Abstract:
BACKGROUND:C-reactive protein (CRP) is a strong predictor of cardiovascular disease, all-cause mortality, and renal allograft loss. Little is known about the effects of immunosuppressive and cardiovascular risk-modifying drugs on CRP in renal transplant recipients. METHODS:We retrospectively identified stable patients with > or =1 highly sensitive CRP measurements between January 1 and August 31, 2005. Variables collected included patient demographics; transplant, dialysis, and cardiovascular disease-related variables; and medication profiles. Univariate correlations with CRP were assessed by unpaired Student t testing, analysis of variance, or chi analysis and followed by multivariate linear regression with stepwise backward elimination until a final stable model was attained. RESULTS:CRP levels were obtained in 298 recipients. In univariate analysis, body mass index (P<0.0001) and systolic blood pressure (P=0.009) showed a positive correlation, whereas number of immunosuppressive drugs (P=0.05) and use of mycophenolate mofetil (MMF) (P=0.003) were negatively correlated with CRP levels. By multivariate analysis, only body mass index (P<0.0001) and MMF dose (P<0.0001) were independently and opposingly correlated with CRP. Mean CRP level was 5.18+/-5.7 mg/L in patients not taking MMF compared with 3.13+/-3.5 mg/L in those on 2000 mg per day (P=0.002). CONCLUSIONS:MMF use correlates inversely with CRP levels in renal transplant recipients, suggesting that immunosuppressive regime design may alter allograft and cardiovascular disease risk in these patients. Prospective study of the effects of MMF on novel cardiovascular disease risk factors such as CRP is warranted.
journal_name
Transplantationjournal_title
Transplantationauthors
Wong BM,Huang M,Zaltzman JS,Prasad GVdoi
10.1097/01.tp.0000248864.21574.92subject
Has Abstractpub_date
2007-01-15 00:00:00pages
48-53issue
1eissn
0041-1337issn
1534-6080pii
00007890-200701150-00010journal_volume
83pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Zero-time kidney biopsies, obtained at time of transplantation, are performed in many transplant centers worldwide. Decisions on kidney discard, kidney allocation, and choice of peritransplant and posttransplant treatment are sometimes based on the histological information obtained from these biopsies. This comprehens...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001018
更新日期:2016-07-01 00:00:00
abstract::The expression of Ia antigens on leukoagglutinin-induced blast cells was studied using a sensitive protein A-rosetting technique and quantitative absorption with conventional and monoclonal Ia antibodies. By direct testing, 40 to 60% of CBA (Iak) blast cells were shown to be Ia+ (Iak+, Ia.17+, and Ias-), expressing bo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198105010-00005
更新日期:1981-05-01 00:00:00
abstract:BACKGROUND:The quantitation of donor leukocyte chimerism may aid in establishing the etiology of neutropenia after liver transplantation. METHODS:The incidence and clinical and laboratory characteristics of severe neutropenia were studied in adults who have undergone liver transplantation at our institution over the l...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199905270-00011
更新日期:1999-05-27 00:00:00
abstract:BACKGROUND:A 35-year period of clinical development resulted in orthotopic liver transplantation (OLT) becoming a standardized surgical procedure. Despite this progress, the rate of technical complications is still high. Although the main problem in most analyses is vascular or bile duct failure, we observed a remarkab...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200005270-00018
更新日期:2000-05-27 00:00:00
abstract:INTRODUCTION:The purpose of the current study was to investigate the capacity of CD4+, CD8+, or non-T cells to independently initiate acute rejection of allogeneic hepatocytes using reconstituted SCID, CD4 or CD8 knockout (KO) recipient mice. METHODS:Allogeneic hepatocytes (FVB/N, H-2q) were transplanted into C57BL/6....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200012270-00017
更新日期:2000-12-27 00:00:00
abstract:BACKGROUND:Only four centers have reported their results with renal transplantation in human immunodeficiency virus (HIV)+ recipients on highly active antiretroviral therapy, and acute rejection (AR) rates have consistently ranged from 43% to 67%. METHODS:We examined the outcomes of eight adult HIV+ primary renal allo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318177884e
更新日期:2008-07-27 00:00:00
abstract::Successful cardiac transplantation requires suppression of rejection, and endomyocardial biopsy is generally used to quantify this and guide immunotherapy. Biopsy, however, is an invasive, costly, cardiac catheterization with repetition limited. Since rejection requires lymphocyte activation, an alternative method of ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199103000-00018
