Genetic determinants of delayed graft function after kidney transplantation.

abstract：:The study purpose was to identify risks, benefits and costs associated with an expanded donor protocol. The protocol design evaluated organs rescued using expanded donor criteria and weighed all costs associated with doing so. Costs were measured against conditions experienced with expanded and traditional criteria an...

journal_title：Transplantation

authors： Jacobbi LM,McBride VA,Etheredge EE,McDonald JC,Cooper ES,Frey D,Boudreaux JP,Gonzalez F,Van Meter C,McMillan R

更新日期：1995-12-27 00:00:00

abstract：:This study focuses upon two discrete components of posttransplant hepatic reticuloendothelial system (RES) function-phagocytosis and killing of bacteria-under various conditions of ischemic preservation. We had previously reported that, following intravenous injection of rats with 51Cr and 125I double-labeled Escheric...

journal_title：Transplantation

authors： Klein AS,Zhadkevich M,Wang D,Margolick JB,Winkelstein JA,Bulkley GB

更新日期：1996-04-27 00:00:00

abstract：:Limited recovery of contractile function and loss of coronary reactivity have been observed following prolonged hypothermic storage and transplantation of the heart. Since lipid peroxidation has a significant role in these deficits, we investigated the cardioprotective effects of a 21-aminosteroid. U74389G, 3 mg/kg i....

journal_title：Transplantation

authors： Duguay P,Chen H,Daloze P,Dumont L

更新日期：1996-04-15 00:00:00

abstract：BACKGROUND:The clinical symptoms, histological findings, and treatments for antibody-mediated rejection (AMR), which is the leading cause of graft loss in adult ABO-incompatible liver transplantation (ABO-I-LT), have rarely been discussed. METHODS:We performed adult living donor ABO-I-LT on six patients. We used anti-...

journal_title：Transplantation

authors： Morioka D,Togo S,Kumamoto T,Takeda K,Matsuo K,Inayama Y,Yamanaka S,Tanaka K,Endo I,Maegawa J,Shimada H

更新日期：2008-01-27 00:00:00

abstract：BACKGROUND:The role of CD20+ B cells in renal allograft rejection has been reappreciated. Importantly, recent studies suggest a relation between CD20+ B cell aggregates and poorer clinical outcome. In the present study, we attempted to confirm these early reports in a tightly controlled patient population and to differ...

journal_title：Transplantation

authors： Scheepstra C,Bemelman FJ,van der Loos C,Rowshani AT,van Donselaar-Van der Pant KA,Idu MM,ten Berge IJ,Florquin S

更新日期：2008-09-27 00:00:00

abstract：BACKGROUND:Infections and acute graft-versus-host disease (GvHD) represent major complications of allogeneic stem-cell transplantation (SCT). Dendritic cells (DCs) display an extraordinary capacity to induce innate and adaptive immune responses. Therefore, they play a crucial role in the elimination of pathogens and in...

journal_title：Transplantation

authors： Mager K,Wehner R,Bahr F,Oelschlägel U,Platzbecker U,Wermke M,Shayegi N,Middeke JM,Radke J,Röllig C,Schetelig J,Thiede C,Ehninger G,Schmitz M,Bornhäuser M,Tuve S

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:CTLA4 immunoglobulin (Ig)G that binds to B7 effectively inhibits the signaling of CD28/CTLA4-B7 pathway and induces antigen specific T cell unresponsiveness in vitro and in vivo. Using CTLA4IgG, we examined induction of long-term graft survival and the mechanism of maintenance of tolerance in rat allogeneic ...

journal_title：Transplantation

authors： Tarumi K,Murakami M,Yagihashi A,Nakagawa I,Hirata K,Uede T

更新日期：1999-02-27 00:00:00

abstract：:As donation after cardiac death practices expand, the number of institutional policies is increasing. We contacted organ procurement organizations throughout the United States and requested protocols in hospitals in their donor service areas. Sixty-four protocols were obtained with representation from 16 different sta...

journal_title：Transplantation

authors： Fugate JE,Stadtler M,Rabinstein AA,Wijdicks EF

更新日期：2011-02-27 00:00:00

abstract：:To examine whether cyclosporine (CsA) has mutagenic potential against human cells, we analyzed sister chromatid exchange (SCE) induction by CsA using human lymphocytes in vitro. SCE frequencies increased significantly in the lymphocytes treated with 1 microgram/ml and 5 micrograms/ml CsA, though the frequencies seemed...

journal_title：Transplantation

authors： Yuzawa K,Kondo I,Fukao K,Iwasaki Y,Hamaguchi H

更新日期：1986-07-01 00:00:00

abstract：:Seventy-two dog kidneys were stored under hypothermia as described by Collins and Sacks between 24 and 72 hr and then transplanted. The immediate function of the kidneys was measured by p-aminohippuric acid and inulin clearances. Twenty-four hr proved to be the maximum safe preservation time with both methods. The imm...

