A new micromethod for the detection of HL-A antigens on cultured human tumor cells.

abstract：BACKGROUND:Detection of markers predicting allograft rejection is important for risk assessment before kidney transplantation, as well as to minimize posttransplantation immunosuppression. METHODS:We studied the expression of CD25, HLA-DR, CD134, CD62L, and CD44 by flow cytometry in CD4, CD8, and CD3 cells, from pretr...

journal_title：Transplantation

authors： Hueso M,Mestre M,Benavente Y,Bas J,Grinyó JM,Navarro E

更新日期：2011-09-15 00:00:00

abstract：BACKGROUND:At our institution, increased kidney donation from unrelated donors accounts for a steady rise in live donor kidney transplantation rates. We compared outcomes of living related (LRT) versus living unrelated kidney transplants (LURT) and analyzed the effect of early rejection upon graft survival. METHODS:A ...

journal_title：Transplantation

authors： Fuller TF,Feng S,Brennan TV,Tomlanovich S,Bostrom A,Freise CE

更新日期：2004-10-15 00:00:00

abstract：:Because of the inherent difficulties in allele assignment with HLA-DR serological typing, in 1993 our organ procurement organization-based HLA laboratory replaced serology with the molecular method of polymerase chain reaction using sequence-specific primer mixes (PCR-SSP) to type for DR and DQ at a resolution level e...

journal_title：Transplantation

authors： Bryan CF,Harrell KM,Nelson PW,Pierce GE,Ross G,Shield CF 3rd,Warady BA,Aeder MI,Helling TS,Landreneau MD,Luger AM

更新日期：1996-12-27 00:00:00

abstract：:The psychosocial and psychiatric impact of donating bone marrow (BM) has received little study. This mail questionnaire study of bone marrow donors whose recipient had survived more than one year post-BMT was undertaken to document the psychosocial consequences of donation on "successful" BM donors. Demographic, mood ...

journal_title：Transplantation

authors： Wolcott DL,Wellisch DK,Fawzy FI,Landsverk J

更新日期：1986-04-01 00:00:00

abstract：:Potential female donors frequently ask whether unilateral nephrectomy will impair future childbearing capabilities. To address this question, we surveyed 220 women who underwent donor nephrectomy between 1985 and 1992. Of the 144 women who responded, 33 became pregnant after donation for a total of 45 pregnancies. Sev...

journal_title：Transplantation

authors： Wrenshall LE,McHugh L,Felton P,Dunn DL,Matas AJ

更新日期：1996-12-27 00:00:00

abstract：BACKGROUND:At present, it is not clear whether xenogeneic MHC molecules are recognized by T cells directly or indirectly through self-MHC-restricted presentation in a transplantation setting. METHODS:We have transplanted skin from HLA-A2 transgenic (B6.A2) to nontransgenic C57BL/6 (B6) mice and investigated the subseq...

journal_title：Transplantation

authors： Jurcevic S,Chandler P,Sacks SH,Simpson E

更新日期：2001-09-27 00:00:00

abstract：BACKGROUND:The mitochondrial respiratory chain is implicated as a major target of kidney damage after ischemia-reperfusion. This study measures changes in integrated mitochondrial function and in the activity of enzymes of the respiratory chain after cold storage and transplantation-reperfusion in vivo. METHODS:Mitoch...

journal_title：Transplantation

authors： Sammut IA,Burton K,Balogun E,Sarathchandra P,Brooks KJ,Bates TE,Green CJ

更新日期：2000-04-15 00:00:00

abstract：:To determine the importance of static lung inflation during storage, graft performance was evaluated at different levels of intratracheal pressure and varying ischemic intervals. Lewis rat lungs were perfused with low-potassium Euro-Collins and stored for 4 or 8 hr either in atelectasis (4 hr: group I; 8 hr: group IV,...

journal_title：Transplantation

authors： Hausen B,Ramsamooj R,Hewitt CW,Schroder F,Beuke M,Poets CF,Schafers HJ

更新日期：1996-12-27 00:00:00

abstract：:Organ donation after circulatory death (DCD) has been endorsed by the World Health Organization and is practiced worldwide. This overview examines current DCD practices, identifies problems and challenges, and suggests clinical strategies for possible improvement. Although there is uniform agreement on DCD donor candi...

journal_title：Transplantation

authors： Morrissey PE,Monaco AP

更新日期：2014-02-15 00:00:00

abstract：BACKGROUND:Little is known about associations between low physical activity (PA) and its correlates and outcomes in solid organ transplant recipients. This systematic review with meta-analysis examined correlates and outcomes associated with low PA (ie, not meeting individual study's definition of being physically acti...

journal_title：Transplantation

authors： Berben L,Engberg SJ,Rossmeissl A,Gordon EJ,Kugler C,Schmidt-Trucksäss A,Klem ML,Sereika SM,De Simone P,Dobbels F,De Geest SM,B-SERIOUS consortium.

