Induction of kidney allograft tolerance by soluble CD83 associated with prevalence of tolerogenic dendritic cells and indoleamine 2,3-dioxygenase.

abstract：:ICAM-1 is an inducible glycoprotein important in the adhesion, activation, and transmigration of circulating leukocytes across the vascular endothelial monolayer, and it likely plays a key role in the allogeneic response. To determine the reproducibility and significance of variations in resting levels of cell surface...

journal_title：Transplantation

authors： Everett JP,Shipley GD,Mauck KA,Wagner CR,Morris TE,Hosenpud JD

更新日期：1994-10-27 00:00:00

abstract：BACKGROUND:Urothelial carcinoma (UC) is a common complication after renal replacement therapy (RRT) among Chinese end-stage renal disease (ESRD) patients. It is unclear whether there are any differences in the clinicopathologic characteristics of UC between renal transplantation (RT) and dialysis patients; such differe...

journal_title：Transplantation

authors： Zhang B,Shen C,Han WK,Yu W

更新日期：2014-09-15 00:00:00

abstract：BACKGROUND:The autonomic storm accompanying brain death leads to neurogenic pulmonary edema and triggers development of systemic and pulmonary inflammatory responses. Neurogenic vasoplegia exacerbates the pulmonary injury caused by brain death and primes the lung for ischemia reperfusion injury and primary graft dysfun...

journal_title：Transplantation

authors： Rostron AJ,Avlonitis VS,Cork DM,Grenade DS,Kirby JA,Dark JH

更新日期：2008-02-27 00:00:00

abstract：BACKGROUND:A quantitative model of immunosuppression was previously developed based on the rejection of the allogeneic A/J murine tumor sarcoma 1 (Sa1) in immunocompetent mice. Here, the model is used to evaluate the immunologic mechanisms of graft rejection and to determine the potential of this model to detect synerg...

journal_title：Transplantation

authors： Hammond-McKibben D,Saulnier M,Zhang J,Risher N,Lake P,Weetall M

更新日期：2005-04-27 00:00:00

abstract：BACKGROUND:Despite effective antiviral treatment, hundreds of kidneys from deceased donors with hepatitis C virus (HCV) are discarded annually. Little is known about the determinants of willingness to accept HCV-infected kidneys among HCV-negative patients. METHODS:At 2 centers, 189 patients undergoing initial or reev...

journal_title：Transplantation

authors： McCauley M,Mussell A,Goldberg D,Sawinski D,Molina RN,Tomlin R,Doshi SD,Abt P,Bloom R,Blumberg E,Kulkarni S,Esnaola G,Shults J,Thiessen C,Reese PP

更新日期：2018-04-01 00:00:00

abstract：:The number of patients awaiting hepatic transplantation continues to exceed organ donation. As a result, many liver transplant candidates will develop life-threatening complications of their liver disease and not survive the pretransplant waiting period. Recent studies have demonstrated that hepatic lidocaine metaboli...

journal_title：Transplantation

authors： Shiffman ML,Fisher RA,Sanyal AJ,Edinboro LE,Luketic VA,Purdum PP 3rd,Raymond P,Posner MP

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Both discordant and concordant xenogeneic responses are dominated by humoral immunity. Recent advances in molecular engineering approaches may largely prevent rejection by means of this pathway, leaving the cellular arm of the immune response as the principal remaining barrier to successful engraftment. MET...

journal_title：Transplantation

authors： Trani JL,Song HK,Lerner SM,Markmann JW,Barker CF,Naji A,Markmann JF

更新日期：2001-08-15 00:00:00

abstract：:Ninety-five dogs with spontaneous malignant lymphoma in chemotherapy-induced remission were treated with total-body irradiation (TBI) and bone marrow transplantation. Among 38 dogs treated with 8.4 Gy delivered at 4 cGy/min, 9 (24%) became long-term disease-free survivors. Ten of the 38 (26%) died of transplant-relate...

journal_title：Transplantation

authors： Appelbaum FR,Deeg HJ,Storb R,Self S,Graham TC,Sale GE,Weiden PL

更新日期：1985-05-01 00:00:00

abstract：:Increased blood loss is a major contributory factor to postoperative short- and longterm outcome in orthotopic liver transplantation (OLT). Hyperfibrinolysis, occurring mainly in the anhepatic phase, and disseminated intravascular coagulation (DIC), starting immediately after reperfusion, have been observed to paralle...

journal_title：Transplantation

authors： Himmelreich G,Hundt K,Neuhaus P,Roissant R,Riess H

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:The shortage of cadaveric livers has sparked an interest in adult-to-adult living donor transplantation. Right lobe donor hepatectomy is frequently required to obtain a graft of adequate size for adult recipients. Careful donor selection is necessary to minimize complications and assure a functional graft. ...

