Vascular thymus transplantation in rats. Technique, morphology, and function.

Abstract:

:A new method of thymus transplantation is introduced, in which the graft is directly connected with the recipient's vascular system. This procedure was used both in euthymic rats and congenitally athymic nude rats. At all tested intervals after transplantation thymus grafts hardly differed from the recipient's own thymus in immunohistology and lymphocyte yield. In athymic nude rats, T cell-dependent immunity, tested by mitogen- and alloantigen-induced T cell responses, as well as by antibody production and delayed-type hypersensitivity after ovalbumin administration, showed that vascular thymus grafts could generate T cell functions to euthymic control levels. We conclude that the technique of vascular thymus transplantation represents a valuable tool, either in fundamental research on thymus function, or for the purpose of immune (re)constitution.

journal_name

Transplantation

journal_title

Transplantation

authors

Kampinga J,Schuurman HJ,Pol GH,Bartels H,Broekhuizen R,Vaessen LM,Tielen FJ,Rozing J,Blaauw EH,Roser B

doi

10.1097/00007890-199010000-00028

subject

Has Abstract,Author List Incomplete

pub_date

1990-10-01 00:00:00

pages

669-78

issue

4

eissn

0041-1337

issn

1534-6080

journal_volume

50

pub_type

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