Abstract:
BACKGROUND:Patients with von Hippel-Lindau (VHL) disease are at risk for the development of end-stage renal failure from the treatment of localized renal cell carcinoma. Transplantation with its attendant immunosuppression may predispose patients to tumor recurrence; however, there is little information regarding the outcome with this approach. In this article, we review the North American and European experience with renal transplantation in this patient population. METHODS:The study group comprises 32 patients who have VHL rendered anephric secondary to localized renal cell carcinoma and who have undergone renal transplantation. Patients were identified from North American (n=18) and European (n=14) registries. The outcome of the study group is compared with a cohort of 32 renal transplant recipients without VHL from the Cleveland Clinic Unified Transplant Data Base, who were matched for donor source, gender, age, transplant status (primary vs. regraft), and date of transplantation. RESULTS:The 23 men and 9 women in the study group received transplants between 1974 and 1996. The average age at transplantation was 36 years, and the average duration of dialysis before transplantation was 26 months. Patients have been followed for 48+/-35 months. There was no statistically significant difference in graft survival, patient survival, or renal function between the study and control groups. There were five deaths in both the study and control groups. In the study group, three patients died with metastatic disease. There was no difference in the duration of dialysis before transplantation between patients who developed metastatic disease and those who did not. CONCLUSION:These data support the utility of renal transplantation as an effective form of renal replacement therapy in this unique population, with a limited risk of recurrent cancer.
journal_name
Transplantationjournal_title
Transplantationauthors
Goldfarb DA,Neumann HP,Penn I,Novick ACdoi
10.1097/00007890-199712270-00017subject
Has Abstractpub_date
1997-12-27 00:00:00pages
1726-9issue
12eissn
0041-1337issn
1534-6080journal_volume
64pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Machine perfusion (MP) has evolved as a promising approach for the ex situ preservation in organ transplantation. However, the literature on the use of MP in human vascularized composite allografts is scarce. The aim of this study was to evaluate the effects of hypothermic MP with an acellular perfusate in h...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003221
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Extracorporeal membrane oxygenation (ECMO) and mechanical ventilation (MV) can be used as a bridge to heart-lung transplantation (HLT). The goal of this study was to determine if pretransplantation ECMO or MV affects survival in HLT. METHODS:The United Network for Organ Sharing database was reviewed for all...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182a860b8
更新日期:2014-01-15 00:00:00
abstract:BACKGROUND:Abrupt temperature shift from hypothermia to normothermia incurred on reperfusion of organ grafts has been delineated as a genuine factor contributing to reperfusion injury and graft dysfunction after transplantation. METHODS:In a first clinical series of 6 patients, cold-stored livers, all allocated by the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000915
更新日期:2016-01-01 00:00:00
abstract::Cytomegalovirus (CMV) is a major pathogen in transplant recipients and AIDS patients, and the virus may also play a role in allograft rejection. Previous work from this laboratory demonstrated increased cell surface expression of the adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) following CMV infection in vitro. W...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199610270-00014
更新日期:1996-10-27 00:00:00
abstract::Living donor renal allograft survival is superior to that achieved from deceased donors, although graft outcome is suboptimal in some of these patients. In an effort to identify the subset of patients at high risk for poor outcomes we studied donor risk factors in 248 living kidney donor-recipient pairs. Unadjusted do...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000256284.78721.ba
更新日期:2007-03-15 00:00:00
abstract::A total of 159 patients received renal cadaveric grafts under 2 different allocation systems. System 1, a local variance (i.e., a point system different from that of United Network for Organ Sharing [UNOS]), and system 2, the current UNOS point system, differed in the relative emphasis on waiting time and HLA match. T...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-04-15 00:00:00
abstract::Uncontrolled donation after circulatory death (uDCD) refers to donation from persons who die following an unexpected and unsuccessfully resuscitated cardiac arrest. Despite the large potential for uDCD, programs of this kind only exist in a reduced number of countries with a limited activity. Barriers to uDCD are of a...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000003139
