Association of cytomegalovirus DNA concentration in epithelial lining fluid and symptomatic cytomegalovirus infection in lung transplant recipients.

abstract：BACKGROUND:Chronic red cell aplasia can develop in immunocompromised patients including transplant recipients infected with parvovirus B19 (PV B19). Renal involvement with PV B19 infection is not well-recognized. METHODS:We diagnosed erythroid hypoplasia associated with PV B19 infection in three renal transplant recip...

journal_title：Transplantation

authors： Moudgil A,Shidban H,Nast CC,Bagga A,Aswad S,Graham SL,Mendez R,Jordan SC

更新日期：1997-12-27 00:00:00

abstract：BACKGROUND:Systemic inhibition of serum CD26/dipeptidylpeptidase (DPP IV) enzymatic activity abrogated acute rejection of pulmonary allografts, whereas organ-specific inhibition ameliorated ischemia/reperfusion injury in syngeneic transplants. Here, we analyze the effect of allograft-specific inhibitor preconditioning ...

journal_title：Transplantation

authors： Jungraithmayr W,Oberreiter B,De Meester I,Wiedl T,Inci I,Bain M,Augustyns K,Hillinger S,Scharpé S,Weder W,Korom S

更新日期：2009-08-27 00:00:00

abstract：:The primary effects of CsA on human lymphocyte responses in vitro appear to be the inhibition of IL-2 production and the inhibition of cytotoxic T cell activation. Induction of suppressor T cell activity is resistant to the effects of CsA. These data imply two distinct subsets of lymphocytes: CsA-resistant and CsA-sen...

journal_title：Transplantation

authors： Hess AD,Colombani PM

更新日期：1988-08-01 00:00:00

abstract：:The aim of this study was to investigate the combined effect of DLA matching and immunosuppressive therapy on the survival of segmental small-bowel allografts in dogs. Orthotopic segmental small-bowel transplantations (25 to 30% of total small bowel length) were performed in two stages: first a heterotopic segmental s...

journal_title：Transplantation

authors： Meijssen MA,Heineman E,de Bruin RW,Wolvekamp MC,Marquet RL,Molenaar JC

更新日期：1993-11-01 00:00:00

abstract：:Pre-existing alloantibodies against the mismatched HLA-A and HLA-B antigens of the donor, when present in current sera, are believed to be detrimental to kidney graft survival. When these antibodies are present only in historical sera, their immunoglobulin class has reported to be important with respect to the expecte...

journal_title：Transplantation

authors： Roelen DL,van Bree J,Witvliet MD,Habraken I,van Beelen E,van't Sant PH,de Waal LP,van Rood JJ,Claas FH

更新日期：1994-05-15 00:00:00

abstract：:Diarrhea is a frequent but overlooked complication of kidney transplantation. Diarrhea is repeatedly neglected, often considered by patients and clinicians an unavoidable side effect of immunosuppressive regimens. It is, however, associated with a significant impairment in life quality. Severe and chronic posttranspla...

journal_title：Transplantation

authors： Aulagnon F,Scemla A,DeWolf S,Legendre C,Zuber J

更新日期：2014-10-27 00:00:00

abstract：:To determine the impact of different flush and reperfusion techniques on postreperfusion syndrome (PRS) and postoperative graft function, 100 transplants were randomly assigned into four groups as follows: group 1 (n=31), portal vein flush, no vena caval venting; group 2 (n=21), hepatic arterial flush, no vena caval v...

journal_title：Transplantation

authors： Millis JM,Melinek J,Csete M,Imagawa DK,Olthoff KM,Neelankanta G,Braunfeld MY,Sopher MJ,Chan SM,Pregler JL,Yersiz H,Busuttil AA,Shackleton CR,Shaked A,Busuttil RW

更新日期：1997-02-15 00:00:00

abstract：BACKGROUND:In cases where hyperacute rejection has been prevented, pig to primate organ transplantation results in a delayed rejection mediated by graft-infiltrating leukocytes. The migration of human leukocytes across porcine endothelium is poorly characterized, but may offer targets for species-specific antirejection...

