Synergistic immunosuppressive effects of monoclonal antibodies specific for interferon-gamma and tumor necrosis factor alpha. A skin transplantation study in the rhesus monkey.

abstract：BACKGROUND:The clinical impact of chronic transplant glomerulopathy (CTG) on the outcome of kidney allograft receiving calcineurin inhibitors (CNIs) remains uncertain. A retrospective study of renal transplant recipients at Ospedale Maggiore of Milan was undertaken to evaluate the clinical outcome of patients with CTG....

journal_title：Transplantation

authors： Banfi G,Villa M,Cresseri D,Ponticelli C

更新日期：2005-11-27 00:00:00

abstract：:Heart transplantation is considered nowadays the gold standard in the therapy of chronic and terminal heart insufficiency. Primary organ failure after heart transplantation is a severe complication generally related to prolonged ischemia time, poor quality of the organ, or acute rejection. All these factors can potent...

journal_title：Transplantation

authors： Beiras-Fernandez A,Weis FC,Fuchs H,Meiser BM,Reichart B,Weis M

更新日期：2006-10-27 00:00:00

abstract：BACKGROUND:The rate of acute rejection (AR) has decreased significantly, but whether this is associated with improvement in long-term graft survival is controversial. METHODS:We analyzed 1445 consecutive adult deceased donor kidney transplant recipients from 1985 to 2005, over two periods (1985-1995 vs. 1996-2005) to ...

journal_title：Transplantation

authors： Sola E,Gonzalez-Molina M,Cabello M,Burgos D,Ramos J,Gutierrez C,Lopez V,Soler J,de la Vega E,Hernandez D

更新日期：2010-03-27 00:00:00

abstract：BACKGROUND:T-cell receptor transgenic (TCR-tg) mouse models with direct CD4 alloreactivity will help elucidate mechanisms of transplant rejection and tolerance in vivo. Although such models exist, they are limited by unusual strain combinations or are based on model antigens. METHODS:A TCR-tg mouse with direct CD4 spe...

journal_title：Transplantation

authors： Brennan TV,Hoang V,Garrod KR,Liu FC,Hayden T,Kim J,Kang SM

更新日期：2008-01-27 00:00:00

abstract：BACKGROUND:Renal allografts were performed in rhesus monkeys using FN18-CRM9, a potent immunotoxin capable of depleting T cells to less than 1% of baseline levels in blood and lymph nodes, as a preparative agent. We have recently reported that animals pretreated with FN18-CRM9 1 week before transplantation without furt...

journal_title：Transplantation

authors： Fechner JH Jr,Vargo DJ,Geissler EK,Graeb C,Wang J,Hanaway MJ,Watkins DI,Piekarczyk M,Neville DM Jr,Knechtle SJ

更新日期：1997-05-15 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) infection is common in kidney transplantation and is known to affect long-term patient and graft survival, as is time in renal-replacement therapy (RRT). The aim of this study was to investigate HCV in relation to time in RRT and its impact on outcome after transplantation. METHODS:A...

journal_title：Transplantation

authors： Bruchfeld A,Wilczek H,Elinder CG

更新日期：2004-09-15 00:00:00

abstract：BACKGROUND:Mycophenolate mofetil (MMF) therapy compared with azathioprine has not led to improved long-term renal allograft outcomes perhaps as MMF dose is limited by tolerability and dose reduction is associated with inferior graft outcome. The consequences, however, of dose reduction of mycophenolate mofetil relative...

journal_title：Transplantation

authors： Shah S,Collett D,Johnson R,Raftery M,Rudge C,Yaqoob MM

更新日期：2008-10-27 00:00:00

abstract：BACKGROUND:In live donor liver transplantation portal flush only of the graft is done on the bench. There are no data on antegrade arterial flush along with portal flush of the graft. METHODS:Consecutive patients undergoing elective right lobe live donor liver transplantation were block-randomized to receive either po...

journal_title：Transplantation

authors： Pamecha V,Sandhyav R,Sinha PK,Bharathy KGS,Sasturkar S

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a well-documented complication of organ transplantation. Bisphosphonates have been shown to be effective in preventing corticosteroid-induced osteoporosis in renal transplant recipients, but data are lacking for treatment of established osteoporosis. This study reports our clinical experience...

journal_title：Transplantation

authors： Arlen DJ,Lambert K,Ioannidis G,Adachi JD

更新日期：2001-03-15 00:00:00

abstract：:FK-506 is known to suppress the transcription of several genes encoding cytokines (e.g., IL-2, IFN-gamma) thought to play an important role in the allograft response. This general inhibition of cytokine gene transcription and protein production was previously thought to be the main mechanism by which FK-506 suppressed...

