Abstract:
:The ability of the popliteal lymph node assay (PLNA) To detect host-versus-graft activity in response to H-Y antigens was investigated in the rat by using presensitized recipients. It was shown that significant popliteal lymph node (PLN) enlargement in response to H-Y-incompatible lymphocytes from syngeneic donors could be obtained in female recipients that had been preimmunized by the weekly i.p. injection of 1 x 10(7) lymphocytes from males of the same strain. In one rat strain, it was also shown that when male recipients had been similarly preimmunized with lymphocytes from females of the same strain, significant PLN enlargement could be obtained in response to lymphocytes from syngeneic females. The results that we obtained using the PLNA are discussed in comparison with those that have been reported when H-Y-incompatible skin grafts have been used to investigate H-Y antigen in the rat. These results indicate that, in the rat, the PLNA provides a useful alternative method for the investigation of H-Y antigen and may also provide a useful means to investigate the response of male rats to lymphocytes from syngeneic females.
journal_name
Transplantationjournal_title
Transplantationauthors
Markwick JR,Pegrum GDdoi
10.1097/00007890-198103000-00013subject
Has Abstractpub_date
1981-03-01 00:00:00pages
205-9issue
3eissn
0041-1337issn
1534-6080journal_volume
31pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Avoiding donor-specific antibody (DSA) is difficult for sensitized patients. Improved understanding of the risk of low level DSA is needed. METHODS:We retrospectively compared the outcomes of 954 patients transplanted with varied levels of baseline DSA detected by single antigen beads and B flow cytometric ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001619
更新日期:2017-10-01 00:00:00
abstract::The immunosuppressive activity of niridazole in unmatched kidney allografts in nephrectomized dogs was studied. The drug alone was not effective, but improved survival when used with azathioprine and prednisolone or azathioprine alone. However, niridazole was toxic in dogs in the doses used (25 or 50 mg/kg/day). ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198004000-00009
更新日期:1980-04-01 00:00:00
abstract:INTRODUCTION:HMG-CoA reductase inhibitors play several roles in the maintenance of organ transplants. We investigated the role of pitavastatin, a potent and newly developed HMG-CoA reductase inhibitor, in cardiac allograft rejection and mechanism of graft arterial disease (GAD) suppression. METHODS:Balb/c mice hearts ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000259650.67061.16
更新日期:2007-04-27 00:00:00
abstract::A 44-year-old man was maintained on prednisone and azathioprine after renal transplantation. One and a half years after transplantation, he developed multiple perianal Escherichia coli abscesses. These became chronic and resisted antibiotic therapy. Histologically, the lesions were typical of malakoplakia. Peripheral ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1981-02-01 00:00:00
abstract::Publicly available program-specific data from the scientific registry of transplant recipients were used to determine the association between adult lung transplant center volume and 1-year recipient mortality from 2000 to 2007. We found a significant inverse association between the center volume of adult lung transpla...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181ceecf7
更新日期:2010-03-27 00:00:00
abstract:BACKGROUND:The number of living donor kidney transplantations increases steeply in Europeans, whereas the non-Europeans are dependent on deceased donor transplantations. We wondered whether a low attendance or a high decline of potential non-European donors could explain this difference. METHODS:This retrospective stu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181d84ca7
更新日期:2010-05-27 00:00:00
abstract:BACKGROUND:Long-term acceptance of semi-identical orthotopic liver transplants (OLTs) in inbred swine is induced by a 12-day course of FK506. To study whether acceptance is attributable to central or peripheral immune mechanisms, the effect of complete thymectomy was determined. METHODS:Total thymectomy was performed ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000121762.47432.15
更新日期:2004-04-27 00:00:00
abstract::The effects of in vivo administration of monoclonal antibodies directed against the two major mature T cell subsets of miniature swine have been examined. Antibody 76-2-11, specific for the porcine CD8 cell-surface antigen, caused elimination of CD8+ T cells from the peripheral lymphocyte pool by 4-6 days following a ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199007000-00014