更新日期:2020-08-01 00:00:00
abstract::CD4+ cells from CsA-treated DA rats with long-surviving PVG heart allografts specifically suppress the capacity of naive CD4+ cells to restore allograft rejection in irradiated DA rats, but have normal donor-specific alloreactivity in MLC. CD4+ suppressor cells from CsA-treated DA rats cultured for 3 days against eith...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199302000-00027
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Frequencies of alloreactive T cells determined by limiting dilution assays (LDA) may not adequately reflect the donor-reactive immune status in transplant recipients. To reevaluate LDA frequencies, we developed a flow cytometry test for direct determination of alloreactive T-cell frequencies and compared the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200208270-00023
更新日期:2002-08-27 00:00:00
abstract::Two hundred twenty-eight patients from a total of 466 (49%) receiving renal allografts under cyclosporine/prednisone (CsA/Pred) immunosuppression experienced at least one episode of posttransplant hepatotoxicity. All patients were documented to have normal serum bilirubin, serum glutamic oxaloacetic transaminase (SGOT...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198701000-00009
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:In transplantation, novel methods are required to augment the supply of donor organs. We report the first domino liver transplant in which a patient with familial amyloid polyneuropathy (FAP) received an orthotopic split liver graft, and her explanted liver was donated to another patient. Three successful li...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199806150-00016
更新日期:1998-06-15 00:00:00
abstract::The response to IL-2 and IL-4 of several functionally defined lymphoid cell types was assessed at the individual responding cell level in limiting dilution experiments in which exogenous IL-2 or IL-4 was used to promote cellular activation and expansion. Splenic precursors that give rise to alloreactive CTL in LDA sup...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199004000-00018
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:Preoperative mapping of the hepatic venous system of the partial liver graft is indispensable to the success of living-related liver transplantation. We assessed the accuracy of magnetic resonance (MR) venography with angular reconstruction in depicting the tributaries of the middle hepatic vein and left hep...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199907270-00019
更新日期:1999-07-27 00:00:00
abstract:BACKGROUND:Many models of transplant tolerance have been found to depend on the induction of regulatory T cells (Tregs). Innate immune signals are known to suppress Tregs thereby augmenting immunity by abrogating Treg function. Such signals may also provide a barrier to transplantation tolerance mediated by Tregs. A nu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181ba6f85
更新日期:2009-11-27 00:00:00
abstract:BACKGROUND:This 36-month, randomized, parallel-group study compared safety and efficacy of two doses of everolimus with mycophenolate mofetil (MMF) in de novo renal-transplant recipients. METHODS:Renal-allograft recipients received 1.5 mg/day or 3 mg/day of everolimus or 2 g/day of MMF, plus full-dose cyclosporine (Cs...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/01.tp.0000164352.65613.24
更新日期:2005-07-27 00:00:00
abstract:BACKGROUND:After allogeneic hematopoietic stem-cell transplantation (HSCT), donor-derived T cells may elicit graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) responses. The main targets of GVHD and GVT responses after human leukocyte antigen (HLA)-identical HSCT are minor histocompatibility antigens (mHAgs...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181f5470c
更新日期:2010-11-15 00:00:00
abstract::Allograft recipients who have preformed antibodies to MHC determinants or develop these antibodies post-transplantation have a higher incidence of cellular rejection and graft loss. It is unclear whether this association is an etiologic one or whether the presence of these antibodies solely identifies individuals with...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract::Non-A, non-B hepatitis is a significant cause of liver disease among renal allograft recipients. In order to assess the impact and prevalence of hepatitis C in a series of renal allograft recipients, we retrospectively screened 621 consecutive patients transplanted between 1979 and 1989 and 484 cadaver organ donors re...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199102000-00024
