Cyclosporine A sensitizes the kidney to tubulointerstitial fibrosis induced by renal warm ischemia.

abstract：:A prospective randomized trial was performed comparing survival of cadaveric grafts allocated by HLA-A+B matching and HLA-DR matching. The two allocation methods resulted in very similar graft survivals. HLA-A matching had no significant effect on graft survival. HLA-B and HLA-DR matching were shown to have approximat...

journal_title：Transplantation

authors： d'Apice AJ,Sheil AG,Tait BD,Bashir HV

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:The efficiency of islet graft survival after intraportal implantation is compromised by host innate immune responses and the production of proinflammatory cytokines that cause acute cellular injury. This reaction activates intraislet nuclear factor-κB (NF-κB), causing production of gene products that have de...

journal_title：Transplantation

authors： Rink JS,McMahon KM,Zhang X,Chen X,Mirkin CA,Thaxton CS,Kaufman DB

更新日期：2013-11-27 00:00:00

abstract：:Rabbit antisera to rat thoracic duct lymphocytes were examined by absorption analysis with quantitative radioimmunoassays to determine the tissue distribution of the antigens recognised and the amount of antibody against different specificities. Seven of eight sera were remarkably specific for leucocytes and one serum...

journal_title：Transplantation

authors： Fabre JW,Williams AF

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:Dysregulation of the coagulation system due to inflammatory responses and cross-species molecular incompatibilities represents a major obstacle to successful xenotransplantation. We hypothesized that complement inhibition mediated by transgenic expression of human CD46 in pigs might also regulate the coagula...

journal_title：Transplantation

authors： Bongoni AK,Kiermeir D,Schnider J,Jenni H,Garimella P,Bähr A,Klymiuk N,Wolf E,Ayares D,Voegelin E,Constantinescu MA,Seebach JD,Rieben R

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the influence of IL-10 and TGFbeta1 gene polymorphisms on the development of acute rejection and coronary disease in pediatric heart transplant recipients. METHODS:Patients were classified as either Rejectors or Nonrejectors. Coronary artery disease (CAD) was diagnosed by...

journal_title：Transplantation

authors： Di Filippo S,Zeevi A,McDade KK,Bastien O,Webber SA

更新日期：2006-03-27 00:00:00

abstract：:Monocytes from human peripheral blood, when incubated in vitro, spread onto the surface of the glass. Horse antihuman lymphocyte globulin (ALG) added to the incubation chamber inhibits the spreading, while normal horse globulin (NHG) does not. The inhibition depends on the concentration of ALG admixed to the mononucle...

journal_title：Transplantation

authors： Silobrcić V,Mazuran R,Dekaris D,Balner H

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Composite tissue allotransplantation (CTA) has been recently introduced as a potential treatment for tissue loss secondary to burns, injuries, or resections. However, the optimal strategies to prevent CTA rejection remain undefined. Presently, no CTA model exists to evaluate human-specific immunosuppressants...

journal_title：Transplantation

authors： Cendales LC,Xu H,Bacher J,Eckhaus MA,Kleiner DE,Kirk AD

更新日期：2005-11-27 00:00:00

abstract：:The effect of FK506 and cyclosporine on NK and ADCC activity was evaluated. Cytotoxic cells mediating both activities are resistant to FK506. In contrast, preincubation of ADCC and NK effectors with cyclosporine decreases their cytotoxic potential, while adding the drug to the assays is without effect. ...

journal_title：Transplantation

authors： Wasik M,Gorski A,Stepien-Sopniewska B,Lagodzinski Z

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:In experimental brain death models, autonomic storm (AS) triggers severe myocardial dysfunction, which can be attenuated by pharmacologic treatment. The aim of this study was to determine the incidence of AS in a cohort of human organ donors and to evaluate the potential interest of AS treatment on myocardia...

journal_title：Transplantation

authors： Audibert G,Charpentier C,Seguin-Devaux C,Charretier PA,Grégoire H,Devaux Y,Perrier JF,Longrois D,Mertes PM

更新日期：2006-10-27 00:00:00

abstract：BACKGROUND:Hepatic artery thrombosis (HAT) is a significant cause of morbidity after liver transplantation. The aims of this study are to identify and compare risk factors that might contribute to HAT. METHODS:A total of 424 liver transplants performed at the University of Virginia were reviewed. HAT was defined as co...

journal_title：Transplantation

authors： Oh CK,Pelletier SJ,Sawyer RG,Dacus AR,McCullough CS,Pruett TL,Sanfey HA

更新日期：2001-03-27 00:00:00

abstract：:The pig has been considered unsuitable for experimental pancreatic transplantation. In order to develop a model for segmental transplantation, the vascular anatomy was studied in 41 pigs. No variation in venous drainage of the pancrease was found. In contrast, 3 variations of arterial supply were noted. In 29 of the p...

