Anti-CD3 F(ab')2 fragments are immunosuppressive in vivo without evoking either the strong humoral response or morbidity associated with whole mAb.

abstract：BACKGROUND:The authors have investigated the effectiveness of virus detection from bronchoalveolar lavage (BAL) samples for the identification of symptomatic cytomegalovirus (CMV) infection in lung transplant recipients. METHODS:Thus, 275 BAL samples taken from 105 lung transplant recipients during follow-up were anal...

journal_title：Transplantation

authors： Zedtwitz-Liebenstein K,Jaksch P,Bauer C,Popow T,Klepetko W,Hofmann H,Puchhammer-Stöckl E

更新日期：2004-06-27 00:00:00

abstract：BACKGROUND:Pancreas transplantation (PTX) improves lipids in patients with type 1 diabetes mellitus. However, there are patients who have persistent abnormal lipids or develop new hyperlipidemia despite PTX. One factor that may influence the lipid profile is apolipoprotein E (Apo E) genotype. Apo E polymorphism, partic...

journal_title：Transplantation

authors： Balakrishnan S,Colling C,Burkman T,Erickson J,Lyden E,Maheshwari H,Mack-Shipman L,Lane J,Larsen J

更新日期：2002-10-15 00:00:00

abstract：BACKGROUND:Allografts are occasionally accepted in the absence of immunosuppression. Because naturally occurring CD4(+)CD25(+) regulatory T cells (natural CD25(+) Treg cells) have been shown to inhibit allograft rejection, we investigated their influence on the outcome of allografts in nonimmunosuppressed mouse recipie...

journal_title：Transplantation

authors： Benghiat FS,Graca L,Braun MY,Detienne S,Moore F,Buonocore S,Flamand V,Waldmann H,Goldman M,Le Moine A

更新日期：2005-03-27 00:00:00

abstract：:The development of erythrocytosis following renal transplantation has been reported to be caused by a number of factors. These include acute and chronic rejection, hydronephrosis and renal artery stenosis. In this study, seven patients were noted to have erythrocytosis with hematocrits ranging between 53.5 and 66%. Se...

journal_title：Transplantation

authors： Dagher FJ,Ramos E,Erslev AJ,Alongi SV,Karmi SA,Caro J

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:Mixed allogeneic bone marrow chimerism induces tolerance to solid organ grafts. Although we previously reported that partially ablative conditioning with 700 cGy of total body irradiation (TBI) is sufficient to allow for bone marrow engraftment in mice, we determined that a minimum of 1000 cGy was required i...

journal_title：Transplantation

authors： Neipp M,Gammie JS,Exner BG,Li S,Chambers WH,Pham SM,Ildstad ST

更新日期：1999-08-15 00:00:00

abstract：BACKGROUND:Several technical modifications in portal vein (PV) reconstruction have shown excellent outcomes in pediatric liver transplantation (LT); however, which procedure is the best for PV reconstruction of the hypoplastic PV in pediatric LT remains unclear. METHODS:One hundred sixteen pediatric patients aged 1 or...

journal_title：Transplantation

authors： Sakamoto S,Uchida H,Kitajima T,Shimizu S,Yoshimura S,Takeda M,Hirata Y,Fukuda A,Kasahara M

更新日期：2020-01-01 00:00:00

abstract：:Apoptotic cells are endowed with immunomodulatory properties. The authors propose infusing apoptotic cells as a cell-based therapy product to facilitate allogeneic hematopoietic engraftment after a nonmyeloablative conditioning regimen. Such an approach may be used to obtain macrochimerism in combined hematopoietic ce...

journal_title：Transplantation

authors： Kleinclauss F,Perruche S,Cahn JY,Tiberghien P,Saas P

更新日期：2003-05-15 00:00:00

abstract：:Interferon gamma and tumor necrosis factor alpha play a significant role in the upregulation of host immunity and inflammation, for example by induction and enhancement of the expression of major histocompatibility complex class I and II antigens on a wide variety of cell types, both in vitro and in vivo. In this stud...

journal_title：Transplantation

authors： Stevens HP,van der Kwast TH,van der Meide PH,Vuzevski VD,Buurman WA,Jonker M

更新日期：1990-11-01 00:00:00

abstract：:Cytomegalovirus (CMV) is a major pathogen in transplant recipients and AIDS patients, and the virus may also play a role in allograft rejection. Previous work from this laboratory demonstrated increased cell surface expression of the adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) following CMV infection in vitro. W...

journal_title：Transplantation

authors： Craigen JL,Grundy JE

更新日期：1996-10-27 00:00:00

abstract：BACKGROUND:Primary hyperoxaluria is a rare autosomal recessive metabolic disease that often progresses to end-stage renal disease (ESRD). Liver transplantation is curative for patients with the alanine: glyoxylate aminotransferase deficiency. For oxalosis patients with minor enzyme deficiencies, renal transplantation m...

