Abstract:
:Stable renal transplant recipients (RTR) display high rates of atherosclerotic events (AE). Innate immunity and especially vascular inflammation play a role in the pathogenesis of atherosclerosis. It is illustrated both by an increased occurrence of postrenal transplant cardiovascular events in patients with elevated levels of C-reactive protein and by a correlation between posttransplant AE and Toll-like receptor-4 Asp299Gly polymorphism. Here, we analyze the influence NOD2/CARD15 gene polymorphism since NOD2 can modulate macrophage pro-inflammatory activity and macrophage is present in early atherosclerotic lesions. The incidence of single nucleotide polymorphism (SNP) in the three major polymorphic region of NOD2 gene (SNP8, SNP12 and SNP13) was assessed in 182 RTR and the correlation between such polymorphism and the development of AE was analyzed. No correlation was observed between NOD2 gene polymorphism and the occurrence of AE after renal transplantation. NOD2 gene polymorphism thus does not appear to influence cardiovascular complications in RTR.
journal_name
Transplantationjournal_title
Transplantationauthors
Courivaud C,Ferrand C,Deschamps M,Tiberghien P,Chalopin JM,Duperrier A,Saas P,Ducloux Ddoi
10.1097/01.tp.0000202846.17619.a4subject
Has Abstractpub_date
2006-04-27 00:00:00pages
1212-5issue
8eissn
0041-1337issn
1534-6080pii
00007890-200604270-00021journal_volume
81pub_type
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