A prospective randomized trial of matching for HLA-A and B versus HLA-DR in renal transplantation.

abstract：BACKGROUND:Neutrophilic tubulitis accompanied by intratubular neutrophil clusters in the renal allograft is a surrogate marker for urinary tract infection (UTI). Overlapping histologic findings can occur in antibody-mediated rejection, which is characterized by peritubular capillary (PTC) deposition of C4d. This study ...

journal_title：Transplantation

authors： Gupta G,Shapiro R,Girnita A,Batal I,McCauley J,Basu A,Tan H,Randhawa P

更新日期：2009-04-15 00:00:00

abstract：:Cytomegalovirus remains a significant source of morbidity and mortality in immunocompromised hosts. The increased sensitivity of molecular diagnostic techniques (PCR, antigenemia) has resulted in our ability to detect viral replication earlier in the posttransplant period, before the onset of symptoms. With the advent...

journal_title：Transplantation

authors： Abecassis MM,Koffron AJ,Kaplan B,Buckingham M,Muldoon JP,Cribbins AJ,Kaufman DB,Fryer JP,Stuart J,Stuart FP

更新日期：1997-01-27 00:00:00

abstract：BACKGROUND:Whether kidney transplant recipients who were treated for a malignant tumor before transplantation are at an increased risk of developing a tumor posttransplantation has not been adequately quantified and characterized. METHODS:We studied more than 270 000 patients on whom pretransplant and posttransplant m...

journal_title：Transplantation

authors： Unterrainer C,Opelz G,Döhler B,Süsal C,Collaborative Transplant Study.

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Little is known about associations between low physical activity (PA) and its correlates and outcomes in solid organ transplant recipients. This systematic review with meta-analysis examined correlates and outcomes associated with low PA (ie, not meeting individual study's definition of being physically acti...

journal_title：Transplantation

authors： Berben L,Engberg SJ,Rossmeissl A,Gordon EJ,Kugler C,Schmidt-Trucksäss A,Klem ML,Sereika SM,De Simone P,Dobbels F,De Geest SM,B-SERIOUS consortium.

更新日期：2019-04-01 00:00:00

abstract：:We have analyzed PBL from 7 children exposed to CsA in utero and 4 children exposed to AZA in utero. Expression of CD3, CD4, CD8, and CD20 were normal for both groups of children; however, significant differences were detected in the expression of CD45RA, CD45R0, and CD29. While CsA-exposed children had higher density...

journal_title：Transplantation

authors： Pilarski LM,Yacyshyn BR,Lazarovits AI

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:The aim of this article is to report our experience regarding the survival and the evolution of polyneuropathy of the extremities and autonomic dysfunction in 18 liver transplant patients with familial amyloidotic polyneuropathy type I after a mean follow-up of more than 2.5 years for 13 patients. METHODS:T...

journal_title：Transplantation

authors： Parrilla P,Ramirez P,Andreu LF,Bueno SF,Robles R,Miras M,Acosta F,Viader-Farre D,de Mingo P,Bermejo J,Garrido SF,Munar-Ques M

更新日期：1997-08-27 00:00:00

abstract：:Sprague-Dawley rats were treated for 14 days with rapamycin (RAP; 1.5 mg/kg/day i.p.), cyclosporine (15 mg/kg/day by gavage), both drugs in combination, or appropriate drug vehicles. Hematological parameters and biochemical indices of renal and hepatic function were determined throughout the experimental period, at th...

journal_title：Transplantation

authors： Whiting PH,Woo J,Adam BJ,Hasan NU,Davidson RJ,Thomson AW

更新日期：1991-08-01 00:00:00

abstract：:To establish the impact of transplantation on the course of chronic hepatitis B liver disease we performed a prospective study of the clinical and pathological sequelae of hepatitis B disease in all 22 patients who had renal allografts that functioned for more than 1 year and who were hepatitis B surface antigen (HBsA...

journal_title：Transplantation

authors： Parfrey PS,Forbes RD,Hutchinson TA,Kenick S,Farge D,Dauphinee WD,Seely JF,Guttmann RD

更新日期：1985-06-01 00:00:00

abstract：:We have proposed that the mechanisms of alloengraftment and variable acquired tolerance can be facilitated by minimum posttransplant immunosuppression. It was further suggested that the efficacy of minimalistic treatment could be enhanced by preoperative recipient conditioning with an antilymphoid antibody preparation...

journal_title：Transplantation

authors： Marcos A,Eghtesad B,Fung JJ,Fontes P,Patel K,Devera M,Marsh W,Gayowski T,Demetris AJ,Gray EA,Flynn B,Zeevi A,Murase N,Starzl TE

