Abstract:
:The NOD mouse develops immune-mediated diabetes mellitus characterized by T cell infiltration and destruction of pancreatic islet tissue. We wished to determine whether one contributing factor was an abnormality of the NOD pancreas that caused it to elicit an attack by NOD T cells. Therefore we constructed mice that had an NOD immune system and a non-NOD host pancreas. We found that these animals with only an NOD immune system developed both insulitis and diabetes in their non-NOD pancreas. We conclude that the NOD pancreas is not unique in its ability to elicit an autoimmune attack from NOD T cells.
journal_name
Transplantationjournal_title
Transplantationauthors
Stein PH,Rees MA,Singer Adoi
10.1097/00007890-199206000-00032subject
Has Abstractpub_date
1992-06-01 00:00:00pages
1347-52issue
6eissn
0041-1337issn
1534-6080journal_volume
53pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::The results of OKT3 use for steroid-resistant rejection rescue in adult liver transplantation were analyzed retrospectively from a single transplant center. Comparison was made with concurrent patients who had no rejection (NR) or steroid-responsive rejections (SR). The records of 290 patients who underwent 323 liver ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199301000-00017
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Increasing long-term allograft survival is the main challenge in organ transplantation, and allograft loss due to chronic rejection has been found to correlate with episodes of early acute rejection. It is important to understand the mechanisms that maintain the donor-specific hyporesponsive state. This stud...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/TP.0b013e3181af20fd
更新日期:2009-08-15 00:00:00
abstract::The lung is one of the primary targets of acute graft-versus-host disease (GVHD), which is the principal complication that occurs after allogeneic intestinal transplantation. The purpose of this study is to investigate the involvement of Fas/Fas ligand system in pulmonary injury after rat semi-allogeneic intestinal tr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199910150-00006
更新日期:1999-10-15 00:00:00
abstract::Hepatocyte allotransplantation has been performed successfully in several small animal models for the amelioration of inborn metabolic errors. Before a human clinical trial of hepatocyte allotransplantation can be attempted, preliminary experience in a large animal model is needed. We transplanted isolated mongrel hep...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199705150-00003
更新日期:1997-05-15 00:00:00
abstract::The effects of mismatching for DR antigens on renal allograft survival rates have largely been restricted to analyses of cadaver transplant results. Analyses of HLA matching in recipients of transplants from related donors have focused on the number of haplotypes shared between the recipients without regard to DR, or ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198336060-00011
更新日期:1983-12-01 00:00:00
abstract:BACKGROUND:The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular filtration rate (GFR). As a result, one strategy of transplant immunosuppression is calcineurin inhibitor elimination. METHODS:The aim of this study was to determine the outcome of a prospective randomized trial...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e31822805d7
更新日期:2011-10-15 00:00:00
abstract:INTRODUCTION:Organ donation after brain death (DBD) has declined in the United Kingdom, whereas donation after cardiac death (DCD) has increased markedly. We sought to understand the reasons for the decline in DBD and determine whether the increase in DCD was a major factor. METHODS:The UK Transplant Registry was anal...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182007b33
更新日期:2010-12-27 00:00:00
abstract:BACKGROUND:Reactivation of cytomegalovirus (CMV) is frequently observed in recipients of solid organs and bone marrow transplants and is associated with increased risk of acute and chronic allograft rejection, opportunistic infection, graft failure, and patient mortality. The molecular mechanisms by which reactivation ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b242a7
更新日期:2009-09-15 00:00:00
abstract::This study focuses upon two discrete components of posttransplant hepatic reticuloendothelial system (RES) function-phagocytosis and killing of bacteria-under various conditions of ischemic preservation. We had previously reported that, following intravenous injection of rats with 51Cr and 125I double-labeled Escheric...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199604270-00006
更新日期:1996-04-27 00:00:00
abstract::It was the objective of these experiments to study the time-related changes in the responsiveness of the cellular elements of the immune system following contact with single non-H-2 or multiple H-2 histocompatibility antigens. The reactivity of spleen cells from mice that received injections of spleen cells bearing H-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198802000-00047
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:The influence of donor hematopoietic cell microchimerism on organ allograft survival has been studied largely in vascularized transplant models. Here, we examine the impact of donor bone marrow (BM) cells administered intravenously together with transient systemic tacrolimus therapy on microchimerism, the su...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199802270-00005
更新日期:1998-02-27 00:00:00
abstract::The immune response to cytomegalovirus (CMV) infection is highly complex, including humoral, cellular, innate, and adaptive immune responses. Detection of CMV by the innate immune system triggers production of type I IFNs and inflammatory cytokines which initiate cellular and humoral responses that are critical during...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001095
更新日期:2016-03-01 00:00:00
abstract::In liver allograft rejection, interlobular bile ducts are thought to be the main target of rejection. In contrast, in other organ allografts the capillary bed of the graft appears to be the primary target. To determine whether portal tract microvasculature is destroyed in liver allografts during rejection, we have ide...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199307000-00012
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:Extracorporeal support (ECS) during organ procurement from donors after circulatory determination of death (DCDD) could increase the number of donor organs and decrease posttransplant complications. This study reports the experience of a large transplant center with controlled DCDD. METHODS:A retrospective ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000070
更新日期:2014-08-15 00:00:00
abstract::Portal vein thrombosis is the most common cause of portal hypertension in noncirrhotic patients. Variceal bleeding is difficult to treat in these patients, especially those with prehepatic diffuse portal mesenteric thrombosis. In a patient with refractory esophagogastroduodenal variceal bleeding as a result of diffuse...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000168344.16547.da
更新日期:2005-08-27 00:00:00
abstract::Currently trials of immunosuppression in transplantation are in decline because their objectives remain focused on improving acute rejection rates and graft survival in the first 12 months. With 1 year renal graft survival rates of greater than 90% the best that can be hoped for is noninferiority trial outcomes compar...
