Apolipoprotein E gene polymorphism alters lipids before pancreas transplantation.

Abstract:

BACKGROUND:Pancreas transplantation (PTX) improves lipids in patients with type 1 diabetes mellitus. However, there are patients who have persistent abnormal lipids or develop new hyperlipidemia despite PTX. One factor that may influence the lipid profile is apolipoprotein E (Apo E) genotype. Apo E polymorphism, particularly E2 and E4 alleles, increases the risk of dyslipidemia. Apo E2 has also been found to increase risk of diabetic nephropathy and so may be more prevalent in PTX candidates. METHODS:This study evaluated fasting-lipid profiles in type 1 diabetes patients who were pancreas transplant candidates to prospectively evaluate the impact of Apo E genotype on dyslipidemia before and after PTX. RESULTS:Presence of one or more E4 alleles resulted in higher triglycerides ( =0.0446), lower HDL ( =0.0247), and a higher cholesterol-to-HDL (C/H) ratio ( =0.0405) before PTX when compared with those with E3/3 genotype. After PTX, lipids improved so there was no longer a difference in fasting lipids between patients with an E4 allele and E3/3 genotype. Presence of an E2 allele had no significant impact on fasting lipids before or after PTX. CONCLUSIONS:Presence of an Apo E4 allele worsened HDL, triglycerides, and C/H ratio before PTX compared with those with E3/3 genotype, whereas the presence of an Apo E2 allele had no significant effect on lipids before or after PTX. Thus, Apo E4 has a larger impact than Apo E2 on fasting-lipid profile in PTX candidates, and Apo E gene polymorphism does not worsen lipid dyslipidemia after PTX, despite introduction of immunosuppressant medications known to cause dyslipidemia.

journal_name

Transplantation

journal_title

Transplantation

authors

Balakrishnan S,Colling C,Burkman T,Erickson J,Lyden E,Maheshwari H,Mack-Shipman L,Lane J,Larsen J

doi

10.1097/00007890-200210150-00013

subject

Has Abstract

pub_date

2002-10-15 00:00:00

pages

974-7

issue

7

eissn

0041-1337

issn

1534-6080

journal_volume

74

pub_type

杂志文章
  • Infection with human herpesvirus 8 and transplant-associated gammopathy.

    abstract:BACKGROUND:The role of human herpesvirus (HHV)-8 in the pathogenesis of multiple myeloma and its pre-malignant state of monoclonal gammopathy is unclear. HHV-8 is transmitted by organ transplantation, representing a unique model with which to investigate primary HHV-8 infection. METHODS:The authors studied the inciden...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000129065.31427.96

    authors: Regamey N,Hess V,Passweg J,Hess C,Steiger J,Erb P,Cathomas G,Tamm M

    更新日期:2004-05-27 00:00:00

  • Atrial anastomotic thrombus causes neurologic deficits in a lung transplant recipient.

    abstract::Pulmonary thrombus formation in the region of atrial anastomosis following lung transplantation has been reported by several authors. Such patients typically present immediately after surgery with significant hemodynamic compromise causing pulmonary edema and hypoxemia. We describe a patient who presented with bilater...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199609150-00028

    authors: Stang MR,Hinderliter AL,Gott KK,Paradowski LJ,Aris RM

    更新日期:1996-09-15 00:00:00

  • Alloimmunization-activated suppressor cells. II. In vitro activity of suppressor cells implicated in the abrogation of lethal graft-versus-host reaction.

    abstract::Incompatibility for DBA/2 (D2) minor histocompatibility antigens (MiHA) alone leads to a severe lethal graft-versus-host reaction (GVHR) in irradiated (D2 X B10.D2)F1 mice receiving a bone-marrow-plus-spleen-cell graft from B10.D2 donors. This mortality is abrogated when the donors are preimmunized simultaneously agai...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198309000-00016

    authors: Pritchard LL,Halle-Pannenko O

    更新日期:1983-09-01 00:00:00

  • Intact pig pancreatic islet function in the presence of human xenoreactive natural antibody binding and complement activation.

