The prognostic significance of positive CMV cultures during surveillance of renal transplant recipients.

Abstract:

:Renal transplant recipients are at risk of severe morbidity and mortality from CMV disease. We have undertaken routine surveillance for CMV shedding on 133 transplant recipients, using a rapid culture technique, in order to assess the incidence of CMV infection and disease in these patients and to assess the prognostic significance of detection in whole blood, throat swab specimens, or urine. Donor CMV seropositivity was associated with posttransplant CMV infection (P < 0.05) and disease (P = 0.06). CMV infection and disease were associated with the receipt of anti-T-cell antibodies (P < 0.0001 and P = 0.08, respectively). First shedding of virus from any site occurred earlier posttransplant in those recipients who developed disease (median 39 days) than in those who did not (median 55 days)(P < 0.05). Detection of virus in blood occurred at a median time of 16 days before onset of symptoms, compared with 9 days before symptoms in urine, and 3 days after onset of symptoms from throat swab. A positive blood culture represented a relative risk of 7.1 for the subsequent development of disease, compared with 2.1 and 1.8 for positive urine and saliva cultures, respectively. The addition of urine cultures to blood cultures increased the sensitivity for identification of those at risk--however, the relative risk was reduced to 5.8. We conclude that routine surveillance for CMV shedding, especially in blood and urine, can identify recipients at high risk of CMV disease, and propose a trial in which those with asymptomatic viremia are allocated to receive ganciclovir or placebo, in order to assess the efficacy of "preemptive" therapy in this group of patients.

journal_name

Transplantation

journal_title

Transplantation

authors

Pillay D,Ali AA,Liu SF,Kops E,Sweny P,Griffiths PD

doi

10.1097/00007890-199307000-00019

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

103-8

issue

1

eissn

0041-1337

issn

1534-6080

journal_volume

56

pub_type

临床试验,杂志文章
  • New classification of ELPAT for living organ donation.

    abstract::In the literature, varying terminology for living organ donation can be found. However, there seems to be a need for a new classification to avoid confusion. Therefore, we assessed existing terminology in the light of current living organ donation practices and suggest a more straightforward classification. We propose...

    journal_title:Transplantation

    pub_type: 社论

    doi:10.1097/TP.0b013e3182129236

    authors: Dor FJ,Massey EK,Frunza M,Johnson R,Lennerling A,Lovén C,Mamode N,Pascalev A,Sterckx S,Van Assche K,Zuidema WC,Weimar W

    更新日期:2011-05-15 00:00:00

  • Alloantibodies against donor epidermis and early kidney transplant rejection.

    abstract::We have previously observed that transplant recipient sera with endothelial antibodies are bound to epidermal cells, as shown by immunofluorescence on sections of skin. It was also reported that early kidney failures that occurred despite negative T cell crossmatches were associated with, and could have been predicted...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199102000-00019

    authors: Moraes JR,Moraes ME,Luo YM,Stastny P

    更新日期:1991-02-01 00:00:00

  • Monoclonal antibody-toxin conjugates reactive against human T lymphocytes. A comparison of antibody linked to intact ricin toxin with antibody linked to ricin A chain.

    abstract::A non-complement-binding monoclonal antibody, TA-1, recognizing determinants on human T lymphocytes, was linked to the plant seed toxin ricin, either the intact molecule or purified ricin A chain. Peripheral blood lymphocytes were pretreated with conjugate for 2 hr, washed, and then measured in vitro for T cell prolif...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198404000-00015

    authors: Vallera DA,Quinones RR,Azemove SM,Soderling CC

    更新日期:1984-04-01 00:00:00

  • Tolerance induction in a large-animal model using total lymphoid irradiation and intrathymic bone marrow.

    abstract:BACKGROUND:Immunological unresponsiveness of T cells to alloantigen can be induced by intrathymic injection of donor-specific antigen in small-animal models. Intrathymic tolerance to vascularized grafts in large animals has not previously been reported. METHODS:Thirty-two dogs were allocated into dog leukocyte antigen...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181910e67

    authors: Horton PJ,Hawthorne WJ,Walters S,Patel T,Stewart GJ,Allen RD,Chapman JR

    更新日期:2008-12-27 00:00:00

  • Recipient RAS gene variants and renal allograft function.

