Abstract:
OBJECTIVES:To retrospectively compare the accuracy of pretransplant panel of reactivity antibodies (PRA) and serum level of soluble CD30 (sCD30) in predicting early (<6 months) acute rejection (AR) in living-donor and deceased-donor kidney-transplant (KT) patients. METHODS:Pretransplant sera of 24 KT recipients were retrospectively tested for sCD30 and compared with PRA. Inclusion criteria were de novo graft patients on calcineurin-inhibitor-based immunosuppression, minimum follow-up of 1 year, alive with a functioning graft, and stable renal function over the last 12 months. Objective measures were incidence of biopsy-proven AR (BPAR) within 6 months of KT and sCD30 and PRA diagnostic indexes. The relative risk (RR) of BPAR for each test was also obtained. RESULTS:Fourteen (58.3%) patients presented at least one episode of BPAR within 6 months of KT. All rejection episodes were responsive to steroid treatment. PRA was positive in six (25%) patients, and four (66.7%) of them presented at least one episode of BPAR. sCD30 tested positive in nine (37.5%) patients, and all these later presented at least one episode of BPAR. sCD30 and PRA diagnostic indexes in predicting early (< 6months) BPAR were sensitivity 64.2% versus 28.5%; specificity 100% versus 80%; accuracy 79.1% versus 50%; positive predictive value 100% versus 66.6%; and negative predictive value 66.6% versus 44.4%. The RR of early AR was 1.4 in PRA-positive patients and extremely higher in the sCD30-positive group. CONCLUSIONS:Pretransplant sCD30 is a more accurate predictor of AR when compared with PRA. These results support its use in the pretransplant work-up of kidney-graft recipients.
journal_name
Transplantationjournal_title
Transplantationauthors
Cinti P,Pretagostini R,Arpino A,Tamburro ML,Mengasini S,Lattanzi R,De Simone P,Berloco P,Molajoni ERsubject
Has Abstractpub_date
2005-05-15 00:00:00pages
1154-6issue
9eissn
0041-1337issn
1534-6080pii
00007890-200505150-00036journal_volume
79pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:The role of changes in peri-operative blood lactate levels in recipients of living-related liver transplants has not yet been clarified. METHODS:Forty-three recipients were included in this study. Blood lactate, plasma total bilirubin, aminotransferase, body temperature, and gastric mucosal PCO2 levels were...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200005270-00028
更新日期:2000-05-27 00:00:00
abstract::Pregnancy after solid organ transplantation, although considered high risk for maternal, fetal, and neonatal complications, has been quite successful. Tacrolimus pharmacokinetic changes during pregnancy make interpretation of whole blood trough concentrations particularly challenging. There are multiple factors that c...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e318278d367
更新日期:2013-04-15 00:00:00
abstract::Patients awaiting a renal transplant were given 1 HLA-DR antigen-matched blood in order to compare the sensitization and graft outcome of these patients with those of control patients, who had been given random blood before transplantation. No differences in sensitization, measured by the formation of HLA antibodies, ...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-10-15 00:00:00
abstract::Successful cardiac transplantation requires suppression of rejection, and endomyocardial biopsy is generally used to quantify this and guide immunotherapy. Biopsy, however, is an invasive, costly, cardiac catheterization with repetition limited. Since rejection requires lymphocyte activation, an alternative method of ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199103000-00018
更新日期:1991-03-01 00:00:00
abstract::Modified limiting dilution analysis (LDA) techniques were used to evaluate the mobilization of antigen-stimulated helper T lymphocytes (HTL) and cytotoxic T lymphocytes (CTL) following allogeneic heterotopic cardiac transplantation. These modified LDA techniques allow a quantitative comparison of T cells that have bee...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Early allograft dysfunction (EAD) defined by serum total bilirubin (TB) of 10 mg/dL or greater or prothrombin time-international normalized ratio (PT-INR) of 1.6 or greater on postoperative day 7 (POD 7) or aminotransferase greater than 2000 IU/L within the first week, is associated with early graft loss aft...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001959
更新日期:2018-03-01 00:00:00
abstract::Single amino acid disparities in MHC class I molecules can elicit transplantation responses. Since beta 2 microglobulin (beta 2m) is noncovalently associated with class I antigens on the cell membrane we investigated whether the single amino acid polymorphism at position 85 (Asp-->Ala) in the mouse beta 2m molecule ca...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199601270-00023
更新日期:1996-01-27 00:00:00
