Ontogeny of antipig xenoantibody and hyperacute rejection.

abstract：BACKGROUND:Infections are a major cause of morbidity and mortality in kidney allograft recipients. In this post hoc analysis of a randomized clinical trial which tested the effect of denosumab on bone mineral density, we assessed the impact of this drug on the incidence and severity of infections in the first year afte...

journal_title：Transplantation

authors： Bonani M,Frey D,de Rougemont O,Mueller NJ,Mueller TF,Graf N,Wüthrich RP

更新日期：2017-09-01 00:00:00

abstract：:We have proposed that the mechanisms of alloengraftment and variable acquired tolerance can be facilitated by minimum posttransplant immunosuppression. It was further suggested that the efficacy of minimalistic treatment could be enhanced by preoperative recipient conditioning with an antilymphoid antibody preparation...

journal_title：Transplantation

authors： Marcos A,Eghtesad B,Fung JJ,Fontes P,Patel K,Devera M,Marsh W,Gayowski T,Demetris AJ,Gray EA,Flynn B,Zeevi A,Murase N,Starzl TE

更新日期：2004-10-15 00:00:00

abstract：:Endothelial injury plays a central role in the pathophysiologic mechanisms underlying cardiac allograft vasculopathy (CAV). Although the accelerated course of CAV and its localization to the allograft support an important role for the alloimmune response, there is considerable evidence implicating lipoprotein abnormal...

journal_title：Transplantation

authors： Valantine HA

更新日期：2003-09-27 00:00:00

abstract：:The majority of skin tumors induced in mice by ultraviolet (UV) light are rejected when implanted into normal syngeneic recipients. Subcarcinogenic levels of UV light exposure render the normally resistant mice susceptible to tumor challenge. The immunoregulatory effect of UV light appears to be additive, since the gr...

journal_title：Transplantation

authors： Daynes RA,Spellman CW,Woodward JG,Stewart DA

更新日期：1977-04-01 00:00:00

abstract：:After measurement of normal renal function, dog kidneys (n = 52) were subjected to 3, 15, or 30 min of normothermic warm ischemia (WI). After 24 hr of preservation by simple hypothermic storage (SHS) in a modified Collins solution, autotransplant was done and renal function was again measured beginning at 1 hr. Compar...

journal_title：Transplantation

authors： Gregg CM,Lai MK,Mandour WA,Linke CA

更新日期：1986-11-01 00:00:00

abstract：:In a randomized trial conducted in 9 Ontario transplant centers, 107 cadaver kidney donors were randomized so that both kidneys were preserved either by simple cold storage (CS) or by pulsatile perfusion (PP). After exclusions and losses to follow-up, there were 90 patients in the CS group and 91 in the PP group. Tota...

journal_title：Transplantation

authors： Halloran P,Aprile M

更新日期：1987-06-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of prostaglandin E1 on rabbit heart preservation. The hearts were arrested with cardioplegia (CP) solution, followed by intracoronary infusion of Euro-Collins (E-C) solution. They were immersed in E-C solution at 4 degrees C for 9 hr, flushed with terminal warm C...

journal_title：Transplantation

authors： Ueno T,Horita K,Okazaki Y,Itoh T,Natsuaki M

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Small-for-size grafts often cause persistent conjugated hyperbilirubinemia in the recipient after adult-to-adult living donor liver transplantation, but the cause has not yet been clarified. In physiologic status, bilirubin is excreted from hepatocytes to the bile canaliculus by means of multidrug resistance...

journal_title：Transplantation

authors： Chang TH,Hakamada K,Toyoki Y,Tsuchida S,Sasaki M

更新日期：2004-01-15 00:00:00

abstract：:Eradicating transplant tourism depends on complex solutions that include efforts to progress towards self-sufficiency in transplantation. Meanwhile, professionals and authorities are faced with medical, legal, and ethical problems raised by patients who return home after receiving an organ transplant abroad, particula...

journal_title：Transplantation

authors： Domínguez-Gil B,Danovitch G,Martin DE,López-Fraga M,Van Assche K,Morris ML,Lavee J,Erlich G,Fadhil R,Busic M,Rankin G,Al-Rukhaimi M,OʼConnell P,Chin J,Norman T,Massari P,Kamel R,Delmonico FL,Declaration of Istanbul Cu

更新日期：2018-01-01 00:00:00

abstract：:For maximum use of left liver plus caudate lobe grafts, the short hepatic vein draining the caudate lobe should be reconstructed. We devised a new venoplasty technique. On the graft side, a wide venous orifice with a long cuff was formed by gathering the left, middle, and short hepatic veins using a conduit vein graft...

