Abstract:
:Single amino acid disparities in MHC class I molecules can elicit transplantation responses. Since beta 2 microglobulin (beta 2m) is noncovalently associated with class I antigens on the cell membrane we investigated whether the single amino acid polymorphism at position 85 (Asp-->Ala) in the mouse beta 2m molecule can cause skin graft rejection. A B2mb transgene was introduced into CBA(B2ma) mice which subsequently expressed both forms of beta 2m. Skin from these CBA beta 2mb transgenic mice was not rejected by the parental CBA strain. Previous studies showed that cytotoxic T lymphocyte (CTL) responses directed against beta 2mb use H2Kb as a restriction element. We therefore produced mice expressing H2Kb and H2Ab as well as beta 2mb by crossing CBA.beta 2mb mice with either CBA.Kb (CBK) transgenic mice or C3H.SW mice and used these as skin graft donors for beta 2mb negative littermates. In both cases rejection of transgenic skin only occurred when mice had received both a beta 2mb graft and an H2-disparate allograft lying adjacent in the same site. Introduction of the male specific antigen, H-Y, as a helper determinant did not result in rejection of beta 2mb skin. Neither did two CTL determinants (P91A and beta 2mb) on the same graft complement one another to elicit a transplantation response. Prior immunisation with tissues expressing the beta 2m disparity alone did not generate in vivo or in vitro beta 2mb-specific CTL responses, suggesting that this single amino acid difference is not sufficient to elicit a CTL or helper T cell response.
journal_name
Transplantationjournal_title
Transplantationauthors
Hederer RA,Chandler PR,Dyson PJ,Antoniou AN,Millrain MM,Mellor AL,Simpson E,Robinson PJdoi
10.1097/00007890-199601270-00023subject
Has Abstractpub_date
1996-01-27 00:00:00pages
299-304issue
2eissn
0041-1337issn
1534-6080journal_volume
61pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:The increasing demand for transplantation has resulted in a trend toward using virologically compromised donors. We reviewed our experience with liver grafts from hepatitis-B surface antigen (HBsAg)(-), antibody to core antigen (anti-HBc)(+) donors. METHODS:Sixty-two liver transplants using HBsAg(-), anti-H...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000065283.98275.FE
更新日期:2003-04-27 00:00:00
abstract:BACKGROUND:Calcineurin inhibitor (CI)-based immunosuppression has prolonged the survival of heart transplant recipients. However, CI-induced renal injury remains as a major problem in these patients. Sirolimus is an immunosuppressant with no significant impact on renal function. A limited number of recent papers have s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000177644.45192.a3
更新日期:2006-03-15 00:00:00
abstract:BACKGROUND:Systemic amyloidosis complicated by heart failure is associated with high cardiovascular morbidity and mortality. Heart transplantation for patients with systemic amyloidosis is controversial due to recurrence of disease in the transplanted organ or progression of disease in other organs. METHODS:All patien...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000255567.80203.bd
更新日期:2007-03-15 00:00:00
abstract::We report on the to date largest recovery of 11 organs from a single deceased donor with the transplantation of face, bilateral upper extremities, heart, 1 lung, liver (split for 2 recipients), kidneys, pancreas, and intestine. Although logistically challenging, this case demonstrates the feasibility and safety of the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001200
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:In kidney transplant recipients with alemtuzumab induction maintained on mycophenolate mofetil (MMF) immunosuppression, sirolimus (SRL) promotes significant expansion of circulating CD4+CD25high regulatory T cells (Treg). This might translate into more effective protection against chronic graft injury compar...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.tp.0000284808.28353.2c
更新日期:2007-10-27 00:00:00
abstract::It was the objective of these experiments to study the time-related changes in the responsiveness of the cellular elements of the immune system following contact with single non-H-2 or multiple H-2 histocompatibility antigens. The reactivity of spleen cells from mice that received injections of spleen cells bearing H-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198802000-00047
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:Urinary neutrophil gelatinase-associated lipocalin (NGAL) has emerged an early marker protein, predicative of acute kidney injury (AKI) in various clinical settings. Here, we demonstrate urinary NGAL to allow for differential diagnosis of AKI, accurately discriminating acute allograft rejection from other ca...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/TP.0b013e31824fd892