journal_title：Transplantation

authors： Shokouh-Amiri MH,Rahimi-Saber S,Andersen HO

更新日期：1989-01-01 00:00:00

abstract：:Invasive aspergillosis and mucormycosis are life-threatening infections in solid organ and hematopoietic cell transplant recipients. Despite medical advancements in the care of these patients and the availability of new mold-active drugs, the outcomes remain suboptimal. Therefore, there has been increased interest in ...

journal_title：Transplantation

authors： Haidar G,Singh N

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Delayed graft function (DGF) is associated with acute tubular necrosis. In this setting, surviving tubular cells may proliferate and replace injured cells. CD133Pax-2cells may play a role in the regeneration of tubular damage. The aim of this study was to demonstrate the presence of these cells in human kidn...

journal_title：Transplantation

authors： Loverre A,Capobianco C,Ditonno P,Battaglia M,Grandaliano G,Schena FP

更新日期：2008-04-27 00:00:00

abstract：:The survival of semiallogeneic or fully allogeneic rat kidney allografts was prolonged in some strain combinations with immune complexes formed with hapten-conjugated alloantigens (TNP-Ag) of donor origin and a mouse monoclonal antihapten antibody (anti-TNP). Complexes were administered i.v. at the time of operation--...

journal_title：Transplantation

authors： Barber WH,Hutchinson IV,Morris PJ

更新日期：1983-11-01 00:00:00

abstract：:To determine if cold preservation time continues to affect renal transplant outcome, prospectively collected data from 17,937 cadaveric renal transplants performed between 1982 and 1991 were analyzed. Cold preservation intervals of 1-16, 16-32, 32-48, and greater than 48 hr were studied by multi- and univariate method...

journal_title：Transplantation

authors： Peters TG,Shaver TR,Ames JE 4th,Santiago-Delpin EA,Jones KW,Blanton JW

更新日期：1995-01-27 00:00:00

abstract：BACKGROUND:Tacrolimus has been shown to have a less adverse effect on the lipid profiles of transplant patients when the drug is started as induction therapy. In order to determine the effect tacrolimus has on lipid profiles in stable cyclosporine-treated renal transplant patients with established hyperlipidemia, a ran...

journal_title：Transplantation

authors： McCune TR,Thacker LR II,Peters TG,Mulloy L,Rohr MS,Adams PA,Yium J,Light JA,Pruett T,Gaber AO,Selman SH,Jonsson J,Hayes JM,Wright FH Jr,Armata T,Blanton J,Burdick JF

更新日期：1998-01-15 00:00:00

abstract：:Seven murine anti-H-2 and three nonimmune mouse sera were tested for cytotoxicity toward B and T lymphocytes from a panel of human donors. One group of sera, including two anti-H-2.33 sera, exhibited cytotoxicity directed exclusively toward human B but not T cells from all donors. Absorption studies on human lymphobla...

journal_title：Transplantation

authors： Verghese MW,Ward FE

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Recently, methylxanthines such as pentoxifylline (PTX) were shown to be immunosuppressive in vitro. Unfortunately, when used in transplant patients, PTX was poorly active as an immunosuppressant. Here we report that the new methylxanthine derivative A802715 not only is more active than PTX, it also suppresse...

journal_title：Transplantation

authors： Lin Y,Goebels J,Rutgeerts O,Kasran A,Van Gool S,Ceuppens J,Schönharting M,Waer M

更新日期：1997-06-27 00:00:00

abstract：:We reviewed coded autopsy material from 71 dogs, 46 receiving allogeneic and 25 receiving autologous bone marrow transplants, to evaluate the hypothesis that lymphocytic bronchitis is associated with severe acute graft-versus-host disease (GVHD). We found no significant correlation between the presence of lymphocytic ...

journal_title：Transplantation

authors： O'Brien KD,Hackman RC,Sale GE,Prentice R,Deeg J,Thomas ED,Storb R

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND:It is well known that kidney transplant recipients with preformed lymphocytotoxic antibodies against HLA antigens have an increased graft rejection rate. However, the individual contribution of anti-HLA class I and class II antibodies to this phenomenon is poorly understood. We investigated the clinical rele...

journal_title：Transplantation

authors： Süsal C,Opelz G

更新日期：2002-04-27 00:00:00

abstract：BACKGROUND:The clinical symptoms, histological findings, and treatments for antibody-mediated rejection (AMR), which is the leading cause of graft loss in adult ABO-incompatible liver transplantation (ABO-I-LT), have rarely been discussed. METHODS:We performed adult living donor ABO-I-LT on six patients. We used anti-...