journal_title：Transplantation

authors： Cibrik DM,Kaplan B,Arndorfer JA,Meier-Kriesche HU

更新日期：2002-09-15 00:00:00

abstract：BACKGROUND:Tacrolimus has been shown to have a less adverse effect on the lipid profiles of transplant patients when the drug is started as induction therapy. In order to determine the effect tacrolimus has on lipid profiles in stable cyclosporine-treated renal transplant patients with established hyperlipidemia, a ran...

journal_title：Transplantation

authors： McCune TR,Thacker LR II,Peters TG,Mulloy L,Rohr MS,Adams PA,Yium J,Light JA,Pruett T,Gaber AO,Selman SH,Jonsson J,Hayes JM,Wright FH Jr,Armata T,Blanton J,Burdick JF

更新日期：1998-01-15 00:00:00

abstract：:Chronic graft-versus-host disease often results in a combined deficiency of humoral and cell-mediated immunity. Clinical and experimental studies have suggested that the decrease in B cell responsiveness is due to a failure of B cell production in the bone marrow, intrinsic B cell defects, excessive suppressor T cell ...

journal_title：Transplantation

authors： Schreiber KL,Forman J

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Although human herpesvirus (HHV)-6 is now recognized as a frequent pathogen after transplantation, the real impact of this infection in patients undergoing transplantation remains unclear. METHODS:During 27 months, 30 consecutive heart-lung- and lung-transplant recipients were included on the day of transpl...

journal_title：Transplantation

authors： Jacobs F,Knoop C,Brancart F,Gilot P,Mélot C,Byl B,Delforge ML,Estenne M,Liesnard C,Brussels Heart and Lung Transplantation Group.

更新日期：2003-06-27 00:00:00

abstract：BACKGROUND:Patients with long-term functioning organ allografts may have developed different mechanisms that explain the lack of graft rejection. However, it is not known how these mechanisms interplay or whether one of them predominates in such situations. METHODS:The authors analyzed the expression of T-cell surface...

journal_title：Transplantation

authors： Alvarez CM,Paris SC,Arango L,Arbelaez M,Garcia LF,RAD B201 study group.

更新日期：2004-11-27 00:00:00

abstract：BACKGROUND:Cardiovascular disease remains epidemic in transplant recipients, despite aggressive treatment of cardiovascular risk factors. Thus, novel risk factors could play a role in the genesis of cardiovascular events in this population. METHODS:We evaluated the impact of early posttransplant anemia on cardiovascul...

journal_title：Transplantation

authors： Djamali A,Becker YT,Simmons WD,Johnson CA,Premasathian N,Becker BN

更新日期：2003-09-15 00:00:00

abstract：:A 44-year-old man was maintained on prednisone and azathioprine after renal transplantation. One and a half years after transplantation, he developed multiple perianal Escherichia coli abscesses. These became chronic and resisted antibiotic therapy. Histologically, the lesions were typical of malakoplakia. Peripheral ...

journal_title：Transplantation

authors： Biggar WD,Keating A,Bear RA

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:Increased use of pediatric deceased donor kidneys could enlarge the deceased donor kidney pool. Kidney transplant outcomes from small pediatric donors were compared with those from ideal kidney (IK) and expanded criteria kidney (ECK) donors to understand the optimal use of pediatric donor kidneys. METHODS:K...

journal_title：Transplantation

authors： Suneja M,Kuppachi S,Katz D,Hunsicker L

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Recently the United Network for Organ Sharing (UNOS) began a pilot study to evaluate prospectively the merits of an allocation of cadaveric kidneys based on broader classes of HLA antigens, called cross-reactive groups (CREG). The objectives of the pilot study consider patient outcomes, but not the potential...

journal_title：Transplantation

authors： Hollenbeak CS,Woodward RS,Cohen DS,Lowell JA,Singer GG,Tesi RJ,Howard TK,Mohanakumar T,Brennan DC,Schnitzler MA

更新日期：2000-08-15 00:00:00

abstract：BACKGROUND:Optical coherence tomography (OCT) revealed that cells lining proximal convoluted tubules of living donor kidneys (LDKs) procured by laparoscopic procedures were very swollen in response to the brief period of ischemia experienced between the time of arterial vessel clamping and flushing the excised kidney w...

journal_title：Transplantation

authors： Andrews PM,Cooper M,Verbesey J,Ghasemian S,Rogalsky D,Moody P,Chen A,Alexandrov P,Wang HW,Chen Y

更新日期：2014-10-27 00:00:00

abstract：BACKGROUND:The UK Kidney Fast-Track Scheme (KFTS) was introduced in 2012 to identify kidneys at high risk of discard and to rapidly facilitate transplantation. A retrospective analysis of kidneys transplanted through the KFTS was undertaken. METHODS:UK Transplant Registry data were collected on deceased donor kidneys ...

