Immunohistochemical study of actin binding protein (p55) in the human kidney.

Abstract:

BACKGROUND:In clinical transplantation, "passenger" dendritic cells (DCs) in the allograft have been thought to induce allograft rejection. However, the presence of DCs in the normal human kidney is controversial. Most reports have relied on the examination of MHC class I and II antigen expression in combination with DC morphology for identification of DCs. METHODS:The distribution of the p55 antigen (fascin), which is selectively expressed by human blood and lymphoid DCs, was investigated by immunohistochemistry. RESULTS:Our study demonstrates that p55-positive DCs are absent from the normal human kidney and CD1a- and S100-positive cells are absent or very rare. Furthermore, HLA-DR and factor VIII-related antigen show almost complete colocalization in capillaries. In contrast, all 16 kidney biopsies from patients with inflammatory processes demonstrated p55-positive DCs in the cellular infiltrates. CONCLUSIONS:These results suggest that DCs are not present or are very rare in normal renal tissues but may migrate into the renal interstitium with inflammatory changes.

journal_name

Transplantation

journal_title

Transplantation

authors

Sonderbye L,Meehan S,Palsson R,Ahsan N,Ladefoged J,Langhoff E

doi

10.1097/00007890-199804150-00025

subject

Has Abstract

pub_date

1998-04-15 00:00:00

pages

1004-8

issue

7

eissn

0041-1337

issn

1534-6080

journal_volume

65

pub_type

杂志文章
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    更新日期:2008-10-15 00:00:00

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    authors: Shaffer D,Ubhi CS,Simpson MA,Gottschalk R,Milford EL,Maki T,Monaco AP

    更新日期:1991-12-01 00:00:00

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    更新日期:1989-06-01 00:00:00

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    更新日期:2008-06-15 00:00:00

  • Reduction of fatal graft-versus-host disease by 3H-thymidine suicide of donor cells cultured with host cells.

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    doi:10.1097/00007890-197704000-00001

    authors: Cheever MA,Einstein AB Jr,Kempf RA,Fefer A

    更新日期:1977-04-01 00:00:00

  • CD4 Th2 cells do not functionally suppress CTL generation in neonatal tolerant mice.

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    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Gao Q,Chen N,Field EH

    更新日期:1995-12-15 00:00:00

  • Resolution and relapse of osteopetrosis in mice transplanted with myeloid tissue of variable histocompatibility.

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    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197910000-00004

    authors: Nisbet NW,Menage J,Loutit JF

    更新日期:1979-10-01 00:00:00

  • Treatment of hypercholesterolemia in the Watanabe rabbit using allogeneic hepatocellular transplantation under a regeneration stimulus.

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    journal_title:Transplantation

    pub_type: 杂志文章

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    更新日期:1996-09-15 00:00:00

  • Massive pseudolymphomatous pericardial effusion in the posttransplant setting mimicking posttransplant lymphoproliferative disease.

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    authors: Hudnall SD,Melez K,Galindo A,Bryson Y

    更新日期:1996-06-27 00:00:00

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    doi:

    authors: Tamura K,Fujimura T,Tsutsumi T,Nakamura K,Ogawa T,Atumaru C,Hirano Y,Ohara K,Ohtsuka K,Shimomura K

    更新日期:1995-06-15 00:00:00

  • Signaling through CD31 protects endothelial cells from apoptosis.

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    更新日期:2001-02-15 00:00:00

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    更新日期:1975-09-01 00:00:00

  • Five-year follow-up of two siblings with aspartylglucosaminuria undergoing allogeneic stem-cell transplantation from unrelated donors.

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    journal_title:Transplantation

    pub_type: 杂志文章

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    authors: Malm G,Månsson JE,Winiarski J,Mosskin M,Ringdén O

    更新日期:2004-08-15 00:00:00

  • Lymphoma and hypercalcemia in a pediatric orthotopic liver transplant patient.

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    journal_title:Transplantation

    pub_type: 杂志文章

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    authors: Nakazato P,Esquivel CO,Urbach AH,Makowka L,Scantlebury V,Jaffe R,Starzl TE

    更新日期:1989-12-01 00:00:00

  • Use of the methylxanthine derivative A802715 in transplantation immunology: I. Strong in vitro inhibitory effects on CD28-costimulated T cell activities.

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    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199706270-00019

    authors: Lin Y,Goebels J,Rutgeerts O,Kasran A,Van Gool S,Ceuppens J,Schönharting M,Waer M

    更新日期:1997-06-27 00:00:00

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    pub_type: 杂志文章

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    authors: Desai KK,Mora-Esteves C,Holland BK,Dikdan G,Fisher A,Wilson DJ,Koneru B

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    authors: Fugate JE,Stadtler M,Rabinstein AA,Wijdicks EF

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    journal_title:Transplantation

    pub_type: 杂志文章

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    authors: Papadimitriou JC,Drachenberg CB,Wiland A,Klassen DK,Fink J,Weir MR,Cangro C,Schweitzer EJ,Bartlett ST

    更新日期:1998-12-27 00:00:00

  • Spontaneous reestablishment of self-tolerance in BB/Pfd rats.

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    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Mathieu C,Kuttler B,Waer M,Bouillon R,Hahn HJ

    更新日期:1994-08-15 00:00:00

  • The role of PCR in the diagnosis and management of CMV in solid organ recipients: what is the predictive value for the development of disease and should PCR be used to guide antiviral therapy?

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    journal_title:Transplantation

    pub_type: 杂志文章

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    authors: Abecassis MM,Koffron AJ,Kaplan B,Buckingham M,Muldoon JP,Cribbins AJ,Kaufman DB,Fryer JP,Stuart J,Stuart FP

    更新日期:1997-01-27 00:00:00

  • Lymphoma in cardiac allotransplant recipients. Clinical and histological features and immunological phenotype.

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    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31825ace2c

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    authors: Wolpaw T,Deal CL,Fleming-Brooks S,Bartucci MR,Schulak JA,Hricik DE

    更新日期:1994-12-15 00:00:00

  • Morphometric analysis of neointimal formation in murine cardiac grafts: III. Dissociation of intestitial fibrosis from neointimal formation.

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    更新日期:1997-10-27 00:00:00

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    authors: Gotoh M,Porter J,Kanai T,Monaco AP,Maki T

    更新日期:1988-06-01 00:00:00

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