Abstract:
:A murine monoclonal antihuman T cell antibody is described that is pan-T in that it reacts with all T cells, including those from thymus, but not with B cells or other cells, except for a small subpopulation of null cells. Biochemical analysis demonstrated that the antigen detected is a glycoprotein, Mr 50,000 daltons, in which sialic acid, alpha-fucose and alpha-mannose are the important terminal or subterminal carbohydrates. Further analysis indicated that the antigen is the E-rosette-forming-cell (ERFC) receptor or a closely associated structure. Three patients with renal allograft rejection were treated with the pan-T cell monoclonal antibody and, although the antibody was in excess and bound to circulating T cells, no lasting effect on T cell numbers or graft rejection was noted.
journal_name
Transplantationjournal_title
Transplantationauthors
Thurlow PJ,Lovering E,d'Apice AJ,McKenzie IFdoi
10.1097/00007890-198309000-00013subject
Has Abstractpub_date
1983-09-01 00:00:00pages
293-8issue
3eissn
0041-1337issn
1534-6080journal_volume
36pub_type
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