    abstract:BACKGROUND:Genetic variants of the renin-angiotensin system (RAS) have been implicated in the progression of native kidney diseases. A decreased long-term renal allograft function has also been associated with increased activity of RAS, which may be genetically determined. METHODS:The effect of the angiotensinogen (AG...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200203270-00023

    authors: Nicod J,Richard A,Frey FJ,Ferrari P

    更新日期:2002-03-27 00:00:00

  • The alloantigen-specific immunosuppressive activity of estradiol-chlorambucil conjugate (KM2210) and its beneficial effect on allogeneic bone marrow transplantation in mice.

    abstract::KM2210, a conjugate of estradiol and chlorambucil (CBL), which was originally developed as an anti-breast cancer agent, inhibits proliferative response of human mononuclear cells to alloantigens in mixed lymphocyte culture in a dose-dependent manner, but has no effect on their response to phytohemagglutinin. Neither e...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199210000-00022

    authors: Matsudaira T,Kodo H,Okamoto S,Tani K,Tojo A,Ozawa K,Asano K,Asano S

    更新日期:1992-10-01 00:00:00

  • Induction of antiidiotypic antibodies by donor-specific blood transfusions. Establishment of a human-mouse hybridoma secreting the MLR-inhibiting factor.

    abstract::We describe a patient transfused with 200 ml of donor fresh whole blood three times at 2-week intervals. Three weeks after the last transfusion, transplantation and splenectomy were done at the same time. Splenic cells from this DST pretreated patient were fused with murine myeloma cells (X63-Ag8, 653). With DST pretr...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198909000-00022

    authors: Kawamura T,Sakagami K,Haisa M,Morisaki F,Takasu S,Inagaki M,Oiwa T,Orita K

    更新日期:1989-09-01 00:00:00

  • Comparison of University of Wisconsin and St Thomas' Hospital solutions on endothelium-derived hyperpolarizing factor-mediated function in coronary micro-arteries.

    abstract:BACKGROUND:It is controversial whether coronary endothelial function is impaired after cold exposure to University of Wisconsin (UW) or St. Thomas' Hospital (ST) solution during heart transplantation. We therefore examined the effects of cold storage of coronary micro-arteries with UW or ST solution on endothelium-deri...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Ge ZD,He GW

    更新日期:2000-07-15 00:00:00

  • Combined liver-kidney transplantation is preferable to liver transplant alone for cirrhotic patients with renal failure.

    abstract:BACKGROUND:The role of combined liver-kidney transplantation (CLKT) for cirrhotic patients with renal failure (RF) is controversial. Since the model for end-stage liver disease era, there has been a rise in the number of CLKT. Using the Organ Procurement Transplant Network/United Network for Organ Sharing database, thi...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3182590d6b

    authors: Fong TL,Khemichian S,Shah T,Hutchinson IV,Cho YW

    更新日期:2012-08-27 00:00:00

  • Activation of the purine salvage pathway in mononuclear cells of cardiac recipients treated with mycophenolate mofetil.

    abstract:BACKGROUND:The objective of this study was to investigate purine nucleotide metabolism in peripheral blood mononuclear cells (PBMC) of cardiac transplant recipients switched from azathioprine to mycophenolate mofetil (MMF). METHODS:Concentrations of guanosine 5'triphosphate (GTP) and adenosine 5'triphosphate (ATP), th...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.tp.0000225759.54343.23

    authors: Devyatko E,Zuckermann A,Bohdjalian A,Roedler S,Dunkler D,Grimm M,Weigel G

    更新日期:2006-07-15 00:00:00

  • Risk-stratified screening for ischemic heart disease in kidney transplant candidates.

