

authors： Kai N,Motojima K,Tsunoda T,Kanematsu T

更新日期：1993-04-01 00:00:00

abstract：:Cell-mediated cytotoxicity directed toward pancreatic islets plays a significant role in the pathogenesis of type 1 diabetes mellitus. Histologically, autoimmune insulitis appears as mononuclear infiltrates that precede actual beta cell loss. Experimental studies by Bartlett et al. on the BB rat model suggest that who...

journal_title：Transplantation

authors： Drachenberg CB,Papadimitriou JC,Weir MR,Klassen DK,Hoehn-Saric E,Bartlett ST

更新日期：1996-12-27 00:00:00

abstract：BACKGROUND:Treatment of chronic hepatitis C virus (HCV) infection after renal allograft transplantation has been an obstacle because of contraindications associated with IFN-based therapies. Direct-acting antiviral agents are highly efficient treatment options that do not require IFN and may not require ribavirin. Ther...

journal_title：Transplantation

authors： Eisenberger U,Guberina H,Willuweit K,Bienholz A,Kribben A,Gerken G,Witzke O,Herzer K

更新日期：2017-05-01 00:00:00

abstract：:Cytomegalovirus (CMV) is a major pathogen in transplant recipients and AIDS patients, and the virus may also play a role in allograft rejection. Previous work from this laboratory demonstrated increased cell surface expression of the adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) following CMV infection in vitro. W...

journal_title：Transplantation

authors： Craigen JL,Grundy JE

更新日期：1996-10-27 00:00:00

abstract：:The effect of the quinoline-3-carboxamide LS-2616 (Linomide), given alone or together with cyclosporine, was studied in the first set cardiac allograft transplantation model in the rat. PVG rat hearts were transplanted heterotopically to Wistar/Kyoto rat recipients on day 0. The recipients were given LS-2616 orally on...

journal_title：Transplantation

authors： Wanders A,Larsson E,Gerdin B,Tufveson G

更新日期：1989-02-01 00:00:00

abstract：:Published data on the guinea pig-to-rat hepatic xenotransplant model describe problems concerning poor graft reperfusion. To further investigate this phenomenon, orthotopic liver xenotransplantation between weight-matched guinea pigs and rats were performed using Kamada's technique. On reperfusion, all cases had porta...

journal_title：Transplantation

authors： Delriviere LD,Havaux X,Gibbs P,Gianello PR

更新日期：1998-07-15 00:00:00

abstract：:Suppressor cell activity in the spleen of 4-5-day-old mice is high and can be assayed in mixed lymphocyte cultures. The suppressor cells inhibit the proliferation of adult mouse spleen cells responding in vitro to an allogeneic stimulus. This suppressor cell activity can be increased by injecting the mice, on the day ...

journal_title：Transplantation

authors： Argyris BF

更新日期：1984-09-01 00:00:00

abstract：:Thymectomy of mice aged 6-8 weeks causes a disproportion of splenic T cell sets, the Ly123 set being relatively decreased and the Ly23 set relatively increased (Ly123 decrease: Ly23 increase). A similar disproportion of splenic T cell sets was found to occur spontaneously with advancing age (12-18 months). By PA-SRBC ...

journal_title：Transplantation

authors： Newcomb EW,Goldberg EH,de Sousa M,Goldstein G,Boyse EA,Scheid MP

更新日期：1985-11-01 00:00:00

abstract：:Ling Zhi-8 (LZ-8) is a protein derived from the fungus Ganoderma lucidum and has immunomodulatory capacities. It was shown to be mitogenic toward mouse splenocytes in vitro and immunosuppressive in vivo by reducing antigen-induced antibody formation and by preventing completely the incidence of autoimmune diabetes in ...

journal_title：Transplantation

authors： van der Hem LG,van der Vliet JA,Bocken CF,Kino K,Hoitsma AJ,Tax WJ

更新日期：1995-09-15 00:00:00

abstract：BACKGROUND:Induction therapy is associated with excellent short-term kidney graft outcome. The aim of this study was to evaluate differences in the intragraft transcriptome after successful induction therapy using two rabbit antithymocyte globulins. METHODS:The expression of 376 target genes involved in tolerance, inf...

journal_title：Transplantation

authors： Urbanova M,Brabcova I,Girmanova E,Zelezny F,Viklicky O

更新日期：2012-03-27 00:00:00

abstract：:Ninety-eight renal transplant recipients who had been followed for 1-6.5 years (median 3.2 years) were reviewed to determine the effect of donor and recipient hepatitis B surface antigen status on the incidence of hepatitis and on patient survival. The cumulative risk of developing hepatitis posttransplant was signifi...

journal_title：Transplantation

authors： Chan PC,Lok AS,Cheng IK,Chan MK

更新日期：1992-01-01 00:00:00

abstract：:Pulmonary endothelium is considered the compartment most susceptible to preservation damage. This investigation was designed to analyze the efficacy of an original, University of Parma low-potassium-albumin solution (SPAL UP) on cultured human pulmonary artery endothelial cells (HPAEC) and to compare its effects with ...

journal_title：Transplantation

authors： Spaggiari L,Rusca M,Carbognani P,Alfieri R,Urbani S,Cattelani L,Petronini P,Solli P,Borghetti AF,Bobbio P

更新日期：1996-11-15 00:00:00