A Scandinavian two-center study of BMA 031 in steroid-resistant rejection of renal grafts.

Abstract:

:BMA 031 (Behring Monoclonal Antibody) was given to 25 renal graft recipients with biopsy-proven steroid-resistant rejections. A dose of 50 mg of BMA 031 was given i.v. on 7 consecutive days concomitantly with a standard triple-drug regimen. No premedication was administered before the first BMA 031 dose. After the first dose, 7 patients experienced moderate fever (< 39 degrees C), 5 patients had high fever (> 39 degrees C), 4 patients had nausea/vomiting, 3 diarrhea, 1 headache, and 1 hypertension. These reactions were seen only after the first dose except for 1 patient who developed urticaria on days 3-4. All the rejection episodes were reversed or partially reversed. Twenty-one patients experienced re-rejections 3-46 days after the last BMA 031 dose, and were treated with methylprednisolone and/or rabbit antihuman thymocyte globulin. Seven patients lost their grafts within 1 year (28%), including 2 patients who died of infection with a functioning graft. BMA 031 seems to be a safe drug with only few mild side effects, and it effectively reverses steroid-resistant rejections. Re-rejections were frequent, but mostly reversible.

journal_name

Transplantation

journal_title

Transplantation

authors

Pfeffer PF,Ohlman S,Jakobsen A,Fauchald P,Leivestad T,Tydén G,Flatmark A

doi

10.1097/00007890-199308000-00009

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

304-7

issue

2

eissn

0041-1337

issn

1534-6080

journal_volume

56

pub_type

临床试验,杂志文章,多中心研究
  • Cytomegalovirus serostatus pairing and deceased donor kidney transplant outcomes in adult recipients with antiviral prophylaxis.

    abstract:BACKGROUND:The objectives of this study are to investigate the impact of cytomegalovirus (CMV) donor (D)/recipient (R) serostatus on kidney transplant outcomes in recipients who received CMV prophylaxis and to investigate the association of individual antiviral agents (acyclovir, ganciclovir, and valganciclovir) with o...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181f7c053

    authors: Kuo HT,Ye X,Sampaio MS,Reddy P,Bunnapradist S

    更新日期:2010-11-27 00:00:00

  • Detection of anti-HLA antibodies with flow cytometry in needle core biopsies of renal transplants recipients with chronic allograft nephropathy.

    abstract::The aim of this study was to assess the feasibility of detecting anti-HLA antibodies in eluates from needle core biopsies of renal transplants with chronic allograft nephropathy. Two methods of screening, the enzyme-linked immunosorbent assay (ELISA) and flow cytometry (FlowPRA) were compared. Twenty renal transplants...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000156164.54216.de

    authors: Martin L,Guignier F,Bocrie O,D'Athis P,Rageot D,Rifle G,Justrabo E,Mousson C

    更新日期:2005-05-27 00:00:00

  • A prospective randomized trial of tacrolimus and prednisone versus tacrolimus, prednisone, and mycophenolate mofetil in primary adult liver transplant recipients: an interim report.

    abstract:BACKGROUND:Tacrolimus (Tac) and mycophenolate mofetil (MMF) are newly approved immunosuppressive agents. However, the safety and efficacy of the combination of MMF and Tac in primary liver transplantation has not been determined. METHODS:An Institutional Review Board-approved, open-label prospective randomized protoco...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007890-199811270-00024

    authors: Jain AB,Hamad I,Rakela J,Dodson F,Kramer D,Demetris J,McMichael J,Starzl TE,Fung JJ

    更新日期:1998-11-27 00:00:00

  • Adenovirus infection of the renal allograft with sparing of pancreas graft function in the recipient of a combined kidney-pancreas transplant.

