Risk score predicting decline in renal function postliver transplant: role in patient selection for combined liver kidney transplantation.

abstract：BACKGROUND:Although human herpesvirus (HHV)-6 is now recognized as a frequent pathogen after transplantation, the real impact of this infection in patients undergoing transplantation remains unclear. METHODS:During 27 months, 30 consecutive heart-lung- and lung-transplant recipients were included on the day of transpl...

journal_title：Transplantation

authors： Jacobs F,Knoop C,Brancart F,Gilot P,Mélot C,Byl B,Delforge ML,Estenne M,Liesnard C,Brussels Heart and Lung Transplantation Group.

更新日期：2003-06-27 00:00:00

abstract：BACKGROUND:Cold ischemia-reperfusion injury is unavoidable during organ transplantation, and prolonged preservation is associated with poorer function recovery. Cardiotrophin-1 (CT-1) is an IL-6 family cytokine with cytoprotective properties. This preclinical study in rats tested whether CT-1 mitigates cold renal ische...

journal_title：Transplantation

authors： García-Cenador B,Blanco-Gozalo V,López-Montañés D,Sanz Giménez-Rico JR,López-Novoa JM,López-Hernández FJ

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:We have previously shown that both thymic immigrants (graft to thymus pathway) and thymic emigrants (thymus to graft pathway) are involved in tolerance to renal allografts in miniature swine treated with a short course of calcineurin inhibitors. This study investigates the role of these pathways in cardiac t...

journal_title：Transplantation

authors： Yamamoto S,Teranishi K,Kamano C,Samelson-Jones E,Arakawa H,Nobori S,Okumi M,Houser S,Shimizu A,Sachs DH,Yamada K

更新日期：2006-02-27 00:00:00

abstract：BACKGROUND:In the United States, 1 in 10 infants and 1 in 20 older children die on the liver transplant waiting list. Increasing split liver transplantation could increase organ availability for these children, without decreasing transplants in adults. METHODS:Using United Network for Organ Sharing Standard Transplant...

journal_title：Transplantation

authors： Perito ER,Roll G,Dodge JL,Rhee S,Roberts JP

更新日期：2019-03-01 00:00:00

abstract：:In keeping with the in vitro mitogenic properties of anti-CD3 MoAbs, the first injections of anti-CD3 are invariably responsible for an in vivo cellular activation. This activation induces a massive cytokine release in the circulation (TNF, IFN gamma, IL-2, IL-6, and IL-3). Paralleling this release, a severe clinical ...

journal_title：Transplantation

authors： Ferran C,Dy M,Merite S,Sheehan K,Schreiber R,Leboulenger F,Landais P,Bluestone J,Bach JF,Chatenoud L

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Cidofovir (CDV) is a nucleotide analogue with proven in vitro effects against cytomegalovirus (CMV) and adenovirus and has been successfully used in the treatment of CMV retinitis in AIDS patients. METHODS:We performed a prospective study to evaluate the efficacy of CDV in 17 patients with hematological mal...

journal_title：Transplantation

authors： Platzbecker U,Bandt D,Thiede C,Helwig A,Freiberg-Richter J,Schuler U,Plettig R,Geissler G,Rethwilm A,Ehninger G,Bornhäuser M

更新日期：2001-04-15 00:00:00

abstract：:Glutathione and glyoxalase II levels were evaluated in cytosolic and mitochondrial compartments of rat liver after 7 and 24 hr of cold storage in University of Wisconsin (UW) and Euro-Collins solutions. 1-4 A similar time-dependent depletion of cytosolic glutathione up to about 60% of control values was observed in bo...

journal_title：Transplantation

authors： Jassem W,Ciarimboli C,Cerioni PN,Saba V,Norton SJ,Principato G

更新日期：1996-05-15 00:00:00

abstract：BACKGROUND:This 36-month, randomized, parallel-group study compared safety and efficacy of two doses of everolimus with mycophenolate mofetil (MMF) in de novo renal-transplant recipients. METHODS:Renal-allograft recipients received 1.5 mg/day or 3 mg/day of everolimus or 2 g/day of MMF, plus full-dose cyclosporine (Cs...

journal_title：Transplantation

authors： Lorber MI,Mulgaonkar S,Butt KM,Elkhammas E,Mendez R,Rajagopalan PR,Kahan B,Sollinger H,Li Y,Cretin N,Tedesco H,B251 Study Group.