更新日期:1991-03-01 00:00:00
abstract::Antithymocyte globulin (ATG) has been used successfully for induction therapy as well as for treatment of established allograft rejection. However, this therapy has often been associated with problems of overimmunosuppression and increased costs. In a randomized clinical trial, we compared the immunosuppressive benefi...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-06-15 00:00:00
abstract::The presence of major histocompatibility complex (MHC)-encoded antigens (RT1) on endothelium of rat kidneys was investigated using hyperimmune allogeneic rat sera (HIS) in an indirect immunofluorescence technique with kidney sections. Endothelial antigens detected with anti-MHC sera segregated in an F2 generation with...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198209000-00002
更新日期:1982-09-01 00:00:00
abstract:BACKGROUND:Recent changes in policies guiding allocation of transplant kidneys are predicted to increase sharing between distant geographic regions. The potential exists for an increase in cold ischemia time (CIT) with resulting increases in delayed graft function (DGF) and transplant-related costs (TRC). We sought to ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002309
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Globalization and migration patterns have increased the number of donors from countries with high incidence rates of tuberculosis (TB) in low incidence countries, with the subsequent increase in risk of TB transmission to the recipients. METHODS:Retrospective cohort study, including all actual deceased dono...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182977adf
更新日期:2013-07-27 00:00:00
abstract:BACKGROUND:Ischemia-reperfusion (I/R) injury after lung transplantation causes alveolar damage, lung edema, and acute rejection. Poly(adenosine diphosphate-ribose) polymerase (PARP) is a single-stranded DNA repair enzyme that induces apoptosis and necrosis after DNA damage caused by reactive oxygen species. We evaluate...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000305
更新日期:2014-09-27 00:00:00
abstract:BACKGROUND:The influence of donor hematopoietic cell microchimerism on organ allograft survival has been studied largely in vascularized transplant models. Here, we examine the impact of donor bone marrow (BM) cells administered intravenously together with transient systemic tacrolimus therapy on microchimerism, the su...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199802270-00005
更新日期:1998-02-27 00:00:00
abstract:BACKGROUND:Although human herpesvirus (HHV)-6 is now recognized as a frequent pathogen after transplantation, the real impact of this infection in patients undergoing transplantation remains unclear. METHODS:During 27 months, 30 consecutive heart-lung- and lung-transplant recipients were included on the day of transpl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000058809.42027.66
更新日期:2003-06-27 00:00:00
abstract:BACKGROUND:The results of the transplantation of marginal donor kidneys remain controversial. This study aimed to investigate the impact of donor risk factors as predictors of kidney-graft outcome. METHODS:Allograft failure risk factors were studied in 7,209 cadaveric kidney-transplant recipients reporting to the Etab...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000044171.97375.61
更新日期:2003-02-15 00:00:00
abstract:BACKGROUND:The vast majority of polyomavirus nephropathy (PVN) are due to BK virus, but rare cases result from JC virus reactivation. To date, only a handful of biopsy-proven JC-PVN cases have been reported. Here, we describe the clinical and pathologic findings in 7 patients with biopsy-proven JC-PVN. METHODS:Search ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003363
更新日期:2020-06-17 00:00:00
abstract:BACKGROUND:Cytotoxic IgG against class I antigens can contribute to renal dysfunction or failure after transplantation. However, the clinical relevance of IgG measured by flow cytometric cross-matching is controversial. This study correlated pre- and postoperative flow reactivity with clinical outcome among renal trans...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199802150-00029
更新日期:1998-02-15 00:00:00
abstract:BACKGROUND:In France, the need for continuous monitoring of transplant center performance has recently become apparent. Cumulative sum (CUSUM) monitoring of transplantation is already been used to monitor transplant outcomes in the United Kingdom and in the United States. Because CUSUM monitoring can be applied by diff...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002591
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:The expression of xenogeneic epitopes and the activation of human complement by adult pig islets after prolonged culture have hitherto not been described. MATERIALS AND METHODS:Freshly isolated and cultured islets were analyzed by fluorescence-activated cell sorter analysis, fluorescence microscopy, and imm...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199705270-00015