    abstract:BACKGROUND:Few studies have examined the effectiveness of a risk-stratified approach to screening kidney transplantation candidates for ischemic heart disease (IHD). METHODS:We retrospectively reviewed records from all adult patients (n = 514) placed on the deceased donor kidney transplantation waiting list at a singl...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000173652.87417.ca

    authors: Kasiske BL,Malik MA,Herzog CA

    更新日期:2005-09-27 00:00:00

  • Preoperative factors associated with outcome and their impact on resource use in 1148 consecutive primary liver transplants.

    abstract:BACKGROUND:Hepatic transplantation is a highly effective but costly treatment for end-stage hepatic dysfunction. One approach to improve efficiency in the use of scarce organs for transplantation is to identify preoperative factors that are associated with poor outcome posttransplantation. This may assist both in selec...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200109270-00023

    authors: Markmann JF,Markmann JW,Markmann DA,Bacquerizo A,Singer J,Holt CD,Gornbein J,Yersiz H,Morrissey M,Lerner SM,McDiarmid SV,Busuttil RW

    更新日期:2001-09-27 00:00:00

  • Solid Organ Transplantation in Patients With Preexisting Malignancies in Remission: A Propensity Score Matched Cohort Study.

    abstract:BACKGROUND:Solid-organ transplant recipients with pretransplant malignancies (PTM) have worse overall survival (OS) compared to recipients without history of malignancy. However, it is unknown whether the increased risk of mortality is due to recurrent cancer-related deaths. METHODS:All solid-organ transplant recipien...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002178

    authors: Acuna SA,Sutradhar R,Kim SJ,Baxter NN

    更新日期:2018-07-01 00:00:00

  • Vascular thymus transplantation in rats. Technique, morphology, and function.

    abstract::A new method of thymus transplantation is introduced, in which the graft is directly connected with the recipient's vascular system. This procedure was used both in euthymic rats and congenitally athymic nude rats. At all tested intervals after transplantation thymus grafts hardly differed from the recipient's own thy...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199010000-00028

    authors: Kampinga J,Schuurman HJ,Pol GH,Bartels H,Broekhuizen R,Vaessen LM,Tielen FJ,Rozing J,Blaauw EH,Roser B

    更新日期:1990-10-01 00:00:00

  • Association of polymorphisms of interleukin-8, CXCR1, CXCR2, and selectin with allograft outcomes in kidney transplantation.

    abstract:BACKGROUND:Both chemokines and adhesion molecules mediate allograft rejection by recruiting leukocytes into the allograft. We investigated the association of six single nucleotide polymorphisms (SNPs) located in interleukin (IL)-8, CXCR1, CXCR2, and selectin with kidney allograft outcomes. METHODS:The promoter regions...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/tp.0b013e3181fd0195

    authors: Ro H,Hwang YH,Kim H,Jeong JC,Lee H,Doh YS,Park HC,Oh KH,Park MH,Ha J,Yang J,Ahn C

    更新日期:2011-01-15 00:00:00

  • Resolution and relapse of osteopetrosis in mice transplanted with myeloid tissue of variable histocompatibility.

    abstract::Osteopetrotic microphthalmic mice (mi/mi) were treated by injections of suspensions of myeloid tissue, newborns i.p., and weanlings i.v. Donated syngeneic material effected permanent cure of oteopetrosis provided that the dose was large enough (10(8) cells of bone marrow). H-2-compatible allogeneic bone marrow was ini...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197910000-00004

    authors: Nisbet NW,Menage J,Loutit JF

    更新日期:1979-10-01 00:00:00

  • Fractionation of feline bone marrow with the soybean agglutinin lectin yields populations enriched for erythroid and myeloid elements: transplantation of soybean agglutinin-negative cells into lethally irradiated recipients.