更新日期：2004-10-15 00:00:00

abstract：BACKGROUND:Short-term outcomes using steroid-free immunosuppression after renal transplantation have been promising. No studies have examined the incidence of and reasons for steroid-avoidance protocol failures. METHODS:We present a single-center analysis of steroid-free immunosuppression failures among 129 pediatric ...

journal_title：Transplantation

authors： Sutherland S,Li L,Concepcion W,Salvatierra O,Sarwal MM

更新日期：2009-06-15 00:00:00

abstract：:Despite previous attempts there is currently no suitable animal model available for xenogeneic graft versus host disease (XGVHD) mediated via human immunocompetent cells. Recently, we have developed an efficient protocol to engraft SCID mice with human peripheral blood lymphocytes (Hu-PBLs). The engraftment efficiency...

journal_title：Transplantation

authors： Sandhu JS,Gorczynski R,Shpitz B,Gallinger S,Nguyen HP,Hozumi N

更新日期：1995-07-27 00:00:00

abstract：BACKGROUND:Recently the United Network for Organ Sharing (UNOS) began a pilot study to evaluate prospectively the merits of an allocation of cadaveric kidneys based on broader classes of HLA antigens, called cross-reactive groups (CREG). The objectives of the pilot study consider patient outcomes, but not the potential...

journal_title：Transplantation

authors： Hollenbeak CS,Woodward RS,Cohen DS,Lowell JA,Singer GG,Tesi RJ,Howard TK,Mohanakumar T,Brennan DC,Schnitzler MA

更新日期：2000-08-15 00:00:00

abstract：:Increased blood loss is a major contributory factor to postoperative short- and longterm outcome in orthotopic liver transplantation (OLT). Hyperfibrinolysis, occurring mainly in the anhepatic phase, and disseminated intravascular coagulation (DIC), starting immediately after reperfusion, have been observed to paralle...

journal_title：Transplantation

authors： Himmelreich G,Hundt K,Neuhaus P,Roissant R,Riess H

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Focal segmental glomerulosclerosis (FSGS), the second leading cause of end stage renal disease in children, appears to be increasing. Moreover, posttransplantation FSGS recurrence is a major problem, and there is concern that children receiving kidneys from living donors (LD) have increased recurrence risk. ...

journal_title：Transplantation

authors： Nehus EJ,Goebel JW,Succop PS,Abraham EC

更新日期：2013-09-01 00:00:00

abstract：:Pancreas transplantation utilizing portal venous and enteric exocrine drainage has potential benefits over the standard systemic venous and bladder exocrine drainage method. Unfortunately, technical difficulties are often experienced with the arterial anastomosis after the portal venous anastomosis is completed. We ha...

journal_title：Transplantation

authors： Bigam DL,Hemming AW,Sanabria JR,Cattral MS

更新日期：1999-07-27 00:00:00

abstract：BACKGROUND:This study aimed at investigating the efficacy of the novel immunosuppressant FK778 to prevent the development and progression of chronic allograft vasculopathy (CAV). METHODS:Orthotopic aortic transplantations were performed in the PVG-to-ACI rat model and followed over the course of 120 days. Immunosuppre...

journal_title：Transplantation

authors： Deuse T,Hoyt G,Koyanagi T,Robbins RC,Schrepfer S

更新日期：2008-03-27 00:00:00

abstract：BACKGROUND:Cardiac allograft vasculopathy (CAV) is a major limitation in long-term graft survival after heart transplantation (HTx). Its prediction and detection at an early stage is a challenge because an accurate, minimally invasive blood test is lacking. The aim of this study was to analyze the relationship of Tact ...

journal_title：Transplantation

authors： Roldán C,Mirabet S,Cecilia C,Brossa V,Roig E,Martín C,Gelpí C

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Localization of inflammatory stimuli may direct lung allografts to different phenotypes of chronic dysfunction, such as bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS). We hypothesized that airway stimulation with lipopolysaccharide (LPS) in rats leads to airway-centered infla...

journal_title：Transplantation

authors： Takahagi A,Sato M,Chen-Yoshikawa TF,Miyamoto E,Saito M,Gochi F,Hamaji M,Yoshizawa A,Terasaki Y,Urushiyama H,Aoyama A,Sonobe M,Date H

更新日期：2020-06-01 00:00:00

abstract：:The aim of our study was to sensitize cells in vitro, follow their proliferative and cytotoxic responses, and determine their ability to cause lethal graft-versus-host disease (GVHD). C57BL/6 (H2b) spleen cells were incubated with irradiated BALB/C (H2d) Moloney lymphoma cells (LSTRA) in mixed leukocyte culture condit...

journal_title：Transplantation

authors： Einstein AB Jr,Cheever MA,Fefer A

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND:An elevated terminal creatinine is frequently used as a reason for organ refusal in pediatric kidney transplantation. There is increasing evidence that adults who receive kidneys from donors with moderate to severe acute kidney injury (AKI) have similar outcomes to recipients who receive kidneys from donors ...