更新日期：2019-04-01 00:00:00

abstract：:A considerable amount of data indicates that transplanted patients are at increased risk for de novo and recurrent cancer. Treatment of this population is difficult. It remains unclear if the immunosuppressive therapy should be continued, tapered or even stopped or if immunosuppressive drugs with antiproliferative pro...

journal_title：Transplantation

authors： Andrassy J,Graeb C,Rentsch M,Jauch KW,Guba M

更新日期：2005-09-27 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Kidney transplant graft survival is almost uniformly superior for initial transplants compared to repeat transplants. We investigate the association between first second kidney transplant graft survival in patients who underwent initial transplant during their pediatric years whether age at se...

journal_title：Transplantation

authors： Gupta M,Wood A,Mitra N,Furth SL,Abt PL,Levine MH

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Ischemia-reperfusion injury (IRI) plays key roles in graft viability and posttransplantation function. Caspase-3 associated with apoptosis and inflammation is up-regulated by IRI. We propose that naked small interfering RNA (siRNA) targeting caspase-3 may prevent IRI and improve kidney preservation. METHODS...

journal_title：Transplantation

authors： Yang B,Hosgood SA,Nicholson ML

更新日期：2011-03-15 00:00:00

abstract：BACKGROUND:The shortage of livers for transplantation has prompted transplant centers to seek alternatives to conventional cadaveric liver transplantation. Left lateral segmentectomy from living donors has proven to be a safe operation for the donor with excellent results in the pediatric population. Left lobectomy, co...

journal_title：Transplantation

authors： Marcos A,Fisher RA,Ham JM,Shiffman ML,Sanyal AJ,Luketic VA,Sterling RK,Posner MP

更新日期：1999-09-27 00:00:00

abstract：BACKGROUND:This study analyzes the biochemical, serological, and virological efficacy and the safety of adefovir dipivoxil in patients with renal disturbances. METHODS:Twelve patients with lamivudine-resistant hepatitis B virus (HBV) chronic infection were treated for a median time of 15 (3-19) months. The daily dosag...

journal_title：Transplantation

authors： Fontaine H,Vallet-Pichard A,Chaix ML,Currie G,Serpaggi J,Verkarre V,Varaut A,Morales E,Nalpas B,Brosgart C,Pol S

更新日期：2005-10-27 00:00:00

abstract：BACKGROUND:Early outcomes after human immunodeficiency virus (HIV) + liver transplantation (LT) are encouraging, but data are lacking regarding long-term outcomes and comparisons with matched HIV- patients. METHODS:We examined outcomes among 180 HIV+ LT, and compared outcomes to matched HIV- counterfactuals (Scientifi...

journal_title：Transplantation

authors： Locke JE,Durand C,Reed RD,MacLennan PA,Mehta S,Massie A,Nellore A,DuBay D,Segev DL

更新日期：2016-01-01 00:00:00

abstract：:Although liver transplantation (LT) is the best treatment for patients with localized hepatocellular carcinoma (HCC), recurrence occurs in 6%-18% of patients. Several factors, particularly morphological criteria combined with dynamic parameters, known before LT modify this risk and combined in prediction models may be...

journal_title：Transplantation

authors： Berenguer M,Burra P,Ghobrial M,Hibi T,Metselaar H,Sapisochin G,Bhoori S,Kwan Man N,Mas V,Ohira M,Sangro B,van der Laan LJW

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Treatment of fetal pancreas (FP) isografts with insulin-like growth factor-I greatly improves the rate of conversion to euglycemia in diabetic rats. Complete knowledge of other factors that may facilitate the engraftment and function of FP in vivo is still embryonic. Augmenter of liver regeneration (ALR) is ...

journal_title：Transplantation

authors： Adams GA,Maestri M,Squiers EC,Alfrey EJ,Starzl TE,Dafoe DC

更新日期：1998-01-15 00:00:00

abstract：:Tolerogen-specific alloreactivity, in the form of mixed lymphocyte responses and cell mediated lympholysis, was measured in vitro using lymphocytes from mice that received neonatal inoculations of H-2 semiallogeneic hematopoietic cells. It was found that depletion of specific alloreactivity, as detected by these assay...

journal_title：Transplantation

authors： Streilein JW,Strome P,Wood PJ

更新日期：1989-10-01 00:00:00

abstract：:Recipients of solid organ allografts require lifelong immunosuppression in order to prevent graft rejection and to maintain graft function. In general, such immunosuppression greatly impairs the cellular immune system, as this level of the immune system is principally responsible for self and non-self recognition. The...