更新日期:1997-05-27 00:00:00
abstract::Endothelial cells serve an important role in augmenting immune responses through enhanced expression of MHC class II antigens. Immune-mediated vascular injury associated with rejection requires reendothelialization to restore vascular integrity. The origin of the reparative endothelial cells can be determined when ABO...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199102000-00033
更新日期:1991-02-01 00:00:00
abstract::Vascular endothelial cells (VEC) are clearly immunogenic and express antigens unique to vascular endothelial cells. The observation that peripheral blood monocytes also express this VEC antigen system made prospective testing feasible. Preformed antibody to the VEC/monocyte antigen system of the donor usually leads to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198503000-00016
更新日期:1985-03-01 00:00:00
abstract::Nippostrongylus infection strongly stimulates TH2 activity in vivo. Given the evidence of cross regulation between TH2 and TH1 cells, and the link between TH1 activity and graft rejection, we examined the effects of Nippostrongylus infection on the fate of kidney allografts in rats. Both prior Nippostrongylus infectio...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199601270-00003
更新日期:1996-01-27 00:00:00
abstract::To investigate whether graft-versus-host reactivity (GVHR) and the graft-versus-leukemia (GVL) effect can be differentiated, C3H-->AKR mixed bone marrow (BM) chimeras were prepared using two different conditioning regimens. Total body irradiation (TBI) chimeras were induced by infusing 5 x 1O(6) T cell depleted syngen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199603150-00025
更新日期:1996-03-15 00:00:00
abstract:BACKGROUND:Allogeneic bone marrow transplantation is under investigation for a range of nonmalignant indications, including tolerance induction through mixed chimerism. This strategy has so far been tested experimentally only in young recipients. Due to immunosenescence, older patients have an increase in memory T cell...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182954618
更新日期:2013-06-27 00:00:00
abstract:BACKGROUND:Chronic lung disease and pulmonary failure are complications that can occur after bone marrow transplantation (BMT) and are associated with severe morbidity and mortality. METHODS:We report on four patients who developed chronic, progressive, and irreversible lung disease 1 to 3 years after allogeneic BMT i...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200112270-00020
更新日期:2001-12-27 00:00:00
abstract::The mixed lymphocyte culture tests between one patient with acute lymphocytic leukemia and her mother and between another patient with aplastic anemia and his mother were found nonreactive, despite a one-haplotype difference for HL-A. Two crossovers in each family at the MLC locus or a specific defect in lymphocyte r...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197501000-00008
更新日期:1975-01-01 00:00:00
abstract::Numerous studies have reported successful allotransplantation of hepatocytes. However, none have shown long-term correction of a liver-related metabolic defect. In this study, we used a method of regional hepatocyte transplantation and subsequent induction of transplanted cell proliferation by regeneration response in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199609150-00008
更新日期:1996-09-15 00:00:00
abstract:BACKGROUND:Donor hepatectomy with maximal safety while preserving graft viability is of principal concern in living donor liver transplantation. There are compelling reasons for avoiding blood transfusion, even with autologous blood, to avoid the potential risks it imposes on healthy donors. This study aims to describe...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200006270-00018
更新日期:2000-06-27 00:00:00
abstract:BACKGROUND:Murine umbilical cord blood cells (UCBCs) were studied for their ability to reconstitute the hematopoietic system. METHODS:On average, 150 microL of cord blood per fetus containing 1.2 to 2 x 10(4) nucleated cells were collected from day 18.5 fetal umbilical cord, and 3 to 6 x 10(3) cells per fetus were obt...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000065295.99190.03
更新日期:2003-06-15 00:00:00
abstract::Stable renal transplant recipients (RTR) display high rates of atherosclerotic events (AE). Innate immunity and especially vascular inflammation play a role in the pathogenesis of atherosclerosis. It is illustrated both by an increased occurrence of postrenal transplant cardiovascular events in patients with elevated ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000202846.17619.a4
更新日期:2006-04-27 00:00:00