更新日期:2012-06-27 00:00:00
abstract:BACKGROUND:Increased use of pediatric deceased donor kidneys could enlarge the deceased donor kidney pool. Kidney transplant outcomes from small pediatric donors were compared with those from ideal kidney (IK) and expanded criteria kidney (ECK) donors to understand the optimal use of pediatric donor kidneys. METHODS:K...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000002706
更新日期:2019-12-01 00:00:00
abstract::In mice, "helper/inducer" T cells can be depleted by treatment with a rat monoclonal antibody to the cell surface antigen, L3T4, which is homologous to the human antigen T4 (CD4). In order to examine the contribution of "helper/inducer" T cells to cellular immunity, C57BL/6 (H-2b) mice were treated weekly with 1 mg i....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198612000-00012
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:Delayed graft function (DGF) is associated with acute tubular necrosis. In this setting, surviving tubular cells may proliferate and replace injured cells. CD133Pax-2cells may play a role in the regeneration of tubular damage. The aim of this study was to demonstrate the presence of these cells in human kidn...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816a8891
更新日期:2008-04-27 00:00:00
abstract::Previously, we demonstrated that the dose-normalized tacrolimus blood concentration after renal transplantation was associated with a single nucleotide polymorphism (SNP) in the CYP3AP1 gene, probably through linkage with an SNP in the CYP3A5 gene. Individuals with at least one CYP3A5*1 allele synthesize CYP3A5 and CY...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000151766.73249.12
更新日期:2005-02-27 00:00:00
abstract::The intestinal phase of the graft-versus-host reaction (GVHR) has been investigated in adult F1 mice bearing grafts of fetal gut using an H-2-incompatible and an H-2-compatible, Mls-incompatible combination. The results indicate that the mitotic activity of the intestinal crypts and the number of intraepithelial lymph...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198109000-00011
更新日期:1981-09-01 00:00:00
abstract:BACKGROUND:Early enteral nutrition with solutions containing prebiotics (fiber) and probiotics (Lactobacillus) is suggested to reduce bacterial translocation and minimize the incidence of infections after liver transplantation. METHODS:In a prospective, randomized placebo-controlled trial consisting of 95 patients, we...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-200207150-00021
更新日期:2002-07-15 00:00:00
abstract:BACKGROUND:Donor hepatectomy and liver implantation time reduce long-term graft and patient survival after liver transplantation. It is not known whether these surgical times influence early outcomes after liver transplantation. METHODS:This single-center study evaluated the effect of donor hepatectomy and implantatio...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003335
更新日期:2020-05-28 00:00:00
abstract:BACKGROUND:The authors have previously demonstrated that inhibition of CD28 and CD40 ligand (CD40L) co-stimulatory signals by adenovirus-mediated cytotoxic T-lymphocyte-associated (CTL) antigen 4 (A4) immunoglobulin (Ig) and CD40Ig gene therapies induces tolerance or long-term acceptance in rat liver and heart allograf...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000144324.83846.a9
更新日期:2004-11-27 00:00:00
abstract::Cytomegalovirus disease is an important cause of morbidity following liver transplantation. To date there has not been an effective prophylaxis for CMV disease after liver transplantation. One hundred forty-three patients were randomized to receive either high dose oral acyclovir (800 mg 4 times a day) alone for 3 mon...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199410150-00005
更新日期:1994-10-15 00:00:00
abstract:BACKGROUND:Natural antibodies that react with galactose-alpha(1,3)galactose [galalpha(1,3)gal] carbohydrate epitopes exist in humans and Old World primates because of the inactivation of the alpha1,3-galactosyltransferase (alpha1,3GT) gene in these species and the subsequent production of antibodies to environmental mi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200107150-00028
更新日期:2001-07-15 00:00:00
abstract:BACKGROUND:Suppressive dendritic cells (DCs) are a promising tool for tolerance induction in transplantation. A human DCs subpopulation, which constitutively expresses indoleamine-2,3-dioxygenase (IDO), a molecule shown to prevent the rejection of fetus during pregnancy, has recently been described. This subset, charac...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000251646.09702.ec
更新日期:2007-02-27 00:00:00