    abstract:BACKGROUND:The expression of xenogeneic epitopes and the activation of human complement by adult pig islets after prolonged culture have hitherto not been described. MATERIALS AND METHODS:Freshly isolated and cultured islets were analyzed by fluorescence-activated cell sorter analysis, fluorescence microscopy, and imm...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199705270-00015

    authors: Mirenda V,Le Mauff B,Cassard A,Huvelin JM,Boeffard F,Faivre A,Soulillou JP,Anegon I

    更新日期:1997-05-27 00:00:00

  • Increased risk of all-cause mortality and renal graft loss in stable renal transplant recipients with hyperparathyroidism.

    abstract:BACKGROUND:Hyperparathyroidism is reported in 10% to 66% of renal transplant recipients (RTR). The influence of persisting hyperparathyroidism on long-term clinical outcomes in RTR has not been examined in a large prospective study. METHODS:We investigated the association between baseline parathyroid hormone (PTH) lev...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000000583

    authors: Pihlstrøm H,Dahle DO,Mjøen G,Pilz S,März W,Abedini S,Holme I,Fellström B,Jardine AG,Holdaas H

    更新日期:2015-02-01 00:00:00

  • Monocyte-derived dendritic cell precursors facilitate tolerance to heart allografts after total lymphoid irradiation.

    abstract:BACKGROUND:Previous studies have shown that posttransplant total lymphoid irradiation, anti-thymocyte globulin, and an intravenous donor blood cell infusion induce tolerance to ACI heart allografts in Lewis rat hosts. METHODS:In the current study, fresh ACI monocytes and dendritic cell precursors, derived from short-t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199811270-00004

    authors: Hayamizu K,Huie P,Sibley RK,Strober S

    更新日期:1998-11-27 00:00:00

  • Studies on heterophile antibodies in transplantation sera.

    abstract::By means of double diffusion in gel reactions, "heterophile" antibodies were demonstrated in human renal transplantation sera. Of thirty-two recipients of renal allografts, 12 (37 per cent) had antibodies to extract of bovine erythrocyte stromata, and 5 (19 per cent) of 26 recipients produced antibodies to extract of ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197501000-00004

    authors: Kano K,Loza U,Gerbasi JR,Milgrom F

    更新日期:1975-01-01 00:00:00

  • Differential immune response of congenic mice to ultraviolet-treated major histocompatibility complex class II-incompatible skin grafts.

    abstract::The influence of ultraviolet (UVB) irradiation on the survival of H-2 class II-disparate skin grafts was studied in congenic mouse strains. Isolated skin was UVB irradiated in vitro at a dose of 40 mJ/cm2 from both sides to remove Ia immunogenicity. Immediately after irradiation the skin was transplanted onto the flan...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198803000-00020

    authors: Vermeer BJ,Santerse B,Van De Kerckhove BA,Schothorst AA,Claas FH

    更新日期:1988-03-01 00:00:00

  • The case to abandon human leukocyte antigen matching for kidney allocation: would it be wise to throw out the baby with the bathwater?

    abstract::Since major histocompatibility (MHC) antigen matching was introduced in the early 1970s as the key factor determining kidney transplant allocation, several studies, mainly arising from organ-sharing organizations in the United States and Europe, have debated this complex issue. The first fundamental concern is the int...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/01.tp.0000103730.16444.e7

    authors: Hiesse C,Pessione F,Houssin D

    更新日期:2004-02-27 00:00:00

  • Proteomic bronchiolitis obliterans syndrome risk monitoring in lung transplant recipients.

    abstract:BACKGROUND:Obliterative bronchiolitis poses a primary obstacle for long-term survival of lung transplant recipients and manifests clinically as bronchiolitis obliterans syndrome (BOS). Establishing a molecular level screening method to detect BOS-related proteome changes before its diagnosis by forced expiratory volume...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318224c109

    authors: Wolf T,Oumeraci T,Gottlieb J,Pich A,Brors B,Eils R,Haverich A,Schlegelberger B,Welte T,Zapatka M,von Neuhoff N