journal_title：Transplantation

authors： Van Thiel DH,Finkel R,Friedlander L,Gavaler JS,Wright HI,Gordon R

更新日期：1992-08-01 00:00:00

abstract：:During anesthesia 5 mg of muromonab CD3 (OKT3), an anti-CD3 monoclonal antibody, was administered prophylactically to twelve patients undergoing cadaveric renal transplantation. Preoperatively, all patients were at or near their dry body weights. Methylprednisolone 500 mg on call to or in the operating room, azathiopr...

journal_title：Transplantation

authors： Robinson ST,Barry JM,Norman DJ

更新日期：1993-08-01 00:00:00

abstract：:We have previously demonstrated that the placental spongiotrophoblast and yolk sac venous plexus express paternally derived H-2K and D (class I) antigens in a manner accessible to maternal circulation, and that the placenta serves to prevent antipaternal antibodies from reaching the fetus. Kinetic studies indicated th...

journal_title：Transplantation

authors： Raghupathy R,Singh B,Wegmann TG

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND:Humanized Fc receptor (FcR)-nonbinding antibodies against CD3 are promising immunosuppressive agents that may overcome both the neutralizing response to and the cytokine release syndrome seen with conventional monoclonal antibodies against CD3. In addition, evidence from several murine models suggests that t...

journal_title：Transplantation

authors： Chau LA,Tso JY,Melrose J,Madrenas J

更新日期：2001-04-15 00:00:00

abstract：:Most alloreactive T cells specifically recognize peptides bound to donor MHC molecules. In addition to peptides, solvent accessible MHC residues also may stimulate alloreactive T cells. We studied T cell receptor (TCR) usage by 16 independent anti-HLA-B7 alloreactive cytolytic T lymphocyte (CTL) clones. Most or all of...

journal_title：Transplantation

authors： Li YY,Smith KD,Shi Y,Lutz CT

更新日期：1996-10-15 00:00:00

abstract：BACKGROUND:Intracellular concentration of reactive oxygen species is held within tight physiological limits by enzymes with scavenging and repair functions. Under extreme conditions such as prolonged cold ischemia, these enzymes may be unable to adequately protect the organ, resulting in reperfusion injury that renders...

journal_title：Transplantation

authors： St Peter SD,Imber CJ,Jones DC,Fuggle SV,Watson CJ,Friend PJ,Marshall SE

更新日期：2002-09-27 00:00:00

abstract：BACKGROUND:The authors investigated the relationship between therapeutic blood transfusion before renal transplantation and rejection rates in cyclosporine- and tacrolimus-treated patients. METHODS:In one center, 265 consecutive recipients were studied. Protocol induction was with azathioprine, prednisolone, and cyclo...

journal_title：Transplantation

authors： Higgins RM,Raymond NT,Krishnan NS,Veerasamy M,Rahmati M,Lam FT,Kashi H,West N

更新日期：2004-02-15 00:00:00

abstract：BACKGROUND:Membrane CD30 is an important costimulatory molecule for activated T lymphocytes, and serum level of soluble CD30 (sCD30) is considered a marker for predicting outcome in kidney transplantation. METHODS:We investigated the kinetics of CD30 expression on CD4 and CD8 T-cell populations and the source of sCD30...

journal_title：Transplantation

authors： Velásquez SY,García LF,Opelz G,Alvarez CM,Süsal C

更新日期：2013-07-27 00:00:00

abstract：:Patients receiving allogeneic marrow transplantation for hematologic malignancies commonly are conditioned with total body irradiation (TBI) and given methotrexate (MTX) in an attempt to prevent graft-versus-host disease. To study the effects of TBI with or without MTX on bronchoalveolar cells and proteins, we perform...

journal_title：Transplantation

authors： Springmeyer SC,Kopecky KJ,Deeg HJ,Whitehead J,Altman LC,Storb R

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND:To determine the prevalence of GB virus-C/hepatitis G virus (GBV-C/HGV) infection in liver transplant recipients transplanted for non-hepatitis C virus indications, 44 patients transplanted for cryptogenic, autoimmune, hepatitis B, or cholestatic liver disease and 91 non-liver transplantation (LT) patients w...

journal_title：Transplantation

authors： Dickson RC,Qian KP,Lau JY

更新日期：1997-06-15 00:00:00

abstract：BACKGROUND:Our objective was to evaluate graft equilibration with high viscosity (University of Wisconsin solution [UW]) or low viscosity (Bretschneider's histidine-tryptophan-ketoglutarate [HTK]) during liver procurement from non-heart beating donors (NHBD) and the potential impact of a preceding fibrinolysis with str...

journal_title：Transplantation

authors： Minor T,Hachenberg A,Tolba R,Pauleit D,Akbar S

更新日期：2001-06-27 00:00:00