Complement inhibition with an anti-C5 monoclonal antibody prevents hyperacute rejection in a xenograft heart transplantation model.

abstract：:It has been demonstrated both in vivo and in vitro that cytomegalovirus regulates not only MHC class I but also class II antigen expression on vascular endothelial cells. The CMV-linked MHC induction is believed to be involved in acute rejection mechanisms and chronic vasculopathy after transplantation. In this study,...

journal_title：Transplantation

authors： Ustinov JA,Lahtinen TT,Bruggeman CA,Häyry PJ,Lautenschlager IT

更新日期：1994-11-15 00:00:00

abstract：:Recipient dogs were conditioned with 9.2 Gy of total-body irradiation followed by the infusion of bone marrow and peripheral blood leukocytes from a DLA-haploidentical littermate (N = 10) or a completely allogeneic unrelated donor (n = 9). Graft-vs.-host disease (GVHD) prophylaxis consisted of methotrexate (MTX) and c...

journal_title：Transplantation

authors： Deeg HJ,Severns E,Raff RF,Sale GE,Storb R

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:The organ donor shortage has led to a reconsideration of the use of non-heart-beating donors (NHBDs). However, graft injury due to warm ischemia in NHBD livers strongly affects posttransplant outcome. The present study was aimed at investigating the role of the cellular cyclic (c)AMP second messenger signal ...

journal_title：Transplantation

authors： Minor T,Akbar S

更新日期：1998-10-27 00:00:00

abstract：:A murine IgG1 antibody specific for the IL-2-binding site on the human lymphocyte IL-2 receptor beta chain (CD25) was evaluated in 11 patients who developed acute graft-versus-host disease following allogeneic marrow transplantation. All patients had received cyclosporine and methotrexate for prophylaxis of GVHD, eith...

journal_title：Transplantation

authors： Anasetti C,Martin PJ,Hansen JA,Appelbaum FR,Beatty PG,Doney K,Harkonen S,Jackson A,Reichert T,Stewart P

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:We previously reported that no cytotoxic T-lymphocyte precursor frequencies (CTLpf) were found in 60% of patients on azathioprine or mycophenolate mofetil+Pred long after kidney transplantation. We questioned whether the absence of donor-specific CTLpf was associated with low levels of stimulatory Th1 (tumor...

journal_title：Transplantation

authors： van Besouw NM,de Kuiper R,van der Mast BJ,van de Wetering J,Baan CC,Weimar W

更新日期：2009-05-27 00:00:00

abstract：:Graft and patient survival rates after transplantation of ABO-incompatible liver allografts have been poor. We used plasmapheresis and a potent immunosuppressive regimen to control hemagglutinin levels and prevent early rejection. Ten patients who had a United Network for Organ Sharing status of 4 received ABO-incompa...

journal_title：Transplantation

authors： Mor E,Skerrett D,Manzarbeitia C,Sheiner PA,Schwartz ME,Emre S,Thung SN,Miller CM

更新日期：1995-04-15 00:00:00

abstract：:The proliferation and differentiation of donor hematopoietic progenitor cells in bone marrow transplantation (BMT) recipients is influenced by hematopoietic growth factors, which could derive from either T cells or adherent stromal bone marrow cells, or both. In this study of 20 BMT recipients, we asked whether T lymp...

journal_title：Transplantation

authors： Thomas S,Clark SC,Rappeport JM,Nathan DG,Emerson SG

更新日期：1990-04-01 00:00:00

abstract：:Four skin graft models are created which vary in the rates of lymphatic and vascular reconstitution. Rat allografts (Brown Norway or (L times BN)F1 hybrid) transplanted to Lewis recipients by conventional (immediate lymphatic, delayed vascular), surgical anastomosis (immediate lymphatic, immediate vascular) or isolate...

journal_title：Transplantation

authors： Wustrack KO,Gruber RP,Lucas ZJ

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:The mitochondrial respiratory chain is implicated as a major target of kidney damage after ischemia-reperfusion. This study measures changes in integrated mitochondrial function and in the activity of enzymes of the respiratory chain after cold storage and transplantation-reperfusion in vivo. METHODS:Mitoch...

journal_title：Transplantation

authors： Sammut IA,Burton K,Balogun E,Sarathchandra P,Brooks KJ,Bates TE,Green CJ

更新日期：2000-04-15 00:00:00

abstract：:Renal transplant recipients are at risk of severe morbidity and mortality from CMV disease. We have undertaken routine surveillance for CMV shedding on 133 transplant recipients, using a rapid culture technique, in order to assess the incidence of CMV infection and disease in these patients and to assess the prognosti...

