Early expression of interferon-gamma inducible protein 10 and monokine induced by interferon-gamma in cardiac allografts is mediated by CD8+ T cells.

abstract：BACKGROUND:During allograft rejection, up-regulation of cytokine-inducible nitric oxide synthase (iNOS) leads to the production of large amounts of nitric oxide (NO). The net effect of NO on the alloimmune response is, however, difficult to predict because of its diverse biological effects, which include potentially op...

journal_title：Transplantation

authors： Casey JJ,Wei XQ,Orr DJ,Gracie JA,Huang FP,Bolton EM,Liew FY,Bradley JA

更新日期：1997-08-27 00:00:00

abstract：BACKGROUND:If pancreas transplantation is a validated alternative for type 1 diabetic patients with end-stage renal disease, the management of patients who have lost their primary graft is poorly defined. This study aims at evaluating pancreas retransplantation outcome. METHODS:Between 1976 and 2008, 569 pancreas tran...

journal_title：Transplantation

authors： Buron F,Thaunat O,Demuylder-Mischler S,Badet L,Brunet M,Ber CE,Thivolet C,Martin X,Berney T,Morelon E

更新日期：2013-01-27 00:00:00

abstract：BACKGROUND:Small bowel transplantation in children weighing less than 10 kg is hindered by the lack of size-matched donors. The ability to create reduced size small bowel grafts from adult cadaveric donors suitable for use in young children has been studied. METHODS:Volumetric assessment of computed tomography scans w...

journal_title：Transplantation

authors： Delrivière L,Muiesan P,Marshall M,Davenport M,Dhawan A,Kane P,Karani J,Rela M,Heaton N

更新日期：2000-04-15 00:00:00

abstract：BACKGROUND:Treatment with a donor-specific transfusion (DST) and a brief course of anti-mouse CD154 (anti-CD40-ligand) monoclonal antibody (mAb) prolongs the survival of both allografts and rat xenografts in mice. The mechanism by which allograft survival is prolonged is incompletely understood, but depends in part on ...

journal_title：Transplantation

authors： Gordon EJ,Woda BA,Shultz LD,Rossini AA,Greiner DL,Mordes JP

更新日期：2001-01-27 00:00:00

abstract：BACKGROUND:The emergence of a ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) strain in a heart transplant recipient (HTR) coinfected by multiple HCMV strains was investigated. METHODS:A HTR with primary HCMV infection was treated with three induction courses of intravenous GCV followed by a 2-month maintenan...

journal_title：Transplantation

authors： Baldanti F,Simoncini L,Sarasini A,Zavattoni M,Grossi P,Revello MG,Gerna G

更新日期：1998-08-15 00:00:00

abstract：:Pulmonary complications are often lethal components of acute graft-vs.-host disease (GVHD). Although interstitial pneumonitis and lymphocytic bronchitis have been implicated as elements of acute GVHD, previous studies have not determined a correlation between the onset of these histopathologies or their contribution t...

journal_title：Transplantation

authors： Workman DL,Clancy J Jr

更新日期：1994-07-27 00:00:00

abstract：:Single amino acid disparities in MHC class I molecules can elicit transplantation responses. Since beta 2 microglobulin (beta 2m) is noncovalently associated with class I antigens on the cell membrane we investigated whether the single amino acid polymorphism at position 85 (Asp-->Ala) in the mouse beta 2m molecule ca...

journal_title：Transplantation

authors： Hederer RA,Chandler PR,Dyson PJ,Antoniou AN,Millrain MM,Mellor AL,Simpson E,Robinson PJ

更新日期：1996-01-27 00:00:00

abstract：BACKGROUND:An increase in serum alpha-glutathione S-transferase concentration (GST) has been shown to be a more sensitive and specific marker of hepatocellular damage than equivalent increases in transaminase activities. A randomized clinical trial of 60 liver transplants in 49 patients was carried out to assess the cl...

journal_title：Transplantation

authors： Hughes VF,Trull AK,Gimson A,Friend PJ,Jamieson N,Duncan A,Wight DG,Prevost AT,Alexander GJ

更新日期：1997-11-27 00:00:00

abstract：:BMA 031 (Behring Monoclonal Antibody) was given to 25 renal graft recipients with biopsy-proven steroid-resistant rejections. A dose of 50 mg of BMA 031 was given i.v. on 7 consecutive days concomitantly with a standard triple-drug regimen. No premedication was administered before the first BMA 031 dose. After the fir...

journal_title：Transplantation

authors： Pfeffer PF,Ohlman S,Jakobsen A,Fauchald P,Leivestad T,Tydén G,Flatmark A

更新日期：1993-08-01 00:00:00

abstract：:To determine whether a disparity at a single miH genetic loci are sufficient to generate GVHD in mice, we focused on well-known genetic alleleic differences at the miH gene loci, H3 and H4. For H3 congenic GVHD studies, C57BL/10 (H2b) mice were used as recipients of miH-disparate B10.LP-H3b donor cells. For H4 congeni...

