Tools for human leukocyte antigen antibody detection and their application to transplanting sensitized patients.

abstract：UNLABELLED:Most isolated intestinal graft losses are immunological. We conducted a pilot study to evaluate the feasibility of national sharing of HLA no-mismatch allografts for cadaveric isolated intestinal transplantation. METHODS:UNOS data were analyzed in a theoretical model. Part I: All solid organ donors between ...

journal_title：Transplantation

authors： Fishbein TM,Bodian CA,Miller CM

更新日期：2000-03-15 00:00:00

abstract：:We developed a hepatic arterialization technique in living donor liver transplantation. The technique was indicated in patients with a left graft from donors with a right hepatic artery originated from superior mesenteric artery or a right graft from donors with a left hepatic artery from left gastric artery. The dono...

journal_title：Transplantation

authors： Aramaki O,Sugawara Y,Kokudo N,Takayama T,Makuuchi M

更新日期：2006-12-15 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor. Currently, liver transplantation may be the optimal treatment for HCC in cirrhotic patients. Patient selection is currently based on tumor size. We developed a program to offer liver transplantation to selected patients with HCC...

journal_title：Transplantation

authors： Victor DW 3rd,Monsour HP Jr,Boktour M,Lunsford K,Balogh J,Graviss EA,Nguyen DT,McFadden R,Divatia MK,Heyne K,Ankoma-Sey V,Egwim C,Galati J,Duchini A,Saharia A,Mobley C,Gaber AO,Ghobrial RM

更新日期：2020-01-01 00:00:00

abstract：:CD4+ T cells are obvious targets for immunotherapy since they appear to be pivotal in rejection responses. Current interest in clinical transplantation is focused on the potential use of nondepleting anti-CD4 antibodies largely because depletion of CD4+ T cells may lead to prolonged periods of nonspecific immunosuppre...

journal_title：Transplantation

authors： Darby CR,Bushell A,Morris PJ,Wood KJ

更新日期：1994-05-27 00:00:00

abstract：:Immunosuppression with sirolimus and low-dose tacrolimus has facilitated successful clinical islet transplantation (CIT). Because the long-term effects on the kidney are unknown and immunosuppressant drugs can be nephrotoxic, CIT is currently restricted to patients with preserved renal function or a functioning renal ...

journal_title：Transplantation

authors： Senior PA,Shapiro AM,Ackerman TE,Ryan EA,Paty BW,Bhargava R

更新日期：2004-09-27 00:00:00

abstract：:The potential role of donor's mature T lymphocytes on the recovery of various immunological functions and hematopoiesis was investigated in lethally irradiated BALB/c mice by studying reconstitution with normal, as compared with T-cell-depleted, syngeneic marrow grafts. Recovery of total, as well as mononuclear, perip...

journal_title：Transplantation

authors： Shalit M,Ayalon M,Weiss L,Leshem B,Kedar E,Slavin S

更新日期：1986-08-01 00:00:00

abstract：:Teratoma 402 AX is an embryo-like tumor cell line originally derived from the testicles of strain 129/J mice. This teratocarcinoma grows well in males and pregnant females but poorly in virgin females when given in small doses. Induction of growth of this tumor is syngeneic and allogeneic virgin females was achieved b...

journal_title：Transplantation

authors： Isa AM,Sanders BR

更新日期：1975-10-01 00:00:00

abstract：BACKGROUND:Oral ingestion of potassium dichromate produces a complex spectrum of complications. It has an extremely poor prognosis and usually leads to rapid death. METHODS:We report the case of a 16-year-old male patient who was admitted to hospital after oral ingestion of potassium dichromate with suicidal intention...

journal_title：Transplantation

authors： Stift A,Friedl J,Längle F,Berlakovich G,Steininger R,Mühlbacher F

更新日期：2000-06-15 00:00:00

abstract：:We have previously demonstrated that subclinical chronic rejection (CR) induces structural and functional alterations in enteric smooth muscle and nerves in a rat model of small intestinal transplantation. This study was designed to investigate the effect of prolonged FK506 rescue therapy on these sequelae of CR. Immu...

journal_title：Transplantation

authors： Heeckt PF,Lee KK,Halfter WM,Schraut WH,Bauer AJ

更新日期：1995-01-27 00:00:00

abstract：:Chronic kidney disease is common in patients with multiple myeloma. Historically, individuals with end-stage renal disease and multiple myeloma did poorly with renal transplantation due to higher mortality rates from the malignancy itself or associated comorbidities. However, over the past 2 decades, there have been s...

journal_title：Transplantation

authors： Huskey JL,Heilman RL,Khamash H,Fonseca R

更新日期：2018-12-01 00:00:00

abstract：:Multiple pretransplant sera obtained from alloimmunized renal transplant recipients were tested for the presence of antiidiotypic-like antibodies (AB2) that inhibit donor-specific HLA antibodies in the microlymphocytotoxicity assay. Fourteen patients received repetitive single-donor blood transfusions (SDT). In this p...

