Progressive cardiac amyloidosis following liver transplantation for familial amyloid polyneuropathy: implications for amyloid fibrillogenesis.

abstract：:Posttransplant lymphoproliferative disorders (PTLD) are EBV-associated lymphoid neoplasms that are caused by the uncontrolled growth of EBV-infected B lymphocytes. The clinical presentation of PTLD can range from benign polygonal lymphoproliferative disorders to aggressive monoclonal immunoblastic lymphomas. In this r...

journal_title：Transplantation

authors： Mentzer SJ,Longtine J,Fingeroth J,Reilly JJ,DeCamp MM,O'Donnell W,Swanson SJ,Faller DV,Sugarbaker DJ

更新日期：1996-06-27 00:00:00

abstract：:The histopathological changes and the course of graft-versus-host (GVH) disease were studied in the rat model of small-bowel transplantation using the Lewis----LBN-F1 strain combination. Allograft-induced GVH disease led to the recipients' death from enteritis, dermatitis and emaciation after 14.4 +/- 2.9 days (hetero...

journal_title：Transplantation

authors： Schraut WH,Lee KK,Dawson PJ,Hurst RD

更新日期：1986-03-01 00:00:00

abstract：:Brainstem death is associated with endocrine and metabolic alterations that can result in donor hemodynamic instability. It has been suggested that these changes can be reversed through hormonal manipulation of the donor. We measured thyroid hormone levels (free triiodothyronine [fT3], free tetraiodothyronine [fT4], r...

journal_title：Transplantation

authors： Karayalçin K,Umaña JP,Harrison JD,Buckels JA,McMaster P,Mayer AD

更新日期：1994-03-15 00:00:00

abstract：:Thromboxane (Tx) plays a vital role in the dysfunction and ultimate rejection of MHC-disparate renal allografts. In addition to its potent vasoconstrictory properties, in vivo studies have implied that Tx is capable of promoting immune cytotoxic T cell function within transplants. In this study, we have examined the i...

journal_title：Transplantation

authors： Ruiz P,Rey L,Spurney R,Coffman T,Viciana A

更新日期：1992-09-01 00:00:00

abstract：:Using liposomes, multilamellar lipid vesicles (MLV), we have found that liposome-incorporated cyclosporine is not only less toxic but also more effective in prolonging survival of cardiac allografts in mice. Following intravenous injection of liposome-incorporated drug, cyclosporine levels in blood were shown to decre...

journal_title：Transplantation

authors： Górecki DC,Jakóbisiak M,Kruszewski A,Lasek W

更新日期：1991-11-01 00:00:00

abstract：:Gastrointestinal infection due to cytomegalovirus occurs frequently in liver transplant recipients. Upper gastrointestinal cytomegalovirus infection is associated with subjective complaints of nausea, a sense of abdominal fullness, and occasionally emesis and/or dysphagia. In order to determine whether these symptoms ...

journal_title：Transplantation

authors： Van Thiel DH,Gavaler JS,Schade RR,Chien MC,Starzl TE

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Immunomodulatory protocols including intravenous immunoglobulin/rituximab (IVIG/R) are employed to decrease anti-human leukocyte antigen (HLA) antibody levels for patients broadly sensitized to HLA and increase chances for transplantation with a compatible deceased donor (DD). The aim of our study was to ide...

journal_title：Transplantation

authors： Lai CH,Cao K,Ong G,Naim M,Wang Q,Mirocha J,Vo A,Jordan SC,Reinsmoen NL

更新日期：2011-07-15 00:00:00

abstract：BACKGROUND:The number of living donor kidney transplantations increases steeply in Europeans, whereas the non-Europeans are dependent on deceased donor transplantations. We wondered whether a low attendance or a high decline of potential non-European donors could explain this difference. METHODS:This retrospective stu...

journal_title：Transplantation

authors： Roodnat JI,van de Wetering J,Zuidema W,van Noord MA,Kal-van Gestel JA,Ijzermans JN,Weimar W

更新日期：2010-05-27 00:00:00

abstract：BACKGROUND:Most transplant centers in the United States, including our own, use creatinine clearance (Ccr) to estimate glomerular filtration rate (GFR) in potential living kidney donors. The purpose of this study was to evaluate our experience with estimation of donor GFR by Ccr and to explore other potential strategie...

journal_title：Transplantation

authors： Bertolatus JA,Goddard L

更新日期：2001-01-27 00:00:00

abstract：BACKGROUND:The use of kidneys from non-heartbeating donors (NHB) remains controversial. An increased incidence of delayed primary function and primary nonfunction is common. We report a characteristic syndrome of transaminitis and thrombocytopenia after NHB renal transplantation, which may be predictive of graft outcom...