journal_title：Transplantation

authors： Callaghan CJ,Mumford L,Pankhurst L,Baker RJ,Bradley JA,Watson CJE

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Although longer pretransplant dialysis has been associated with poor kidney transplant outcome, no data about this association exist from the current era or from Europe. We studied the association of pretransplant dialysis duration on outcomes after kidney transplantation across two different time periods. ...

journal_title：Transplantation

authors： Helanterä I,Salmela K,Kyllönen L,Koskinen P,Grönhagen-Riska C,Finne P

更新日期：2014-08-27 00:00:00

abstract：:Data from 60 consecutive ABO-incompatible kidney transplantations performed in Stockholm, Sweden; Freiburg, Germany; and Uppsala, Sweden, revealed significant variation in preoperative A/B antibody levels, with median titers of 1:32, 1:128, and 1:8, respectively. We wanted to investigate whether these differences were...

journal_title：Transplantation

authors： Kumlien G,Wilpert J,Säfwenberg J,Tydén G

更新日期：2007-12-27 00:00:00

abstract：BACKGROUND:Encapsulation of islets has been widely investigated as a treatment for diabetes. The characteristics and dynamics of insulin secretion by encapsulated islets in response to glucose and other secretagogues are not well understood. METHODS:In our study, macroencapsulated syngeneic islets at 3-4 wk after tran...

journal_title：Transplantation

authors： Trivedi N,Keegan M,Steil GM,Hollister-Lock J,Hasenkamp WM,Colton CK,Bonner-Weir S,Weir GC

更新日期：2001-01-27 00:00:00

abstract：BACKGROUND:Treatment of fetal pancreas (FP) isografts with insulin-like growth factor-I greatly improves the rate of conversion to euglycemia in diabetic rats. Complete knowledge of other factors that may facilitate the engraftment and function of FP in vivo is still embryonic. Augmenter of liver regeneration (ALR) is ...

journal_title：Transplantation

authors： Adams GA,Maestri M,Squiers EC,Alfrey EJ,Starzl TE,Dafoe DC

更新日期：1998-01-15 00:00:00

abstract：:In the DA-to-Lewis renal allograft model, donor whole blood enhanced renal allograft survival (14.5 +/- 7.6 days versus 6.9 +/- 0.6 days in controls [P less than 0.01]). The effect of individual cell components given in numbers equivalent to those present in the enhancing volumes of donor whole blood was studied. Immu...

journal_title：Transplantation

authors： El-Malik F,Malik ST,Varghese Z,Sweny P,Moorhead JF

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Calcineurin is a ubiquitously expressed calcium-dependent phosphatase that is inhibited by the immunosuppressant drugs cyclosporine and tacrolimus. Measuring calcineurin activity in transplant patients has been complicated by a lack of consistent correlation between drug level and enzyme activity, particular...

journal_title：Transplantation

authors： Pena JA,Titus L,Jackson J,Kirk AD,Gooch JL

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:The induction of tolerance to pig antigens in primates may facilitate the development of successful clinical xenotransplantation protocols. The infusion of mobilized porcine peripheral blood leukocytes (PBPCs, comprised of approximately 2% peripheral blood progenitor cells) into splenectomized preconditioned...

journal_title：Transplantation

authors： Appel JZ 3rd,Alwayn IP,Correa LE,Cooper DK,Robson SC

更新日期：2001-10-15 00:00:00

abstract：BACKGROUND:Status 1A patients are prioritized over liver disease patients regardless of Model for End-stage Liver Disease (MELD) score. We aimed to identify groups with high waitlist mortality in Status 1A and MELD ≥40 patients to determine who would most benefit from transplantation. METHODS:Data on patients listed a...

journal_title：Transplantation

authors： Safwan M,Nwagu U,Collins K,Abouljoud M,Nagai S

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Assays of drug blood levels are used for therapeutic immunosuppressive drug monitoring (pharmacokinetics, PK). We monitored lymphocyte functions (pharmacodynamics, PD) in allograft recipients treated with mycophenolic acid (MPA) to determine its mechanisms and the relationships among dose levels, PK, PD, and...

journal_title：Transplantation

authors： Gummert JF,Barten MJ,van Gelder T,Billingham ME,Morris RE

更新日期：2000-10-15 00:00:00

abstract：BACKGROUND:Hepatic ischemia-reperfusion (IR) injury is frequently followed by cholestatic liver disease. Cytokines released by Kupffer cells following hepatic IR injury may subsequently regulate hepatic transporter expression. The purpose of this study was to determine whether hepatic IR injury and the resultant Kupffe...

journal_title：Transplantation

authors： Tanaka Y,Chen C,Maher JM,Klaassen CD

更新日期：2006-07-27 00:00:00