Abstract:
:Using liposomes, multilamellar lipid vesicles (MLV), we have found that liposome-incorporated cyclosporine is not only less toxic but also more effective in prolonging survival of cardiac allografts in mice. Following intravenous injection of liposome-incorporated drug, cyclosporine levels in blood were shown to decrease rapidly, while concentrations in spleen were higher (when compared with concentration following administration of commercial preparation). In this context, possible mechanisms of the beneficial effect of liposome-incorporated cyclosporine are discussed.
journal_name
Transplantationjournal_title
Transplantationauthors
Górecki DC,Jakóbisiak M,Kruszewski A,Lasek Wdoi
10.1097/00007890-199111000-00002subject
Has Abstractpub_date
1991-11-01 00:00:00pages
766-9issue
5eissn
0041-1337issn
1534-6080journal_volume
52pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:We have reported the protective role of heme oxygenase-1 (HO-1) in the mechanism of hypoxic preconditioning. We wish to investigate the role of HO-1 in remote preconditioning (RP) against hepatic ischemia/reperfusion (I/R) injury in rats. METHODS:The remote preconditioning was produced by four cycles of 10-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000203555.14546.63
更新日期:2006-05-15 00:00:00
abstract:INTRODUCTION:The purpose of the current study was to investigate the capacity of CD4+, CD8+, or non-T cells to independently initiate acute rejection of allogeneic hepatocytes using reconstituted SCID, CD4 or CD8 knockout (KO) recipient mice. METHODS:Allogeneic hepatocytes (FVB/N, H-2q) were transplanted into C57BL/6....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200012270-00017
更新日期:2000-12-27 00:00:00
abstract:BACKGROUND:The increasing demand for transplantation has resulted in a trend toward using virologically compromised donors. We reviewed our experience with liver grafts from hepatitis-B surface antigen (HBsAg)(-), antibody to core antigen (anti-HBc)(+) donors. METHODS:Sixty-two liver transplants using HBsAg(-), anti-H...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000065283.98275.FE
更新日期:2003-04-27 00:00:00
abstract::Antibody-mediated rejection (AMR) is an important cause of graft loss and continues to present a formidable obstacle to successful transplantation. Unresolved problems continue to be the absence of effective strategies to ablate the donor-specific antibody (DSA) response as well as to attenuate the antibody-mediated g...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003298
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Two patients underwent cadaver transplantation with kidneys from a donor with a history of World Health Organization Class IV/V lupus nephritis, and we report their clinical and pathological outcome. METHODS:The donor had a diagnosis of lupus nephritis made by renal biopsy 5 years before donation. At the ti...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200003270-00030
更新日期:2000-03-27 00:00:00
abstract::Reduced-size liver transplantation in the rat has been useful in the study of hepatic regeneration. We describe a modified technique for partial liver transplantation in the rat using a 50% reduced-size graft. Male Lewis rats (RT1(1)), weighing 250 to 280 g, were used as donors and recipients. The harvested donor live...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199607270-00023
更新日期:1996-07-27 00:00:00
abstract:BACKGROUND:Treatment of chronic hepatitis C virus (HCV) infection after renal allograft transplantation has been an obstacle because of contraindications associated with IFN-based therapies. Direct-acting antiviral agents are highly efficient treatment options that do not require IFN and may not require ribavirin. Ther...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001414
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:PG490-88, a semisynthetic derivative of a novel compound PG490 (triptolide) purified from a Chinese herb (Tripterygium wilfordii Hook F), is effective in prevention of murine graft-versus-host disease (GVHD). METHODS:PG490-88 was administrated into recipients in a model (B10.D2 [H2d, Mls-2b, Mls-3b]-->BALB/...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200201150-00022
更新日期:2002-01-15 00:00:00
abstract:BACKGROUND:The innovative pure laparoscopic living donor right hepatectomy (LLDRH) procedure for liver transplantation has never been fully compared to open living donor right hepatectomy (OLDRH). We aimed to compare the donor safety and graft results of pure LLDRH to those of OLDRH. METHODS:From May 2013 to July 2017...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002834
更新日期:2019-10-01 00:00:00
abstract::In this study we examined the functional capacity of unseparated, IL-2R positive and IL-2R negative leukocytes infiltrating BN rat hearts or kidneys grafted into allogeneic LEW rats. Upon adoptive transfer into syngeneic LEW recipients, splenocytes or day-3 graft infiltrate cells of either cardiac or renal transplants...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199007000-00019
更新日期:1990-07-01 00:00:00
abstract::A prospective randomized trial was performed comparing survival of cadaveric grafts allocated by HLA-A+B matching and HLA-DR matching. The two allocation methods resulted in very similar graft survivals. HLA-A matching had no significant effect on graft survival. HLA-B and HLA-DR matching were shown to have approximat...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-198407000-00010
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND:Posttransplantation measurement of soluble CD30 (sCD30) may be useful for identifying kidney graft recipients at risk of impending graft rejection in the early posttransplantation period. METHODS:We measured plasma sCD30 levels and evaluated the levels in relation to the diagnosis of rejection. RESULTS:Rec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000044702.18327.66
更新日期:2003-02-15 00:00:00
abstract:OBJECTIVES:En bloc pediatric kidney transplants (EBPKT) are still a subject of controversy. The aim of this study was to determine whether acceptable long-term graft survival and function can be achieved in EBPKT compared with the transplant of single, cadaveric, adult donor kidneys. METHODS:A retrospective review was...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000090395.98045.09
更新日期:2003-10-27 00:00:00
abstract:BACKGROUND:Immunogenicity of a graft depends on its expression of major histocompatability complex (MHC) antigens and adhesion molecules and on the amount of intragraft leukocytes, the so-called passenger leukocytes. Although long-term culture reduces passenger leukocytes, permanent acceptance is not necessarily observ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200208270-00003