journal_title：Transplantation

authors： Andrews PA,Denton MD,Compton FC,Koffman CG

更新日期：1997-05-27 00:00:00

abstract：BACKGROUND:Ischemia-reperfusion injury (IRI) plays key roles in graft viability and posttransplantation function. Caspase-3 associated with apoptosis and inflammation is up-regulated by IRI. We propose that naked small interfering RNA (siRNA) targeting caspase-3 may prevent IRI and improve kidney preservation. METHODS...

journal_title：Transplantation

authors： Yang B,Hosgood SA,Nicholson ML

更新日期：2011-03-15 00:00:00

abstract：:Adhesion of leukocytes to vascular endothelium is a necessary step leading to the migration of cells into underlying tissues. Vascular adhesion molecules regulate this process and may play an important role in graft rejection. Immunocytochemical studies have been used to investigate the expression of vascular adhesion...

journal_title：Transplantation

authors： Taylor PM,Rose ML,Yacoub MH,Pigott R

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Gastrointestinal complications are common in patients who undergo kidney transplantation and may affect posttransplant outcomes. We examined the incidence and predictors of gastroesophageal reflux disease (GERD) and dyspepsia and their associations with graft survival and mortality after transplant. METHODS...

journal_title：Transplantation

authors： Neri L,Rocca Rey LA,Pinsky BW,Lentine KL,Salvalaggio PR,Machnicki G,Willoughby L,Burroughs TE,Takemoto SK,Schnitzler MA

更新日期：2008-02-15 00:00:00

abstract：BACKGROUND:Imported pancreata accumulate cold ischemia time (CIT), limiting utilization and worsening outcomes. Flow cytometric crossmatching (FXM) is a standard method to assess recipient and donor compatibility, but can prolong CIT. Single-antigen bead assays allow for detection of recipient donor-specific HLA antibo...

journal_title：Transplantation

authors： Eby BC,Redfield RR,Ellis TM,Leverson GE,Schenian AR,Odorico JS

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Langerhans cells (LCs) are self-renewing epidermal myeloid cells that can migrate and mature into dendritic cells. Recipient LCs that survive cytotoxic therapy given in preparation for allogeneic hematopoietic cell transplantation may prime donor T cells to mediate cutaneous graft-versus-host disease (GVHD)....

journal_title：Transplantation

authors： Mielcarek M,Kirkorian AY,Hackman RC,Price J,Storer BE,Wood BL,Leboeuf M,Bogunovic M,Storb R,Inamoto Y,Flowers ME,Martin PJ,Collin M,Merad M

更新日期：2014-09-15 00:00:00

abstract：BACKGROUND:In clinical transplantation, "passenger" dendritic cells (DCs) in the allograft have been thought to induce allograft rejection. However, the presence of DCs in the normal human kidney is controversial. Most reports have relied on the examination of MHC class I and II antigen expression in combination with D...

journal_title：Transplantation

authors： Sonderbye L,Meehan S,Palsson R,Ahsan N,Ladefoged J,Langhoff E

更新日期：1998-04-15 00:00:00

abstract：:Moderate hyperhomocysteinemia, an independent cardiovascular risk factor, has been reported in renal transplant recipients. In the present study, plasma concentrations of total homocysteine were significantly increased in 120 renal transplant recipients as compared with 60 healthy controls (19.0 +/- 6.9 vs. 11.6 +/- 2...

journal_title：Transplantation

authors： Arnadottir M,Hultberg B,Vladov V,Nilsson-Ehle P,Thysell H

更新日期：1996-02-15 00:00:00

abstract：BACKGROUND:Serum citrulline is a marker for acute cellular rejection (ACR) after intestinal transplantation; however, its clinical utility has not yet been established. The goal of this study was to determine clearcut serum levels beyond which the diagnosis of acute rejection could be supported or refuted, and predicto...

journal_title：Transplantation

authors： David AI,Selvaggi G,Ruiz P,Gaynor JJ,Tryphonopoulos P,Kleiner GI,Moon JI,Nishida S,Pappas PA,Conanan L,Weppler D,Esquenazi V,Levi DM,Kato T,Tzakis AG

更新日期：2007-11-15 00:00:00

abstract：:Loss of renal mass has been associated with the development of glomerular sclerosis in animals and human beings. The pathophysiology of this renal injury is unknown, but glomerular sclerosis in animals can be aggravated or accelerated following exposure to nephrotoxic antibodies, puromycin aminoglycoside or renal irra...

journal_title：Transplantation

authors： Parfrey PS,Hollomby DJ,Gilmore NJ,Knaack J,Schur PH,Guttmann RD

更新日期：1984-10-01 00:00:00

abstract：:Spodoptera frugiperda (Sf9) insect cells secreted a class I MHC RT1.Aa heavy chain protein when infected with baculovirus that bore a construct that contained a honeybee melittin secretion (ms) signal attached to RT1.Aa cDNA. The RT1.Aa heavy chain protein in the culture supernatant and cell lysate immunoprecipitated ...

journal_title：Transplantation

authors： Wang M,Stepkowski SM,Wang ME,Tian L,Qu X,Tu Y,He G,Kahan BD

更新日期：1996-02-15 00:00:00

abstract：BACKGROUND:Mycophenolate mofetil (MMF), compared to azathioprine (AZA), reduces acute rejection and treatment failure in cyclosporine (CsA) and steroid regimens, but its effect on graft survival is unproven from prospective studies and prolonged use is costly. This study evaluated the efficacy and tolerability of repla...

journal_title：Transplantation

authors： Sadek S,Medina J,Arias M,Sennesael J,Squifflet JP,Vogt B,Neo Int-05 Study group.