    更新日期:2011-08-27 00:00:00

  • A monoclonal anti-pan-T-cell antibody. In vitro and in vivo studies.

    abstract::A murine monoclonal antihuman T cell antibody is described that is pan-T in that it reacts with all T cells, including those from thymus, but not with B cells or other cells, except for a small subpopulation of null cells. Biochemical analysis demonstrated that the antigen detected is a glycoprotein, Mr 50,000 daltons...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198309000-00013

    authors: Thurlow PJ,Lovering E,d'Apice AJ,McKenzie IF

    更新日期:1983-09-01 00:00:00

  • Determination of tolerance to self E alpha peptides by clonal elimination of H-2E reactive T cells and antigen presentation by H-2A molecules.

    abstract::A series of three synthetic peptides spanning H-2E alpha k chain residues (90-110), (110-130), and (130-150) were synthesized and purified. Mice representative of H-2E- (B6, B10, B10.M, B10.Q, B10.S) and H-2E+ (B10.D2, B10.K, B10.RIII) were immunized with individual peptides and lymph node cells challenged in vitro. B...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199211000-00029

    authors: Krco CJ,Beito TG,David CS

    更新日期:1992-11-01 00:00:00

  • Antileukocyte antibody in postpartum and renal transplant subjects. A comparison of capillary agglutination and lymphocytotoxicity reactions.

    abstract::Sera were obtained from 48 gravida II prenatal and 211 multiparous nonpregnant females and examined for leukocyte antibodies comparing a standard lymphocytotoxicity (CY) test with capillary agglutination (CA). Antibody was detected in 41% of the samples in both groups but only CA tests were positive with approximately...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197602000-00001

    authors: Thompson JS,Jackson D,Greazel NA,Parmely MJ,Severson CD

    更新日期:1976-02-01 00:00:00

  • "Natural" human leukocyte antigen antibodies found in nonalloimmunized healthy males.

    abstract:BACKGROUND:Human leukocyte antigen (HLA) antibodies were normally not found in subjects who have not been immunized by pregnancies, transfusions, or transplants. But with new methodology, we now see that HLA antibodies are often found in nonalloimmunized males. METHODS:The sera of 424 healthy male donors were tested w...

    journal_title:Transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1097/TP.0b013e318186d87b

    authors: Morales-Buenrostro LE,Terasaki PI,Marino-Vázquez LA,Lee JH,El-Awar N,Alberú J

    更新日期:2008-10-27 00:00:00

  • Urine cytologic profile in renal allograft recipients determined by monoclonal antibodies. Diagnosis of allograft rejection.

    abstract::Controversy exists as to the type of cells present in the urine during renal allograft rejection. In order to resolve this controversy as well as to evaluate the value of urine sediment examination as a means of detecting AR, we quantitated the different cells present in urine during AR using an immunoperoxidase techn...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198903000-00017

    authors: Segasothy M,Birch DF,Fairley KF,Kincaid-Smith P

    更新日期:1989-03-01 00:00:00

  • Detection of antibody to hepatitis C virus in renal transplant recipients.

    abstract::Non-A, non-B hepatitis is a significant cause of liver disease among renal allograft recipients. In order to assess the impact and prevalence of hepatitis C in a series of renal allograft recipients, we retrospectively screened 621 consecutive patients transplanted between 1979 and 1989 and 484 cadaver organ donors re...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199102000-00024

    authors: Roth D,Fernandez JA,Burke GW,Esquenazi V,Miller J

    更新日期:1991-02-01 00:00:00

  • Inhibition of cell-mediated microcytotoxicity and stimulation of mixed lymphocyte reactivity by mouse pregnancy serum.

