Donor thyroid function does not affect outcome in orthotopic liver transplantation.

Abstract:

:Brainstem death is associated with endocrine and metabolic alterations that can result in donor hemodynamic instability. It has been suggested that these changes can be reversed through hormonal manipulation of the donor. We measured thyroid hormone levels (free triiodothyronine [fT3], free tetraiodothyronine [fT4], reverse triiodothyronine) and thyroid-stimulating hormone (TSH) in 50 consecutive adult brain dead multiorgan donors. Recipient graft function was assessed using peak and day 5 aspartate aminotransferase, peak serum bilirubin, and minimum prothrombin time during the first week after OLT. Free T3 was low in 32/50 donors and was associated with a low fT4 in 24 cases. TSH was normal in 35 donors and we found no correlation between TSH levels and fT3 or fT4. Reverse triiodothyronine was normal or high in 96% of donors. Patient and graft survival were 96% for both the low and high fT3 groups. These data suggest that euthyroid sick syndrome is the most likely cause for the endocrine and metabolic alterations seen in brainstem-dead donors. This does not appear to influence liver recipient or graft survival.

journal_name

Transplantation

journal_title

Transplantation

authors

Karayalçin K,Umaña JP,Harrison JD,Buckels JA,McMaster P,Mayer AD

doi

10.1097/00007890-199403150-00007

subject

Has Abstract

pub_date

1994-03-15 00:00:00

pages

669-72

issue

5

eissn

0041-1337

issn

1534-6080

journal_volume

57

pub_type

杂志文章
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    authors: Chan PC,Lok AS,Cheng IK,Chan MK

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  • Upregulation of CD59: potential mechanism of accommodation in a large animal model.

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    更新日期:2009-05-15 00:00:00

  • Prolongation of second heart transplants in rats.

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    更新日期:1992-10-01 00:00:00

  • Inhibitor against coagulation factor V after liver transplantation.

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  • Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours.

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    更新日期:2020-09-01 00:00:00

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    authors: Dumont L,Chen H,Daloze P,Xu D,Garceau D

    更新日期:1993-07-01 00:00:00

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    更新日期:2001-10-27 00:00:00

  • The effect of cyclosporine on agonist-stimulated glomerular and mesangial cell vasodilatory prostaglandin production.

    abstract::Cyclosporine A administration produces an increase in renal vascular resistance and a decrease in glomerular filtration rate in both human and animal models. CsA usage in humans has also been shown to alter the ability of the kidney to adapt to alterations in renal hemodynamics. CsA alters the production of prostaglan...

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    更新日期:1991-10-01 00:00:00

  • Ontogeny of antipig xenoantibody and hyperacute rejection.

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    pub_type: 评论,杂志文章

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    更新日期:2000-08-27 00:00:00

  • Transmembrane signalling via the T cell antigen receptor heterodimer and the CD2 antigen. A synergistic pathway for activation of T cells.

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    doi:10.1097/00007890-198902000-00033

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    更新日期:1989-02-01 00:00:00

  • Combined liver-kidney transplantation in primary hyperoxaluria type 1. Bone histopathology and oxalate body content.

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  • Effect of core pancreas temperature during cadaveric procurement on human islet isolation and functional viability.

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  • The clinical utility of whole blood versus plasma cytomegalovirus viral load assays for monitoring therapeutic response.

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    authors: Lisboa LF,Asberg A,Kumar D,Pang X,Hartmann A,Preiksaitis JK,Pescovitz MD,Rollag H,Jardine AG,Humar A

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  • An extraperitoneal isolated vascularized bone marrow transplant model in the rat.

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  • Functional evaluation of T helper, T suppressor, and B lymphocytes in lethally irradiated rhesus monkeys injected with autologous bone marrow.

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    pub_type: 杂志文章

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    更新日期:1983-11-01 00:00:00

  • The role of self-expandable metallic stents for the treatment of airway complications after lung transplantation.

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    authors: Saad CP,Ghamande SA,Minai OA,Murthy S,Pettersson G,DeCamp M,Mehta AC

    更新日期:2003-05-15 00:00:00

  • Kidney transplant recipients with long incubation-positive antiglobulin-negative T cell crossmatches.

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    更新日期:1995-01-27 00:00:00

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  • Risk score predicting decline in renal function postliver transplant: role in patient selection for combined liver kidney transplantation.

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    doi:10.1097/TP.0b013e3181d9e195

    authors: O'Riordan A,Donaldson N,Cairns H,Wendon J,O'Grady JG,Heaton N,Hendry BM

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