HuM291(Nuvion), a humanized Fc receptor-nonbinding antibody against CD3, anergizes peripheral blood T cells as partial agonist of the T cell receptor.

abstract：:Leflunomide is a compound recently shown to reduce T and B cell-mediated responses in a number of experimental rat, mouse, and human systems. To explore its potential as an immunosuppressant, we studied leflunomide in 128 Brown-Norway/Lewis cardiac transplants and in 48 unoperated Lewis rats. At doses ranging from 0.6...

journal_title：Transplantation

authors： Williams JW,Xiao F,Foster P,Clardy C,McChesney L,Sankary H,Chong AS

更新日期：1994-04-27 00:00:00

abstract：:Between December 1983 and August 1985, 110 cadaver transplants were performed at our institution. All were started on cyclosporine (CsA) and prednisone (P) for immunosuppressive therapy. Of the 110 patients, 46 were converted from CsA to azathioprine (AZA) for a variety of reasons (cost, toxicity, patient preference, ...

journal_title：Transplantation

authors： Gonwa TA,Nghiem DD,Schulak JA,Corry RJ

更新日期：1987-02-01 00:00:00

abstract：:Organ shortage in liver transplantation has led the transplant community to expand the donor organ pool and reduce waiting list mortality by using so-called marginal donor or extended criteria donor (ECD) livers. The exact impact of these criteria on graft function and recipient survival are still under investigation....

journal_title：Transplantation

authors： Mittler J,Pascher A,Neuhaus P,Pratschke J

更新日期：2008-10-15 00:00:00

abstract：BACKGROUND:Anticytomegalovirus (CMV) prophylaxis prevents the acute disease but its impact on subclinical infection and allograft outcome is unknown. We sought to determine whether CMV prophylaxis administered for three months after heart transplant would improve patient outcomes. METHODS:This prospective cohort study...

journal_title：Transplantation

authors： Potena L,Holweg CT,Chin C,Luikart H,Weisshaar D,Narasimhan B,Fearon WF,Lewis DB,Cooke JP,Mocarski ES,Valantine HA

更新日期：2006-08-15 00:00:00

abstract：:Suppressor cell activity in the spleen of 4-5-day-old mice is high and can be assayed in mixed lymphocyte cultures. The suppressor cells inhibit the proliferation of adult mouse spleen cells responding in vitro to an allogeneic stimulus. This suppressor cell activity can be increased by injecting the mice, on the day ...

journal_title：Transplantation

authors： Argyris BF

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Clinical trial data suggest that continuous hypothermic machine perfusion (HMP) during the entire preservation period reduces the incidence of delayed graft function and improves graft survival. This study evaluates whether short-term MP after cold storage (CS) is also effective. METHODS:Kidney function aft...

journal_title：Transplantation

authors： Gallinat A,Paul A,Efferz P,Lüer B,Kaiser G,Wohlschlaeger J,Treckmann J,Minor T

更新日期：2012-04-27 00:00:00

abstract：:Fine-needle aspiration biopsies were used for clinical monitoring of liver allografts; 21 patients with an inflammatory episode of acute rejection (12.0 +/- 3.3 CIU at the peak) were studied; all episodes were reversible. The inflammatory infiltrate consisted mainly of lymphoid cells, including lymphoid blasts, with i...

journal_title：Transplantation

authors： Lautenschlager I,Höckerstedt K,Salmela K,Isoniemi H,Holmberg C,Jalanko H,Häyry P

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:The emergence of a ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) strain in a heart transplant recipient (HTR) coinfected by multiple HCMV strains was investigated. METHODS:A HTR with primary HCMV infection was treated with three induction courses of intravenous GCV followed by a 2-month maintenan...

journal_title：Transplantation

authors： Baldanti F,Simoncini L,Sarasini A,Zavattoni M,Grossi P,Revello MG,Gerna G

更新日期：1998-08-15 00:00:00

abstract：BACKGROUND:Over 85% of US centers adhere to practice guidelines that consider morbid obesity to be a contraindication to liver transplantation (LT). The relationship of morbid obesity with LT outcomes and survival benefit in the current era is unknown. METHODS:We investigated the association of body mass index with wa...

journal_title：Transplantation

authors： Schlansky B,Naugler WE,Orloff SL,Enestvedt CK

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:In an attempt to reduce chronic calcineurin inhibitor induced allograft nephropathy in first cadaver and human leukocyte antigen non-identical living-donor renal transplantation, sirolimus (Siro) or mycophenolate mofetil (MMF) was tested as adjunctive therapy, with planned dose reductions of tacrolimus (Tacr...

journal_title：Transplantation

authors： Ciancio G,Burke GW,Gaynor JJ,Mattiazzi A,Roth D,Kupin W,Nicolas M,Ruiz P,Rosen A,Miller J