journal_title：Transplantation

authors： Pillay D,Ali AA,Liu SF,Kops E,Sweny P,Griffiths PD

更新日期：1993-07-01 00:00:00

abstract：:The mortality rates for CVDs in transplant recipients are greater than those in the general population (13). CVDs are a major cause of both patient and graft loss in renal transplant recipients, and improving cardiovascular health may help to extend both patient and graft survival. A complication of chronic renal fail...

journal_title：Transplantation

authors： Wheeler DC,Steiger J

更新日期：2000-12-15 00:00:00

abstract：:The glycosaminoglycan hyaluronan is not only involved in cellular differentiation and migration but may also play a role in several inflammatory diseases. We have previously demonstrated an increased local production of hyaluronan in chronically rejected kidneys and the correspondingly affected renal vessels. In this ...

journal_title：Transplantation

authors： Wells A,Larsson E,Hanás E,Laurent T,Hällgren R,Tufveson G

更新日期：1993-06-01 00:00:00

abstract：:Currently it is not feasible to isolate sufficient numbers of islets from a single pancreas for clinical transplantation. We examined whether small numbers of islets obtained from multiple donors could be used for transplantation. Islets were isolated from four inbred strains of mice (DBA/2, DBA/1, C3H, and A.SW) by a...

journal_title：Transplantation

authors： Gotoh M,Porter J,Kanai T,Monaco AP,Maki T

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:The clinical significance of HLA-directed antibodies newly detected after transplantation (HT) is controversial. METHODS:Seventy-one HT recipients consented to enroll. Mean follow-up time was 28 months (range 6-48). Panel reactive antibody (PRA) analysis was performed on posttransplant sera (2 weeks, 1, 2, ...

journal_title：Transplantation

authors： Tambur AR,Pamboukian SV,Costanzo MR,Herrera ND,Dunlap S,Montpetit M,Heroux A

更新日期：2005-10-27 00:00:00

abstract：BACKGROUND:The aim of this article is to report our experience regarding the survival and the evolution of polyneuropathy of the extremities and autonomic dysfunction in 18 liver transplant patients with familial amyloidotic polyneuropathy type I after a mean follow-up of more than 2.5 years for 13 patients. METHODS:T...

journal_title：Transplantation

authors： Parrilla P,Ramirez P,Andreu LF,Bueno SF,Robles R,Miras M,Acosta F,Viader-Farre D,de Mingo P,Bermejo J,Garrido SF,Munar-Ques M

更新日期：1997-08-27 00:00:00

abstract：BACKGROUND:Recent evidence suggests that living kidney donors are at an increased risk of end-stage renal disease. However, predicting which donors will have renal dysfunction remains challenging, particularly among those with no clinical evidence of disease at the time of donation. Although renal biopsies are not rout...

journal_title：Transplantation

authors： Fahmy LM,Massie AB,Muzaale AD,Bagnasco SM,Orandi BJ,Alejo JL,Boyarsky BJ,Anjum SK,Montgomery RA,Dagher NN,Segev DL

更新日期：2016-06-01 00:00:00

abstract：:Glutathione and glyoxalase II levels were evaluated in cytosolic and mitochondrial compartments of rat liver after 7 and 24 hr of cold storage in University of Wisconsin (UW) and Euro-Collins solutions. 1-4 A similar time-dependent depletion of cytosolic glutathione up to about 60% of control values was observed in bo...

journal_title：Transplantation

authors： Jassem W,Ciarimboli C,Cerioni PN,Saba V,Norton SJ,Principato G

更新日期：1996-05-15 00:00:00

abstract：BACKGROUND:Patients with von Hippel-Lindau (VHL) disease are at risk for the development of end-stage renal failure from the treatment of localized renal cell carcinoma. Transplantation with its attendant immunosuppression may predispose patients to tumor recurrence; however, there is little information regarding the o...

journal_title：Transplantation

authors： Goldfarb DA,Neumann HP,Penn I,Novick AC

更新日期：1997-12-27 00:00:00

abstract：:SLT presents an interesting concept to alleviate the organ shortage for children with end-stage liver disease. The procedure has, however, not gained wide acceptance. This is not only related to the complexity of the procedure, but also to the poorer results and the complications reported on the right side graft. We r...

journal_title：Transplantation

authors： Rogiers X,Malago M,Habib N,Knoefel WT,Pothmann W,Burdelski M,Meyer-Moldenhauer WH,Broelsch CE

更新日期：1995-04-27 00:00:00

abstract：BACKGROUND:Xenogeneic corneal fragments (guinea pig) are highly resistant to immune rejection in the anterior chamber of mouse eyes. Because guinea pigs and mice are discordant (i.e., mouse serum normally contains guinea pig reactive xenoantibodies), we wished to determine the extent to which xenogeneic corneal fragmen...

