Abstract:
:Renal transplant recipients are at risk of severe morbidity and mortality from CMV disease. We have undertaken routine surveillance for CMV shedding on 133 transplant recipients, using a rapid culture technique, in order to assess the incidence of CMV infection and disease in these patients and to assess the prognostic significance of detection in whole blood, throat swab specimens, or urine. Donor CMV seropositivity was associated with posttransplant CMV infection (P < 0.05) and disease (P = 0.06). CMV infection and disease were associated with the receipt of anti-T-cell antibodies (P < 0.0001 and P = 0.08, respectively). First shedding of virus from any site occurred earlier posttransplant in those recipients who developed disease (median 39 days) than in those who did not (median 55 days)(P < 0.05). Detection of virus in blood occurred at a median time of 16 days before onset of symptoms, compared with 9 days before symptoms in urine, and 3 days after onset of symptoms from throat swab. A positive blood culture represented a relative risk of 7.1 for the subsequent development of disease, compared with 2.1 and 1.8 for positive urine and saliva cultures, respectively. The addition of urine cultures to blood cultures increased the sensitivity for identification of those at risk--however, the relative risk was reduced to 5.8. We conclude that routine surveillance for CMV shedding, especially in blood and urine, can identify recipients at high risk of CMV disease, and propose a trial in which those with asymptomatic viremia are allocated to receive ganciclovir or placebo, in order to assess the efficacy of "preemptive" therapy in this group of patients.
journal_name
Transplantationjournal_title
Transplantationauthors
Pillay D,Ali AA,Liu SF,Kops E,Sweny P,Griffiths PDdoi
10.1097/00007890-199307000-00019subject
Has Abstractpub_date
1993-07-01 00:00:00pages
103-8issue
1eissn
0041-1337issn
1534-6080journal_volume
56pub_type
临床试验,杂志文章相关文献
TRANSPLANTATION文献大全abstract::In the literature, varying terminology for living organ donation can be found. However, there seems to be a need for a new classification to avoid confusion. Therefore, we assessed existing terminology in the light of current living organ donation practices and suggest a more straightforward classification. We propose...
journal_title:Transplantation
pub_type: 社论
doi:10.1097/TP.0b013e3182129236
更新日期:2011-05-15 00:00:00
abstract::We have previously observed that transplant recipient sera with endothelial antibodies are bound to epidermal cells, as shown by immunofluorescence on sections of skin. It was also reported that early kidney failures that occurred despite negative T cell crossmatches were associated with, and could have been predicted...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199102000-00019
更新日期:1991-02-01 00:00:00
abstract::A non-complement-binding monoclonal antibody, TA-1, recognizing determinants on human T lymphocytes, was linked to the plant seed toxin ricin, either the intact molecule or purified ricin A chain. Peripheral blood lymphocytes were pretreated with conjugate for 2 hr, washed, and then measured in vitro for T cell prolif...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198404000-00015
更新日期:1984-04-01 00:00:00
abstract:BACKGROUND:Immunological unresponsiveness of T cells to alloantigen can be induced by intrathymic injection of donor-specific antigen in small-animal models. Intrathymic tolerance to vascularized grafts in large animals has not previously been reported. METHODS:Thirty-two dogs were allocated into dog leukocyte antigen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181910e67
更新日期:2008-12-27 00:00:00
abstract:BACKGROUND:Genetic variants of the renin-angiotensin system (RAS) have been implicated in the progression of native kidney diseases. A decreased long-term renal allograft function has also been associated with increased activity of RAS, which may be genetically determined. METHODS:The effect of the angiotensinogen (AG...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200203270-00023
更新日期:2002-03-27 00:00:00
abstract::KM2210, a conjugate of estradiol and chlorambucil (CBL), which was originally developed as an anti-breast cancer agent, inhibits proliferative response of human mononuclear cells to alloantigens in mixed lymphocyte culture in a dose-dependent manner, but has no effect on their response to phytohemagglutinin. Neither e...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199210000-00022
更新日期:1992-10-01 00:00:00
abstract::We describe a patient transfused with 200 ml of donor fresh whole blood three times at 2-week intervals. Three weeks after the last transfusion, transplantation and splenectomy were done at the same time. Splenic cells from this DST pretreated patient were fused with murine myeloma cells (X63-Ag8, 653). With DST pretr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198909000-00022
