Increase of proliferating renal progenitor cells in acute tubular necrosis underlying delayed graft function.

abstract：:Immunosuppressive therapy increases the risk of recurrence of initial cancers in organ transplant patients, and compelling therapeutic protocols are needed to suppress the malignancy and protect the allograft. We examined the potential use of 15-deoxyspergualin (DSG) in relation to organ transplantation and cancer. Th...

journal_title：Transplantation

authors： Ohsawa I,Uemoto S,Kobayashi E,Murakami T

更新日期：2007-08-15 00:00:00

abstract：:Patient entry is now complete in a prospective trial of anti-Tac, a murine IgG2a monoclonal antibody directed against the p55 chain of the human IL-2 receptor, for the prevention of renal allograft rejection. Recipients of primary cadaver allografts were randomized to receive either anti-Tac (20 mg q.d. x 10 days begi...

journal_title：Transplantation

authors： Kirkman RL,Shapiro ME,Carpenter CB,McKay DB,Milford EL,Ramos EL,Tilney NL,Waldmann TA,Zimmerman CE,Strom TB

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:The induction of tolerance to pig antigens in primates may facilitate the development of successful clinical xenotransplantation protocols. The infusion of mobilized porcine peripheral blood leukocytes (PBPCs, comprised of approximately 2% peripheral blood progenitor cells) into splenectomized preconditioned...

journal_title：Transplantation

authors： Appel JZ 3rd,Alwayn IP,Correa LE,Cooper DK,Robson SC

更新日期：2001-10-15 00:00:00

abstract：:The frequency of donor-reactive and of third party-reactive cytotoxic T lymphocyte precursors (CTLp) was determined by limiting dilution analysis in the peripheral blood of 13 liver allograft recipients before (pre-tpx) and at various intervals (4 to 22 months) after (post-tpx) transplantation. In 6 of 13 patients wit...

journal_title：Transplantation

authors： Eberspächer ML,Otto G,Herfarth C,Kabelitz D

更新日期：1994-06-27 00:00:00

abstract：:Untreated anephric LEW rats die ca. 9 days following transplantation of LBNF1 kidney allografts. Although treatment with ART-18, a mouse antirat IL-2R mAb (300 micrograms/kg/day x 10 days), prolonged graft survival to ca. 3 weeks, the severely impaired renal function was comparable to untreated controls (creatinine le...

journal_title：Transplantation

authors： Ueda H,Hancock WW,Cheung YC,Diamantstein T,Tilney NL,Kupiec-Weglinski JW

更新日期：1990-10-01 00:00:00

abstract：:We have studied organ allograft survival in rhesus monkeys conditioned with myeloablative total-body irradiation and T cell-depleted autologous bone marrow transplantation then given a heterotopic MHC-mismatched cardiac allograft in the immediate postmyeloablative period. This model has enabled us to investigate the r...

journal_title：Transplantation

authors： Moses RD,Sundeen JT,Orr KS,Roberts RR,Gress RE

更新日期：1989-11-01 00:00:00

abstract：:Clinical observations suggest that recipients of multiorgan transplants from the same donor can have disparate immunological reactions to each organ. We studied this phenomenon in 36 diabetic (streptozotocin-induced), bilaterally nephrectomized immunosuppressed (cyclosporine, azathioprine, prednisone) pig recipients o...

journal_title：Transplantation

authors： Gruessner RW,Nakhleh R,Tzardis P,Schechner R,Platt JL,Gruessner A,Tomadze G,Najarian JS,Sutherland DE

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:To date, the outcomes of transplant tourism have not been reported extensively. In addition, data about the accuracy of urine cytology for the detection and the role of the BK virus (BKV) in the carcinogenesis of urothelial carcinoma (UC) after renal transplantation are lacking. METHODS:Three hundred seven ...

journal_title：Transplantation

authors： Tsai HL,Chang JW,Wu TH,King KL,Yang LY,Chan YJ,Yang AH,Chang FP,Pan CC,Yang WC,Loong CC

更新日期：2014-07-15 00:00:00

abstract：:It has been demonstrated both in vivo and in vitro that cytomegalovirus regulates not only MHC class I but also class II antigen expression on vascular endothelial cells. The CMV-linked MHC induction is believed to be involved in acute rejection mechanisms and chronic vasculopathy after transplantation. In this study,...

journal_title：Transplantation

authors： Ustinov JA,Lahtinen TT,Bruggeman CA,Häyry PJ,Lautenschlager IT

更新日期：1994-11-15 00:00:00

abstract：BACKGROUND:Our aim was to evaluate the effect of FTY720 in discordant islet xenotransplantation. METHODS:Fetal porcine islet-like cell clusters (ICCs) were transplanted into normoglycemic rats that were either left untreated or treated with FTY720 only, with FTY720 plus cyclosporine A (CsA) or with CsA only. Twelve or...