    abstract::Blocking activity of mouse pregnancy serum was investigated using a well defined one-way mixed lymphocyte culture and a cell-mediated microcytotoxicity test. Allogeneic (C57BL (H-2b) X CBA/Ca (H-2k)) and syngeneic (C57BL (H-2b) X C57BL (H-2b)) pregnancy and postpartum sera were found to stimulate rather than inhibit t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197811000-00002

    authors: Smith G

    更新日期:1978-11-01 00:00:00

  • Late onset of severe graft-versus-host disease in a pediatric liver transplant recipient.

    abstract::We report the management of a patient with the late onset of chronic graft-versus-host disease (GVHD) after orthotopic liver transplantation. GVHD is a rare complication of solid organ transplants that usually presents early after transplantation and is fatal in the majority of cases. Our patient differs from the typi...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200105270-00022

    authors: Dunn SP,Krueger LJ,Butani L,Punnett H

    更新日期:2001-05-27 00:00:00

  • Long-term outlook for renal transplant recipients with one-year function. "Doctor, what are my chances"?

    abstract::Patients with renal transplants that survive the first year often ask about the chance of long-term function. We studied 1850 patients with primary transplants from June 7, 1963 to September 1, 1988 who had graft survival of greater than 1 year. Patients were grouped by donor type, diabetic status, and whether or not ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199101000-00018

    authors: Fischel RJ,Payne WD,Gillingham KJ,Dunn DL,Sutherland DE,Matas AJ,Najarian JS

    更新日期:1991-01-01 00:00:00

  • Outcomes in diabetic patients after simultaneous pancreas-kidney versus kidney alone transplantation.

    abstract:BACKGROUND:Previous studies have identified more morbidity in simultaneous pancreas-kidney (SPK) transplant recipients compared with kidney alone (KA) recipients. With the development of novel immunosuppressive drugs, studies are needed to determine optimal treatment regimens in specific patient populations. METHODS:W...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007890-199711150-00010

    authors: Lee CM,Scandling JD,Krieger NR,Dafoe DC,Alfrey EJ

    更新日期:1997-11-15 00:00:00

  • Failure of cyclosporine-treated renal allograft recipients to increase glomerular filtration rate following an amino acid infusion.

    abstract::Renal allograft recipients treated with cyclosporine (CsA) have increased renal vascular resistance that falls when CsA is stopped. With the aim of identifying whether CsA-treated patients with excellent renal function also have an alteration in renal vascular tone and to investigate which vessels are affected, we hav...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198807000-00014

    authors: Cairns HS,Raval U,Neild GH

    更新日期:1988-07-01 00:00:00

  • A quantitative survey of Western Muslim attitudes to solid organ donation.

    abstract:BACKGROUND:It is imperative for healthcare providers to examine Western Muslim attitudes on organ donation, because they are reluctant donors. We explored such opinion with the aid of a quantitative survey. METHODS:Voluntary completion of an anonymous survey was promoted (online and paper sampling). For a population t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318231ea17

    authors: Sharif A,Jawad H,Nightingale P,Hodson J,Lipkin G,Cockwell P,Ball S,Borrows R

    更新日期:2011-11-27 00:00:00

  • Lack of GVHD across classical, single minor histocompatibiliTy (miH) locus barriers in mice.

    abstract::To determine whether a disparity at a single miH genetic loci are sufficient to generate GVHD in mice, we focused on well-known genetic alleleic differences at the miH gene loci, H3 and H4. For H3 congenic GVHD studies, C57BL/10 (H2b) mice were used as recipients of miH-disparate B10.LP-H3b donor cells. For H4 congeni...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199602270-00017

    authors: Blazar BR,Roopenian DC,Taylor PA,Christianson GJ,Panoskaltsis-Mortari A,Vallera DA

    更新日期:1996-02-27 00:00:00

  • T suppressor cells induced by transfusions and cyclosporine. Studies in the murine cardiac allograft model.

    abstract::Pregraft transfusion combined with immunosuppression at the time of grafting improves the survival of clinical and experimental allografts. The mechanisms responsible for this effect were investigated in the murine model of cardiac transplantation, combining transfusions 7 to 30 days prior to transplantation with cycl...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199012000-00026

    authors: Mottram PL,Mirisklavos A,Dumble LJ,Clunie GJ

    更新日期:1990-12-01 00:00:00

  • Split tolerance induced by immunotoxin in a rhesus kidney allograft model.