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND:Allografts are occasionally accepted in the absence of immunosuppression. Because naturally occurring CD4(+)CD25(+) regulatory T cells (natural CD25(+) Treg cells) have been shown to inhibit allograft rejection, we investigated their influence on the outcome of allografts in nonimmunosuppressed mouse recipie...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000155179.61445.78
更新日期:2005-03-27 00:00:00
abstract:BACKGROUND:The use of anti-B-cell and T-cell immunosuppressive agents leads to only a few weeks' survival of mouse-to-rat cardiac xenografts. METHODS:BALB/c cardiac xenografts were transplanted to Lewis rats treated with cyclosporine (CsA) and/or cobra venom factor (CVF). RESULTS:CsA alone did not prolong xenograft s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199805150-00012
更新日期:1998-05-15 00:00:00
abstract::A series of rat monoclonal antibodies against the human leukocyte-common antigen were isolated and, by means of competitive binding assays with purified antigen, two distinct groups were defined that recognize different epitopes of the molecule. None of these antibodies were lytic with human complement, but when antib...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198511000-00013
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Circulation of leukocytes via blood, tissue and lymph is integral to adaptive immunity. Afferent lymphatics form CCL21 gradients to guide dendritic cells and T cells to lymphatics and then to draining lymph nodes (dLN). Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 (V...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000561
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Remote ischemic preconditioning (RIPC) protects against liver ischemia reperfusion (IR) injury. An essential circulating mediator of this protection is nitric oxide (NO) induced by lower limb RIPC. One of the mechanisms through which NO generally acts is the soluble guanylyl cyclase-cyclic GMP (sGC-cGMP) pat...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31824cd59d
更新日期:2012-05-15 00:00:00
abstract::Over the decade between 2003 and 2012, the UK has seen major changes in how organ donation and transplantation is delivered. The number of deceased organ donors has increased from 709 (12.0 per million population [pmp]) to 1,164 (18.3 pmp); this increase has been predominantly a result of an increase in donors after c...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000438215.16737.68
更新日期:2014-01-15 00:00:00
abstract:BACKGROUND:The need to find a safe, effective liver support system for patients with fulminant hepatic failure (FHF) continues to be unmet. A system using immortalized human hepatocytes was originally developed in the early 1990s. A modified version of the initial extracorporeal liver-assist device (ELAD) was recently ...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-200212270-00016
更新日期:2002-12-27 00:00:00
abstract::Disseminated varicella-zoster (VZV) infection is a rare complication after renal allotransplantation in adults. We report four patients, among them one with combined VZV and cytomegalovirus infection. The main complications were hepatitis, pneumonitis, and disseminated intravascular coagulation. A review of the litera...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200202270-00023
更新日期:2002-02-27 00:00:00
abstract:BACKGROUND:Significant disparity exists in the United Kingdom between the need for organ transplant and supply of deceased donor organs. In the recent years, efforts to increase donation has improved the rate of mainly deceased donors after circulatory death and from older donors. The rate of donation from pediatric po...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000575
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:The management of ureteral strictures in transplanted kidney is challenging. Open surgical treatment is effective but entails significant convalescence. Holmium:yttrium-aluminum-garnet (Ho:YAG) laser endoureterotomy is useful for other types of ureteral obstruction, and we aimed to assess its long-term succe...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816c7f19
更新日期:2008-05-15 00:00:00
abstract::There is a striking consistency in the total number of heart beats accrued over a lifetime across a range of animal species despite vast differences in size. Moreover, an inverse relationship is observed between heart rate and lifespan, leading to speculation that elevated heart rate could significantly affect longevi...
