Abstract:
:Osteopetrotic microphthalmic mice (mi/mi) were treated by injections of suspensions of myeloid tissue, newborns i.p., and weanlings i.v. Donated syngeneic material effected permanent cure of oteopetrosis provided that the dose was large enough (10(8) cells of bone marrow). H-2-compatible allogeneic bone marrow was initially as effective, but relapse ensued in immunocompetent mice. H-2-incompatible marrow was ineffecitve except in one set of newborn tolerant mice. Total body X-radiation in sublethal doses to recipients allowed permanent cure with H-2-compatible, and, in one circumstance, with H-2-incompatible marrow in smaller doses. The best results were obtained after lethal irradiation and the smaller dose of marrow. Results were checked by chromosome assay demonstrating that cure or relapse was correlated with permanent take or rejection, respectively, of a transplant in a recipient's bone marrow. Retention of donor lymphocytes alone was not associated with effective bony resorption; the candidate cell line for effectiveness remains the haematopoietic stem cell-monocyte-tissue phagocyte.
journal_name
Transplantationjournal_title
Transplantationauthors
Nisbet NW,Menage J,Loutit JFdoi
10.1097/00007890-197910000-00004subject
Has Abstractpub_date
1979-10-01 00:00:00pages
285-90issue
4eissn
0041-1337issn
1534-6080journal_volume
28pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Whether cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) at prophylaxis cessation predicts D+/R+ kidney transplants at risk of late-onset CMV infection after receiving distinct induction therapies is still not well characterized. METHODS:We prospectively assessed CMV-specific CMI predicting late-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002421
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Evidence on prevalence and correlates of pretransplant medication nonadherence (MNA) is limited. The present study explored self-reported prevalence and correlates of MNA before heart, liver, and lung transplantation. METHODS:This cross-sectional descriptive study included 174 patients: 69 lung, 33 heart, a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000158430.06507.87
更新日期:2005-06-15 00:00:00
abstract:BACKGROUND:Sotrastaurin (STN), a novel oral protein kinase C inhibitor that inhibits early T-cell activation, was assessed in non-human primate recipients of life-supporting kidney allografts. METHODS:Cynomolgus monkey recipients of life-supporting kidney allografts were treated orally with STN alone or in combination...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31823cf92f
更新日期:2012-01-27 00:00:00
abstract:BACKGROUND:Individuals undergoing therapeutic immunosuppression are at risk of severe varicella-zoster virus (VZV) infection, particularly those without evidence of previous infection. METHODS:Eleven children, median age 10 months (range 5.5 months to 7 years and 9 months) received one dose of varicella vaccine (Varil...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200011150-00023
更新日期:2000-11-15 00:00:00
abstract:BACKGROUND:Abrupt temperature shift from hypothermia to normothermia incurred on reperfusion of organ grafts has been delineated as a genuine factor contributing to reperfusion injury and graft dysfunction after transplantation. METHODS:In a first clinical series of 6 patients, cold-stored livers, all allocated by the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000915
更新日期:2016-01-01 00:00:00
abstract::Consecutive patients transplanted between January 1984 and December 1988 were followed until August 1992 to detect fatal and nonfatal thromboembolic complications, including sudden death, acute and chronic myocardial infarction, pulmonary and peripheral embolisms, stroke, and thrombophlebitis. The probability of devel...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199603150-00015
更新日期:1996-03-15 00:00:00
abstract::We have investigated the influence of phenobarbitone ([PB]; 40 mg/kg/day), an inducer of hepatic drug metabolism, on high-dose cyclosporine ([CsA] 40 mg/kg/day) nephrotoxicity in normal Lewis (Lew) and renal allografted (DA X Lew F1----Lew) rats of both sexes. In untreated normal animals, CsA nephrotoxicity, assessed ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198804000-00005
更新日期:1988-04-01 00:00:00
abstract::Adult male B6AF1 (H-2KIb/kDb/d) mice were given skin allografts from adult male C3H (H-2k) mice, with and without contralateral cotransplants. The cotransplants were of either adult or neonatal (less than 24 hr) C3H skin. In recipient mice treated peritransplantation with antilymphocyte serum and posttransplantation w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199012000-00001