journal_title：Transplantation

authors： Blazar BR,Roopenian DC,Taylor PA,Christianson GJ,Panoskaltsis-Mortari A,Vallera DA

更新日期：1996-02-27 00:00:00

abstract：:The ability of the popliteal lymph node assay (PLNA) To detect host-versus-graft activity in response to H-Y antigens was investigated in the rat by using presensitized recipients. It was shown that significant popliteal lymph node (PLN) enlargement in response to H-Y-incompatible lymphocytes from syngeneic donors cou...

journal_title：Transplantation

authors： Markwick JR,Pegrum GD

更新日期：1981-03-01 00:00:00

abstract：:In a cross-sectional survey of the quality of life of 45 liver transplant recipients, physical and psychological status, physical complaints, capability to participate in daily life, social support, and global quality of life were assessed. The average time of follow-up was 9 months after transplantation. Nine patient...

journal_title：Transplantation

authors： Leyendecker B,Bartholomew U,Neuhaus R,Hörhold M,Blumhardt G,Neuhaus P,Klapp BF

更新日期：1993-09-01 00:00:00

abstract：:Programmed cell death (PCD) is currently one of the most intensively studied areas in cell biology. Substantial evidence now exists demonstrating the integral role of PCD in many fundamental immunologic processes; therefore, understanding the mechanisms of PCD may provide advances with broad implications in immunobiol...

journal_title：Transplantation

authors： Woodle ES,Kulkarni S

更新日期：1998-09-27 00:00:00

abstract：BACKGROUND:Both T and B cells have been shown to be implicated in the pathogenesis of bronchiolitis obliterans syndrome, which is considered to represent chronic lung allograft rejection. However, the relative contributions of T cells and alloantibodies in the pathogenesis of the disease are still unknown. In this stud...

journal_title：Transplantation

authors： Higuchi T,Jaramillo A,Kaleem Z,Patterson GA,Mohanakumar T

更新日期：2002-09-15 00:00:00

abstract：BACKGROUND:Hepatic ischemia-reperfusion (IR) injury is frequently followed by cholestatic liver disease. Cytokines released by Kupffer cells following hepatic IR injury may subsequently regulate hepatic transporter expression. The purpose of this study was to determine whether hepatic IR injury and the resultant Kupffe...

journal_title：Transplantation

authors： Tanaka Y,Chen C,Maher JM,Klaassen CD

更新日期：2006-07-27 00:00:00

abstract：BACKGROUND:Extracorporeal membrane oxygenation (ECMO) and mechanical ventilation (MV) can be used as a bridge to heart-lung transplantation (HLT). The goal of this study was to determine if pretransplantation ECMO or MV affects survival in HLT. METHODS:The United Network for Organ Sharing database was reviewed for all...

journal_title：Transplantation

authors： Jayarajan SN,Taghavi S,Komaroff E,Brann S,Horai T,Cordova F,Patel N,Guy TS,Toyoda Y

更新日期：2014-01-15 00:00:00

abstract：BACKGROUND:Recipients with multiple (more than one) acute rejection (AR) episodes have significantly lower graft survival rates than those with no AR or only one treated episode. However, fewer than 50% of recipients treated for one AR episode will have another episode. METHODS:We studied recipients with at least one ...

journal_title：Transplantation

authors： Humar A,Payne WD,Sutherland DE,Matas AJ

更新日期：2000-06-15 00:00:00

abstract：:In a murine strain combination disparate in both H-2 antigens and minor histocompatibility antigens consisting of C57BL/6 (B6; H-2b, Mls-1b) mice as recipients and AKR/J (AKR; H-2k, Mls-1a) mice as donors, we reported that the administration of anti-TCR-alpha beta mAb nonspecifically suppresses the ability to reject a...

journal_title：Transplantation

authors： Nomoto K,Yung-Yun K,Omoto K,Umesue M,Murakami Y,Matsuzaki G,Nomoto K

更新日期：1995-02-15 00:00:00

abstract：BACKGROUND:In Th (T helper) 1/Th2 balance in response to signals given during donor antigen presentation, induction of allograft prolongation is more often related to Th2-type than with Th1-type immunity. Here, we examined the effect of interleukin (IL)-33, a novel member of the IL-1 family, on cardiac allograft surviv...

journal_title：Transplantation

authors： Yin H,Li XY,Jin XB,Zhang BB,Gong Q,Yang H,Zheng F,Gong FL,Zhu JY

更新日期：2010-05-27 00:00:00

abstract：BACKGROUND:Donor hepatectomy with maximal safety while preserving graft viability is of principal concern in living donor liver transplantation. There are compelling reasons for avoiding blood transfusion, even with autologous blood, to avoid the potential risks it imposes on healthy donors. This study aims to describe...

journal_title：Transplantation

authors： Chen CL,Chen YS,de Villa VH,Wang CC,Lin CL,Goto S,Wang SH,Cheng YF,Huang TL,Jawan B,Cheung HK