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:It is controversial whether coronary endothelial function is impaired after cold exposure to University of Wisconsin (UW) or St. Thomas' Hospital (ST) solution during heart transplantation. We therefore examined the effects of cold storage of coronary micro-arteries with UW or ST solution on endothelium-deri...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:2000-07-15 00:00:00
abstract:BACKGROUND:The role of combined liver-kidney transplantation (CLKT) for cirrhotic patients with renal failure (RF) is controversial. Since the model for end-stage liver disease era, there has been a rise in the number of CLKT. Using the Organ Procurement Transplant Network/United Network for Organ Sharing database, thi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182590d6b
更新日期:2012-08-27 00:00:00
abstract:BACKGROUND:The objective of this study was to investigate purine nucleotide metabolism in peripheral blood mononuclear cells (PBMC) of cardiac transplant recipients switched from azathioprine to mycophenolate mofetil (MMF). METHODS:Concentrations of guanosine 5'triphosphate (GTP) and adenosine 5'triphosphate (ATP), th...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000225759.54343.23
更新日期:2006-07-15 00:00:00
abstract:BACKGROUND:Few studies have examined the effectiveness of a risk-stratified approach to screening kidney transplantation candidates for ischemic heart disease (IHD). METHODS:We retrospectively reviewed records from all adult patients (n = 514) placed on the deceased donor kidney transplantation waiting list at a singl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000173652.87417.ca
更新日期:2005-09-27 00:00:00
abstract:BACKGROUND:Hepatic transplantation is a highly effective but costly treatment for end-stage hepatic dysfunction. One approach to improve efficiency in the use of scarce organs for transplantation is to identify preoperative factors that are associated with poor outcome posttransplantation. This may assist both in selec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200109270-00023
更新日期:2001-09-27 00:00:00
abstract:BACKGROUND:Solid-organ transplant recipients with pretransplant malignancies (PTM) have worse overall survival (OS) compared to recipients without history of malignancy. However, it is unknown whether the increased risk of mortality is due to recurrent cancer-related deaths. METHODS:All solid-organ transplant recipien...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002178
更新日期:2018-07-01 00:00:00
abstract::A new method of thymus transplantation is introduced, in which the graft is directly connected with the recipient's vascular system. This procedure was used both in euthymic rats and congenitally athymic nude rats. At all tested intervals after transplantation thymus grafts hardly differed from the recipient's own thy...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199010000-00028
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND:Both chemokines and adhesion molecules mediate allograft rejection by recruiting leukocytes into the allograft. We investigated the association of six single nucleotide polymorphisms (SNPs) located in interleukin (IL)-8, CXCR1, CXCR2, and selectin with kidney allograft outcomes. METHODS:The promoter regions...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/tp.0b013e3181fd0195
更新日期:2011-01-15 00:00:00
abstract::Osteopetrotic microphthalmic mice (mi/mi) were treated by injections of suspensions of myeloid tissue, newborns i.p., and weanlings i.v. Donated syngeneic material effected permanent cure of oteopetrosis provided that the dose was large enough (10(8) cells of bone marrow). H-2-compatible allogeneic bone marrow was ini...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197910000-00004
更新日期:1979-10-01 00:00:00
abstract::Feline bone marrow cells treated with the soybean agglutinin (SBA) lectin are separated into two populations, the agglutinated SBA(+) fraction containing predominantly cells of myeloid origin and the nonagglutinated SBA(-) fraction consisting of cells primarily of the erythroid lineage. FACScan analyses revealed a cle...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199708150-00022
更新日期:1997-08-15 00:00:00
abstract:BACKGROUND:While previous surveys have demonstrated the psychological impact on living-related liver transplantation (LRLT) donors, such as anxiety, depression, ambivalence and anger, the details regarding the relevant factors that affect donors' psychological status have not been well described. METHODS:To evaluate e...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000287455.70815.9e
更新日期:2007-11-27 00:00:00