journal_title：Transplantation

authors： Hashimoto T,Sugawara Y,Tamura S,Kaneko J,Motomura N,Takamoto S,Makuuchi M

更新日期：2007-01-27 00:00:00

abstract：BACKGROUND:Allograft rejection is mediated by cytokines. As polymorphism in cytokine genes can result in interindividual differences in cytokine production, we hypothesize that some patients may have an increased risk of rejection. METHODS:We have related polymorphisms that influence cytokine production in the tumor n...

journal_title：Transplantation

authors： Turner D,Grant SC,Yonan N,Sheldon S,Dyer PA,Sinnott PJ,Hutchinson IV

更新日期：1997-09-15 00:00:00

abstract：:Hepatic venoocclusive disease is a frequent lethal complication of bone marrow transplantation. It has also been associated with hepatic irradiation and administration of chemotherapeutic agents without BMT. The pathogenesis and therapy of VOD are unclear. The present studies were directed at developing a canine model...

journal_title：Transplantation

authors： Epstein RB,Min KW,Anderson SL,Syzek L

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:The need for renal replacement therapy (RRT) either before or after orthotopic liver transplant (OLTX) has been reported to be a poor prognostic indicator for survival. Use of continuous veno-venous hemodialysis (CVVHD) for RRT has been reported in three series of OLTX patients with high 90-day mortality rat...

journal_title：Transplantation

authors： Gonwa TA,Mai ML,Melton LB,Hays SR,Goldstein RM,Levy MF,Klintmalm GB

更新日期：2001-05-27 00:00:00

abstract：BACKGROUND:We have previously demonstrated that in a concordant hamster-to-nude rat cardiac transplant model, T-independent specific B-lymphocyte and natural killer (NK)-cell tolerance could be induced, leading to long-term xenograft (Xg) survival. Here, we investigated whether the same could be achieved in a clinicall...

journal_title：Transplantation

authors： Ji P,Xia G,Sefrioui H,Rutgeerts O,Segers C,Waer M

更新日期：1999-07-15 00:00:00

abstract：BACKGROUND:In experimental brain death models, autonomic storm (AS) triggers severe myocardial dysfunction, which can be attenuated by pharmacologic treatment. The aim of this study was to determine the incidence of AS in a cohort of human organ donors and to evaluate the potential interest of AS treatment on myocardia...

journal_title：Transplantation

authors： Audibert G,Charpentier C,Seguin-Devaux C,Charretier PA,Grégoire H,Devaux Y,Perrier JF,Longrois D,Mertes PM

更新日期：2006-10-27 00:00:00

abstract：:Little is known of the host immune mechanisms responsible for initiation and progression of chronic rejection. We describe immunopathologic features associated with progressively deteriorating function of kidney allografts in the F344-to-Lewis rat strain combination, which differ at MHC and non-MHC loci. Initial rejec...

journal_title：Transplantation

authors： Hancock WH,Whitley WD,Tullius SG,Heemann UW,Wasowska B,Baldwin WM 3rd,Tilney NL

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:There is a debate about the relative contribution of immunologic (rejection) and nonimmunologic (limited nephron mass) factors in long-term graft survival. METHODS:Using multivariate analysis, we studied the association of the following variables with outcome: delayed graft function (DGF), acute rejection, ...

journal_title：Transplantation

authors： Matas AJ,Gillingham KJ,Humar A,Dunn DL,Sutherland DE,Najarian JS

更新日期：2000-01-15 00:00:00

abstract：BACKGROUND:Localization of inflammatory stimuli may direct lung allografts to different phenotypes of chronic dysfunction, such as bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS). We hypothesized that airway stimulation with lipopolysaccharide (LPS) in rats leads to airway-centered infla...

journal_title：Transplantation

authors： Takahagi A,Sato M,Chen-Yoshikawa TF,Miyamoto E,Saito M,Gochi F,Hamaji M,Yoshizawa A,Terasaki Y,Urushiyama H,Aoyama A,Sonobe M,Date H

更新日期：2020-06-01 00:00:00

abstract：:Donor-specific transfusion effects were studied in the ACI-to-Lewis rat heterotopic heart allograft model using cyclosporine immunosuppression. Low-dose CsA for 1 week plus a single fresh or stored DST given 1 day before allografting significantly prolonged graft survival over CsA therapy alone (median survival time 2...

journal_title：Transplantation

authors： Brunson ME,Tchervenkov JI,Alexander JW

更新日期：1991-09-01 00:00:00

abstract：:Ultraviolet (UV)-irradiated mice were compared with unirradiated mice for their susceptibility to primary and transplanted tumors etiologically unrelated to UV radiation. Although UV-irradiated mice are unable to reject transplants of highly antigenic syngeneic tumors induced by UV light, the growth of syngeneic, non-...