journal_title：Transplantation

authors： Phelan DL,Rodey GE,Anderson CB

更新日期：1989-07-01 00:00:00

abstract：:Discordant xenogeneic organ transplantation is a potential solution to the critical shortage of suitable donor organs. However, clinical application of xenotransplantation with physiologically suitable organs such as those from the pig, is currently limited by the lack of agents to prevent antibody and complement-medi...

journal_title：Transplantation

authors： Kennedy SP,Rollins SA,Burton WV,Sims PJ,Bothwell AL,Squinto SP,Zavoico GB

更新日期：1994-05-27 00:00:00

abstract：:Despite human leukocyte antigen (HLA) identity between donor and recipient, several patients develop acute graft-versus-host disease (aGVHD) after hematopoetic stem cell transplantation (HSCT) because of minor histocompatibility antigen (mHag) incompatibilities. The impact of multiple mHag disparities on the clinical ...

journal_title：Transplantation

authors： Heinemann FM,Ferencik S,Ottinger HD,Beelen DW,Grosse-Wilde H

更新日期：2004-04-15 00:00:00

abstract：:The interactions of steroid hormones and human peripheral blood lymphocytes (PBLs) have been investigated following glass-wool column separation of PBLs and incubation in a serum-free medium in the presence of phytohemagglutinin (PHA). Addition of hydrocortisone or progesterone above physiological concentrations resul...

journal_title：Transplantation

authors： Neifeld JP,Tormey DC

更新日期：1979-05-01 00:00:00

abstract：:We studied major histocompatibility complex (MHC) and cytokine mRNA induction after renal injury in the absence of interferon-gamma (IFN-gamma) using IFN-gamma gene knockout (GKO) mice. The left renal pedicle of normal (wild-type) and GKO BALB/c mice was clamped for 60 minutes; cytokine and MHC mRNA expression were mo...

journal_title：Transplantation

authors： Goes N,Urmson J,Vincent D,Halloran PF

更新日期：1995-12-27 00:00:00

abstract：BACKGROUND:Donor organ shortage represents a major problem in lung transplantation. Donation after cardiac death could help to expand the pool of organs, but the additional period of warm ischemia after cardiac arrest aggravates primary graft dysfunction. The pulmonary endothelium of the graft constitutes an important ...

journal_title：Transplantation

authors： Preissler G,Loehe F,Huff IV,Ebersberger U,Shuvaev VV,Bittmann I,Hermanns I,Kirkpatrick JC,Fischer K,Eichhorn ME,Winter H,Jauch KW,Albelda SM,Muzykantov VR,Wiewrodt R

更新日期：2011-08-27 00:00:00

abstract：BACKGROUND:Organ donors are frequently trauma victims, but the impact of donor hemorrhagic shock and resuscitation (HSR) on pulmonary graft function has not been assessed. L-arginine treatment during reperfusion increases the production of endothelial nitric oxide and thus ameliorates ischemia-reperfusion injury. Objec...

journal_title：Transplantation

authors： Preissler G,Löhe F,Ebersberger U,Huff I,Bittmann I,Messmer K,Jauch KW,Angele MK

更新日期：2009-06-15 00:00:00

abstract：BACKGROUND:Donor hepatectomy with maximal safety while preserving graft viability is of principal concern in living donor liver transplantation. There are compelling reasons for avoiding blood transfusion, even with autologous blood, to avoid the potential risks it imposes on healthy donors. This study aims to describe...

journal_title：Transplantation

authors： Chen CL,Chen YS,de Villa VH,Wang CC,Lin CL,Goto S,Wang SH,Cheng YF,Huang TL,Jawan B,Cheung HK

更新日期：2000-06-27 00:00:00

abstract：:A novel method for quantifying the fatty change of the graft liver by characterizing the optical property of the tissue was introduced. A wide range of lipid content in the rat liver was obtained by using different feeding regimens, with lipotropic chow (choline/methionine deficient or low chow). The liver was removed...

journal_title：Transplantation

authors： Kitai T,Beauvoit B,Chance B

更新日期：1996-09-15 00:00:00

abstract：:Although liver transplantation (LT) is the best treatment for patients with localized hepatocellular carcinoma (HCC), recurrence occurs in 6%-18% of patients. Several factors, particularly morphological criteria combined with dynamic parameters, known before LT modify this risk and combined in prediction models may be...

journal_title：Transplantation

authors： Berenguer M,Burra P,Ghobrial M,Hibi T,Metselaar H,Sapisochin G,Bhoori S,Kwan Man N,Mas V,Ohira M,Sangro B,van der Laan LJW