更新日期：2004-01-27 00:00:00

abstract：BACKGROUND:Renal ischemia-reperfusion (I/R) injury causes renal tubular necrosis, apoptosis, and inflammation leading to acute renal dysfunction. Recent studies have revealed that deletion of Gα12 mitigates the renal damage due to I/R injury. Our previous study showed that activation of dopamine D3 receptor (D3R) incre...

journal_title：Transplantation

authors： Wang Z,Guan W,Han Y,Ren H,Tang X,Zhang H,Liu Y,Fu J,He D,Asico LD,Jose PA,Zhou L,Chen L,Zeng C

更新日期：2015-11-01 00:00:00

abstract：:Chronic hepatitis C is a common cause of viral liver disease in kidney transplant (KT) recipients. To assess the efficacy and safety of therapy with interferon alpha we conducted a prospective study where 14 cadaveric KT recipients with chronic hepatitis C received recombinant interferon alpha-2b (IFNa) 3 million unit...

journal_title：Transplantation

authors： Rostaing L,Izopet J,Baron E,Duffaut M,Puel J,Durand D

更新日期：1995-05-27 00:00:00

abstract：BACKGROUND:Recipients with multiple (more than one) acute rejection (AR) episodes have significantly lower graft survival rates than those with no AR or only one treated episode. However, fewer than 50% of recipients treated for one AR episode will have another episode. METHODS:We studied recipients with at least one ...

journal_title：Transplantation

authors： Humar A,Payne WD,Sutherland DE,Matas AJ

更新日期：2000-06-15 00:00:00

abstract：BACKGROUND:Recent evidence suggests that living kidney donors are at an increased risk of end-stage renal disease. However, predicting which donors will have renal dysfunction remains challenging, particularly among those with no clinical evidence of disease at the time of donation. Although renal biopsies are not rout...

journal_title：Transplantation

authors： Fahmy LM,Massie AB,Muzaale AD,Bagnasco SM,Orandi BJ,Alejo JL,Boyarsky BJ,Anjum SK,Montgomery RA,Dagher NN,Segev DL

更新日期：2016-06-01 00:00:00

abstract：:Potential female donors frequently ask whether unilateral nephrectomy will impair future childbearing capabilities. To address this question, we surveyed 220 women who underwent donor nephrectomy between 1985 and 1992. Of the 144 women who responded, 33 became pregnant after donation for a total of 45 pregnancies. Sev...

journal_title：Transplantation

authors： Wrenshall LE,McHugh L,Felton P,Dunn DL,Matas AJ

更新日期：1996-12-27 00:00:00

abstract：BACKGROUND:NKp46 expression in natural killer (NK) cells has recently been shown to affect the responsiveness to antiviral treatment in hepatitis C virus (HCV)-infected patients. However, the density of NKp46 on intrahepatic NK cells is remarkably higher than that on peripherally circulating NK cells, whereas the bioph...

journal_title：Transplantation

authors： Tanimine N,Tanaka Y,Abe T,Piao J,Chayama K,Ohdan H

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Renal allograft rejection is associated with the expression of adhesion molecules on vascular endothelial and tubular epithelial cells. METHODS:To assess whether the number of cell adhesion molecules expressed in donor kidneys can predict early rejection or delayed graft function, kidney biopsies from 20 li...

journal_title：Transplantation

authors： Schwarz C,Regele H,Steininger R,Hansmann C,Mayer G,Oberbauer R

更新日期：2001-06-15 00:00:00

abstract：BACKGROUND:Obesity is a common problem following renal transplantation. Rimonabant, a cannabinoid-1 receptor blocker, offers a new approach for reducing obesity. METHODS:The potential pharmacokinetic interaction between rimonabant and cyclosporine A (CsA, n=10) and tacrolimus (Tac, n=8) was assessed in stable renal tr...

journal_title：Transplantation

authors： Amundsen R,Asberg A,Robertsen I,Vethe NT,Bergan S,Hartmann A,Midtvedt K

更新日期：2009-04-27 00:00:00

abstract：BACKGROUND:Early calcineurin inhibitor (CNI) withdrawal with mycophenolate mofetil (MMF) has not become routine practice, due to concerns about excess acute rejection. Therapeutic drug monitoring may be advantageous when the CNI or MMF is withdrawn. METHODS:This prospective, randomized, concentration-controlled withdr...

journal_title：Transplantation

authors： Mourer JS,Hartigh Jd,van Zwet EW,Mallat MJ,Dubbeld J,de Fijter JW

更新日期：2012-05-15 00:00:00

abstract：BACKGROUND:Live liver donation requires extended liver resection in the donor with transection of the middle hepatic vein. This leads to focal outflow obstruction in the remnant liver or the partial graft. This study was designed to characterize the pathophysiological correlate of focal outflow obstruction in a small-f...