    abstract::We report a case of adenovirus infection of the renal allograft in a combined kidney/pancreas transplant recipient. The clinical presentation was renal allograft failure, which eventually reversed. The pancreatic graft function remained stable. A renal biopsy showed massive tubular necrosis associated with a prominent...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199801150-00027

    authors: Mathur SC,Squiers EC,Tatum AH,Szmalc FS,Daucher JW,Welker DM,Shanley PF

    更新日期:1998-01-15 00:00:00

  • Evidence that glucocorticosteroids block expression of the human interleukin-6 gene by accessory cells.

    abstract::The mode of action of glucocorticosteroids as immunosuppressive and antiinflammatory agents is not fully understood. Glucocorticosteroids block synthesis of interleukin 1 by interfering with the transcription of the IL-1 beta gene. Glucocorticosteroids may also induce rapid degradation of IL-1 mRNA. In the presence of...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199001000-00040

    authors: Zanker B,Walz G,Wieder KJ,Strom TB

    更新日期:1990-01-01 00:00:00

  • Prolonged reversal of diabetes in the rat by transplantation of allogeneic islets from a single donor and cyclosporine treatment.

    abstract::Islets were isolated using neutral red as a dye to exclude lymphatic and acinar impurities in the transplant preparation. In a one donor-one recipient model, intraportally transplanted isogeneic islets survived indefinitely. Mean graft survival could be prolonged from 5 to 90 days, using a 3-dose rejection prophylaxis...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198604000-00003

    authors: Dibelius A,Königsberger H,Walter P,Permanetter W,Brendel W,von Specht BU

    更新日期:1986-04-01 00:00:00

  • Cold-storage preservation of the canine and rat pancreas prior to islet isolation.

    abstract::Cold-storage preservation of the canine pancreas prior to islet isolation has previously been noted to reduce the intrasplenic islet autograft success rate; but the mechanism of this deleterious effect has not been determined. We undertook a study in both outbred dogs and Lewis (RT1-1) rats to determine the influence ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198901000-00007

    authors: Munn SR,Kaufman DB,Field MJ,Viste AB,Sutherland DE

    更新日期:1989-01-01 00:00:00

  • Incidence and risk factors of glucose metabolism disorders in kidney transplant recipients: role of systematic screening by oral glucose tolerance test.

    abstract:BACKGROUND:New-onset diabetes after transplantation (NODAT) increases infectious and cardiovascular complications and reduces patient and graft survival. We assessed the incidence and the risk factors for glucose metabolism abnormalities before and after kidney transplantation using an oral glucose tolerance test (OGTT...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31820f0877

    authors: Caillard S,Eprinchard L,Perrin P,Braun L,Heibel F,Moreau F,Kessler L,Moulin B

    更新日期:2011-04-15 00:00:00

  • The role of graft and host accommodation in a hamster-to-rat cardiac transplantation model.

    abstract:BACKGROUND:We evaluated the importance and mechanism of graft and host accommodation in hamster-to-rat cardiac xenotransplantation models. METHODS:To evaluate graft accommodation, accommodated hamster grafts (Group 2) were transplanted to naïve host rats treated with FK506, and compared with naïve hamster grafts (Grou...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000296030.88283.92

    authors: Komori K,Fuchimoto Y,Morikawa Y,Obara H,Kawachi S,Tanabe M,Hoshino K,Shimazu M,Matsuzaki Y,Kitajima M

    更新日期:2008-01-15 00:00:00

  • Initial liver involvement in acute GVHD is predictive for nonrelapse mortality.

    abstract:BACKGROUND:Current grading systems in acute graft-versus-host disease (GVHD) are not able to identify patients with poor prognosis at time of onset, because they take into account maximal grade. The aim of this study was to evaluate potential predictors for overall survival at disease onset. METHODS:The study sample w...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181bc2583

    authors: Robin M,Porcher R,de Castro R,Fisher G,de Latour RP,Ribaud P,Petropoulou AD,Rocha V,Devergie A,Mary JY,Socié G

    更新日期:2009-11-15 00:00:00

  • Interaction of mycophenolate mofetil and HLA matching on renal allograft survival.