更新日期：2000-06-27 00:00:00

abstract：BACKGROUND:Information on the risk factors, particularly kidney function, and impact of long-term cardiovascular events (CVE) after liver transplantation (LT) remains scarce. METHODS:This is a retrospective, single-center study that included consecutive LT recipients between 2007 and 2017. The incidence of CVE, their ...

journal_title：Transplantation

authors： Sastre L,García R,Gándara JG,Ruiz P,Lombardo J,Colmenero J,Navasa M,Crespo G

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:The deceased donor score (DDS), expanded criteria donor (ECD) definition, and resistive index (RI) were developed for pretransplant evaluation of donors. DDS and ECD are determined by a calculation of risk from donor variables, while RI is determined from flow characteristics of kidneys during machine preser...

journal_title：Transplantation

authors： Nyberg SL,Baskin-Bey ES,Kremers W,Prieto M,Henry ML,Stegall MD

更新日期：2005-10-15 00:00:00

abstract：:To evaluate the efficacy of University of Wisconsin (UW) solution for lung preservation, we performed canine lung allotransplantation with lungs preserved in UW solution. Donor lungs from eight dogs were flushed with UW solution and lungs from four dogs with Euro-Collins solution, and these were preserved for 24 hr in...

journal_title：Transplantation

authors： Kawahara K,Itoyanagi N,Takahashi T,Akamine S,Kobayashi M,Tomota M

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Warm ischemia/reperfusion injury during liver transplantation is the most important cause of primary nonfunction of liver allografts. Tumor-necrosis factor (TNF)-alpha apparently mediates tissue damage by inducing apoptosis and/or necrosis in liver transplants. The aim of the study was to determine, using an...

journal_title：Transplantation

authors： Ben-Ari Z,Hochhauser E,Burstein I,Papo O,Kaganovsky E,Krasnov T,Vamichkim A,Vidne BA

更新日期：2002-06-27 00:00:00

abstract：BACKGROUND:Motexafin lutetium (Lu-Tex) is a photodynamic therapy (PDT) agent that localizes in atheromatous plaque in which it can be activated by far-red light. Lu-Tex biolocalization was examined in graft coronary artery disease (GCAD) with a rodent allograft model. After photoactivation, the effect on intimal prolif...

journal_title：Transplantation

authors： Yamaguchi A,Woodburn KW,Hayase M,Hoyt G,Robbins RC

更新日期：2001-06-15 00:00:00

abstract：:In a canine model of dog leukocyte antigen (DLA)-identical nonmyeloablative marrow transplantation including postgrafting immunosuppression with cyclosporine (CSP) and mycophenolate mofetil (MMF), engraftment was only transient with 100 cGy total body irradiation (TBI) conditioning, indicating suboptimal pretransplant...

journal_title：Transplantation

authors： Panse JP,Storb R,Storer B,Santos EB,Wentzel C,Sandmaier BM

更新日期：2005-11-27 00:00:00

abstract：BACKGROUND:Despite early skepticism, the field of vascularized composite allotransplantation (VCA) has demonstrated feasibility. The ethics of VCA have moved past doubts about the morality of attempting such transplants to how to conduct them ethically. METHODS:Leaders of each program performing and/or evaluating VCA ...

journal_title：Transplantation

authors： Caplan AL,Parent B,Kahn J,Dean W,Kimberly LL,Lee WPA,Rodriguez ED

更新日期：2019-06-01 00:00:00

abstract：:Since June 1979, percutaneous transluminal angioplasty (PTA) has been the procedure of choice for renal transplant artery stenosis (RTAS) at the Hospital of the University of Pennsylvania. Of 241 renal allograft recipients, 17 (7%) when studied by arteriogram because of suspected RTAS proved to have significant stenos...

journal_title：Transplantation

authors： Grossman RA,Dafoe DC,Shoenfeld RB,Ring EJ,McLean GK,Oleaga JA,Freiman DB,Naji A,Perloff LJ,Barker CF

更新日期：1982-12-01 00:00:00

abstract：:Antibody-mediated rejection (AMR) is an important cause of graft loss and continues to present a formidable obstacle to successful transplantation. Unresolved problems continue to be the absence of effective strategies to ablate the donor-specific antibody (DSA) response as well as to attenuate the antibody-mediated g...

journal_title：Transplantation

authors： Miyairi S,Baldwin WM 3rd,Valujskikh A,Fairchild RL

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Preexisting IgG antibodies to donor human leukocyte antigens (HLA) are a risk factor for rapid allograft rejection. However, non-HLA antibodies, of the IgM class, also called autoreactive antibodies, are not believed to affect graft survival. The aim of this study was to determine the incidence and clinical ...

journal_title：Transplantation

authors： Smith JD,Hamour IM,Burke MM,Mahesh B,Stanford RE,Haj-Yahia S,Robinson DR,Kaul P,Yacoub MH,Banner NR,Rose ML

更新日期：2009-03-27 00:00:00