journal_title：Transplantation

authors： Hauzenberger E,Hauzenberger D,Hultenby K,Holgersson J

更新日期：2000-05-15 00:00:00

abstract：:Currently trials of immunosuppression in transplantation are in decline because their objectives remain focused on improving acute rejection rates and graft survival in the first 12 months. With 1 year renal graft survival rates of greater than 90% the best that can be hoped for is noninferiority trial outcomes compar...

journal_title：Transplantation

authors： OʼConnell PJ,Kuypers DR,Mannon RB,Abecassis M,Chadban SJ,Gill JS,Murphy B,Nickerson PW,Schold JD,Stock PG,Seron D,Alloway RR,Bromberg JS,Budde K,Jordan SC,Legendre C,Lefaucheur C,Sarwall M,Segev DL,Stegall MD,Tull

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Although human herpesvirus (HHV)-6 is now recognized as a frequent pathogen after transplantation, the real impact of this infection in patients undergoing transplantation remains unclear. METHODS:During 27 months, 30 consecutive heart-lung- and lung-transplant recipients were included on the day of transpl...

journal_title：Transplantation

authors： Jacobs F,Knoop C,Brancart F,Gilot P,Mélot C,Byl B,Delforge ML,Estenne M,Liesnard C,Brussels Heart and Lung Transplantation Group.

更新日期：2003-06-27 00:00:00

abstract：BACKGROUND:The potential risk of transmission of porcine endogenous retroviruses (PERV) from xenogeneic donors into humans has been widely debated. Because we were involved in a phase I/II clinical trial using a bioartificial liver support system (BLSS), we proceeded to evaluate the biosafety of this device. MATERIALS...

journal_title：Transplantation

authors： Kuddus R,Patzer JF 2nd,Lopez R,Mazariegos GV,Meighen B,Kramer DJ,Rao AS

更新日期：2002-02-15 00:00:00

abstract：BACKGROUND:In a pilot trial we evaluated the toxicity and efficacy of sirolimus (rapamycin) as second-line therapy for the treatment of acute graft-versus-host disease (GVHD) in 21 patients (1-46 years of age) after allogeneic hematopoietic stem cell transplantation (HSCT). METHODS:All patients were treated with methy...

journal_title：Transplantation

authors： Benito AI,Furlong T,Martin PJ,Anasetti C,Appelbaum FR,Doney K,Nash RA,Papayannopoulou T,Storb R,Sullivan KM,Witherspoon R,Deeg HJ

更新日期：2001-12-27 00:00:00

abstract：:Endothelial injury plays a central role in the pathophysiologic mechanisms underlying cardiac allograft vasculopathy (CAV). Although the accelerated course of CAV and its localization to the allograft support an important role for the alloimmune response, there is considerable evidence implicating lipoprotein abnormal...

journal_title：Transplantation

authors： Valantine HA

更新日期：2003-09-27 00:00:00

abstract：:Patients who require cystectomy are usually treated with an ileal conduit or intestinal neobladder for urinary control. In some of them, however, the bowel segment cannot be used because of previous abdominal surgery or radiation treatment. Bladder transplantation from cadavers may be beneficial to these patients, if ...

journal_title：Transplantation

authors： Takeuchi K,Takechi S,Ohoka H,Yokoyama M,Iwata H,Takeuchi M,Matsuda S

更新日期：1997-04-15 00:00:00

abstract：BACKGROUND:Deciphering the mechanisms of tolerance and chronic rejection (CR) remains a major goal in transplantation. Data in rodents suggest that Toll-like receptors (TLR), regulators of innate immune responses, play a role in determining graft outcome. However, few studies have focused on TLR expression in human kid...

journal_title：Transplantation

authors： Braudeau C,Ashton-Chess J,Giral M,Dugast E,Louis S,Pallier A,Braud C,Moreau A,Renaudin K,Soulillou JP,Brouard S

更新日期：2008-07-15 00:00:00

abstract：BACKGROUND:Intestinal allograft mucosa undergoes repopulation with host immunocytes. However, critical changes within key immunocyte subsets are not known. METHODS:To explain acute cellular rejection after intestine transplantation (ITx) on the basis of altered mucosal immunocytes, rejecting and rejection-free ITx all...

