Cardiac allograft survival across major histocompatibility complex barriers in the rhesus monkey following T lymphocyte-depleted autologous marrow transplantation. III. Late allograft rejection.

abstract：:Graft and patient survival rates were analyzed in 239 consecutive first cadaver renal transplants as a function of time of administration of blood transfusion and the number of units given. There was no statistically significant difference in patient survival in comparing patients who were never transfused, patients n...

journal_title：Transplantation

authors： Corry RJ,West JC,Hunsicker LG,Schanbacher BA,Lachenbruch PA

更新日期：1980-12-01 00:00:00

abstract：BACKGROUND:Endomyocardial biopsy (EMB) remains the gold standard for acute cellular rejection (ACR) diagnosis in cardiac transplantation yet is subject to interobserver variability. A method that could avoid discordant EMB analysis would be desirable. The apoptosis rate in EMB correlates with ACR severity. Apollon inhi...

journal_title：Transplantation

authors： Aharinejad S,Andrukhova O,Gmeiner M,Thomas A,Krenn K,Zuckermann A,Grimm M

更新日期：2010-01-27 00:00:00

abstract：:Our current knowledge of cytotoxic T lymphocytes (CTL) is largely derived from studies of effector populations generated in allogeneic mixed leukocyte cultures (MLC) and assayed for lytic activity to lymphoid cell (LC) targets. We herein report that the CTL response to allogeneic renal epithelial cell lines (REC) is d...

journal_title：Transplantation

authors： Hadley GA,Rostapshova EA,Bartlett ST

更新日期：1996-07-15 00:00:00

abstract：:It has been reported that cultured keratinocyte (CK) allografts are not rejected in mice, unlike in other species. Several reports have suggested that mouse CK allografts are incapable of stimulating a primary alloresponse, including sensitization of recipients to alloantigens. In this study, we investigated the immun...

journal_title：Transplantation

authors： Cairns BA,deSerres S,Matsui M,Frelinger JA,Meyer AA

更新日期：1994-07-15 00:00:00

abstract：BACKGROUND:The envelope glycoprotein gB of human cytomegalovirus (CMV) occurs as one of four main genotypes. Some previous studies have proposed a relationship of CMV gB genotype to the frequency of symptomatic infection and to clinical outcomes in both transplant and human immunodeficiency virus-infected populations. ...

journal_title：Transplantation

authors： Rosen HR,Corless CL,Rabkin J,Chou S

更新日期：1998-12-27 00:00:00

abstract：:Using C1q binding, Kg binding, and Raji cell radioimmunoassays, the relationship between renal allograft rejection and the circulating immune complexes was examined in 90 patients with renal transplants. The data showed that there was a significant quantitative correlation between C1q-binding and Raji-cell-binding act...

journal_title：Transplantation

authors： Fukuda M

更新日期：1983-08-01 00:00:00

abstract：:The monoclonal antibodies (MoAb) CR11-351 and KS1 are secreted by hybridomas generated with splenocytes from BALB/c mice immunized with the cultured human B lymphoid cells LG-2 (HLA-A2,A2,B27,B27). The 2 monoclonal antibodies immunoprecipitated components with a superimposable 2-dimensional gel electrophoretic profile...

journal_title：Transplantation

authors： Tsujisaki M,Sakaguchi K,Igarashi M,Richiardi P,Perosa F,Ferrone S

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:Circulating transthyretin (TTR) is derived from the liver, and orthotopic liver transplantation (OLT) is widely performed for variant TTR-associated familial amyloid polyneuropathy (FAP). The effect of OLT on FAP-related cardiac amyloid is of particular interest because wild-type TTR can itself be deposited ...

journal_title：Transplantation

authors： Stangou AJ,Hawkins PN,Heaton ND,Rela M,Monaghan M,Nihoyannopoulos P,O'Grady J,Pepys MB,Williams R

更新日期：1998-07-27 00:00:00

abstract：:The antibody response to the pregnancy-associated (Pa) antigen in the pregnant female segregated with the major histocompatibility complex (MHC) when the female progeny in the (PVG x WF)F1 x PVG testcross, in which the PVG strain is a low responder to Pa and the WF strain is a high responder, were mated to DA male rat...

journal_title：Transplantation

authors： Kunz HW,Gill TJ 3rd

更新日期：1986-08-01 00:00:00

abstract：:Crigler-Najjar type 1 disease (CNS1) is the result of a genetic defect, leading to complete functional loss of an enzyme which glucuronidates bilirubin. As a consequence, unconjugated bilirubin accumulates and may cause kernicterus, the most serious complication in adolescents. Phototherapy effectively adjusts bilirub...