journal_title：Transplantation

authors： Marcos A,Fisher RA,Ham JM,Olzinski AT,Shiffman ML,Sanyal AJ,Luketic VA,Sterling RK,Olbrisch ME,Posner MP

更新日期：2000-06-15 00:00:00

abstract：:The psychosocial and psychiatric impact of donating bone marrow (BM) has received little study. This mail questionnaire study of bone marrow donors whose recipient had survived more than one year post-BMT was undertaken to document the psychosocial consequences of donation on "successful" BM donors. Demographic, mood ...

journal_title：Transplantation

authors： Wolcott DL,Wellisch DK,Fawzy FI,Landsverk J

更新日期：1986-04-01 00:00:00

abstract：:After measurement of normal renal function, dog kidneys (n = 52) were subjected to 3, 15, or 30 min of normothermic warm ischemia (WI). After 24 hr of preservation by simple hypothermic storage (SHS) in a modified Collins solution, autotransplant was done and renal function was again measured beginning at 1 hr. Compar...

journal_title：Transplantation

authors： Gregg CM,Lai MK,Mandour WA,Linke CA

更新日期：1986-11-01 00:00:00

abstract：:Suspensions of viable lymph node cells (LNCs), both unlabeled and 3H-uridine labeled, from adult Fischer (FI) rats were inoculated into the lumens of established, surgically isolated segments of ileum in adult (FI x DA)F1 hybrid hosts. Vascular, lymphatic, and nerve supplies of the isolated segment were preserved. It ...

journal_title：Transplantation

authors： Seelig LL Jr,Billingham RE

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:Monoclonal antibody induced tolerance to high doses of multiple lymphocyte stimulating (MLS)+minor mismatched bone marrow has recently been associated with clonal deletion, as reported in fully allogeneic models of bone marrow transplantation. FasL-induced apoptosis has been shown to mediate antigen-specific...

journal_title：Transplantation

authors： Honey K,Bemelman F,Cobbold SP,Waldmann H

更新日期：2000-04-27 00:00:00

abstract：BACKGROUND:The pathogenesis of acute pulmonary xenograft injury has not yet been determined. The present study evaluates the role of complement in mediating pulmonary xenograft dysfunction by using cobra venom factor (CVF) to deplete recipient complement and transgenic swine, which express human regulators of complemen...

journal_title：Transplantation

authors： Yeatman M,Daggett CW,Parker W,Byrne GW,Logan JS,Platt JL,Davis RD

更新日期：1998-04-27 00:00:00

abstract：:Agarose is known to inhibit nonspecifically the cytotoxic effects of normal sera on xenogeneic lymphoid cells. To find an explanation for this agarose effect we have studied its requirements using guinea pig and human sera as the source of activity and rat thymocytes as target cells. Control assays were performed usin...

journal_title：Transplantation

authors： Budzko DB,Kierszenbaum F

更新日期：1977-04-01 00:00:00

abstract：:Retrospective mixed leukocyte culture studies were performed in eight patients who had either rejected their marrow grafts or experienced graft-versus-host disease and in seven patients with successful marrow engraftment. In tests of pre-and post-transplant lymphocytes we found no evidence that rejection or graft-vers...

journal_title：Transplantation

authors： Opelz G,Gale RP

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:One of the alternative options to simultaneous pancreas-kidney transplantation (SPKT) for type I diabetics with renal failure is sequential transplant of a living donor kidney followed by a deceased donor pancreas transplant (pancreas after living donor kidney transplant [PALK]). We retrospectively compared ...

journal_title：Transplantation

authors： Poommipanit N,Sampaio MS,Cho Y,Young B,Shah T,Pham PT,Wilkinson A,Danovitch G,Bunnapradist S

更新日期：2010-06-27 00:00:00

abstract：:Donor graft major histocompatibility complex class I antigens are targets for both allogeneic and xenogeneic rejection. Mice homozygous for beta 2-microglobulin gene disruption express reduced amounts of surface MHC class I antigens. Liver cells from such mutant mice were transplanted into isogeneic, allogeneic, and x...

journal_title：Transplantation

authors： Li X,Faustman D

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:A 35-year period of clinical development resulted in orthotopic liver transplantation (OLT) becoming a standardized surgical procedure. Despite this progress, the rate of technical complications is still high. Although the main problem in most analyses is vascular or bile duct failure, we observed a remarkab...

journal_title：Transplantation

authors： Soliman T,Langer F,Puhalla H,Pokorny H,Grunberger T,Berlakovich GA,Langle F,Muhlbacher F,Steininger R