    abstract::Feline bone marrow cells treated with the soybean agglutinin (SBA) lectin are separated into two populations, the agglutinated SBA(+) fraction containing predominantly cells of myeloid origin and the nonagglutinated SBA(-) fraction consisting of cells primarily of the erythroid lineage. FACScan analyses revealed a cle...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199708150-00022

    authors: Gengozian N,Reyes L,Pu R,Homer BL,Bova FJ,Yamamoto JK

    更新日期:1997-08-15 00:00:00

  • Relevant factors to psychological status of donors before living-related liver transplantation.

    abstract:BACKGROUND:While previous surveys have demonstrated the psychological impact on living-related liver transplantation (LRLT) donors, such as anxiety, depression, ambivalence and anger, the details regarding the relevant factors that affect donors' psychological status have not been well described. METHODS:To evaluate e...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000287455.70815.9e

    authors: Hayashi A,Noma S,Uehara M,Kuwabara H,Tanaka S,Furuno Y,Hayashi T

    更新日期:2007-11-27 00:00:00

  • Crossreactivity between human and canine Ia antigens using a mouse monoclonal antibody (CIA).

    abstract::A mouse monoclonal antibody (CIA) produced against human Ia antigens that reacts with 20-30% of human peripheral blood lymphocytes was found to react with more than 90% of dog lymphocytes. Less than 41% of the Ia-positive dog lymphocytes expressed surface immunoglobulins. Immunoprecipitation studies with 125I-labeled ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198308000-00016

    authors: Iwaki Y,Terasaki PI,Kinukawa T,Thai TH,Root T,Billing R

    更新日期:1983-08-01 00:00:00

  • Diagnostic accuracy of donor-derived cell-free DNA in renal-allograft rejection: a meta-analysis.

    abstract:BACKGROUND:Donor-derived cell-free DNA (dd-cfDNA) is a potential noninvasive molecular marker of graft rejection after kidney transplant, whose diagnostic accuracy remains controversial. METHODS:We performed a systematic review and meta-analysis to evaluate the diagnostic accuracy of dd-cfDNA. Relevant literature was ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000003443

    authors: Xiao H,Gao F,Pang Q,Xia Q,Zeng X,Peng J,Fan L,Liu J,Wang Z,Li H

    更新日期:2020-09-02 00:00:00

  • Prolongation of adult skin allograft survival by cotransplantation of neonatal skin in antilymphocyte serum and donor bone marrow cell-treated mice.

    abstract::Adult male B6AF1 (H-2KIb/kDb/d) mice were given skin allografts from adult male C3H (H-2k) mice, with and without contralateral cotransplants. The cotransplants were of either adult or neonatal (less than 24 hr) C3H skin. In recipient mice treated peritransplantation with antilymphocyte serum and posttransplantation w...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199012000-00001

    authors: Markees TG,De Fazio SR,Gozzo JJ

    更新日期:1990-12-01 00:00:00

  • Interstitial pneumonitis following autologous bone marrow transplantation.

    abstract::The incidence of interstitial pneumonitis (IP) was reviewed in 70 consecutive patients who received autologous marrow transplants for hematologic malignancies. All patients were treated with total-body irradiation (TBI), with or without other chemotherapeutic agents. Seven patients (10%) developed IP, 3 were due to cy...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198611000-00015

    authors: Pecego R,Hill R,Appelbaum FR,Amos D,Buckner CD,Fefer A,Thomas ED

    更新日期:1986-11-01 00:00:00

  • Histological study of urinary bladder transplantation in rats.

    abstract::Patients who require cystectomy are usually treated with an ileal conduit or intestinal neobladder for urinary control. In some of them, however, the bowel segment cannot be used because of previous abdominal surgery or radiation treatment. Bladder transplantation from cadavers may be beneficial to these patients, if ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199704150-00002

    authors: Takeuchi K,Takechi S,Ohoka H,Yokoyama M,Iwata H,Takeuchi M,Matsuda S

    更新日期:1997-04-15 00:00:00

  • Glycans derived from porcine stomach mucin are effective inhibitors of natural anti-alpha-galactosyl antibodies in vitro and after intravenous infusion in baboons.