journal_title：Transplantation

authors： Solomon S,Hayde N

更新日期：2020-03-01 00:00:00

abstract：:For the development of liver injury during preservation for transplantation, phospholipid degradation may be of importance. We therefore measured the degradation of [3H]-arachidonic acid (20:4)- and [14C]-linoleic acid (18:2)-labeled phospholipids during cold and warm preservation of rat livers in Eurocollins, Univers...

journal_title：Transplantation

authors： Ar'Rajab A,Ahrén B,Nilsson A

更新日期：1994-04-27 00:00:00

abstract：BACKGROUND:Posttransplant lymphoproliferative disease (PTLD) after pediatric liver transplantation has been associated with high mortality rates. METHODS:The present study examined 282 consecutive pediatric liver transplant recipients from October 1989 to June 1996 who received primary tacrolimus immunosuppression. Th...

journal_title：Transplantation

authors： Cacciarelli TV,Green M,Jaffe R,Mazariegos GV,Jain A,Fung JJ,Reyes J

更新日期：1998-10-27 00:00:00

abstract：:We have done a comparative analysis of two consecutive clinical trials at our center: the first in 56 patients who received blood transfusions from their prospective donors (DST group), and the second in 36 patients who received such transfusions while they were taking Imuran in an attempt to reduce the incidence of s...

journal_title：Transplantation

authors： Glass NR,Miller DT,Sollinger HW,Belzer FO

更新日期：1983-12-01 00:00:00

abstract：:Endothelial injury plays a central role in the pathophysiologic mechanisms underlying cardiac allograft vasculopathy (CAV). Although the accelerated course of CAV and its localization to the allograft support an important role for the alloimmune response, there is considerable evidence implicating lipoprotein abnormal...

journal_title：Transplantation

authors： Valantine HA

更新日期：2003-09-27 00:00:00

abstract：:Millions of people want to donate their organs after they die for transplantation, and many of them have registered their wish to do so or told their family and friends about their decision. For most of them, however, this wish is unlikely to be fulfilled, as only a small number of deaths (1% in the United Kingdom) oc...

journal_title：Transplantation

authors： Shaw D,Georgieva D,Haase B,Gardiner D,Lewis P,Jansen N,Wind T,Samuel U,McDonald M,Ploeg R,ELPAT Working Group on Deceased Donation.

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Neonatal primates have been reported to receive pig hearts without hyperacute rejection (HAR). We examined the ontogeny of the anti-pig xenoantibody (XenoAb) and HAR in the neonatal and infant monkeys. METHODS:Twenty-six serum samples from 15 monkeys ages 14-192 days were subjected to hemagglutination titra...

journal_title：Transplantation

authors： Kawauchi M,Nakajima J,Endoh M,Oka T,Takamoto S

更新日期：2000-08-27 00:00:00

abstract：BACKGROUND:Since 1995, dual-kidney transplantation using organs from marginal donors has been used at our center to expand the organ donor pool and decrease the waiting time for deceased donor kidney transplantation. This approach has allowed for a shorter waiting period without compromising outcome in the early posttr...

journal_title：Transplantation

authors： Tan JC,Alfrey EJ,Dafoe DC,Millan MT,Scandling JD

更新日期：2004-09-15 00:00:00

abstract：BACKGROUND:Scarring can greatly impact quality of life for individuals (ie, causing depression posttraumatic stress disorder, body image issues). Those who wish to be anonymous live liver donors are warned of the potential negative psychological impacts associated with the large scar left from liver donation surgery. G...

journal_title：Transplantation

authors： Krause S,Pritlove C,Abbey S,Jung J

更新日期：2020-05-25 00:00:00

abstract：BACKGROUND:Endomyocardial biopsy (EMB) remains the gold standard for acute cellular rejection (ACR) diagnosis in cardiac transplantation yet is subject to interobserver variability. A method that could avoid discordant EMB analysis would be desirable. The apoptosis rate in EMB correlates with ACR severity. Apollon inhi...

journal_title：Transplantation

authors： Aharinejad S,Andrukhova O,Gmeiner M,Thomas A,Krenn K,Zuckermann A,Grimm M

更新日期：2010-01-27 00:00:00

abstract：BACKGROUND:Recipients of vascularized composite allografts require aggressive and lifelong immunosuppression, and because the surgery is usually performed in nonlife-threatening situations, the development of strategies to minimize immunosuppression is especially pertinent for this procedure. We investigated how comple...

journal_title：Transplantation

authors： Zhu P,Bailey SR,Lei B,Paulos CM,Atkinson C,Tomlinson S

更新日期：2017-04-01 00:00:00