更新日期:2002-08-27 00:00:00
abstract::The lung is one of the primary targets of acute graft-versus-host disease (GVHD), which is the principal complication that occurs after allogeneic intestinal transplantation. The purpose of this study is to investigate the involvement of Fas/Fas ligand system in pulmonary injury after rat semi-allogeneic intestinal tr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199910150-00006
更新日期:1999-10-15 00:00:00
abstract::We have done a comparative analysis of two consecutive clinical trials at our center: the first in 56 patients who received blood transfusions from their prospective donors (DST group), and the second in 36 patients who received such transfusions while they were taking Imuran in an attempt to reduce the incidence of s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198336060-00009
更新日期:1983-12-01 00:00:00
abstract::Unrelated cord blood (UCB) hematopoietic stem cells were serially transplanted into two human leukocyte antigen (HLA)-identical siblings with T cell, B cell, natural killer cell severe combined immunodeficiency. Brother A received a 4/6-matched, HLA DRbeta1-identical but class I-disparate UCB graft after myeloablative...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000209659.59606.f2
更新日期:2006-06-15 00:00:00
abstract:BACKGROUND:Proteinuria is associated with endothelial dysfunction (ED) and increased mortality. We investigated whether urinary protein excretion (UPE) is correlated with markers of ED and whether these markers affect the association of proteinuria with mortality in renal transplant recipients (RTR). METHODS:Six hundr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181903d25
更新日期:2008-12-27 00:00:00
abstract:BACKGROUND:Umbilical cord blood transplantation (UCBT) is increasingly used and produces similar results to matched unrelated donor transplantation. METHODS:We performed a retrospective single-center analysis of 50 umbilical cord blood transplantations UCBTs performed from 2001 to 2010, including 37 single and 13 doub...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31826c39b2
更新日期:2012-11-27 00:00:00
abstract:BACKGROUND:To date, the outcomes of transplant tourism have not been reported extensively. In addition, data about the accuracy of urine cytology for the detection and the role of the BK virus (BKV) in the carcinogenesis of urothelial carcinoma (UC) after renal transplantation are lacking. METHODS:Three hundred seven ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000023
更新日期:2014-07-15 00:00:00
abstract:BACKGROUND:Delayed graft function and acute rejections adversely affect the long-term survival of kidney transplantation. To decrease the incidences of these phenomena, we changed the initial immunosuppressive protocol in pediatric kidney transplantation in The Netherlands. METHODS:We compared a cohort (n=123) treated...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0b013e318187c3ad
更新日期:2008-11-15 00:00:00
abstract::Human epidermal cells were grown serially in surface culture by inoculation of suspensions of disaggregated cells. Single cells grew into colonies and the colonies fused to make a confluent epithelium. The epithelium was detached as a unit and transplanted onto a graft bed prepared in athymic mice. Such grafts formed ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198004000-00010
更新日期:1980-04-01 00:00:00
abstract::The effects of pretreatment with cyclosporine, allopurinol, or methylprednisolone on ischemia-reperfusion injury of the liver were investigated. A total of 32 adult mongrel dogs that received one of the pretreatments were divided into four groups and were subjected to 90 min liver ischemia. Serum activities of asparta...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199107000-00005
更新日期:1991-07-01 00:00:00
abstract::Controversy exists as to the type of cells present in the urine during renal allograft rejection. In order to resolve this controversy as well as to evaluate the value of urine sediment examination as a means of detecting AR, we quantitated the different cells present in urine during AR using an immunoperoxidase techn...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198903000-00017
更新日期:1989-03-01 00:00:00
abstract::The prevalence of angiographically proven coronary artery disease (CAD) in adults with end-stage liver disease who undergo evaluation for liver transplantation is unknown; also it is unclear if cholestatic liver disease represents an independent risk factor. Patients with end-stage liver disease over age 50 having liv...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-03-27 00:00:00
abstract:BACKGROUND:Better preservation strategies for the storage of donation after circulatory death grafts are essential to improve graft function and to increase the kidney donor pool. We compared continuous normothermic ex vivo kidney perfusion (NEVKP) with hypothermic anoxic machine perfusion (HAMP) and static cold storag...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003066
更新日期:2020-05-01 00:00:00
abstract::To investigate the role of natural killer (NK) cells in the induction and pathogenesis of graft-versus-host (GVH) disease, +/beige (+/bg; normal NK cell activity) and beige/beige (bg/bg; deficient NK cell activity) parental C57BL/6 (B6) lymphoid cells were used to induce GVH reactions in either B6 X C3H/Hej +/bg (+/bg...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198708000-00017
更新日期:1987-08-01 00:00:00
abstract::Athymic PVG-rnu/rnu (RT1c) rats were grafted with skin bearing isolated MHC disparities 7-14 days in advance of cell transfer. The ability of naive CD4+ or CD8+ thoracic duct lymphocytes to induce rejection was assessed by adoptive transfer of one or both T cell subsets into nude recipients bearing congenic PVG.r1 (MH...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND:The aim of this single-center study was to investigate whether trough level adjusted mycophenolate mofetil (MMF) is more efficacious in combination with tacrolimus (TAC) or cyclosporine (CsA) and to evaluate the impact of either drug on MMF dosage. METHODS:Sixty patients (TAC, n = 30; CsA, n = 30) undergoin...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.tp.0000129814.52456.25
更新日期:2004-08-27 00:00:00
abstract::The effect of protein depletion on immune responsiveness was examined using a skin allograft model. Protein depletion was induced in adult Fischer (F344) male rats by the ad libitum provision of a 5% protein diet. Total serum protein, total body weight, total body nitrogen, and total body lipid were all markedly decre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198009000-00012
更新日期:1980-09-01 00:00:00