journal_title：Transplantation

authors： Kripke ML,Thorn RM,Lill PH,Civin CI,Pazmiño NH,Fisher MS

更新日期：1979-09-01 00:00:00

abstract：:Three groups of patients were reviewed. Primary carcinomas were found in donors kidneys of 47 recipients. In 30 instances a tumor was present at harvesting. When a neoplasm was removed immediately pretransplantation or early posttransplantation there were no recurrences in 14 recipients. In another two instances, a tu...

journal_title：Transplantation

authors： Penn I

更新日期：1995-02-27 00:00:00

abstract：:Precision medicine is an emerging integrative approach for disease prevention, early detection, and treatment which takes into account individual variability in genetic and other molecular measurements, medical history, environmental exposures, and lifestyle. The development and availability of genomic and other molec...

journal_title：Transplantation

authors： Sirota M,Sarwal MM

更新日期：2017-08-01 00:00:00

abstract：:IL-10 is a regulatory cytokine of both T cells and monocytes. We have investigated the ability of IL-10 to regulate responses to alloantigens in vitro and in vivo. Addition of IL-10 to mixed lymphocyte cultures profoundly decreased the proliferation and IL-2 production by donor B10.BR cells stimulated with CBA cells e...

journal_title：Transplantation

authors： Krenger W,Snyder K,Smith S,Ferrara JL

更新日期：1994-12-15 00:00:00

abstract：INTRODUCTION:Organ donation after brain death (DBD) has declined in the United Kingdom, whereas donation after cardiac death (DCD) has increased markedly. We sought to understand the reasons for the decline in DBD and determine whether the increase in DCD was a major factor. METHODS:The UK Transplant Registry was anal...

journal_title：Transplantation

authors： Summers DM,Counter C,Johnson RJ,Murphy PG,Neuberger JM,Bradley JA

更新日期：2010-12-27 00:00:00

abstract：:Heterotopic abdominal rat heart transplantation has been extensively used to investigate ischemic-reperfusion injury, immunological consequences during heart transplantations and also to study remodeling of the myocardium due to volume unloading. We provide a unique review on the latter and present a summary of the ex...

journal_title：Transplantation

authors： Benke K,Sayour AA,Mátyás C,Ágg B,Németh BT,Oláh A,Ruppert M,Hartyánszky I,Szabolcs Z,Radovits T,Merkely B,Szabó G

更新日期：2017-03-01 00:00:00

abstract：:To determine the nature and sequence of the histologic changes in the early rejection of pancreaticoduodenal allografts and to assess the correlation between pancreaticoduodenal biopsy findings and the pathologic changes in the graft, we performed serial cystoscopically directed needle biopsies of pancreaticoduodenal ...

journal_title：Transplantation

authors： Carpenter HA,Barr D,Marsh CL,Miller AR,Perkins JD

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) is a strong predictor of cardiovascular disease, all-cause mortality, and renal allograft loss. Little is known about the effects of immunosuppressive and cardiovascular risk-modifying drugs on CRP in renal transplant recipients. METHODS:We retrospectively identified stable patients...

journal_title：Transplantation

authors： Wong BM,Huang M,Zaltzman JS,Prasad GV

更新日期：2007-01-15 00:00:00

abstract：BACKGROUND:Current grading systems in acute graft-versus-host disease (GVHD) are not able to identify patients with poor prognosis at time of onset, because they take into account maximal grade. The aim of this study was to evaluate potential predictors for overall survival at disease onset. METHODS:The study sample w...

journal_title：Transplantation

authors： Robin M,Porcher R,de Castro R,Fisher G,de Latour RP,Ribaud P,Petropoulou AD,Rocha V,Devergie A,Mary JY,Socié G

更新日期：2009-11-15 00:00:00

abstract：:Longitudinal studies over an eight-month period have been performed to follow the T killer response restoration after allogeneic bone marrow transplantation (BMT). The capacity of the patient's peripheral blood mononuclear cells (PBM) to develop cytotoxic effector cells directed either against allogeneic cells or agai...

journal_title：Transplantation

authors： Tilkin AF,Bagot M,Dreyfus F,Kayibanda M,Cordonnier C,Vernant JP,Levy JP

更新日期：1987-08-01 00:00:00

abstract：:The incidence of malignant disease (renal cancer and skin cancer excluded) was analyzed in 934 renal transplant patients from one center, transplanted between 1965 and 1981, and followed through 1983. National Cancer Registry data were used for statistical comparison. Cancers of the lip, vulva, and anus and malignant ...

journal_title：Transplantation

authors： Blohmé I,Brynger H

更新日期：1985-01-01 00:00:00