journal_title：Transplantation

authors： Maeda A,Goto M,Zhang J,Bennet W,Groth CG,Korsgren O,Wennberg L

更新日期：2003-04-27 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) infection is common in kidney transplantation and is known to affect long-term patient and graft survival, as is time in renal-replacement therapy (RRT). The aim of this study was to investigate HCV in relation to time in RRT and its impact on outcome after transplantation. METHODS:A...

journal_title：Transplantation

authors： Bruchfeld A,Wilczek H,Elinder CG

更新日期：2004-09-15 00:00:00

abstract：BACKGROUND:Since 1995, dual-kidney transplantation using organs from marginal donors has been used at our center to expand the organ donor pool and decrease the waiting time for deceased donor kidney transplantation. This approach has allowed for a shorter waiting period without compromising outcome in the early posttr...

journal_title：Transplantation

authors： Tan JC,Alfrey EJ,Dafoe DC,Millan MT,Scandling JD

更新日期：2004-09-15 00:00:00

abstract：BACKGROUND:Graft thrombosis immediately after surgery remains a problem for successful pancreas transplantation. The present study evaluated the efficacy of computed tomography (CT) angiography for monitoring of graft patency in the immediate postoperative period. METHODS:The study involved 119 patients who underwent ...

journal_title：Transplantation

authors： Kim YH,Park JB,Lee SS,Byun JH,Kim SC,Han DJ

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:Transplantation enhances the risk of malignancies, due to the chronic use of antirejection medication. In the case of Kaposi's sarcoma (KS) the permissive effect of immunosuppression has been extensively studied, and cyclosporine (CsA) appears to play a key role. Here we have compared the incidence of KS in ...

journal_title：Transplantation

authors： Cattaneo D,Gotti E,Perico N,Bertolini G,Kainer G,Remuzzi G

更新日期：2005-09-27 00:00:00

abstract：:The prevalence of angiographically proven coronary artery disease (CAD) in adults with end-stage liver disease who undergo evaluation for liver transplantation is unknown; also it is unclear if cholestatic liver disease represents an independent risk factor. Patients with end-stage liver disease over age 50 having liv...

journal_title：Transplantation

authors： Carey WD,Dumot JA,Pimentel RR,Barnes DS,Hobbs RE,Henderson JM,Vogt DP,Mayes JT,Westveer MK,Easley KA

更新日期：1995-03-27 00:00:00

abstract：:Seven murine anti-H-2 and three nonimmune mouse sera were tested for cytotoxicity toward B and T lymphocytes from a panel of human donors. One group of sera, including two anti-H-2.33 sera, exhibited cytotoxicity directed exclusively toward human B but not T cells from all donors. Absorption studies on human lymphobla...

journal_title：Transplantation

authors： Verghese MW,Ward FE

更新日期：1979-08-01 00:00:00

abstract：:A sensitive micromethod for generating and assaying allogeneically induced cytotoxic human lymphocytes in vitro is described. Responding lymphocytes are cultured with mitomycin-C treated allogeneic stimulating cells in wells of replicate microtrays for both one-way mixed leukocyte culture (MLC) and cell-mediated lymph...

journal_title：Transplantation

authors： Zarling JM,McKeough M,Bach FH

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Plasma level of plasminogen activator inhibitor (PAI)-1 is genetically determined by a polymorphism in the promoter region, involving two alleles, 4G and 5G. Plasma PAI-1 concentrations are higher in subjects homozygous for the 4G allele than other genotypes (5G/5G and 4G/5G). Such genetic variation in fibri...

journal_title：Transplantation

authors： Chow KM,Szeto CC,Szeto CY,Poon P,Lai FM,Li PK

更新日期：2002-12-27 00:00:00

abstract：:FK506 (tacrolimus) is a strong immunosuppressant: it has been approved as a drug for liver transplantation in Japan, the United States, and the United Kingdom. One of its main adverse effects is hyperglycemia. Thus, in this study, we investigated the mechanism and the reversibility of the hyperglycemia caused by FK506...

journal_title：Transplantation

authors： Tamura K,Fujimura T,Tsutsumi T,Nakamura K,Ogawa T,Atumaru C,Hirano Y,Ohara K,Ohtsuka K,Shimomura K

更新日期：1995-06-15 00:00:00

abstract：:Natural killer (NK) cells effect hybrid resistance, in which parental hematopoietic cell grafts are rejected by F1 recipients. NK cells can also resist engraftment of fully MHC-mismatched allogeneic marrow. However, studies of NK cell-mediated alloresistance have relied on short-term proliferation, colony, or survival...