journal_title:Transplantation
pub_type: 社论,评审
doi:10.1097/TP.0b013e31826bc42a
更新日期:2013-01-27 00:00:00
abstract::BK polyoma virus causes allograft dysfunction as a result of tubulo-interstitial nephritis in 2% to 5% of renal transplant recipients. The incidence of BK virus infection among renal transplant recipients in India is unknown. We used routine histologic examination, immunohistochemistry, and electron microscopy to retr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000113163.02039.30
更新日期:2004-02-15 00:00:00
abstract::By cytolysis and monolayer absorption tests, the kinetics of the generation of CBA/H cytotoxic lymphocytes (Tc) in response to stimulation by H-2b antigens have been analyzed in vitro. The Tc population which reacts with public antigens of H-2b and H-2d strains shows peak activity in culture at 4 to 5 days, then rapi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198006000-00012
更新日期:1980-06-01 00:00:00
abstract:BACKGROUND:Composite tissue allotransplantation (CTA) has been recently introduced as a potential treatment for tissue loss secondary to burns, injuries, or resections. However, the optimal strategies to prevent CTA rejection remain undefined. Presently, no CTA model exists to evaluate human-specific immunosuppressants...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000183292.57349.27
更新日期:2005-11-27 00:00:00
abstract::To determine the importance of static lung inflation during storage, graft performance was evaluated at different levels of intratracheal pressure and varying ischemic intervals. Lewis rat lungs were perfused with low-potassium Euro-Collins and stored for 4 or 8 hr either in atelectasis (4 hr: group I; 8 hr: group IV,...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199612270-00004
更新日期:1996-12-27 00:00:00
abstract::Based upon encouraging experimental results, we began employing a synthetic perfusate for cadaver kidney preservation. The new perfusate contains hydroxyethyl starch (HES) as the sole colloid for oncotic support; 107 cadaver kidneys were preserved and transplanted (93 primary, 14 nonprimary) using the HES solution and...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198901000-00008
更新日期:1989-01-01 00:00:00
abstract::The addition of prostaglandin to the single-flush technique of lung preservation is considered to enhance subsequent graft function. We have evaluated the use of the prostacyclin analog, Iloprost, in an animal model of unilateral lung transplantation. Group 1 (n = 5) received Iloprost as a pretreatment intravenously (...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199003000-00003
更新日期:1990-03-01 00:00:00
abstract::The influence of race on the outcome of cadaver renal transplantation (CRT) continues to be controversial even in the cyclosporine era. The present study examines the effect of race in 343 adult CRT performed from 1/1/82 through 10/1/88 with regard to the incidence of delayed function (DF), graft survival (GS), and pa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199001000-00014
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Altered expression of murine MD-1, a molecule controlling expression of members of the interleukin (IL)-1 receptor family of signaling proteins, regulates antigen-presenting cell-induced alloreactions. We investigated the effect of treatment with antisense deoxyoligonucleotides or antibodies to MD-1 in vivo ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200206150-00013
更新日期:2002-06-15 00:00:00
abstract:BACKGROUND:Upon the availability of a cadaveric donor kidney, a delicate allocation process precedes every transplantation. A remodeled Eurotransplant Kidney Allocation System (ETKAS)-derived from simulation studies-was installed in March 1996. The purpose was to adjust long waiting times and international exchange bal...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199811150-00007
更新日期:1998-11-15 00:00:00
abstract:BACKGROUND:More than 60% children with small bowel transplantation (SBTx) experience acute cellular rejection. PURPOSE/METHODS:To identify children at risk of rejection, donor- and third-party-induced proliferation of T-helper and T cytotoxic (Tc) cells, and their naïve and memory (M) subsets was evaluated simultaneou...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181d98c0f
更新日期:2010-06-15 00:00:00
abstract::Dendritic cell (DC) progenitors were propagated in liquid culture from nonparenchymal cells resident in normal mouse (B10.BR; H-2k, I-E+) liver in response to granulocyte-macrophage colony stimulating factor (GM-CSF). The liver-derived DC progenitors were MHC class II-/dim and did not express counter receptors for CTL...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199502270-00019
更新日期:1995-02-27 00:00:00