abstract::Recipients of solid organ allografts require lifelong immunosuppression in order to prevent graft rejection and to maintain graft function. In general, such immunosuppression greatly impairs the cellular immune system, as this level of the immune system is principally responsible for self and non-self recognition. The...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199208000-00015
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Waiting time to deceased donor kidney transplant varies greatly across the United States. This variation violates the final rule, a federal mandate, which demands geographic equity in organ allocation for transplantation. METHODS:Retrospective analysis of the United States Renal Data System and United Netwo...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/01.tp.0000438623.89310.dc
更新日期:2014-05-27 00:00:00
abstract:BACKGROUND:Leflunomide is a novel immunosuppressive agent with promising activity for xenotransplantation. It is not clear yet which mechanisms of action of leflunomide are responsible for that. METHODS:In a hamster-to-C57BL/6 nude mouse heart transplantation model, a 2-week course of leflunomide was used after transp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000147464.63188.4b
更新日期:2005-01-27 00:00:00
abstract:BACKGROUND:Diarrhea is common in solid organ transplant recipients. Colonoscopy with random biopsies is performed frequently in the diagnostic evaluation of the posttransplant population with diarrhea. The purpose of this study was to determine the sensitivity of colonoscopy with random biopsy in determining a specific...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181ae98ab
更新日期:2009-08-15 00:00:00
abstract:BACKGROUND:Donor T cells are primarily responsible for graft-versus-host disease (GVHD). Three effector pathways have been described for T-cell cytotoxicity: granzyme B/perforin, Fas/Fas ligand (FasL), and secreted molecules such as tumor necrosis factor (TNF)-alpha. Therefore, this study evaluates the gene expression ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000100465.83529.42
更新日期:2004-01-27 00:00:00
abstract:BACKGROUND:Solitary pancreas transplants, both pancreas transplant alone (PTA) and pancreas after kidney (PAK), have higher rejection rates and lower graft survivals than simultaneous pancreas-kidney transplants (SPK). The aim of this study is to compare three different antibody induction regimens in solitary pancreas ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200111270-00017
更新日期:2001-11-27 00:00:00
abstract::As a first step in the study of the possible relationship between the T/t and H-2 complexes, the H-2 antigenic composition of the strains carrying factors t12, tw32, tw2, tw8, t1, t0, t6, tw1, tw71, tw73, tw12, tw5, tw75, and t38 was studied by using a battery of antisera containing antibodies against inbred-derived H...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197603000-00004
更新日期:1976-03-01 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) after living donor liver transplantation (LDLT) is associated with increased mortality. We sought to identify associations between intraoperative hemodynamic variables and postoperative AKI. METHODS:We retrospectively reviewed 734 cases of LDLT. Intraoperative hemodynamic variables...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002584
更新日期:2019-09-01 00:00:00
abstract::Although ELISA on purified HLA molecules for detecting anti-HLA antibody (P-S ELISA) does detect some antibodies previously missed by the conventional complement dependent cytotoxicity method (C Cytotox), HLA ELISA should not fail to detect antibodies already detected by the conventional reference method to be able to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199611270-00031
更新日期:1996-11-27 00:00:00
abstract::A rapid microcytotoxicity assay for the detection of HL-A antigens on tissue culture cells derived from human solid tumors is described. Tumor cells were prelabeled with 125Iododeoxyuridine. Isotopically labeled tumor cells were reacted with up to 37 highly selected HL-A antisera and diluted rabbit complement. Results...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197509000-00005
更新日期:1975-09-01 00:00:00
abstract:BACKGROUND:Live liver donation requires extended liver resection in the donor with transection of the middle hepatic vein. This leads to focal outflow obstruction in the remnant liver or the partial graft. This study was designed to characterize the pathophysiological correlate of focal outflow obstruction in a small-f...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816631f9
更新日期:2008-03-15 00:00:00
abstract::Pancreatic transplantation is intended to normalize carbohydrate metabolism in insulin-dependent diabetics by restoring endogenous insulin release, and it is usually performed together with kidney transplantation in patients with end-stage renal failure. A major problem in these patients is the daily control of the gr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198304000-00016
更新日期:1983-04-01 00:00:00