journal_title：Transplantation

authors： Lee LA,Sergio JJ,Sykes M

更新日期：1996-01-15 00:00:00

abstract：:Lethally irradiated rhesus monkeys were treated with autologous bone marrow that had either been (1) nontreated, i.e., normal; (2) depleted of T lymphocytes with a monoclonal antibody directed against rhesus T lymphocytes; (3) fractionated with the soybean agglutinin (SBA- fraction); or (4) fractionated with SBA and f...

journal_title：Transplantation

authors： Gengozian N,Moriarty C,Good RA

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DC) are important in the development of acute graft-versus-host disease (GVHD) after allogeneic hemopoietic cell transplantation (alloHCT). The trafficking of immature DC from blood to GVHD target organs is likely to be regulated by chemokine receptors. METHODS:We performed flow cytometry t...

journal_title：Transplantation

authors： Shahin K,Sartor M,Hart DN,Bradstock KF

更新日期：2013-10-27 00:00:00

abstract：:Hemorrhagic cystitis (HC) is a major cause of morbidity after BMT; we have analyzed its incidence, risk factors, and complications in 977 patients undergoing BMT between 1974 and 1988. Despite vigorous hydration and frequent voiding in all patients receiving cyclophosphamide, 135/977 (15% by Kaplan-Meier projection) d...

journal_title：Transplantation

authors： Sencer SF,Haake RJ,Weisdorf DJ

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Interleukin- (IL) 10 may be a potent regulator for controlling of allograft rejection. A single administration of IL-10 is not effective for controlling graft rejection. Gene transfer is an attractive vehicle for prolonging the expression of short-lived proteins. METHODS:Donor or recipient livers were trans...

journal_title：Transplantation

authors： Tashiro H,Shinozaki K,Yahata H,Hayamizu K,Okimoto T,Tanji H,Fudaba Y,Yamamoto H,Fan X,Ito H,Asahara T

更新日期：2000-07-27 00:00:00

abstract：BACKGROUND:Toxicity of current immunosuppressive agents to islet grafts is one of the major obstacles to clinical islet transplantation (Tx). This study was designed to assess the efficacy of FTY720, a novel immunomodulator with a unique mechanism of action, on islet graft survival and function in streptozotocin (STZ)-...

journal_title：Transplantation

authors： Fu F,Hu S,Deleo J,Li S,Hopf C,Hoover J,Wang S,Brinkmann V,Lake P,Shi VC

更新日期：2002-05-15 00:00:00

abstract：INTRODUCTION:The use of liver allografts from elderly donors (≥70 years) has increased because of organ shortage and increased life expectancy. The aim of this study is to evaluate the current utilization of elderly donors in United States, recipient selection, and their posttransplant outcomes. METHODS:A linkage betw...

journal_title：Transplantation

authors： Paterno F,Wima K,Hoehn RS,Cuffy MC,Diwan TS,Woodle SE,Abbott DE,Shah SA

更新日期：2016-01-01 00:00:00

abstract：:Heterotopic abdominal rat heart transplantation has been extensively used to investigate ischemic-reperfusion injury, immunological consequences during heart transplantations and also to study remodeling of the myocardium due to volume unloading. We provide a unique review on the latter and present a summary of the ex...

journal_title：Transplantation

authors： Benke K,Sayour AA,Mátyás C,Ágg B,Németh BT,Oláh A,Ruppert M,Hartyánszky I,Szabolcs Z,Radovits T,Merkely B,Szabó G

更新日期：2017-03-01 00:00:00

abstract：:Despite great improvements in renal allograft survival over the last 3 decades, long-term graft loss, particularly through antibody-mediated rejection, remains the bane of kidney transplantation. Interindividual patient variation means that a given immunosuppressive regimen may be inadequate in certain patients and ex...

journal_title：Transplantation

authors： Ashton-Chess J,Giral M,Soulillou JP,Brouard S

更新日期：2009-05-15 00:00:00

abstract：BACKGROUND:For certain uremic, diabetic patients, a sequential transplant of a kidney (usually from a living donor) followed by a cadaver pancreas has become an attractive option. But how long to wait after the kidney transplant before proceeding with a pancreas transplant is unclear. We studied outcomes in recipients ...

journal_title：Transplantation

authors： Humar A,Sutherland DE,Ramcharan T,Gruessner RW,Gruessner AC,Kandaswamy R

更新日期：2000-10-27 00:00:00

abstract：BACKGROUND:Survival following liver transplantation for hepatitis C virus (HCV) is significantly poorer than for liver transplants performed for other causes of chronic liver disease. The factors responsible for the inferior outcome in HCV+ recipients, and whether they differ from factors associated with survival in HC...

journal_title：Transplantation

authors： Velidedeoglu E,Mange KC,Frank A,Abt P,Desai NM,Markmann JW,Reddy R,Markmann JF

更新日期：2004-06-27 00:00:00