journal_title：Transplantation

authors： Tanaka K,Streilein JW

更新日期：2000-02-27 00:00:00

abstract：BACKGROUND:For certain uremic, diabetic patients, a sequential transplant of a kidney (usually from a living donor) followed by a cadaver pancreas has become an attractive option. But how long to wait after the kidney transplant before proceeding with a pancreas transplant is unclear. We studied outcomes in recipients ...

journal_title：Transplantation

authors： Humar A,Sutherland DE,Ramcharan T,Gruessner RW,Gruessner AC,Kandaswamy R

更新日期：2000-10-27 00:00:00

abstract：:Intercellular adhesion molecule-1 (ICAM-1) induction on hepatocytes was investigated in relation to acute liver allograft rejection, CMV infection, and systemic bacterial infections. Twenty-four liver transplant recipients underwent an episode of acute rejection, 13 developed a symptomatic clinical CMV infection, and ...

journal_title：Transplantation

authors： Lautenschlager IT,Höckerstedt KA

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Recently the United Network for Organ Sharing (UNOS) began a pilot study to evaluate prospectively the merits of an allocation of cadaveric kidneys based on broader classes of HLA antigens, called cross-reactive groups (CREG). The objectives of the pilot study consider patient outcomes, but not the potential...

journal_title：Transplantation

authors： Hollenbeak CS,Woodward RS,Cohen DS,Lowell JA,Singer GG,Tesi RJ,Howard TK,Mohanakumar T,Brennan DC,Schnitzler MA

更新日期：2000-08-15 00:00:00

abstract：BACKGROUND:Lipid peroxidation by free radicals is a key step in the development of atherosclerosis. Chronic graft nephropathy (CGN) is a common cause of allograft failure and shares many histologic features with atherosclerosis. Although hyperlipidemia is a common finding in renal transplant recipients, not all patient...

journal_title：Transplantation

authors： Morris-Stiff GJ,Oleesky D,Jurewicz WA

更新日期：2003-10-15 00:00:00

abstract：BACKGROUND:The use of urine flow cytometry (UFC) as a noninvasive tool for the diagnosis of acute and chronic rejection of the renal allograft has been previously reported. METHODS:We analyzed the expression of various cell surface antigens during a 30-day period after the diagnosis and treatment of 24 acute rejection...

journal_title：Transplantation

authors： Roberti I,Reisman L

更新日期：2001-05-15 00:00:00

abstract：:The current shortage of donor organs in liver transplantation has led experienced transplant centers to use more "marginal" grafts. The development of a reliable technique of bile collection gives access to hepatic bile from donors and recipients for bile analysis to characterize the grafts. Proton nuclear magnetic re...

journal_title：Transplantation

authors： Melendez HV,Ahmadi D,Parkes HG,Rela M,Murphy G,Heaton N

更新日期：2001-09-15 00:00:00

abstract：BACKGROUND:Suppressive dendritic cells (DCs) are a promising tool for tolerance induction in transplantation. A human DCs subpopulation, which constitutively expresses indoleamine-2,3-dioxygenase (IDO), a molecule shown to prevent the rejection of fetus during pregnancy, has recently been described. This subset, charac...

journal_title：Transplantation

authors： Löb S,Ebner S,Wagner S,Weinreich J,Schäfer R,Königsrainer A

更新日期：2007-02-27 00:00:00

abstract：:The frequency of donor-reactive and of third party-reactive cytotoxic T lymphocyte precursors (CTLp) was determined by limiting dilution analysis in the peripheral blood of 13 liver allograft recipients before (pre-tpx) and at various intervals (4 to 22 months) after (post-tpx) transplantation. In 6 of 13 patients wit...

journal_title：Transplantation

authors： Eberspächer ML,Otto G,Herfarth C,Kabelitz D

更新日期：1994-06-27 00:00:00

abstract：BACKGROUND:Vascular complications remain an important cause of postoperative morbidity in liver transplant patients. Herein, we present an unusual case of nonanastomotic inferior vena cava (IVC) stenosis in a patient with a "piggyback" caval anastomosis. METHODS:A 59-year-old woman underwent liver transplantation usin...

journal_title：Transplantation

authors： Orons PD,Hari AK,Zajko AB,Marsh JW

更新日期：1997-11-15 00:00:00

abstract：BACKGROUND:Despite proven efficacy of prolonged cytomegalovirus (CMV) prophylaxis using valganciclovir 900 mg/day, some centers use 450 mg/day due to reported success and cost savings. This multicenter, retrospective study compared the efficacy and safety of 6 months of low-dose versus high-dose valganciclovir prophyla...

journal_title：Transplantation

authors： Gabardi S,Asipenko N,Fleming J,Lor K,McDevitt-Potter L,Mohammed A,Rogers C,Tichy EM,Weng R,Lee RA

更新日期：2015-07-01 00:00:00