    abstract:INTRODUCTION:The importance of HLA matching for renal transplantation outcomes has been appreciated for several decades. It has been hypothesized that as pharmacologic immunosuppression becomes stronger and more specific, the impact of HLA matching may be vanishing. Mycophenolate Mofetil (MMF) has been demonstrated to ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200102150-00010

    authors: Meier-Kriesche HU,Ojo AO,Leichtman AB,Magee JC,Rudich SM,Hanson JA,Cibrik DM,Kaplan B

    更新日期:2001-02-15 00:00:00

  • Pretransplant low CD3+CD25high cell counts or a low CD3+CD25high/CD3+HLA-DR+ ratio are associated with an increased risk to acute renal allograft rejection.

    abstract:BACKGROUND:Detection of markers predicting allograft rejection is important for risk assessment before kidney transplantation, as well as to minimize posttransplantation immunosuppression. METHODS:We studied the expression of CD25, HLA-DR, CD134, CD62L, and CD44 by flow cytometry in CD4, CD8, and CD3 cells, from pretr...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3182283c58

    authors: Hueso M,Mestre M,Benavente Y,Bas J,Grinyó JM,Navarro E

    更新日期:2011-09-15 00:00:00

  • Treatment and prevention of acute graft-versus-host disease with thalidomide in a rat model.

    abstract::We have investigated the immunosuppressive effects of thalidomide (Thal) in a bone marrow transplant (BMT) model for graft-versus-host disease (GVHD). Lewis rats received RT1-incompatible marrow transplants from ACI rats after total-body irradiation. Twenty-two of twenty-three rats with established severe acute GVHD w...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198605000-00018

    authors: Vogelsang GB,Hess AD,Gordon G,Santos GW

    更新日期:1986-05-01 00:00:00

  • Risk factors for sensitization by blood transfusions. Comparison of the UW/Madison and UC/San Francisco donor-specific transfusion experience.

    abstract::We have tested the predictive model for risk of sensitization by donor-specific transfusions developed at the University of California, San Francisco for its applicability to the DST experience at UW/Madison. Patient sample sizes between the two groups were similar (n = 249 for UW/Madison, n = 261 for UCSF) and the tw...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198901000-00031

    authors: Burlingham WJ,Stratta R,Mason B,Lorentzen D,Feyzi J,Sollinger HW,Belzer FO

    更新日期:1989-01-01 00:00:00

  • Hyperexpression of Foxp3 and IDO during acute rejection of islet allografts.

    abstract:BACKGROUND:We investigated the hypothesis that Foxp3+ cells are an integral component of antiallograft immunity but are dominated by pathogenic effectors. METHODS:Wild-type H-2b C57BL/6 (B6) mice or B6 mice with a targeted disruption of c-Rel gene (c-Rel-/-) were used as recipients of islet grafts from allogeneic DBA/...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000263991.74052.46

    authors: Yang H,Ding R,Sharma VK,Hilaire FS,Lagman M,Li B,Thomas DA,Luo X,Song P,Stauffer C,August P,Suthanthiran M

    更新日期:2007-06-27 00:00:00

  • Graft-versus-host disease in the absence of the spleen after allogeneic bone marrow transplantation.

    abstract:BACKGROUND:The spleen is considered to be an important secondary lymphoid organ where acute graft-versus-host disease (GVHD) is initiated by donor T cells that recognize host alloantigens after allogeneic bone-marrow transplantation (BMT). The influence of splenectomy on the development of GVHD prior to BMT has yet to ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200205270-00027

    authors: Clouthier SG,Ferrara JL,Teshima T

    更新日期:2002-05-27 00:00:00

  • Donor factors influencing graft outcomes in live donor kidney transplantation.