journal_title：Transplantation

authors： Wang SC,Morel PA,Wang Q,Jordan ML,Simmons RL,Tweardy DJ

更新日期：1993-10-01 00:00:00

abstract：:The purpose of this open-label, prospective study was to compare steady state concentrations and clearances of intravenously administered cyclosporine or tacrolimus with and without concomitant high-dose (400 mg/day) fluconazole in allogeneic BMT patients. Twenty-one patients were evaluable. The mean steady state cycl...

journal_title：Transplantation

authors： Osowski CL,Dix SP,Lin LS,Mullins RE,Geller RB,Wingard JR

更新日期：1996-04-27 00:00:00

abstract：:The immunosuppressive effects of leflunomide and cyclosporine were evaluated in a rat neurovascularized myocutaneous allograft model. Inbred Brown-Norway and Lewis rats were served as donors and recipients, respectively. All recipients were observed for 60 days or until allograft rejection occurred. All isograft contr...

journal_title：Transplantation

authors： Yeh LS,Gregory CR,Griffey SM,Lecouteur RA,Morris RE

更新日期：1996-09-27 00:00:00

abstract：:The use of real-time reverse transcription polymerase chain reaction to compare gene expression in different tissues and conditions requires normalization to an internal control that must be expressed at a constant level. Although a previous validation step is required to confirm that an internal control is appropriat...

journal_title：Transplantation

authors： Rodriguez-Mulero S,Montanya E

更新日期：2005-09-15 00:00:00

abstract：:The dose-response effect of cyclosporine on rat limb transplant prolongation was investigated across the LBN-to-LEW histocompatibility barrier. This composite tissue allograft model has been shown to represent a strong transplantation barrier. Median limb allograft survival times increased in a dose-dependent manner w...

journal_title：Transplantation

authors： Hewitt CW,Black KS,Fraser LA,Howard EB,Martin DC,Achauer BM,Furnas DW

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Significant disparity exists in the United Kingdom between the need for organ transplant and supply of deceased donor organs. In the recent years, efforts to increase donation has improved the rate of mainly deceased donors after circulatory death and from older donors. The rate of donation from pediatric po...

journal_title：Transplantation

authors： Dave RV,Hakeem AR,Dawrant MJ,Ecuyer CL,Lewington AJ,Attia MS,Hostert L,Finlay E,Ahmad N

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Renal warm ischemic injury and immunosuppression with cyclosporin A (CsA) may contribute to chronic allograft nephropathy after cadaveric transplantation. This study establishes whether CsA can sensitize the kidney to injury and fibrosis induced by renal warm ischemia (RWI). METHODS:The left kidney of Sprag...

journal_title：Transplantation

authors： Ahmed A,Huang L,Raftery AT,Ahmed AK,Fahmy H,El Nahas AM,Haylor JL

更新日期：2004-03-15 00:00:00

abstract：BACKGROUND:Acute rejection of allografts remains a significant problem in clinical transplantation, and the fundamental mechanism underlying this rejection are as yet only poorly elucidated. Recently, DNA microarrays have come into use for the study of gene expression profiles, and we have taken advantage of this new t...

journal_title：Transplantation

authors： Saiura A,Mataki C,Murakami T,Umetani M,Wada Y,Kohro T,Aburatani H,Harihara Y,Hamakubo T,Yamaguchi T,Hasegawa G,Naito M,Makuuchi M,Kodama T

更新日期：2001-07-27 00:00:00

abstract：:Although the requirements for the induction of IL-2 receptor expression following lymphocyte stimulation in vitro have been well characterized, little information is available on the role of IL-2 and the IL-2 receptor in lymphocyte activation in vivo. We have established a quantitative assay for the measurement of IL-...

journal_title：Transplantation

authors： Kroczek RA,Black CD,Barbet J,Edison LJ,Shevach EM

更新日期：1987-10-01 00:00:00

abstract：:Healthy rat islets were encapsulated in alginate-polylysine-alginate capsules measuring 0.25-0.35 mm in diameter using a modified encapsulation technique. The encapsulated islets were transplanted intraperitoneally in nonimmunosuppressed streptozotocin-induced diabetic BALB/c mice. The diabetic condition of the experi...

journal_title：Transplantation

authors： Lum ZP,Krestow M,Tai IT,Vacek I,Sun AM

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:The short tolerable cold ischemia time and the importance of other risk factors have generally superseded the role of HLA matching in the allocation of donor hearts. Recent advances in the accuracy and time required to perform HLA typing and crossmatching, however, have led us to re-examine the United Networ...

journal_title：Transplantation

authors： Thompson JS,Thacker LR 2nd,Takemoto S

更新日期：2000-05-27 00:00:00

abstract：BACKGROUND:Although clinical data suggest its existence, little is known about the effect of rapamycin derivatives on wound repair. This study aims to delineate the influence of the mammalian target of rapamycin inhibitor everolimus on wound healing in the rat intestine. METHODS:Four groups of 26 male Wistar rats rece...

