Abstract:
:Non-A, non-B hepatitis is a significant cause of liver disease among renal allograft recipients. In order to assess the impact and prevalence of hepatitis C in a series of renal allograft recipients, we retrospectively screened 621 consecutive patients transplanted between 1979 and 1989 and 484 cadaver organ donors retrieved in the same interval for serologic evidence of hepatitis C viral (HCV) infection using the enzyme-linked assay for anti-HCV antibody. Of 596 HBsAg negative patients, 180 (30%) were anti-HCV positive at the time of transplant. One-year posttransplant, 117 (22%) had detectable levels of anti-HCV antibody. Chemically significant hepatitis developed in 52/234 (22%) anti-HCV positive patients, and 26 of these followed a clinical course consistent with chronic hepatitis. Significantly more males and patients with antibody to HCV detectable at 1 year posttransplant were in the group experiencing an increase in liver enzymes. Ten-year patient and graft survival was 78% and 50%, respectively, for the anti-HCV positive patients who had an elevation of alanine aminotransferase, and 76% and 57% for the cohort maintaining normal liver function (P = NS). There were also no differences in patient and graft survival among the anti-HCV positive group and the consistently sero-negative patients. Of 484 cadaver organ donors with serum available for analysis (out of 1200 retrieved), 67 (14%) were anti-HCV positive at the time of organ donation. Among 23 anti-HCV negative kidney recipients who received a kidney from an HCV antibody positive donor, only one had seroconverted at 1 year posttransplant. Antibody to HCV appears to be widespread among renal transplant recipients and cadaver organ donors. We were unable to demonstrate any evidence of long-term adverse effects on patient and graft survival among anti-HCV positive patients employing the first generation anti-HCV assay.
journal_name
Transplantationjournal_title
Transplantationauthors
Roth D,Fernandez JA,Burke GW,Esquenazi V,Miller Jdoi
10.1097/00007890-199102000-00024subject
Has Abstractpub_date
1991-02-01 00:00:00pages
396-400issue
2eissn
0041-1337issn
1534-6080journal_volume
51pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Fox kidney and skin grafts were transplanted into dog recipients. Fox kidneys, transplanted en bloc into untreated dogs, survived 6.2 +/- 0.4 days. The skin transplants survived 5.9 +/- 1.4 days. The grafted kidneys showed almost normal function before rejection. Both skin and kidney rejection were mediated through a ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197508000-00009
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:Patient-level risk factors for delayed graft function (DGF) have been well described. However, the Organ Procurement and Transplantation Network definition of DGF is based on dialysis in the first week, which is subject to center-level practice patterns. It remains unclear if there are center-level differenc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000450
更新日期:2015-05-01 00:00:00
abstract::A considerable amount of data indicates that transplanted patients are at increased risk for de novo and recurrent cancer. Treatment of this population is difficult. It remains unclear if the immunosuppressive therapy should be continued, tapered or even stopped or if immunosuppressive drugs with antiproliferative pro...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000186912.23630.85
更新日期:2005-09-27 00:00:00
abstract:BACKGROUND:The influence of recipient body mass index (BMI) on pediatric-donor kidney transplant outcomes is unclear. We aimed to determine graft survival and functional outcomes of pediatric-donor kidneys compared with adult kidneys stratified by recipient BMI group. METHODS:Scientific Registry of Transplant Recipien...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318241d57d
更新日期:2012-02-27 00:00:00
abstract:BACKGROUND:The long-term metabolic function of microencapsulated xenogeneic adult porcine islets (API) was assessed in a murine model of type 1 diabetes mellitus. METHODS:API were encapsulated in barium-gelled alginate and transplanted intraperitoneally in diabetic nonobese diabetic (NOD) mice given no immunosuppressi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181abbfc1
更新日期:2009-07-27 00:00:00
abstract::Despite improvements in immunosuppression, rejection occurs in 50% of liver transplant patients and may cause significant morbidity. The most frequent cause of death after liver transplantation is severe infection. Determination of the cytokine network may lead to earlier detection of patients at risk for severe rejec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199611270-00011
更新日期:1996-11-27 00:00:00