abstract::Pre- and post transplant sera from 51 cases of bone marrow transplants performed for severe aplastic anemia were tested on monocytes (M) and corresponding B cells (B) from a panel of unrelated donors. One-third of the sera were cytotoxic for B and M either from different or from the same individuals, while 45% reacted...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198206000-00006
更新日期:1982-06-01 00:00:00
abstract::The properties of rat liver dendritic cells (DC) were analyzed after collagenase digestion of the tissue and enrichment with density gradient centrifugation. The liver macrophages (Kupffer cells) were eliminated by adherence before the gradient centrifugation. The morphology of isolated DC in May-Grunwald-Giemsa (MGG)...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198805000-00019
更新日期:1988-05-01 00:00:00
abstract::Tacrolimus (FK) and cyclosporine (Cs) are potent immunosuppressants that effectively prevent the rejection of transplanted organs including liver and small intestine. Our study examined the effects of these immunosuppressants on Peyer's patches, which play an important role in mucosal immune response through uptake an...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200204150-00006
更新日期:2002-04-15 00:00:00
abstract::Liver transplantation is currently the only established treatment of end-stage liver disease, but it is limited by a severe shortage of viable donor livers. Donors after cardiac death (DCD) are an untapped source that could significantly increase the pool of available livers. Preservation of these DCD livers by conven...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318192df6b
更新日期:2009-01-27 00:00:00
abstract:BACKGROUND:Tacrolimus (TAC) is the cornerstone of immunosuppressive regimen in liver transplantation (LT). Its pharmacokinetics is characterized by a high interpatient and intrapatient variability (IPV) leading to an unpredictable dose-response relationship. The aim of our study was to evaluate the impact of TAC IPV (I...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002052
更新日期:2018-03-01 00:00:00
abstract::We examined the cytokine profiles associated with tolerance and rejection using the mouse model of neonatal tolerance. BALB/c mice primed with CAF1 splenocytes during the neonatal stage showed increased A/J skin graft survival of > 60 days and failed to develop anti-A/J cytotoxic responses, but rejected third-party C5...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199504150-00002
更新日期:1995-04-15 00:00:00
abstract::This is a short review of tolerance from the point of view of the clinician. Various examples of tolerance occurring in patients and animal models that relate to the clinical experience are described. There may be different mechanisms by which tolerance is achieved, but from the patient's point of view operational tol...
journal_title:Transplantation
pub_type: 历史文章,杂志文章
doi:10.1097/01.tp.0000117776.14277.03
更新日期:2004-03-27 00:00:00
abstract::We reviewed the results of all percutaneous fine needle aspirations (FNA) and open lung biopsies (OLB) after bone marrow transplantation at our center (1984-1987) for the evaluation of focal lung lesions that developed or persisted despite antibiotic administration. We sought to determine the prevalence and types of i...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198908000-00017
更新日期:1989-08-01 00:00:00
abstract::A series of three synthetic peptides spanning H-2E alpha k chain residues (90-110), (110-130), and (130-150) were synthesized and purified. Mice representative of H-2E- (B6, B10, B10.M, B10.Q, B10.S) and H-2E+ (B10.D2, B10.K, B10.RIII) were immunized with individual peptides and lymph node cells challenged in vitro. B...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199211000-00029
更新日期:1992-11-01 00:00:00
abstract::The intestinal phase of the graft-versus-host reaction (GVHR) has been investigated in adult F1 mice bearing grafts of fetal gut using an H-2-incompatible and an H-2-compatible, Mls-incompatible combination. The results indicate that the mitotic activity of the intestinal crypts and the number of intraepithelial lymph...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198109000-00011
更新日期:1981-09-01 00:00:00
abstract::The particular T cell subsets involved in the rejection of tumor allografts were examined in mice using two different approaches. In the first, EL4 lymphoma cells or B16 melanoma cells were given to ATXBM-CBA/H mice which had been reconstituted with either naive or sensitized T cells selectively depleted with either L...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198202000-00013
更新日期:1982-02-01 00:00:00
abstract::Effects of liver denervation on bile formation were studied in eight dogs prepared with chronic biliary fistulas. The animals were studied in the basal state, after feeding, and during infusion of glucagon 50 ng/kg/min, secretin 2 U/kg/hr, or somatostatin 200 ng/kg/min. After this first set of experiments the animals ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199207000-00023