更新日期：2005-07-27 00:00:00

abstract：:The potential usefulness of verapamil, a calcium channel blocker to renal allograft preservation, was investigated using the isolated perfused rat kidney. Two models of ischemic injury were used. In the first model, rat kidneys were exposed to 40 min of 37 degrees C ischemia on the perfusion circuit. Addition of verap...

journal_title：Transplantation

authors： Shapiro JI,Cheung C,Itabashi A,Chan L,Schrier RW

更新日期：1985-12-01 00:00:00

abstract：:Eight patients with chronic myeloid leukemia relapse after allogeneic BMT were treated with IFN-alpha and buffy coat transfusions (BC) of the bone marrow donor. The antileukemic effect of this treatment was directly demonstrated in 4 patients by the disappearance of Philadelphia chromosome-positive metaphases or the l...

journal_title：Transplantation

authors： Hertenstein B,Wiesneth M,Novotny J,Bunjes D,Stefanic M,Heinze B,Hübner G,Heimpel H,Arnold R

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Renal ischemia-reperfusion (I/R) injury causes renal tubular necrosis, apoptosis, and inflammation leading to acute renal dysfunction. Recent studies have revealed that deletion of Gα12 mitigates the renal damage due to I/R injury. Our previous study showed that activation of dopamine D3 receptor (D3R) incre...

journal_title：Transplantation

authors： Wang Z,Guan W,Han Y,Ren H,Tang X,Zhang H,Liu Y,Fu J,He D,Asico LD,Jose PA,Zhou L,Chen L,Zeng C

更新日期：2015-11-01 00:00:00

abstract：:We present a case report of a pediatric orthotopic liver transplant recipient who developed lymphoma with hypercalcemia on cyclosporine and prednisone immunosuppression. This is the first reported posttransplant lymphoproliferative disorder complicated by hypercalcemia, with a finding of an elevated 1,25 dihydroxyl vi...

journal_title：Transplantation

authors： Nakazato P,Esquivel CO,Urbach AH,Makowka L,Scantlebury V,Jaffe R,Starzl TE

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Posttransplant diabetes mellitus (PTDM) is common after liver transplantation and was recently identified as a risk factor for hepatitis C progression. Increased levels of oxidative stress have been identified in diabetes and hepatitis C. The aim of this study was to evaluate the relationship among PTDM, oxi...

journal_title：Transplantation

authors： Cotler SJ,Kallwitz E,TenCate V,Bhushan A,Berkes J,Benedetti E,Layden-Almer J,Layden TJ,Valyi-Nagy T,Guzman G

更新日期：2007-09-15 00:00:00

abstract：:Increasing numbers of sensitized patients are either precluded from receiving an allograft or experience accelerated rejection which may be refractory to conventional therapy. Using a rat model, we have shown that accelerated (24 hr) rejection of LBN cardiac Tx in LEW rats sensitized with BN skin grafts 7 days earlier...

journal_title：Transplantation

authors： Hancock WW,DiStefano R,Braun P,Schweizer RT,Tilney NL,Kupiec-Weglinski JW

更新日期：1990-02-01 00:00:00

abstract：:The immunological events mediated by, and antigen specificity of, allograft-bound lymphocytes (ABLs) are poorly understood. To further define the role of antibody-mediated rejection, a rejected allograft from a patient with primary anti-TBM disease was sterilely minced and pressed through a microscreen. The ABLs were ...

journal_title：Transplantation

authors： Jordan SC,Barkley SC,Lemire JM,Sakai RS,Cohen A,Fine RN

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:Immunosuppressive therapy is a risk factor for the increased incidence and metastatic progression of malignancies in organ graft recipients. Transforming growth factor (TGF)-beta(1) has been associated with tumor invasion and metastasis, and we have implicated cyclosporine-associated TGF-beta(1) hyperexpress...

journal_title：Transplantation

authors： Maluccio M,Sharma V,Lagman M,Vyas S,Yang H,Li B,Suthanthiran M

更新日期：2003-08-15 00:00:00

abstract：:We evaluated the influence of dialysis requiring acute tubular necrosis on patient survival, and kidney survival and function in all 182 patients who needed dialysis immediately after transplantation at the University of Minnesota Hospitals. When compared to matched control patients not requiring dialysis, there was n...

journal_title：Transplantation

authors： Brophy D,Najarian JS,Kjellstrand CM

更新日期：1980-03-01 00:00:00

abstract：:Pretransplant sera of 474 kidney graft recipients were tested for IgG-anti-F(ab')2 gamma activity. The patients had significantly higher IgG-anti-F(ab')2 gamma activity than healthy controls (P = 0.0004). Serum lymphocytotoxic antibodies were correlated with IgG-anti-F(ab')2 gamma (P = 0.004), whereas CMV infection an...

journal_title：Transplantation

authors： Süsal C,Groth J,Oberg HH,Terness P,May G,Opelz G

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Thymoglobulin given before allo-hematopoietic stem-cell transplantation (HSCT) from unrelated donors reduces acute graft-versus-host disease (GvHD), but the optimal dose is unknown. METHOD:Four different doses of Thymoglobulin were given to 162 patients with hematologic malignancies undergoing unrelated don...

journal_title：Transplantation

authors： Remberger M,Svahn BM,Mattsson J,Ringdén O

更新日期：2004-07-15 00:00:00

abstract：BACKGROUND:Renal transplant recipients have an increased incidence of cardiovascular disease, but less data exist about cerebrovascular atherosclerosis. In this study, we assessed the prevalence of carotid lesions as evaluated by B-mode ultrasonography in a group of renal transplant recipients, and we evaluated univari...

journal_title：Transplantation

authors： Barbagallo CM,Pinto A,Gallo S,Parrinello G,Caputo F,Sparacino V,Cefalù AB,Novo S,Licata G,Notarbartolo A,Averna MR