abstract:BACKGROUND:This study examined the relationship between transplant vascular sclerosis (TVS) and tissue fibrosis, features of chronic rejection that can develop rapidly in accepted heterotopic murine cardiac allografts. METHODS:The rate of development of interstitial fibrosis or TVS development was determined by comput...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199710270-00020
更新日期:1997-10-27 00:00:00
abstract::We have previously demonstrated that subclinical chronic rejection (CR) induces structural and functional alterations in enteric smooth muscle and nerves in a rat model of small intestinal transplantation. This study was designed to investigate the effect of prolonged FK506 rescue therapy on these sequelae of CR. Immu...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-01-27 00:00:00
abstract:BACKGROUND:The authors have previously demonstrated that inhibition of CD28 and CD40 ligand (CD40L) co-stimulatory signals by adenovirus-mediated cytotoxic T-lymphocyte-associated (CTL) antigen 4 (A4) immunoglobulin (Ig) and CD40Ig gene therapies induces tolerance or long-term acceptance in rat liver and heart allograf...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000144324.83846.a9
更新日期:2004-11-27 00:00:00
abstract:BACKGROUND:Human leukocyte antigen (HLA) antibodies were normally not found in subjects who have not been immunized by pregnancies, transfusions, or transplants. But with new methodology, we now see that HLA antibodies are often found in nonalloimmunized males. METHODS:The sera of 424 healthy male donors were tested w...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0b013e318186d87b
更新日期:2008-10-27 00:00:00
abstract:BACKGROUND:Endomyocardial biopsy (EMB) remains the gold standard for acute cellular rejection (ACR) diagnosis in cardiac transplantation yet is subject to interobserver variability. A method that could avoid discordant EMB analysis would be desirable. The apoptosis rate in EMB correlates with ACR severity. Apollon inhi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181c3c690
更新日期:2010-01-27 00:00:00
abstract::In a cross-sectional survey of the quality of life of 45 liver transplant recipients, physical and psychological status, physical complaints, capability to participate in daily life, social support, and global quality of life were assessed. The average time of follow-up was 9 months after transplantation. Nine patient...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199309000-00013
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:The leflunomide analog, FK778, is a selective pyrimidine synthesis inhibitor. In rodent models, FK778 is efficacious in the prevention of allograft and xenograft rejection, and a combination of FK778 and cyclosporine has synergistic immunosuppressive efficacy. METHODS:Heterotopic renal transplantation was p...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000061789.97072.12
更新日期:2003-04-27 00:00:00
abstract::Cultured BALB/c (H-2d) thyroid, adult pancreatic islet and fetal proislet tissues can be accepted permanently in CBA/H (H-2k) recipients until rejection is triggered by the transfer of antidonor strain activated immune T cells. Class II MHC antigens are not expressed on the accepted grafts and are induced following im...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199204000-00025
更新日期:1992-04-01 00:00:00
abstract::The aim of this study was to investigate excretion of urinary and pancreatic juice neopterin in patients after combined pancreas-kidney transplantation and to relate it to the clinical course. The study design was a prospective observation study. Thirty consecutive patients with end-stage diabetic disease received a s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199204000-00020
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Kidney transplantation (KT) of human immunodeficiency virus (HIV)-positive patients has transformed the management of end-stage kidney disease in this population. Although favourable outcomes have been reported, patients experience high rates of acute allograft rejection (AR). We examined factors associated ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000879
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Urologic complications cause substantial morbidity in the pediatric population after renal transplantation, but their impact on graft survival and transplant costs is poorly understood. In this retrospective review, we evaluated the records of all pediatric renal transplant recipients at our center from 1995...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31818b63da
更新日期:2008-12-15 00:00:00
abstract:BACKGROUND:Although antibody mechanisms play a pathogenetic role in liver allograft rejection, no data exist on B lymphocytes, plasma cells, complement, and chemokines in rejected liver tissue. METHODS:Liver biopsy specimens from 25 patients with acute allograft rejection (AR) (rejection activity index, RAI score: 1-9...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000132324.14207.8b
更新日期:2004-07-15 00:00:00
