Abstract:
BACKGROUND:Acute myeloid leukemia (AML) after solid organ transplantation is rare, with only six AML cases after liver transplantation (LT) being reported. METHODS:Characteristics of three AML cases observed among 799 recipients of LT in the authors' institution and estimation of the standardized incidence ratio (SIR) are presented. RESULTS:Three AML cases were diagnosed (French-American-British classification subtypes M0, M3, and M1) at 38 days, 2 years, and 3.5 years after LT, respectively. The immunosuppressive regimen consisted of cyclosporine A and prednisone. The recipient's origin of blasts could be demonstrated in two cases. All patients achieved complete remission after standard treatment. Nonetheless, disease relapsed in two patients at 2 and 6 months, whereas the patient with acute promyelocytic leukemia remains disease-free 4 years after diagnosis. As compared with the general population, the observed incidence of AML in the authors' series of LT results in a significantly higher SIR of 11.41 (P=0.0023). CONCLUSIONS:The higher SIR found in the authors' series suggests an increased risk of AML in patients undergoing LT.
journal_name
Transplantationjournal_title
Transplantationauthors
Camós M,Esteve J,Rimola A,Grande L,Rozman M,Colomer D,Villamor N,Costa D,Montserrat Edoi
10.1097/01.TP.0000102549.40531.13subject
Has Abstractpub_date
2004-01-27 00:00:00pages
311-3issue
2eissn
0041-1337issn
1534-6080journal_volume
77pub_type
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