abstract::A mouse monoclonal antibody (CIA) produced against human Ia antigens that reacts with 20-30% of human peripheral blood lymphocytes was found to react with more than 90% of dog lymphocytes. Less than 41% of the Ia-positive dog lymphocytes expressed surface immunoglobulins. Immunoprecipitation studies with 125I-labeled ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198308000-00016
更新日期:1983-08-01 00:00:00
abstract:BACKGROUND:Donor-derived cell-free DNA (dd-cfDNA) is a potential noninvasive molecular marker of graft rejection after kidney transplant, whose diagnostic accuracy remains controversial. METHODS:We performed a systematic review and meta-analysis to evaluate the diagnostic accuracy of dd-cfDNA. Relevant literature was ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003443
更新日期:2020-09-02 00:00:00
abstract::Adult male B6AF1 (H-2KIb/kDb/d) mice were given skin allografts from adult male C3H (H-2k) mice, with and without contralateral cotransplants. The cotransplants were of either adult or neonatal (less than 24 hr) C3H skin. In recipient mice treated peritransplantation with antilymphocyte serum and posttransplantation w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199012000-00001
更新日期:1990-12-01 00:00:00
abstract::The incidence of interstitial pneumonitis (IP) was reviewed in 70 consecutive patients who received autologous marrow transplants for hematologic malignancies. All patients were treated with total-body irradiation (TBI), with or without other chemotherapeutic agents. Seven patients (10%) developed IP, 3 were due to cy...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198611000-00015
更新日期:1986-11-01 00:00:00
abstract::Patients who require cystectomy are usually treated with an ileal conduit or intestinal neobladder for urinary control. In some of them, however, the bowel segment cannot be used because of previous abdominal surgery or radiation treatment. Bladder transplantation from cadavers may be beneficial to these patients, if ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199704150-00002
更新日期:1997-04-15 00:00:00
abstract::The current shortage of donor organs has stimulated investigation of pig-to-human xenotransplantation as a practical alternative to allotransplantation. However, a major obstacle to this xenotransplantation is hyperacute rejection, which is believed to be initiated by the interaction of natural anti-alpha-galactosyl (...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199611150-00026
更新日期:1996-11-15 00:00:00
abstract:BACKGROUND:Two side effects of irradiation are premature ovarian failure (POF) and osteoporosis, both of which are concerns not only clinically, for patients, but also experimentally, for animals. We examine whether bone marrow transplantation (BMT) can correct the POF induced by radiation and also address whether allo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181ca86bb
更新日期:2010-02-27 00:00:00
abstract:BACKGROUND:Microvascular endothelial cells (ECs) are central to an allograft's immunogenicity. Cold ischemia and reperfusion injury associated with static cold storage and warm reperfusion activates ECs and increases the immunogenicity of the allograft. After reperfusion, mitochondrial permeability transition pore (mPT...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002163
更新日期:2018-06-01 00:00:00
abstract::The results presented in this report demonstrate that T cells, isolated from AGUS rats bearing long-term (WAG X AGUS)F1 spleen allografts adoptively transferred to irradiated AGUS recipients could not mediate the rejection of WAG hearts but rejected PVG. A hearts in acute fashion. Further, unresponsive T cells were ab...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198709000-00024
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:It is well known that kidney transplant recipients with preformed lymphocytotoxic antibodies against HLA antigens have an increased graft rejection rate. However, the individual contribution of anti-HLA class I and class II antibodies to this phenomenon is poorly understood. We investigated the clinical rele...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200204270-00014
更新日期:2002-04-27 00:00:00
abstract:BACKGROUND:Combined lung and liver transplantation (Lu-LTx) is a therapeutic option for selected patients with coexisting lung and liver disease. For several reasons, Lu-LTx is performed in few centers and information about the technical issues, posttransplant management and long-term outcomes associated with this proc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181636f3f
更新日期:2008-02-27 00:00:00
abstract::Multiple variations of the basic lymphocytotoxicity test have been reported to increase test sensitivity. Although these modifications are used routinely in crossmatch tests, as required by federal regulation, there has been no methodical assessment of the relative sensitivities and specificities of these techniques w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199509000-00016
更新日期:1995-09-15 00:00:00