journal_title：Transplantation

authors： Schauer R,Lang T,Zimmermann A,Stangl M,Da Silva L,Schildberg FW,Rau HG

更新日期：2002-01-15 00:00:00

abstract：BACKGROUND:The currently used macrolide immunosuppressants, i.e., cyclosporine and tacrolimus, exert considerable nephrotoxicity. We aimed to avoid the nephrotoxic effects by applying a cyclosporine-free regimen for the induction as well as for the maintenance treatment of renal allograft recipients using mycophenolate...

journal_title：Transplantation

authors： Zanker B,Schneeberger H,Rothenpieler U,Hillebrand G,Illner WD,Theodorakis I,Stangl M,Land W

更新日期：1998-07-15 00:00:00

abstract：:The value of percutaneous core needle biopsy in the immunohistological evaluation of renal allograft dysfunction was studied in 72 consecutive biopsies performed in 42 patients. The phenotypes of infiltrating cells mediating graft destruction were identified with monoclonal antibodies and immunoperoxidase staining tec...

journal_title：Transplantation

authors： Waltzer WC,Miller F,Arnold A,Anaise D,Rapaport FT

更新日期：1987-01-01 00:00:00

abstract：:Islets were isolated from the pancreata of Sprague-Dawley rats and transplanted into streptozotocin-induced diabetic outbred Wistar rats. The effect of transplantation of islets into the cisterna magna on the diabetic state of the recipients was compared with that of the conventional transplantation of islets into liv...

journal_title：Transplantation

authors： Lee HC,Ahn KJ,Lim SK,Kim KR,Ahn YS,Lee KE,Huh KB

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Pancreatic islets are avascular immediately after transplantation and depend on revascularization. Recently, the authors found decreased vascular density in mouse islets 1 month after implantation into nondiabetic recipients. This study investigated possible differences in revascularization between islets im...

journal_title：Transplantation

authors： Mattsson G,Jansson L,Nordin A,Carlsson PO

更新日期：2003-03-15 00:00:00

abstract：BACKGROUND:This study investigated the use of deceased heart-beating donor livers offered for transplantation during a 10-year period, during which there has been an increasing disparity between organ supply and demand in the United Kingdom. METHODS:Summary data from the National Transplant Database were analyzed on a...

journal_title：Transplantation

authors： Devey LR,Friend PJ,Forsythe JL,Mumford LL,Wigmore SJ

更新日期：2007-07-15 00:00:00

abstract：:Since 1981, when the liver transplantation program was initiated at the University of Pittsburgh, we have been impressed with the prevalence of pancreatitis occurring following liver transplantation in patients transplanted for hepatitis B-related liver disease. To either confirm this clinical impression or refute it,...

journal_title：Transplantation

authors： Alexander JA,Demetrius AJ,Gavaler JS,Makowka L,Starzl TE,Van Thiel DH

更新日期：1988-06-01 00:00:00

abstract：:We have recently demonstrated that three synthetic peptides corresponding to the donor class I RT1.Aa molecule induce long-term survival of cardiac allografts in the PVG.R8-to-PVG.1U rat strain combination (disparate for one isolated class I, RT1.A, molecule) when presented to the recipient immune system in the thymus...

journal_title：Transplantation

authors： Shirwan H,Wu GD,Barwari L,Liu A,Cramer DV

更新日期：1997-12-27 00:00:00

abstract：BACKGROUND:Existing data indicate that non-human leukocyte antigen (HLA) immunogenetic polymorphisms influence the risk of complications after allogeneic hemopoietic stem-cell transplantation. However, prior studies have been limited by small sample size and limited genotyping. METHODS:We examined 22 polymorphisms in ...

journal_title：Transplantation

authors： Mullighan C,Heatley S,Doherty K,Szabo F,Grigg A,Hughes T,Schwarer A,Szer J,Tait B,To B,Bardy P

更新日期：2004-02-27 00:00:00

abstract：BACKGROUND:Avoiding donor-specific antibody (DSA) is difficult for sensitized patients. Improved understanding of the risk of low level DSA is needed. METHODS:We retrospectively compared the outcomes of 954 patients transplanted with varied levels of baseline DSA detected by single antigen beads and B flow cytometric ...

journal_title：Transplantation

authors： Schinstock CA,Gandhi M,Cheungpasitporn W,Mitema D,Prieto M,Dean P,Cornell L,Cosio F,Stegall M

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:We report long-term outcomes and side effects after transplantation for hepatocellular carcinoma (HCC) using de novo, sirolimus-based immunosuppression (IS). METHODS:A total of 70 patients with HCC (mean age: 54.4+/-7 years, female/male: 12/58) were transplanted and included in the study. Immunosuppression ...

journal_title：Transplantation

authors： Toso C,Meeberg GA,Bigam DL,Oberholzer J,Shapiro AM,Gutfreund K,Ma MM,Mason AL,Wong WW,Bain VG,Kneteman NM