journal_title：Transplantation

authors： Grundmann R,Strümper R,Eichmann J,Pichlmaier H

更新日期：1977-05-01 00:00:00

abstract：:Although the cornea is considered to be an immunological privileged site, corneal transplantation can result in immunological rejection followed by graft failure, especially in patients with vascularized corneas. Several studies suggest a beneficial effect of matching for the HLA class I antigens on corneal graft surv...

journal_title：Transplantation

authors： Roelen DL,van Beelen E,van Bree SP,van Rood JJ,Völker-Dieben HJ,Claas FH

更新日期：1995-04-15 00:00:00

abstract：BACKGROUND:Many models of transplant tolerance have been found to depend on the induction of regulatory T cells (Tregs). Innate immune signals are known to suppress Tregs thereby augmenting immunity by abrogating Treg function. Such signals may also provide a barrier to transplantation tolerance mediated by Tregs. A nu...

journal_title：Transplantation

authors： Sonawane SB,Kim JI,Lee MK,Lee SH,Duff PE,Moore DJ,Lian MM,Deng S,Choi Y,Yeh H,Caton AJ,Markmann JF

更新日期：2009-11-27 00:00:00

abstract：METHODS:Two hundred twenty-three recipients of first cadaveric kidney allografts were randomized to receive tacrolimus (TAC) + mycophenolate mofetil (MMF), TAC + azathioprine (AZA), or cyclosporine (Neoral; CsA) + MMF. All regimens contained corticosteroids, and antibody induction was used only in patients who experien...

journal_title：Transplantation

authors： Gonwa T,Johnson C,Ahsan N,Alfrey EJ,Halloran P,Stegall M,Hardy M,Metzger R,Shield C 3rd,Rocher L,Scandling J,Sorensen J,Mulloy L,Light J,Corwin C,Danovitch G,Wachs M,VanVeldhuisen P,Leonhardt M,Fitzsimmons WE

更新日期：2003-06-27 00:00:00

abstract：:BK polyoma virus causes allograft dysfunction as a result of tubulo-interstitial nephritis in 2% to 5% of renal transplant recipients. The incidence of BK virus infection among renal transplant recipients in India is unknown. We used routine histologic examination, immunohistochemistry, and electron microscopy to retr...

journal_title：Transplantation

authors： Sachdeva MS,Nada R,Jha V,Sakhuja V,Joshi K

更新日期：2004-02-15 00:00:00

abstract：BACKGROUND:Obesity is a common problem following renal transplantation. Rimonabant, a cannabinoid-1 receptor blocker, offers a new approach for reducing obesity. METHODS:The potential pharmacokinetic interaction between rimonabant and cyclosporine A (CsA, n=10) and tacrolimus (Tac, n=8) was assessed in stable renal tr...

journal_title：Transplantation

authors： Amundsen R,Asberg A,Robertsen I,Vethe NT,Bergan S,Hartmann A,Midtvedt K

更新日期：2009-04-27 00:00:00

abstract：:Using antisera to human beta2-microglobulin and an immunofluorescent technique, beta2-microglobulin was found to be localized along tubular and glomerular basement membranes of renal bipsies studied. Since beta2-microglobulin is a subunit of HLA preparations, it may also serve as an indirect marker for the presence of...

journal_title：Transplantation

authors： Ooi BS,Rubin SC,Pesce AJ,Pollak VE

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND:Over 85% of US centers adhere to practice guidelines that consider morbid obesity to be a contraindication to liver transplantation (LT). The relationship of morbid obesity with LT outcomes and survival benefit in the current era is unknown. METHODS:We investigated the association of body mass index with wa...

journal_title：Transplantation

authors： Schlansky B,Naugler WE,Orloff SL,Enestvedt CK

更新日期：2016-12-01 00:00:00

abstract：:Histoincompatible-complete radiation chimeras, after resolving acute graft-versus-host disease (GVHD), establish specific tolerance to host and donor alloantigens. This tolerance can be perturbed with immunosuppressive agents and infusions of small numbers of donor-type cells, with infusions of massive numbers of dono...

journal_title：Transplantation

authors： Tutschka PJ,Hess AD,Beschorner WE,Santos GW

更新日期：1981-09-01 00:00:00

abstract：:Possible explanations for the immune deficiency usually associated with graft-versus-host disease include defective lymphocyte differentiation and active suppressor cell mechanisms. The present observations in a patient with chronic graft-versus-host disease delineate yet another possible mechanism: a failure of succe...

journal_title：Transplantation

authors： Dosch HM,Gelfand EW

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Long-term use of immunosuppressants is associated with significant morbidity and mortality in transplant recipients. A simple whole blood assay that has U.S. Food and Drug Administration clearance directly assesses the net state of immune function of allograft recipients for better individualization of thera...

journal_title：Transplantation

authors： Kowalski RJ,Post DR,Mannon RB,Sebastian A,Wright HI,Sigle G,Burdick J,Elmagd KA,Zeevi A,Lopez-Cepero M,Daller JA,Gritsch HA,Reed EF,Jonsson J,Hawkins D,Britz JA