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:Umbilical cord blood transplantation (UCBT) is increasingly used and produces similar results to matched unrelated donor transplantation. METHODS:We performed a retrospective single-center analysis of 50 umbilical cord blood transplantations UCBTs performed from 2001 to 2010, including 37 single and 13 doub...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31826c39b2
更新日期:2012-11-27 00:00:00
abstract:BACKGROUND:Immunogenicity of a graft depends on its expression of major histocompatability complex (MHC) antigens and adhesion molecules and on the amount of intragraft leukocytes, the so-called passenger leukocytes. Although long-term culture reduces passenger leukocytes, permanent acceptance is not necessarily observ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200208270-00003
更新日期:2002-08-27 00:00:00
abstract:BACKGROUND:Human herpesvirus-6 (HHV-6) has been implicated in bone marrow suppression, interstitial pneumonitis, and fatal meningoencephalitis in bone marrow transplant (BMT) recipients. METHODS:We describe the case of a woman with acute myeloid leukemia in second remission who developed febrile meningoencephalitis 8 ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199805270-00024
更新日期:1998-05-27 00:00:00
abstract:BACKGROUND:In the acute rejection of allografts, the interaction between Fas (CD95) and its ligand (FasL; CD95L) has been shown to be involved in mediating apoptotic cell death. The role, however, of these molecules in the pathogenesis of transplant vascular sclerosis is as yet undetermined. The present study was there...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199905270-00001
更新日期:1999-05-27 00:00:00
abstract:BACKGROUND:Impaired pretransplant performance status (PS) is associated with chronic liver disease (CLD). We studied its impact on hospital length of stay (LOS), complications and readmissions in the first year after liver transplantation. METHOD:The Standard National Liver Transplant Registry was linked to a hospital...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003484
更新日期:2020-10-08 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate familial amyloidotic polyneuropathy, Portuguese type patients' endocrine cell content in the stomach and duodenum before and after liver transplantation, and to relate the findings to the patients' gastrointestinal disturbances. METHODS:Ten liver-transplanted familia...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200009150-00015
更新日期:2000-09-15 00:00:00
abstract:INTRODUCTION:Celsior (CEL) was formulated specifically for heart preservation. Recently some preliminary reports have suggested that CEL is also effective for liver preservation. In this study liver preservation with CEL was compared to colloid-free University of Wisconsin solution (MUW). METHODS:Arterialized rat live...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200010270-00002
更新日期:2000-10-27 00:00:00
abstract:BACKGROUND:Intrahepatic bile duct strictures are a serious complication after non-heart-beating (NHB) liver transplantation. Bile salt toxicity has been identified as an important factor in the pathogenesis of bile duct injury and cholangiopathies. The role of bile salt toxicity in the development of biliary strictures...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318170f5f7
更新日期:2008-06-15 00:00:00
abstract:BACKGROUND:The short tolerable cold ischemia time and the importance of other risk factors have generally superseded the role of HLA matching in the allocation of donor hearts. Recent advances in the accuracy and time required to perform HLA typing and crossmatching, however, have led us to re-examine the United Networ...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/00007890-200005270-00038
更新日期:2000-05-27 00:00:00
abstract::The effects of FK506 on exocrine function of the pancreas in Sprague-Dawley rats were examined and compared with those of cyclosporine. FK506 did not affect the levels of amylase and lipase in the pancreas of rats given the drug orally in a daily dose of 1 or 5 mg/kg for 2 weeks. Furthermore, the pancreas of the rats ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199211000-00023
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Renal interstitial fibrosis (IF) is the main histopathological feature of chronic allograft injury. IF is currently assessed by semiquantitative analysis, but automatic color image analysis may be more reliable and reproducible. We performed a retrospective analysis to calculate IF on routine renal biopsies ...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/01.tp.0000295749.50525.bd