更新日期：1999-02-15 00:00:00

abstract：BACKGROUND:To determine the prevalence of GB virus-C/hepatitis G virus (GBV-C/HGV) infection in liver transplant recipients transplanted for non-hepatitis C virus indications, 44 patients transplanted for cryptogenic, autoimmune, hepatitis B, or cholestatic liver disease and 91 non-liver transplantation (LT) patients w...

journal_title：Transplantation

authors： Dickson RC,Qian KP,Lau JY

更新日期：1997-06-15 00:00:00

abstract：:Our current knowledge of cytotoxic T lymphocytes (CTL) is largely derived from studies of effector populations generated in allogeneic mixed leukocyte cultures (MLC) and assayed for lytic activity to lymphoid cell (LC) targets. We herein report that the CTL response to allogeneic renal epithelial cell lines (REC) is d...

journal_title：Transplantation

authors： Hadley GA,Rostapshova EA,Bartlett ST

更新日期：1996-07-15 00:00:00

abstract：BACKGROUND:Recently, methylxanthines such as pentoxifylline (PTX) were shown to be immunosuppressive in vitro. Unfortunately, when used in transplant patients, PTX was poorly active as an immunosuppressant. Here we report that the new methylxanthine derivative A802715 not only is more active than PTX, it also suppresse...

journal_title：Transplantation

authors： Lin Y,Goebels J,Rutgeerts O,Kasran A,Van Gool S,Ceuppens J,Schönharting M,Waer M

更新日期：1997-06-27 00:00:00

abstract：:The lung is one of the primary targets of acute graft-versus-host disease (GVHD), which is the principal complication that occurs after allogeneic intestinal transplantation. The purpose of this study is to investigate the involvement of Fas/Fas ligand system in pulmonary injury after rat semi-allogeneic intestinal tr...

journal_title：Transplantation

authors： Hiroyasu S,Shiraishi M,Koji T,Mamadi T,Sugawa H,Tomori H,Muto Y

更新日期：1999-10-15 00:00:00

abstract：BACKGROUND:The present study was undertaken to determine whether anti-complement 5 (C5) monoclonal antibodies (mAb) prevent hyperacute rejection (HAR) in a rat-to-presensitized mouse heart transplantation model and whether these mAb, combined with cyclosporine (CsA) and cyclophosphamide (CyP), can achieve long-term gra...

journal_title：Transplantation

authors： Wang H,Rollins SA,Gao Z,Garcia B,Zhang Z,Xing J,Li L,Kellersmann R,Matis LA,Zhong R

更新日期：1999-12-15 00:00:00

abstract：:: Hepatitis C virus (HCV) infection is common in solid organ allograft recipients and is a significant cause of morbidity and mortality after transplantation, so effective management will improve outcomes. In this review, we discuss the extent of the problem associated with HCV infection in donors and kidney, heart, a...

journal_title：Transplantation

authors： Carbone M,Mutimer D,Neuberger J

更新日期：2013-03-27 00:00:00

abstract：BACKGROUND:Natural antibodies that react with galactose-alpha(1,3)galactose [galalpha(1,3)gal] carbohydrate epitopes exist in humans and Old World primates because of the inactivation of the alpha1,3-galactosyltransferase (alpha1,3GT) gene in these species and the subsequent production of antibodies to environmental mi...

journal_title：Transplantation

authors： Nozawa S,Xing PX,Wu GD,Gochi E,Kearns-Jonker M,Swensson J,Starnes VA,Sandrin MS,McKenzie IF,Cramer DV

更新日期：2001-07-15 00:00:00

abstract：:Genetic manipulation of pancreatic islets before transplantation has the potential to alter cellular immunity as well as islet function. The purpose of this study was to examine the feasibility of gene transfer to islets, using replication-defective adenoviral vectors. Newborn mouse islets were infected with AdHCMVsp1...

journal_title：Transplantation

authors： Csete ME,Benhamou PY,Drazan KE,Wu L,McIntee DF,Afra R,Mullen Y,Busuttil RW,Shaked A

更新日期：1995-01-27 00:00:00

abstract：BACKGROUND:Recent evidence has suggested that inconsistencies in human-islet yields after collagenase digestion are attributed to the activation of endogenous enzymes of the cadaveric donor pancreas. Inhibition of protease activity by Pefabloc (0.4 mM; Roche Biochemicals Inc., Indianapolis, IN) has recently been shown ...

journal_title：Transplantation

authors： Rose NL,Palcic MM,Helms LM,Lakey JR

更新日期：2003-02-27 00:00:00

abstract：:By cytolysis and monolayer absorption tests, the kinetics of the generation of CBA/H cytotoxic lymphocytes (Tc) in response to stimulation by H-2b antigens have been analyzed in vitro. The Tc population which reacts with public antigens of H-2b and H-2d strains shows peak activity in culture at 4 to 5 days, then rapi...

journal_title：Transplantation

authors： Schnagl HY,Boyle W

更新日期：1980-06-01 00:00:00