abstract::Patients with short-gut syndrome may develop total parenteral nutrition-associated liver disease, which may preclude them from isolated intestinal transplantation and require combined liver and intestinal transplantation. Traditionally, these multiorgan transplantations are performed using en bloc liver and intestinal...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000045711.68765.84
更新日期:2003-02-27 00:00:00
abstract::Cell surface markers of isolated graft-infiltrating cells (GIC) were studied, and functional in vitro assays performed in 8 cases of acute irreversible rejection of human renal allografts. The GIC were mostly activated T cells (OKT11+, OKT3+, Ia+), with predominance of the cytotoxic/suppressor T cell phenotype (OKT8+)...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198707000-00010
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:Pregnancy after heart transplantation (HTx) may expose the recipient to hemodynamic and immunologic risks and the newborn to toxic effects of immunosuppressive therapy. Adequate preconception counseling is crucial to identify optimal timing and to modify immunosuppressive therapy to minimize risks for both t...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000002281
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor. Currently, liver transplantation may be the optimal treatment for HCC in cirrhotic patients. Patient selection is currently based on tumor size. We developed a program to offer liver transplantation to selected patients with HCC...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002835
更新日期:2020-01-01 00:00:00
abstract::The interaction of T cell costimulatory molecules with their ligands is required for optimal T cell activation. Interference with such interactions can induce antigen unresponsiveness and delay xeno- and allograft rejection. We have previously shown that LFA3TIP, a soluble human lymphocyte function-associated antigen ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199602150-00004
更新日期:1996-02-15 00:00:00
abstract:BACKGROUND:Vascular complications remain an important cause of postoperative morbidity in liver transplant patients. Herein, we present an unusual case of nonanastomotic inferior vena cava (IVC) stenosis in a patient with a "piggyback" caval anastomosis. METHODS:A 59-year-old woman underwent liver transplantation usin...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199711150-00020
更新日期:1997-11-15 00:00:00
abstract::Rapamycin prolongs allograft survival and induces donor-specific tolerance in some small animal transplant models. Large animal studies, however, are limited. We studied rapamycin in a porcine renal allograft model. Donor-recipient combinations were chosen based on high response in pretransplant MLCs. Allografts were ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:Organ donors are frequently trauma victims, but the impact of donor hemorrhagic shock and resuscitation (HSR) on pulmonary graft function has not been assessed. L-arginine treatment during reperfusion increases the production of endothelial nitric oxide and thus ameliorates ischemia-reperfusion injury. Objec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a52ce1
更新日期:2009-06-15 00:00:00
abstract:BACKGROUND:Two patients underwent cadaver transplantation with kidneys from a donor with a history of World Health Organization Class IV/V lupus nephritis, and we report their clinical and pathological outcome. METHODS:The donor had a diagnosis of lupus nephritis made by renal biopsy 5 years before donation. At the ti...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200003270-00030
更新日期:2000-03-27 00:00:00
abstract:BACKGROUND:Aspartylglucosaminuria is a rare, inherited lysosomal disease characterized by a slowly progressive mental retardation and coarse facial and body features. With the intent to provide the deficient enzyme aspartylglucosaminidase, allogeneic stem-cell transplantation (ASCT) has been attempted. Only a few cases...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200408150-00015
更新日期:2004-08-15 00:00:00
abstract:BACKGROUND:Graft coronary artery disease (CAD) is an increasingly important problem during long-term survival after heart transplantation, but the importance of cellular rejection, in particular late after transplantation, remains undetermined. METHODS AND RESULTS:We analyzed 492 coronary angiographies (967+/-705 days...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199802270-00015
更新日期:1998-02-27 00:00:00
abstract::Patients who require cystectomy are usually treated with an ileal conduit or intestinal neobladder for urinary control. In some of them, however, the bowel segment cannot be used because of previous abdominal surgery or radiation treatment. Bladder transplantation from cadavers may be beneficial to these patients, if ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199704150-00002
更新日期:1997-04-15 00:00:00