journal_title:Transplantation
pub_type:
doi:10.1097/TP.0000000000001648
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Success of human pancreatic islet isolation depends largely on the techniques used during pancreas procurement and the quality of the gland. Warm ischemia of the pancreas of any duration during organ procurement may be detrimental to subsequent islet yield and functional viability of the islets. The aim of t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200204150-00016
更新日期:2002-04-15 00:00:00
abstract::Plasma levels of main granulocyte components of patients after cadaveric renal transplantation were compared 9 days postoperative with the plasma levels of patients undergoing aortofemoral and iliacofemoral bypass operation or abdominal surgery. Lactoferrin values were significantly lower in patients under immunosuppr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198901000-00032
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:More than 60% children with small bowel transplantation (SBTx) experience acute cellular rejection. PURPOSE/METHODS:To identify children at risk of rejection, donor- and third-party-induced proliferation of T-helper and T cytotoxic (Tc) cells, and their naïve and memory (M) subsets was evaluated simultaneou...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181d98c0f
更新日期:2010-06-15 00:00:00
abstract::Alemtuzumab is a humanized CD52-specific monoclonal antibody that is increasingly used off-label as an induction agent in solid organ transplantation, particularly in the setting of maintenance immunosuppression minimization protocols. In this review, we briefly discuss this agent's mechanisms of action and summarize ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000296680.75175.67
更新日期:2007-12-27 00:00:00
abstract:BACKGROUND:Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO in clinical transplantation is difficult due to its delivery in a controlled manner. A manganese-containing CO releasing molecules (CORM)-401 has recently...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002201
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Neighborhood poverty has been associated with worse outcomes after live donor kidney transplantation (LDKT), and prior work suggests that women with kidney disease may be more susceptible to the negative influence of poverty than men. As such, our goal was to examine whether poverty differentially affects wo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002654
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Antipig antibodies are a barrier to clinical xenotransplantation. We evaluated antibody binding of waitlisted renal transplant patients to 3 glycan knockout (KO) pig cells and class I swine leukocyte antigens (SLA). METHODS:Peripheral blood mononuclear cells from SLA identical wild type (WT), α1, 3-galactos...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001646
更新日期:2017-04-01 00:00:00
abstract::The overall incidence of malignancy in renal transplant recipients is 100-fold higher compared with age matched controls. Routine clinical evaluation therefore often includes the determination of serum tumor markers AFP, CA19-9, CEA, CA125, CA15-3, PSA, and calcitonin. We evaluated the specificity and the sensitivity ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199611270-00021
更新日期:1996-11-27 00:00:00
abstract:BACKGROUND:Chronic renal allograft failure remains a major challenge to overcome. Factors such as donor quality, delayed graft function (DGF), acute rejection, and immunosuppression are known to affect long-term outcome, but their relationship to histological damage to graft outcome is unclear. METHODS:Protocol kidney...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200102270-00006
更新日期:2001-02-27 00:00:00
abstract:BACKGROUND:Hepatic artery thrombosis (HAT) is a significant cause of morbidity after liver transplantation. The aims of this study are to identify and compare risk factors that might contribute to HAT. METHODS:A total of 424 liver transplants performed at the University of Virginia were reviewed. HAT was defined as co...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200103270-00014
更新日期:2001-03-27 00:00:00
abstract:BACKGROUND:Interleukin- (IL) 10 may be a potent regulator for controlling of allograft rejection. A single administration of IL-10 is not effective for controlling graft rejection. Gene transfer is an attractive vehicle for prolonging the expression of short-lived proteins. METHODS:Donor or recipient livers were trans...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200007270-00018
更新日期:2000-07-27 00:00:00
abstract::Late deaths (after more than 1 year) after liver transplantation were analyzed in a series of 464 consecutive patients who received liver grafts between 1982 and 1993. Recipients who survived the first posttransplant year (n = 365) had actuarial 5- and 10-year survival rates of 92% and 84%, respectively. Thirty-five p...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199605150-00016
更新日期:1996-05-15 00:00:00
abstract:BACKGROUND:We hypothesized that tissue-engineered contractile cardiomyocyte sheets without a scaffold would show histological and electrical integration with impaired myocardium, leading to the regeneration of infarcted myocardium. METHODS:Neonatal rat cardiomyocytes were cultured on Poly(N-isopropylacrylamide)-grafte...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000181163.69108.dd
更新日期:2005-12-15 00:00:00
abstract:BACKGROUND:The organ donor shortage has led to a reconsideration of the use of non-heart-beating donors (NHBDs). However, graft injury due to warm ischemia in NHBD livers strongly affects posttransplant outcome. The present study was aimed at investigating the role of the cellular cyclic (c)AMP second messenger signal ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199810270-00004
更新日期:1998-10-27 00:00:00