更新日期：2007-05-15 00:00:00

abstract：:A retrospective masked study of 120 consecutive renal transplant biopsies was performed to evaluate the potential associations of cyclosporine (CsA) therapy and other factors on the degree and progression of interstitial fibrosis (IF). Allograft biopsies were obtained from patients receiving CsA (CsA+; n = 59) and not...

journal_title：Transplantation

authors： Ruiz P,Kolbeck PC,Scroggs MW,Sanfilippo F

更新日期：1988-01-01 00:00:00

abstract：:The NOD mouse develops immune-mediated diabetes mellitus characterized by T cell infiltration and destruction of pancreatic islet tissue. We wished to determine whether one contributing factor was an abnormality of the NOD pancreas that caused it to elicit an attack by NOD T cells. Therefore we constructed mice that h...

journal_title：Transplantation

authors： Stein PH,Rees MA,Singer A

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Although human herpesvirus (HHV)-6 is now recognized as a frequent pathogen after transplantation, the real impact of this infection in patients undergoing transplantation remains unclear. METHODS:During 27 months, 30 consecutive heart-lung- and lung-transplant recipients were included on the day of transpl...

journal_title：Transplantation

authors： Jacobs F,Knoop C,Brancart F,Gilot P,Mélot C,Byl B,Delforge ML,Estenne M,Liesnard C,Brussels Heart and Lung Transplantation Group.

更新日期：2003-06-27 00:00:00

abstract：:Effects of liver denervation on bile formation were studied in eight dogs prepared with chronic biliary fistulas. The animals were studied in the basal state, after feeding, and during infusion of glucagon 50 ng/kg/min, secretin 2 U/kg/hr, or somatostatin 200 ng/kg/min. After this first set of experiments the animals ...

journal_title：Transplantation

authors： Cucchiaro G,Branum GD,Farouk M,Mansour G,Kuhn CM,Anthony DC,Meyers WC

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Donation after circulatory death (DCD) provides an alternative pathway to deceased organ transplantation. Although clinical DCD lung, liver, and kidney transplantation are well established, transplantation of hearts retrieved from DCD donors has reached clinical translation only recently. Progress has been l...

journal_title：Transplantation

authors： Iyer A,Chew HC,Gao L,Villanueva J,Hicks M,Doyle A,Kumarasinghe G,Jabbour A,Jansz PC,Feneley MP,Harvey RP,Graham RM,Dhital KK,Macdonald PS

更新日期：2016-12-01 00:00:00

abstract：:After the progressive improvement in the results of organ transplantation we now face the challenge of shortage in organ supply. The decreasing number of organ retrievals performed in 1990 at our hospital has raised questions concerning loss of potential organ donors and opposition to donation by the next of kin. We i...

journal_title：Transplantation

authors： Faltin DL,Jeannet M,Suter PM

更新日期：1992-07-01 00:00:00

abstract：:We have investigated retrospectively sera from 70 renal allograft recipients for the presence of antibodies binding to a preanastomosis biopsy of the donor kidney by an indirect immunoperoxidase technique. All recipients had a negative T cell lymphocytotoxic crossmatch. A positive immunoperoxidase crossmatch for kidne...

journal_title：Transplantation

authors： Evans PR,Trickett LP,Gosney AR,Hodges E,Shires S,Wilson PJ,MacIver AG,Gardner B,Slapak M,Smith JL

更新日期：1988-12-01 00:00:00

abstract：:Two anti-H-2Ld sera were analyzed, BALB/c-H-2dm2 anti-BALB/cBy and (C3H X BALB/c-H-2dm2)F1 anti-BALB/cHe, the latter also containing anti-Qa antibodies. Their reaction patterns were compared with an anti-Qa serum (C3H X BALB/cBy)F1 anti-BALB/cHe. Four H-2 specificities could be detected by the anti-H-2Ld sera, two alr...

journal_title：Transplantation

authors： Oudshoorn-Snoek M,Iványi D,Démant P

更新日期：1981-08-01 00:00:00

abstract：:Whole-body irradiation has been extensively used to ablate immune responsiveness in rodent recipients in adoptive allograft assays. This study was undertaken to determine the relative radioresistance and the tempo of regeneration, following whole-body irradiation, of cells involved in the allograft response. Six disti...

journal_title：Transplantation

authors： Farnsworth A,Wotherspoon JS,Dorsch SE

更新日期：1988-09-01 00:00:00

abstract：:To formulate a model predicting survival after liver retransplantation, we analyzed in detail the last 150 cases of hepatic retransplantation at UCLA. Cox proportional hazards regression analysis identified five variables that demonstrated independent simultaneous prognostic value in estimating patient survival after ...

journal_title：Transplantation

authors： Markmann JF,Gornbein J,Markowitz JS,Levy MF,Klintmalm GB,Yersiz H,Morrisey M,Drazan K,Farmer DG,Ghobrial RM,Goss J,Seu P,Martin P,Goldstein LI,Busuttil RW

更新日期：1999-02-15 00:00:00