更新日期：2000-05-27 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia (AML) after solid organ transplantation is rare, with only six AML cases after liver transplantation (LT) being reported. METHODS:Characteristics of three AML cases observed among 799 recipients of LT in the authors' institution and estimation of the standardized incidence ratio (SIR)...

journal_title：Transplantation

authors： Camós M,Esteve J,Rimola A,Grande L,Rozman M,Colomer D,Villamor N,Costa D,Montserrat E

更新日期：2004-01-27 00:00:00

abstract：BACKGROUND:The success of clinical xenotransplantation will depend on induction of xenotolerance. We have previously shown that combined xenothymus and vascularized xenoheart transplantation under the coverage of a tolerizing regimen (TR) can induce and maintain full xenotolerance. Here, induction/maintenance of xenoto...

journal_title：Transplantation

authors： Yu L,Yan Y,Li S,Rutgeerts O,Goebels J,Segers C,Lin Y,Vandeputte M,Waer M

更新日期：2005-03-15 00:00:00

abstract：BACKGROUND:Cold ischemia-reperfusion injury is unavoidable during organ transplantation, and prolonged preservation is associated with poorer function recovery. Cardiotrophin-1 (CT-1) is an IL-6 family cytokine with cytoprotective properties. This preclinical study in rats tested whether CT-1 mitigates cold renal ische...

journal_title：Transplantation

authors： García-Cenador B,Blanco-Gozalo V,López-Montañés D,Sanz Giménez-Rico JR,López-Novoa JM,López-Hernández FJ

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Targeting 2-hr postdose cyclosporine (C2) levels to 1,000 to 1,700 mg/dL during the first 6 months after renal transplantation is recommended for triple immunosuppressive regimens. This trial determines whether lower C2 levels could be targeted safely in de novo kidney transplant recipients under a quadruple...

journal_title：Transplantation

authors： Hardinger KL,Schnitzler MA,Koch MJ,Enkvetchakul D,Desai N,Jendrisak M,Lowell JA,Miller B,Shenoy S,Brennan DC

更新日期：2004-10-27 00:00:00

abstract：BACKGROUND:Preliminary studies showed an excellent success rate of kidney grafts in patients with high pretransplantation serum levels of IgA autoantibodies directed against the Fab region of the human IgG molecule. METHODS:With the collaboration of 30 centers from around the world, we attempted to verify the role of ...

journal_title：Transplantation

authors： Süsal C,Döhler B,Opelz G

更新日期：2000-04-15 00:00:00

abstract：:Cross sensitization between the products of the H-2K and H-2D loci has been demonstrated by an experimental design in which recipients were sensitized with tissue bearing determinants controlled by one locus (e.g., H-2K), and then challenged with skin grafts expressing determinants controlled by the other locus (e.g.,...

journal_title：Transplantation

authors： Murphy DB,Shreffler DC

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND:The ability to induce tolerance, or at least minimize the need for immunosuppressive therapy, is a high priority in organ transplantation. Accomplishing this goal requires a novel method for determining when a patient has become tolerant to or is rejecting their graft. Here, we sought to develop an efficient...

journal_title：Transplantation

authors： Lim DG,Park YH,Kim SE,Jung EJ,Jeong SH,Lee H,Shin SJ,Park CS,Han DJ,Kim SC

更新日期：2012-10-27 00:00:00

abstract：:Calcium channel blockade has been shown to prevent warm renal ischemic damage. The ability of verapamil to decrease the severity of acute tubular necrosis (ATN) after 24-hr cold storage and autotransplantation was studied in a randomized paired study of 12 dogs. Experimental animals pretreated with intraarterial verap...

journal_title：Transplantation

authors： Agatstein EH,Farrer JH,Kaplan LM,Randazzo RF,Glassock RJ,Kaufman JJ

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND:Socioeconomic variables including low income and noncompliance impact negatively upon long-term renal allograft survival, especially in African Americans. We sought to determine whether other socioeconomic variables contributed to noncompliance and allograft survival. METHODS:A detailed history of socioecon...

journal_title：Transplantation

authors： Butkus DE,Dottes AL,Meydrech EF,Barber WH

更新日期：2001-07-27 00:00:00

abstract：:The results of kidney retransplantation in the cyclosporine era remain to be determined. Over a 42-month period, 76 nonprimary renal transplants (66 second, 7 third, 3 fourth allografts) were performed in 73 recipients under cyclosporine immunosuppression. The patient population was predominantly white (90.4%) with a ...

journal_title：Transplantation

authors： Stratta RJ,Oh CS,Sollinger HW,Pirsch JD,Kalayoglu M,Belzer FO

更新日期：1988-01-01 00:00:00