    abstract:BACKGROUND:Renal allografts were performed in rhesus monkeys using FN18-CRM9, a potent immunotoxin capable of depleting T cells to less than 1% of baseline levels in blood and lymph nodes, as a preparative agent. We have recently reported that animals pretreated with FN18-CRM9 1 week before transplantation without furt...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199705150-00023

    authors: Fechner JH Jr,Vargo DJ,Geissler EK,Graeb C,Wang J,Hanaway MJ,Watkins DI,Piekarczyk M,Neville DM Jr,Knechtle SJ

    更新日期:1997-05-15 00:00:00

  • Dog leukocyte antigen-haploidentical stem cell allografts after anti-CD44 therapy and nonmyeloablative conditioning in a preclinical canine model.

    abstract:BACKGROUND:We previously described a reduced-intensity hematopoietic cell transplantation (HCT) regimen in dog leukocyte antigen (DLA)-haploidentical littermate recipients consisting of 450 cGy total body irradiation (TBI) and anti-CD44 monoclonal antibody (mAb) S5 before and mycophenolate mofetil (MMF)/cyclosporine (C...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000228908.10775.b0

    authors: Fukuda T,Kerbauy FR,Gooley T,Santos EB,Storb R,Sandmaier BM

    更新日期:2006-08-15 00:00:00

  • The specificity of nephritogenic antibodies. IV. Binding of monoclonal antithymocyte antibodies to rat kidney.

    abstract::Polyclonal rabbit antirat thymocyte serum (ATS) has been shown to form in situ glomerular immune aggregates following perfusion into normal rat kidney ex vivo. This may be due to the presence of T-cell-like epitopes in the rat kidney, or it may be a result of contaminating anti-connective-tissue antibodies in ATS. To ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198606000-00015

    authors: Bagchus WM,Donga J,Rozing J,Hoedemaeker PJ,Bakker WW

    更新日期:1986-06-01 00:00:00

  • Clinical utility of a quantitative polymerase chain reaction for diagnosis of cytomegalovirus disease in solid organ transplant patients.

    abstract:BACKGROUND:Accurate and rapid diagnosis of human cytomegalovirus (HCMV) disease in solid organ transplant patients remains a challenge. We evaluated the clinical utility of a quantitative polymerase chain reaction (QPCR) method to diagnose transplant patients with HCMV disease. METHODS:A total of 429 plasma samples fr...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007890-199910150-00016

    authors: Ferreira-Gonzalez A,Fisher RA,Weymouth LA,Langley MR,Wolfe L,Wilkinson DS,Garrett CT

    更新日期:1999-10-15 00:00:00

  • Differential immune response to influenza and pneumococcal vaccination in immunosuppressed patients after heart transplantation.

    abstract:INTRODUCTION:Patients after solid organ transplantation are at an increased risk for microbial infections. Due to therapeutic immunosuppression, the response to active immunizations may be reduced. The serological efficacy of pneumococcal and influenza vaccination was studied in heart transplant recipients. PATIENTS A...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199811270-00014

    authors: Dengler TJ,Strnad N,Bühring I,Zimmermann R,Girgsdies O,Kubler WE,Zielen S

    更新日期:1998-11-27 00:00:00

  • Reduction of degranulation of polymorphonuclear leukocytes by immunosuppression in patients following cadaveric renal transplantation.

    abstract::Plasma levels of main granulocyte components of patients after cadaveric renal transplantation were compared 9 days postoperative with the plasma levels of patients undergoing aortofemoral and iliacofemoral bypass operation or abdominal surgery. Lactoferrin values were significantly lower in patients under immunosuppr...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198901000-00032

    authors: Hörl WH,Wanner C,Riegel W,Schlosser W,Wilms H,Schollmeyer P

    更新日期:1989-01-01 00:00:00