journal_title：Transplantation

authors： van der Vliet JA,Willems MC,de Man BM,Lomme RM,Hendriks T

更新日期：2006-12-15 00:00:00

abstract：:Heterotopic renal allografts following bilateral nephrectomies were placed in 21 healthy mongrel dogs. One group of 11 dogs received cyclosporine (5 mg/kg/24 hr, orally), and 1 group of 10 dogs received cyclosporine and mizoribine (5 mg/kg and 3 mg/kg/24 hr, orally). Body weights, blood cell counts, serum chemistry pr...

journal_title：Transplantation

authors： Gregory CR,Gourley IM,Cain GR,Broaddus TW,Cowgill LD,Willits NH,Patz JD,Ishizaki G

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Renal dysfunction early after kidney transplantation has multiple causes including ischemia-reperfusion (I/R) injury and drug-induced nephrotoxicity. This study assesses the acute nephrotoxicity of tacrolimus (Tac) and sirolimus (Sir) in a rat renal isograft model. METHODS:Lewis renal isografts and uninephr...

journal_title：Transplantation

authors： Ninova D,Covarrubias M,Rea DJ,Park WD,Grande JP,Stegall MD

更新日期：2004-08-15 00:00:00

abstract：:Tolerance induction by CD45RB monoclonal antibody (mAb) in murine allograft models is associated with an alteration in the CD45RBlo/CD45RBhi T-cell ratio in favor of CD45RBlo T cells, which can function as regulatory cells and promote tolerance. It has been proposed that inversion of the CD45RBhi/CD45RBlo normal T-cel...

journal_title：Transplantation

authors： Luke PP,Deng JP,O'Brien CA,Everest M,Hall AV,Chakrabarti S,O'Connell PJ,Zhong R,Jevnikar AM

更新日期：2003-07-27 00:00:00

abstract：BACKGROUND:Although inactivated vaccines are recommended for immunocompromized patients, efficacy and safety of diphtheria and tetanus immunization in renal transplant recipients have received little attention so far. The aim of the study was to investigate the response to a standard diphtheria and tetanus booster vacc...

journal_title：Transplantation

authors： Enke BU,Bökenkamp A,Offner G,Bartmann P,Brodehl J

更新日期：1997-07-27 00:00:00

abstract：:Liver-derived dendritic cell (DC) progenitors propagated in liquid culture in granulocyte/macrophage colony-stimulating factor exhibit low levels both of cell surface MHC class II antigens and of counter-receptors for CTLA-4/CD28. They fail to stimulate allogeneic T cells in mixed leukocyte cultures. To evaluate their...

journal_title：Transplantation

authors： Rastellini C,Lu L,Ricordi C,Starzl TE,Rao AS,Thomson AW

更新日期：1995-12-15 00:00:00

abstract：BACKGROUND:Graft-versus-host disease (GVHD) is a major complication after bone marrow transplantation, which may be refractory to immunosuppressive drugs. As preliminary case reports suggested that extracorporeal photochemotherapy (ECP) using a Therakos device might be beneficial, we conducted a pilot study to assess t...

journal_title：Transplantation

authors： Besnier DP,Chabannes D,Mahé B,Mussini JM,Baranger TA,Muller JY,Milpied N,Esnault VL

更新日期：1997-07-15 00:00:00

abstract：:Nuclear imaging is used to evaluate renal allografts demonstrating delayed function after transplantation. Interpretation of the nuclear scan in the context of clinical data, provides helpful information in the management of the transplant recipient. The better quality of images obtained with technetium-99m mercaptoac...

journal_title：Transplantation

authors： Mange KC,Scheff A,Brayman K,Mozley D,Grossman RA,Naji A,Aradhye S

更新日期：1997-11-27 00:00:00

abstract：BACKGROUND:Cell-based insulin therapies can potentially improve glycemic regulation in insulin-dependent diabetic patients. Enteroendocrine cells engineered to secrete recombinant insulin have exhibited glycemic efficacy, but have been primarily studied as uncontrollable growth systems in immune incompetent mice. Furth...

journal_title：Transplantation

authors： Tiernan AR,Thulé PM,Sambanis A

更新日期：2014-09-15 00:00:00

abstract：BACKGROUND:Ischemia-reperfusion (I/R) injury after lung transplantation causes alveolar damage, lung edema, and acute rejection. Poly(adenosine diphosphate-ribose) polymerase (PARP) is a single-stranded DNA repair enzyme that induces apoptosis and necrosis after DNA damage caused by reactive oxygen species. We evaluate...

journal_title：Transplantation

authors： Hatachi G,Tsuchiya T,Miyazaki T,Matsumoto K,Yamasaki N,Okita N,Nanashima A,Higami Y,Nagayasu T

更新日期：2014-09-27 00:00:00