更新日期：2002-08-27 00:00:00

abstract：BACKGROUND:In 2013, the public health service (PHS) changed the criteria intended to identify organ donors that put the associated organ recipients at increased risk for acquiring human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). The changing donor demographics, organ utilization...

journal_title：Transplantation

authors： Pruett TL,Clark MA,Taranto SE

更新日期：2017-07-01 00:00:00

abstract：:The major role of anti-alphaGal antibodies in the hyperacute rejection of pig organs by humans and baboons has been clearly demonstrated. Spacered alpha-galactose disaccharide (Gal(alpha1)-3Gal) hapten was produced by chemical synthesis and covalently attached to a flexible, hydrophilic polymer (PAA), which in turn wa...

journal_title：Transplantation

authors： Taniguchi S,Neethling FA,Korchagina EY,Bovin N,Ye Y,Kobayashi T,Niekrasz M,Li S,Koren E,Oriol R,Cooper DK

更新日期：1996-11-27 00:00:00

abstract：:Immunosuppression with sirolimus and low-dose tacrolimus has facilitated successful clinical islet transplantation (CIT). Because the long-term effects on the kidney are unknown and immunosuppressant drugs can be nephrotoxic, CIT is currently restricted to patients with preserved renal function or a functioning renal ...

journal_title：Transplantation

authors： Senior PA,Shapiro AM,Ackerman TE,Ryan EA,Paty BW,Bhargava R

更新日期：2004-09-27 00:00:00

abstract：BACKGROUND:We began a clinical trial in African Americans comparing sirolimus-tacrolimus to standard immunosuppression. We report two African American male living donor kidney recipients who developed acute renal failure after exposure to sirolimus-tacrolimus. METHODS:Both patients received similar doses of sirolimus ...

journal_title：Transplantation

authors： Lawsin L,Light JA

更新日期：2003-01-15 00:00:00

abstract：BACKGROUND:Composite tissue allotransplantation (CTA) has been recently introduced as a potential treatment for tissue loss secondary to burns, injuries, or resections. However, the optimal strategies to prevent CTA rejection remain undefined. Presently, no CTA model exists to evaluate human-specific immunosuppressants...

journal_title：Transplantation

authors： Cendales LC,Xu H,Bacher J,Eckhaus MA,Kleiner DE,Kirk AD

更新日期：2005-11-27 00:00:00

abstract：BACKGROUND:Thromboembolism has been reported as a frequent complication after cardiac transplantation. Many risk factors for thrombosis may explain this, such as metabolic alterations and the use of cyclosporine. In the general population, two single nucleotide polymorphisms (SNPs), factor V Leiden and prothrombin G202...

journal_title：Transplantation

authors： Miriuka SG,Langman LJ,Evrovski J,Miner SE,Kozuszko S,D'Mello N,Delgado DH,Wong BY,Ross HJ,Cole DE

更新日期：2005-09-15 00:00:00

abstract：BACKGROUND:Recent evidence has suggested that inconsistencies in human-islet yields after collagenase digestion are attributed to the activation of endogenous enzymes of the cadaveric donor pancreas. Inhibition of protease activity by Pefabloc (0.4 mM; Roche Biochemicals Inc., Indianapolis, IN) has recently been shown ...

journal_title：Transplantation

authors： Rose NL,Palcic MM,Helms LM,Lakey JR

更新日期：2003-02-27 00:00:00

abstract：:Although cyclosporine has high specificity for the immune system, immunosuppressive therapy with CsA is often complicated by nephrotoxicity. The main morphologic targets of CsA nephrotoxicity include the tubular epithelial and endothelial cells. These cells were investigated in vitro. CsA caused a dose- and time-depen...

journal_title：Transplantation

authors： Ryffel B,Foxwell BM,Gee A,Greiner B,Woerly G,Mihatsch MJ

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND:Combined liver and kidney transplantation (CLKT) is a surgical challenge in small children because of technical aspects, lack of pediatric donors, and restrictions related to the size of the abdominal cavity. We report outcomes after CLKT in this challenging group of smaller children. METHOD:A review of pro...

journal_title：Transplantation

authors： Perera MT,Silva MA,Sharif K,McKiernan PJ,Kelly DA,Lloyd C,Milford DV,Mayer DA,Mirza DF

更新日期：2009-09-15 00:00:00