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND:Deep venous thrombosis (DVT) is a common problem with potentially devastating results in patients undergoing major surgical procedures. Certain renal transplant recipients are particularly at risk for allograft loss as a consequence of renal vein and artery thrombosis. Over the past few years, low molecular ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199808270-00020
更新日期:1998-08-27 00:00:00
abstract::The effects of mismatching for DR antigens on renal allograft survival rates have largely been restricted to analyses of cadaver transplant results. Analyses of HLA matching in recipients of transplants from related donors have focused on the number of haplotypes shared between the recipients without regard to DR, or ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198336060-00011
更新日期:1983-12-01 00:00:00
abstract::Rat recipients of renal allografts and unilaterally nephrectomized control rats were studied to evaluate the response in blood pressure to prednisolone in diverse doses, and to determine the dosage required to achieve adequate immunosuppression without undue complication of hypertension. While a continuous infusion of...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198703000-00007
更新日期:1987-03-01 00:00:00
abstract::Data of 32,000 donors were utilized for a computer simulation to analyze the effect of selection parameters on the outcome of kidney transplants. If the HLA match grade is considered for organ allocation, the overall 1-year graft survival rate is up to 7% higher for first cadaver transplants and up to 12% higher for s...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::Hepatitis C virus (HCV) remains the leading indication for liver transplant in much of the world and has traditionally been associated with diminished posttransplant survival due to recurrent HCV-related liver disease. This field has been dramatically changed by the advent of safe and effective direct-acting antiviral...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001688
更新日期:2017-05-01 00:00:00
abstract::Since 1989, the U.S. Food and Drug Administration (FDA) has encouraged the study of new drug and therapeutic products in elderly patients. However, despite the aging population in the United States, elderly patients continue to be underrepresented in clinical trials across a variety of therapeutic areas, including tra...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31828279d9
更新日期:2013-04-15 00:00:00
abstract::We have noted a decrease in the time to development of posttransplant lymphoproliferative disorder (PTLD) over the last two and one-half years in our multiorgan transplant program. From February 1965 until December 1990, 1622 transplants were performed including 1489 kidneys (KTxp), 87 livers (LTxp), and 46 pancreata....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199208000-00012
更新日期:1992-08-01 00:00:00
abstract::Second clinical kidney grafts often survive longer than first grafts. Using a rat cardiac allograft model, we examined the conditions under which survival of a second graft can be longer than first graft survival. In the BUF-to-LEW combination, following rejection of the first transplant, second cardiac allografts fro...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199210000-00025
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:Pneumocystis jiroveci pneumonia may be a life-threatening opportunistic infection in immunosuppressed solid organ transplant recipients. Despite effective treatment with high-dose trimethoprim-sulfamethoxazole and steroids, morbidity is often severe and lethality remains high. New therapeutic approaches are ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000280546.91617.6c
更新日期:2007-09-27 00:00:00
abstract::To determine the impact of different flush and reperfusion techniques on postreperfusion syndrome (PRS) and postoperative graft function, 100 transplants were randomly assigned into four groups as follows: group 1 (n=31), portal vein flush, no vena caval venting; group 2 (n=21), hepatic arterial flush, no vena caval v...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199702150-00012
更新日期:1997-02-15 00:00:00
abstract:OBJECTIVES:To retrospectively compare the accuracy of pretransplant panel of reactivity antibodies (PRA) and serum level of soluble CD30 (sCD30) in predicting early (<6 months) acute rejection (AR) in living-donor and deceased-donor kidney-transplant (KT) patients. METHODS:Pretransplant sera of 24 KT recipients were r...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:2005-05-15 00:00:00
abstract::The renal handling of cyclosporine was studied in ischemically damaged kidneys in New Zealand White rabbits and nonischemic control animals. CsA, 25 mg/kg/day, was administered intravenously for 10 days starting with the day of operation. Blood CsA (B CsA) was higher in the ischemic group compared with the controls (m...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199003000-00004
更新日期:1990-03-01 00:00:00