更新日期:2007-12-27 00:00:00
abstract::A portable hypothermic perfusion system for storage of hearts has been developed. The system uses the airlift pump principle, whereby the flow of gas maintains circulation of the perfusate through the heart; no other energy source is required. Performance on ex vivo functional testing of 10 pig hearts stored for 20 to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198211000-00002
更新日期:1982-11-01 00:00:00
abstract::Natural xenoantibodies are believed to be IgM in nature and are known to play a critical role in the hyperacute rejection of distantly related xenografts. The purpose of this study was to determine whether the reducing agent DL-penicillamine could inactivate baboon natural xenoantibodies to pig splenocytes. Pooled bab...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-12-27 00:00:00
abstract::A retrospective study was performed to identify risk factors affecting the fate of liver allografts transplanted across the ABO barrier. Over a 5-year period, 30 patients received 31 emergency OLTs with ABO-incompatible allografts. One-year graft and patient survival rates were 37.1% and 48.4%, respectively. This grou...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199409150-00003
更新日期:1994-09-15 00:00:00
abstract:BACKGROUND:Selective inhibition of lymphocyte activation through abrogation of signal 3-cytokine transduction emerges as a new strategy for immunosuppression. This is the first report on the novel Janus kinase (JAK)1/3 inhibitors R507 and R545 for prevention of acute allograft rejection. METHODS:Pharmacokinetic and in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182660496
更新日期:2012-10-15 00:00:00
abstract:BACKGROUND:The subclass of IgG antibodies contributes to their capability to activate complement. It is currently unknown whether the pretransplant IgG subclass composition allows distinguishing harmful from presumably irrelevant donor-specific human leukocyte antigen (HLA) antibodies (HLA-DSA) detected by single-antig...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31821cdf0d
更新日期:2011-07-15 00:00:00
abstract::Predictors of survival after lung transplant were analyzed in a large cohort of 990 lung transplanted patients from a single center. The overall survival was 41.6%, (41.5% in males, and 41.8% in females), the average length of the follow up was 45.84+/-51.98 months (range 0-282.47 months). Females tend to live longer ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816c2fae
更新日期:2008-04-27 00:00:00
abstract::We developed a new and simplified donor-specific blood transfusion (DSBT) protocol for prospective kidney transplant recipients from one-haplotype-mismatched related donors. Prospective kidney donors gave 450 ml of blood in a quad-pack unit, and the blood was stored in a blood bank. Twenty-five patients were transfuse...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198411000-00012
更新日期:1984-11-01 00:00:00
abstract::We have previously demonstrated that the placental spongiotrophoblast and yolk sac venous plexus express paternally derived H-2K and D (class I) antigens in a manner accessible to maternal circulation, and that the placenta serves to prevent antipaternal antibodies from reaching the fetus. Kinetic studies indicated th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198403000-00016
更新日期:1984-03-01 00:00:00
abstract::In vivo cell-mediated effector mechanisms of allograft destruction were investigated in a canine single-lung transplantation model. This large animal model permits direct longitudinal studies of immune effector cells from the grafts of individual recipients by bronchoalveolar lavage (BAL). Evidence was obtained that t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198911000-00026
更新日期:1989-11-01 00:00:00
abstract::The beneficial effect of deoxyspergualin (DSG, NKT-01) on lethal graft-versus-host disease in mice has been studied in a major histoincompatible donor-recipient combination. Suppression of the effector mechanisms responsible for the lethal outcome in this GVHD model is also noted. This study reveals: (1) DSG has a mar...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199103000-00032
更新日期:1991-03-01 00:00:00
abstract::Chronic hepatitis C is a common cause of viral liver disease in kidney transplant (KT) recipients. To assess the efficacy and safety of therapy with interferon alpha we conducted a prospective study where 14 cadaveric KT recipients with chronic hepatitis C received recombinant interferon alpha-2b (IFNa) 3 million unit...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-199505270-00012
更新日期:1995-05-27 00:00:00