更新日期：2006-09-15 00:00:00

abstract：BACKGROUND:Tacrolimus pharmacokinetic characteristics vary greatly among individuals. Tacrolimus is a substrate of cytochrome p450 (CYP), of subfamily CYP3A. CYP3A activity is the sum of the activities of the family of CYP3A genes, including CYP3A5. Subjects with the CYP3A5*1/*1 genotype express large amounts of CYP3A5...

journal_title：Transplantation

authors： Thervet E,Anglicheau D,King B,Schlageter MH,Cassinat B,Beaune P,Legendre C,Daly AK

更新日期：2003-10-27 00:00:00

abstract：:Human herpesvirus type 6 (HHV-6) causes roseola infantum (exanthema subitum) upon primary infection in young children. Thereafter it persists lifelong in the organism. Like other herpesviruses, HHV-6 can be reactivated in periods of immunosuppression - e.g., after organ transplantation. In order to study the incidence...

journal_title：Transplantation

authors： Schmidt CA,Wilbron F,Weiss K,Brinkmann V,Oettle H,Lohmann R,Langrehr JM,Neuhaus P,Siegert W

更新日期：1996-02-27 00:00:00

abstract：:Lethally irradiated rhesus monkeys were treated with autologous bone marrow that had either been (1) nontreated, i.e., normal; (2) depleted of T lymphocytes with a monoclonal antibody directed against rhesus T lymphocytes; (3) fractionated with the soybean agglutinin (SBA- fraction); or (4) fractionated with SBA and f...

journal_title：Transplantation

authors： Gengozian N,Moriarty C,Good RA

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Pharmacokinetic modeling supports trough monitoring of everolimus, but prospective data comparing this approach versus mycophenolate mofetil (MMF) in de novo cardiac transplant recipients are currently unavailable. METHODS:In a 12-month multicenter open-label study, cardiac transplant patients received ever...

journal_title：Transplantation

authors： Lehmkuhl HB,Arizon J,Viganò M,Almenar L,Gerosa G,Maccherini M,Varnous S,Musumeci F,Hexham JM,Mange KC,Livi U,2411 Study Investigators.

更新日期：2009-07-15 00:00:00

abstract：BACKGROUND:Transplant vasculopathy in kidney and heart allografts is associated with marked elevation of endothelin-1 (ET-1), but a role for ET-1 in the pathogenesis of transplant vasculopathy and chronic rejection has not been established. We, therefore, tested whether inhibition of ET-1-converting enzyme by phosphora...

journal_title：Transplantation

authors： Simonson MS,Herman WH,Robinson A,Schulak J,Hricik DE

更新日期：1999-06-27 00:00:00

abstract：BACKGROUND:A quantitative model of immunosuppression was previously developed based on the rejection of the allogeneic A/J murine tumor sarcoma 1 (Sa1) in immunocompetent mice. Here, the model is used to evaluate the immunologic mechanisms of graft rejection and to determine the potential of this model to detect synerg...

journal_title：Transplantation

authors： Hammond-McKibben D,Saulnier M,Zhang J,Risher N,Lake P,Weetall M

更新日期：2005-04-27 00:00:00

abstract：:The purpose of this study was to determine the changes of hepatic sinusoidal endothelial cell (SEC) function in acute liver rejection with respect to receptor-mediated endocytosis. Orthotopic rat liver transplantation was performed in Lewis rats grafted with DA livers and in Lewis rats grafted with Lewis livers as rej...

journal_title：Transplantation

authors： Yokoi Y,Nakamura S,Muro H,Baba S

更新日期：1994-01-01 00:00:00

abstract：:Following liver transplantation bile formation may be influenced by hepatic denervation and cyclosporine therapy. To better establish any effect of liver transplantation on bile secretion, 6 mongrel dogs were studied: 3 underwent liver denervation by a modified autotransplantation procedure and insertion of a Thomas c...

journal_title：Transplantation

authors： Sutherland FR,Preshaw RM,Shaffer EA

更新日期：1993-02-01 00:00:00

abstract：:The use of anti-CD3 monoclonal antibodies to treat organ allograft rejection has been complicated by (1) the morbidity associated with the initial dose, (2) the humoral response of the patients against the mAbs, and (3) the generalized immunosuppression induced by the mAbs. We investigated the potential of F(ab')2 fra...

journal_title：Transplantation

authors： Hirsch R,Bluestone JA,DeNenno L,Gress RE

更新日期：1990-06-01 00:00:00

abstract：:We have previously shown that trophic factor supplementation (TFS) of University of Wisconsin (UW) solution enhanced kidney viability after cold storage. Here, we use an in vitro model to study the effect of TFS on early apoptotic changes after cold ischemic storage. Mitochondrial membrane potential was determined by ...

journal_title：Transplantation

authors： Kwon YS,Foley JD,Murphy CJ,McAnulty JF

更新日期：2007-01-15 00:00:00