    abstract::The current shortage of donor organs has stimulated investigation of pig-to-human xenotransplantation as a practical alternative to allotransplantation. However, a major obstacle to this xenotransplantation is hyperacute rejection, which is believed to be initiated by the interaction of natural anti-alpha-galactosyl (...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199611150-00026

    authors: Li SF,Neethling FA,Taniguchi S,Yeh JC,Kobayashi T,Ye Y,Koren E,Cummings RD,Cooper DK

    更新日期:1996-11-15 00:00:00

  • Prevention of premature ovarian failure and osteoporosis induced by irradiation using allogeneic ovarian/bone marrow transplantation.

    abstract:BACKGROUND:Two side effects of irradiation are premature ovarian failure (POF) and osteoporosis, both of which are concerns not only clinically, for patients, but also experimentally, for animals. We examine whether bone marrow transplantation (BMT) can correct the POF induced by radiation and also address whether allo...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181ca86bb

    authors: Feng W,Cui Y,Zhan H,Shi M,Cui W,Guo K,Li Q,Song C,Zhang Y,Mori T,Gershwin ME,Abraham NG,Ikehara S

    更新日期:2010-02-27 00:00:00

  • Impact of Mitochondrial Permeability on Endothelial Cell Immunogenicity in Transplantation.

    abstract:BACKGROUND:Microvascular endothelial cells (ECs) are central to an allograft's immunogenicity. Cold ischemia and reperfusion injury associated with static cold storage and warm reperfusion activates ECs and increases the immunogenicity of the allograft. After reperfusion, mitochondrial permeability transition pore (mPT...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002163

    authors: Tran DT,Esckilsen S,Mulligan J,Mehrotra S,Atkinson C,Nadig SN

    更新日期:2018-06-01 00:00:00

  • Induction of transplantation tolerance in rats by spleen allografts. II. Evidence that W3/25+ T suppressor/inducer and OX8+ T suppressor/effector cells are required to mediate specific unresponsiveness.

    abstract::The results presented in this report demonstrate that T cells, isolated from AGUS rats bearing long-term (WAG X AGUS)F1 spleen allografts adoptively transferred to irradiated AGUS recipients could not mediate the rejection of WAG hearts but rejected PVG. A hearts in acute fashion. Further, unresponsive T cells were ab...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198709000-00024

    authors: Stepkowski SM,Bitter-Suermann H,Duncan WR

    更新日期:1987-09-01 00:00:00

  • Kidney graft failure and presensitization against HLA class I and class II antigens.

    abstract:BACKGROUND:It is well known that kidney transplant recipients with preformed lymphocytotoxic antibodies against HLA antigens have an increased graft rejection rate. However, the individual contribution of anti-HLA class I and class II antibodies to this phenomenon is poorly understood. We investigated the clinical rele...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200204270-00014

    authors: Süsal C,Opelz G

    更新日期:2002-04-27 00:00:00

  • Indications for and outcomes after combined lung and liver transplantation: a single-center experience on 13 consecutive cases.

    abstract:BACKGROUND:Combined lung and liver transplantation (Lu-LTx) is a therapeutic option for selected patients with coexisting lung and liver disease. For several reasons, Lu-LTx is performed in few centers and information about the technical issues, posttransplant management and long-term outcomes associated with this proc...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181636f3f

    authors: Grannas G,Neipp M,Hoeper MM,Gottlieb J,Lück R,Becker T,Simon A,Strassburg CP,Manns MP,Welte T,Haverich A,Klempnauer J,Nashan B,Strueber M

    更新日期:2008-02-27 00:00:00

  • Variations of the lymphocytotoxicity test. An evaluation of sensitivity and specificity.

    abstract::Multiple variations of the basic lymphocytotoxicity test have been reported to increase test sensitivity. Although these modifications are used routinely in crossmatch tests, as required by federal regulation, there has been no methodical assessment of the relative sensitivities and specificities of these techniques w...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199509000-00016

    authors: Zachary AA,Klingman L,Thorne N,Smerglia AR,Teresi GA

    更新日期:1995-09-15 00:00:00