更新日期:1992-07-01 00:00:00
abstract::The stability of HLA alloantibodies was studied in 128 antibody-positive, potential kidney transplant recipients over an average period of 3 years. Antibody detection was performed using an anti-human globulin-complement-dependent cytotoxicity technique. In this study, the specificity of antibodies was categorized as ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199703270-00015
更新日期:1997-03-27 00:00:00
abstract::The lung is one of the primary targets of acute graft-versus-host disease (GVHD), which is the principal complication that occurs after allogeneic intestinal transplantation. The purpose of this study is to investigate the involvement of Fas/Fas ligand system in pulmonary injury after rat semi-allogeneic intestinal tr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199910150-00006
更新日期:1999-10-15 00:00:00
abstract:BACKGROUND:Existing data indicate that non-human leukocyte antigen (HLA) immunogenetic polymorphisms influence the risk of complications after allogeneic hemopoietic stem-cell transplantation. However, prior studies have been limited by small sample size and limited genotyping. METHODS:We examined 22 polymorphisms in ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000111769.45088.a2
更新日期:2004-02-27 00:00:00
abstract::The mixed leukocyte culture (MLC) of peripheral blood lymphocytes (PBLs) from two prospective kidney transplant recipients and their respective donors, produced a primed cell population that functioned as suppressors. The primed cells suppressed the primary and secondary MLC when added as third components, without dem...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198001000-00012
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Our goal was to test the intragraft mRNA expression and production of two chemokines that are potent chemoattractants for antigen-primed T cells, interferon-gamma inducible protein 10 (IP-10) and monokine-induced by IFN-gamma, (Mig), in allogeneic heart grafts. METHODS:Syngeneic or allogeneic A/J (H-2a) hea...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200003270-00020
更新日期:2000-03-27 00:00:00
abstract:BACKGROUND:Arterial hypertension (HT) is common in renal transplant recipients (RTRs). Control of HT is not optimal in this high-risk population despite recommendations for target blood pressure levels under 130/80 mm Hg. METHODS:We performed a cross-sectional analysis of the prevalence of uncontrolled HT, and using a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000467
更新日期:2015-05-01 00:00:00
abstract::Governmental and private programs that pay next of kin who give permission for the removal of their deceased relative's organs for transplantation exist in a number of countries. Such payments, which may be given to the relatives or paid directly for funeral expenses or hospital bills unrelated to being a donor, aim t...
journal_title:Transplantation
pub_type: 指南,杂志文章
doi:10.1097/TP.0000000000001198
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Low-molecular-weight heparin (LMWH) has been shown to prolong survival of rat cardiac allografts independently from immunosuppressive treatment. Furthermore, long-term treatment reduces the development of chronic graft vascular disease after experimental heart transplantation. The aim of the present study wa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200107270-00007
更新日期:2001-07-27 00:00:00
abstract:BACKGROUND:Urologic complications cause substantial morbidity in the pediatric population after renal transplantation, but their impact on graft survival and transplant costs is poorly understood. In this retrospective review, we evaluated the records of all pediatric renal transplant recipients at our center from 1995...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31818b63da
更新日期:2008-12-15 00:00:00
abstract::Dendritic-shaped cells (Thy-1+DC) characterized by the surface phenotype of Thy-1+, asialo GM1+, Ia- are reported to exist exclusively in mice. However, Thy-1+ dendritic cells were observed in the skin of normal athymic nude F344, euthymic F344, and WKAH rats. Their phenotypic markers were Thy-1+, asialo GM1+, Ia-, W3...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199307000-00023
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:It is unclear to what extent cancer history affects posttransplantation mortality in solid organ transplant recipients. METHODS:We identified a Swedish population-based cohort of solid organ transplant recipients in the National Patient Register 1970 to 2008 and linked it to the Cancer and Cause-of-Death Re...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829854b7
更新日期:2013-08-15 00:00:00