journal_title：Transplantation

authors： Morioka D,Togo S,Kumamoto T,Takeda K,Matsuo K,Inayama Y,Yamanaka S,Tanaka K,Endo I,Maegawa J,Shimada H

更新日期：2008-01-27 00:00:00

abstract：BACKGROUND:It has been suggested that T cells primed by processed donor major histocompatibility complex antigen (the "indirect" pathway of allorecognition) may be responsible for mediating chronic allograft rejection. The purpose of this study was to develop a clinically useful assay to study the occurrence of indirec...

journal_title：Transplantation

authors： Vella JP,Spadafora-Ferreira M,Murphy B,Alexander SI,Harmon W,Carpenter CB,Sayegh MH

更新日期：1997-09-27 00:00:00

abstract：:Until recently, islet allotransplantation for type 1 diabetic patients has been largely unsuccessful. Previous pharmacologic studies of single drugs have suggested that one factor contributing to this poor success is toxicity of immunosuppressive drugs on transplanted islets. However, no comprehensive study of agents ...

journal_title：Transplantation

authors： Paty BW,Harmon JS,Marsh CL,Robertson RP

更新日期：2002-02-15 00:00:00

abstract：:In human organ transplantation, the correct diagnosis of rejection may be difficult using clinical and/or histopathologic criteria, and immunologic assays should therefore be considered. We have applied monoclonal antibodies in 2-color flow cytometric (FACS) analysis to study phenotypic patterns of kidney-infiltrating...

journal_title：Transplantation

authors： Tötterman TH,Hanås E,Bergström R,Larsson E,Tufveson G

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Historically, ex vivo physiological evaluation of cadaveric renal allografts has been limited to assessing perfusate flow (PF) during hypothermic perfusion preservation (HPP). Using a small animal model, we have previously described a method for continuous monitoring of glomerular filtration rate (GFR) durin...

journal_title：Transplantation

authors： Inman SR,Osgood RW,Plott WK,Richardson BF,Lewis RM

更新日期：1999-11-27 00:00:00

abstract：BACKGROUND:Mixed lymphohematopoietic chimerism can provide an effective means of inducing longterm immunological tolerance and has been documented in a monkey allograft model. A conditioning regimen including nonmyeloablative or myeloablative irradiation and splenectomy has been used to induce chimerism in a pig-to-pri...

journal_title：Transplantation

authors： Kozlowski T,Monroy R,Xu Y,Glaser R,Awwad M,Cooper DK,Sachs DH

更新日期：1998-07-27 00:00:00

abstract：BACKGROUND:Live liver donation requires extended liver resection in the donor with transection of the middle hepatic vein. This leads to focal outflow obstruction in the remnant liver or the partial graft. This study was designed to characterize the pathophysiological correlate of focal outflow obstruction in a small-f...

journal_title：Transplantation

authors： Dirsch O,Madrahimov N,Chaudri N,Deng M,Madrahimova F,Schenk A,Dahmen U

更新日期：2008-03-15 00:00:00

abstract：BACKGROUND:Data on liver transplant (LT) outcomes using deceased donors with heavy drinking (HD) (>2 drinks per day) are scanty. METHODS:Using the United Network for Organ Sharing database (2002-2014), we examined outcomes after LT in adults comparing deceased HD donors with non-HD (ND) donors. RESULTS:Of 56 182 firs...

journal_title：Transplantation

authors： Arora SS,Chahal KS,Axley P,Eckhoff DE,Kuo YF,Satapathy SK,Wiesner R,Singal AK

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Strong correlations have been described between persistently elevated proportions of CD57+ (CD28-) CD8+high T lymphocytes and cytomegalovirus (CMV) infection, in healthy individuals as well as in transplant patients. We investigated whether secondary exposure to CMV triggers recall responses within the CD8 T...

journal_title：Transplantation

authors： Hazzan M,Labalette M,Noel C,Lelievre G,Dessaint JP

更新日期：1997-03-15 00:00:00

abstract：:Recent reports have demonstrated that humoral factors, especially antibodies elicited by xenoantigens, play an important role in the rejection of concordant cardiac xenografts. These induced antibodies, however, have not been well characterized. Therefore, we investigated the rejection mechanism, especially the role o...

journal_title：Transplantation

authors： Matsumiya G,Shirakura R,Miyagawa S,Izutani H,Sawa Y,Nakata S,Matsuda H

更新日期：1994-06-15 00:00:00