journal_title：Transplantation

authors： Dirsch O,Madrahimov N,Chaudri N,Deng M,Madrahimova F,Schenk A,Dahmen U

更新日期：2008-03-15 00:00:00

abstract：BACKGROUND:Recurrent hepatitis C virus (HCV) after liver transplantation (OLT) is a major cause of graft loss in HCV-positive patients. In this study, we evaluated the efficacy and safety of pegylated interferon alfa-2b (peginterferon) and ribavirin treatment for recurrent HCV after OLT and analyzed the influence of an...

journal_title：Transplantation

authors： Neumann U,Puhl G,Bahra M,Berg T,Langrehr JM,Neuhaus R,Neuhaus P

更新日期：2006-07-15 00:00:00

abstract：BACKGROUND:We have previously shown that an immunomodulatory enzyme, indoleamine 2,3-dioxygenase (IDO) in dermal fibroblasts generates a tryptophan-deficient environment that selectively inhibits proliferation and induces apoptosis of bystander CD4+ and CD8+ T cells, but not pancreatic islets. Because these immune cell...

journal_title：Transplantation

authors： Hosseini-Tabatabaei A,Jalili RB,Khosravi-Maharlooei M,Hartwell R,Kilani RT,Zhang Y,Ghahary A

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Infections and acute graft-versus-host disease (GvHD) represent major complications of allogeneic stem-cell transplantation (SCT). Dendritic cells (DCs) display an extraordinary capacity to induce innate and adaptive immune responses. Therefore, they play a crucial role in the elimination of pathogens and in...

journal_title：Transplantation

authors： Mager K,Wehner R,Bahr F,Oelschlägel U,Platzbecker U,Wermke M,Shayegi N,Middeke JM,Radke J,Röllig C,Schetelig J,Thiede C,Ehninger G,Schmitz M,Bornhäuser M,Tuve S

更新日期：2012-06-27 00:00:00

abstract：:Allogeneic lymphocyte cytotoxicity (ALC) describes the elimination of allogeneic lymphocytes in vivo by an NK-related activity. There is evidence that ALC is demonstrable between donor and recipient when these are incompatible at MHC gene loci alone. Since ALC is a property of T cell-deficient nude rats, the role of t...

journal_title：Transplantation

authors： Ager A,Fajumi J,Sparshott SM,Ford WL,Butcher GW

更新日期：1988-11-01 00:00:00

abstract：:We have recently demonstrated that three synthetic peptides corresponding to the donor class I RT1.Aa molecule induce long-term survival of cardiac allografts in the PVG.R8-to-PVG.1U rat strain combination (disparate for one isolated class I, RT1.A, molecule) when presented to the recipient immune system in the thymus...

journal_title：Transplantation

authors： Shirwan H,Wu GD,Barwari L,Liu A,Cramer DV

更新日期：1997-12-27 00:00:00

abstract：BACKGROUND:Defining the clinical relevance of donor-specific HLA-antibodies detected by single-antigen flow-beads (SAFB) is important because these assays are increasingly used for pretransplant risk assessment and organ allocation. The aims of this study were to investigate to which extent HLA-DSA detected by SAFB rep...

journal_title：Transplantation

authors： Amico P,Hönger G,Mayr M,Steiger J,Hopfer H,Schaub S

更新日期：2009-06-15 00:00:00

abstract：BACKGROUND:Delayed graft function (DGF) after renal transplantation can be diagnosed according to several different definitions, complicating comparison between studies that use DGF as an endpoint. This is a particular problem after transplantation with kidneys from donation after circulatory death (DCD) kidneys, becau...

journal_title：Transplantation

authors： Mallon DH,Summers DM,Bradley JA,Pettigrew GJ

更新日期：2013-11-27 00:00:00

abstract：BACKGROUND:The growing number of patients awaiting a kidney transplant raises questions about allocation of kidneys to the elderly and about the use of elderly donors. In all reported studies analyzing the influence of age on the outcome after renal transplantation, age is investigated as a categorical variable. METHO...

journal_title：Transplantation

authors： Roodnat JI,Zietse R,Mulder PG,Rischen-Vos J,van Gelder T,IJzermans JN,Weimar W

更新日期：1999-02-27 00:00:00

abstract：BACKGROUND:We have reported the protective role of heme oxygenase-1 (HO-1) in the mechanism of hypoxic preconditioning. We wish to investigate the role of HO-1 in remote preconditioning (RP) against hepatic ischemia/reperfusion (I/R) injury in rats. METHODS:The remote preconditioning was produced by four cycles of 10-...

journal_title：Transplantation

authors： Lai IR,Chang KJ,Chen CF,Tsai HW

更新日期：2006-05-15 00:00:00

abstract：BACKGROUND:Chronic allograft nephropathy (CAN) has become the predominant limiting factor for long-term transplant survival. A cardinal histomorphologic correlate for CAN is interstitial fibrosis. Currently, no method has been established in routine use that reliably quantifies the extent of interstitial fibrosis in re...

journal_title：Transplantation

authors： Pape L,Henne T,Offner G,Strehlau J,Ehrich JH,Mengel M,Grimm PC

更新日期：2003-09-27 00:00:00