    abstract::Living donor renal allograft survival is superior to that achieved from deceased donors, although graft outcome is suboptimal in some of these patients. In an effort to identify the subset of patients at high risk for poor outcomes we studied donor risk factors in 248 living kidney donor-recipient pairs. Unadjusted do...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000256284.78721.ba

    authors: Issa N,Stephany B,Fatica R,Nurko S,Krishnamurthi V,Goldfarb DA,Braun WE,Dennis VW,Heeger PS,Poggio ED

    更新日期:2007-03-15 00:00:00

  • Posttransplant Lymphoproliferative Disorder in Pediatric Patients: Characteristics of Disease in EBV-seropositive Recipients.

    abstract:BACKGROUND:Patients at greatest risk of posttransplant lymphoproliferative disorder (PTLD) are those who acquire primary Epstein-Barr virus (EBV) infection after solid organ transplantation. The incidence of PTLD among patients who are EBV-seropositive before transplant is lower, and little is known about the differenc...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002898

    authors: L'Huillier AG,Dipchand AI,Ng VL,Hebert D,Avitzur Y,Solomon M,Ngan BY,Yeung S,Stephens D,Punnett AS,Barton M,Allen UD

    更新日期:2019-11-01 00:00:00

  • The role of bile salt toxicity in the pathogenesis of bile duct injury after non-heart-beating porcine liver transplantation.

    abstract:BACKGROUND:Intrahepatic bile duct strictures are a serious complication after non-heart-beating (NHB) liver transplantation. Bile salt toxicity has been identified as an important factor in the pathogenesis of bile duct injury and cholangiopathies. The role of bile salt toxicity in the development of biliary strictures...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318170f5f7

    authors: Yska MJ,Buis CI,Monbaliu D,Schuurs TA,Gouw AS,Kahmann ON,Visser DS,Pirenne J,Porte RJ

    更新日期:2008-06-15 00:00:00

  • Coronary calcifications detected by computed tomography are not markers of cardiac allograft vasculopathy.

    abstract:BACKGROUND:Cardiac allograft vasculopathy (CAV) still limits survival after heart transplantation. Currently available noninvasive tests are of inferior value to detect CAV, and thus invasive coronary angiography (ICA) is frequently performed. Cardiac dual-source computed tomography calcium scoring (DSCTCS) offers the ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318225281d

    authors: von Ziegler F,Kaczmarek I,Knez A,Greif M,Rümmler J,Meiser B,Reichart B,Becker C,Steinbeck G,Becker A

    更新日期:2011-08-27 00:00:00

  • Functional recovery of chronic paraplegic pigs after autologous transplantation of bone marrow stromal cells.

    abstract:BACKGROUND:Bone marrow stromal cells (BMSC) transplantation offers promise in the treatment of chronic paraplegia in rodents. Here, we report the effect of this cell therapy in adult pigs suffering chronic paraplegia. METHODS:Three months after spinal cord injury, autologous BMSC in autologous plasma was injected into...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318186198f

    authors: Zurita M,Vaquero J,Bonilla C,Santos M,De Haro J,Oya S,Aguayo C

    更新日期:2008-09-27 00:00:00

  • Compatible-incompatible live donor kidney exchanges.

    abstract::The participation of an immunologically compatible donor-intended recipient pair in a kidney exchange that is unnecessary for them can significantly increase the number of kidneys available for transplantation. Despite their utilitarian value transplant ethicists have condemned this type of organ exchange as morally i...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3182047554

    authors: Steinberg D

    更新日期:2011-02-15 00:00:00

  • HCV Antiviral Therapy in Liver Transplant Candidates and Recipients With Renal Insufficiency.

    abstract::Hepatitis C virus (HCV) remains the leading indication for liver transplant in much of the world and has traditionally been associated with diminished posttransplant survival due to recurrent HCV-related liver disease. This field has been dramatically changed by the advent of safe and effective direct-acting antiviral...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000001688

    authors: Verna EC,Brown RS Jr

    更新日期:2017-05-01 00:00:00

  • Comparison of specific radioimmunoassays for cyclosporine.