更新日期：2020-06-01 00:00:00

abstract：:We are participating in a multicenter trial testing the efficacy of a murine monoclonal antihuman peripheral T lymphocyte antibody (OKT3.PAN) as immunosuppressive therapy for the treatment of acute cadaveric renal allograft rejection. Although clinical data indicate that administration of this antibody clears the circ...

journal_title：Transplantation

authors： Bowen A,Edwards LC,Gailiunas P,Helderman JH

更新日期：1984-11-01 00:00:00

abstract：:Using liposomes, multilamellar lipid vesicles (MLV), we have found that liposome-incorporated cyclosporine is not only less toxic but also more effective in prolonging survival of cardiac allografts in mice. Following intravenous injection of liposome-incorporated drug, cyclosporine levels in blood were shown to decre...

journal_title：Transplantation

authors： Górecki DC,Jakóbisiak M,Kruszewski A,Lasek W

更新日期：1991-11-01 00:00:00

abstract：INTRODUCTION:Immune privilege provides a natural paradigm for potentially down-regulating allogeneic and xenogeneic inflammatory immune responses. Fas ligand has been suggested as a general underlying mechanism of immune privilege; the human Fas ligand has been shown to ligate murine Fas in vitro. METHODS:In this stud...

journal_title：Transplantation

authors： Kimmel SG,Ohbatake M,Kushida M,Merguerian P,Clarke ID,Kim PC

更新日期：2000-03-27 00:00:00

abstract：BACKGROUND:Chronic red cell aplasia can develop in immunocompromised patients including transplant recipients infected with parvovirus B19 (PV B19). Renal involvement with PV B19 infection is not well-recognized. METHODS:We diagnosed erythroid hypoplasia associated with PV B19 infection in three renal transplant recip...

journal_title：Transplantation

authors： Moudgil A,Shidban H,Nast CC,Bagga A,Aswad S,Graham SL,Mendez R,Jordan SC

更新日期：1997-12-27 00:00:00

abstract：BACKGROUND:We recently described a new approach that enables the generation of human/mouse chimera by adoptive transfer of human peripheral blood mononuclear cells into lethally irradiated normal strains of mice or rats, radioprotected with bone marrow from donors with severe combined immune deficiency. In such human/m...

journal_title：Transplantation

authors： Burakova T,Marcus H,Canaan A,Dekel B,Shezen E,David M,Lubin I,Segal H,Yair R

更新日期：1997-04-27 00:00:00

abstract：:The expression of some genes has been comparatively studied in transplanted rat liver and in liver reperfused after ischemia in situ. Experiments on protein synthesis by tissue slices from cold-stored or transplanted livers show that rat livers that retain a good capacity for protein synthesis during storage undergo a...

journal_title：Transplantation

authors： Schiaffonati L,Cairo G,Tacchini L,Pappalardo C,Gatti S,Piazzini-Albani A,Bernelli-Zazzera A

更新日期：1993-05-01 00:00:00

abstract：:Experimental studies of vein homografts in rats have shown prolonged patency resulting from an attenuated immune response. This study examined the response to Golden Syrian hamster vein xenografts. While one group of Sprague-Dawley rats served as a control, a second group was sensitized with 5 X 10(6) viable hamster s...

journal_title：Transplantation

authors： Jordan BP,Jones JW,Rodgers GH,Flye MW

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:The chemokine receptor CCR7 plays a pivotal role in the homing of naïve T cells and regulatory T cells to secondary lymphoid organs and the migration of dendritic cells into afferent lymphatic vessels. Antigen presentation, T cell recruitment, and expansion of regulatory cells are crucial events in establish...

journal_title：Transplantation

authors： Ensminger SM,Helm SN,Ohl L,Spriewald BM,Abele S,Wollin M,Wood KJ,Weyand M,Förster R

更新日期：2008-08-27 00:00:00

abstract：:Living-donor liver transplantation has provided a solution to the severe lack of cadaveric grafts for the replacement of livers afflicted with end-stage cirrhosis, fulminant disease, or inborn errors of metabolism. The pioneering experience in Japan in the early 1990s helped open wide the avenues of a new branch of sc...

journal_title：Transplantation

authors： Chen CL,Fan ST,Lee SG,Makuuchi M,Tanaka K

更新日期：2003-02-15 00:00:00

abstract：:Polyclonal rabbit antirat thymocyte serum (ATS) has been shown to form in situ glomerular immune aggregates following perfusion into normal rat kidney ex vivo. This may be due to the presence of T-cell-like epitopes in the rat kidney, or it may be a result of contaminating anti-connective-tissue antibodies in ATS. To ...

journal_title：Transplantation

authors： Bagchus WM,Donga J,Rozing J,Hoedemaeker PJ,Bakker WW

更新日期：1986-06-01 00:00:00