    abstract::This study compares two recently introduced radioimmunoassay kits involving specific monoclonal antibodies to cyclosporine. One kit (Sandimmun) involved 3H-labeled CsA (3H-CsA) as tracer and the other (CY-CLO-Trac-SP) involved a 125I-labeled conjugated derivative of CsA. The kits were nearly equivalent in method perfo...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198904000-00019

    authors: Sgoutas DS,Hammarstrom M

    更新日期:1989-04-01 00:00:00

  • Impact of race on renal transplant outcome.

    abstract::The influence of race on the outcome of cadaver renal transplantation (CRT) continues to be controversial even in the cyclosporine era. The present study examines the effect of race in 343 adult CRT performed from 1/1/82 through 10/1/88 with regard to the incidence of delayed function (DF), graft survival (GS), and pa...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199001000-00014

    authors: Dawidson IJ,Coorpender L,Fisher D,Helderman H,Hull A,Palmer B,Peters P,Sagalowsky A,Sandor ZF,Toto R

    更新日期:1990-01-01 00:00:00

  • Hypersensitivity reactions in the small intestine. 6. Pathogenesis of the graft-versus-host reaction in the small intestinal mucosa of the mouse.

    abstract::The intestinal phase of the graft-versus-host reaction (GVHR) has been investigated in adult F1 mice bearing grafts of fetal gut using an H-2-incompatible and an H-2-compatible, Mls-incompatible combination. The results indicate that the mitotic activity of the intestinal crypts and the number of intraepithelial lymph...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198109000-00011

    authors: Mowat AM,Ferguson A

    更新日期:1981-09-01 00:00:00

  • Long-term Persistence of Innate Lymphoid Cells in the Gut After Intestinal Transplantation.

    abstract:BACKGROUND:Little is known about innate lymphoid cell (ILC) populations in the human gut, and the turnover of these cells and their subsets after transplantation has not been described. METHODS:Intestinal samples were taken from 4 isolated intestine and 3 multivisceral transplant recipients at the time of any operativ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000001593

    authors: Weiner J,Zuber J,Shonts B,Yang S,Fu J,Martinez M,Farber DL,Kato T,Sykes M

    更新日期:2017-10-01 00:00:00

  • Upregulation of CD59: potential mechanism of accommodation in a large animal model.

    abstract:BACKGROUND:Survival of ABO-mismatched kidneys with stable renal function despite the persistence of anti-ABO antibodies is called accommodation. The mechanism of accommodation is unclear, but may involve complement regulatory proteins such as CD59. The development of alpha-1,3-galactosyltransferase knock-out (GalT-KO) ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181a19afc

    authors: Griesemer AD,Okumi M,Shimizu A,Moran S,Ishikawa Y,Iorio J,Arn JS,Yamada K

    更新日期:2009-05-15 00:00:00

  • Sequential antilymphoblast globulin and cyclosporine for renal transplantation.

    abstract::The nephrotoxic effects of cyclosporine (CsA) seem to be augmented by co-existing renal injury. A high rate of prolonged delayed function (acute tubular necrosis [ATN]) and non-function (NF) has been associated with the use of CsA prior to and following renal transplantation. Cyclosporine has also been associated with...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198701000-00019

    authors: Sommer BG,Henry M,Ferguson RM

    更新日期:1987-01-01 00:00:00

  • The genetic control of the antibody response to the Pa antigen in the rat.

    abstract::The antibody response to the pregnancy-associated (Pa) antigen in the pregnant female segregated with the major histocompatibility complex (MHC) when the female progeny in the (PVG x WF)F1 x PVG testcross, in which the PVG strain is a low responder to Pa and the WF strain is a high responder, were mated to DA male rat...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198608000-00022

    authors: Kunz HW,Gill TJ 3rd

    更新日期:1986-08-01 00:00:00