journal_title：Transplantation

authors： Ningappa M,Ashokkumar C,Ranganathan S,Schmitt L,Higgs BW,Sun Q,Branca M,Mazariegos G,Zeevi A,Abu-Elmagd K,Squires R,Rudolph J,Alissa F,Hakonarson H,Sindhi R

更新日期：2012-12-27 00:00:00

abstract：:Studies on liver interstitial dendritic cells (DC) indicate that the maturation and function of these important antigen-presenting cells may be suppressed by continual exposure to microbial products from the gut, in particular, bacterial lipopolysaccharide. New evidence is emerging for a role of specific intracellular...

journal_title：Transplantation

authors： Sumpter TL,Lunz JG 3rd,Demetris AJ,Thomson AW

更新日期：2009-08-15 00:00:00

abstract：:Hepatic artery thrombosis is a continuing source of morbidity and mortality following orthotopic liver transplantation. The cornerstone of therapy has been urgent retransplantation that is limited by organ availability. For this reason we developed a policy of urgent revascularization for allograft rescue. Hepatic art...

journal_title：Transplantation

authors： Langnas AN,Marujo W,Stratta RJ,Wood RP,Li SJ,Shaw BW

更新日期：1991-01-01 00:00:00

abstract：:The immunological events mediated by, and antigen specificity of, allograft-bound lymphocytes (ABLs) are poorly understood. To further define the role of antibody-mediated rejection, a rejected allograft from a patient with primary anti-TBM disease was sterilely minced and pressed through a microscreen. The ABLs were ...

journal_title：Transplantation

authors： Jordan SC,Barkley SC,Lemire JM,Sakai RS,Cohen A,Fine RN

更新日期：1986-02-01 00:00:00

abstract：:In the literature, varying terminology for living organ donation can be found. However, there seems to be a need for a new classification to avoid confusion. Therefore, we assessed existing terminology in the light of current living organ donation practices and suggest a more straightforward classification. We propose...

journal_title：Transplantation

authors： Dor FJ,Massey EK,Frunza M,Johnson R,Lennerling A,Lovén C,Mamode N,Pascalev A,Sterckx S,Van Assche K,Zuidema WC,Weimar W

更新日期：2011-05-15 00:00:00

abstract：BACKGROUND:Altered expression of murine MD-1, a molecule controlling expression of members of the interleukin (IL)-1 receptor family of signaling proteins, regulates antigen-presenting cell-induced alloreactions. We investigated the effect of treatment with antisense deoxyoligonucleotides or antibodies to MD-1 in vivo ...

journal_title：Transplantation

authors： Hadidi S,Chen Z,Phillips J,Yu K,Gorczynski RM

更新日期：2002-06-15 00:00:00

abstract：:To determine if cold preservation time continues to affect renal transplant outcome, prospectively collected data from 17,937 cadaveric renal transplants performed between 1982 and 1991 were analyzed. Cold preservation intervals of 1-16, 16-32, 32-48, and greater than 48 hr were studied by multi- and univariate method...

journal_title：Transplantation

authors： Peters TG,Shaver TR,Ames JE 4th,Santiago-Delpin EA,Jones KW,Blanton JW

更新日期：1995-01-27 00:00:00

abstract：:Idarubicin was conjugated to anti-Ly-2.1 and anti-L3T4 monoclonal antibodies. These conjugates were used to investigate their effects on skin graft survival in mice. Several donor and recipient combinations were used so that the effect of individual or mixtures of conjugates on class I and class II antigenic differenc...

journal_title：Transplantation

authors： Smyth MJ,McKenzie IF,Pietersz GA

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:The functional relevance of HLA-C mismatches in an alloresponse is still much debated, putting into doubt the relevance of matching for this antigen in selection of an allogeneic bone marrow donor. In addition to presenting peptides to T cells, HLA-C also functions as a ligand for killing inhibitory receptor...

journal_title：Transplantation

authors： van der Meer A,Allebes WA,Paardekooper J,Ruiter J,Joosten I

更新日期：2001-09-15 00:00:00

abstract：BACKGROUND:For cyclosporine (CsA), 2-hr postdose level (C2) is the best single time point predictor of the area under the curve and a critical measure for effective dosing. The therapeutic CsA microemulsion (Neoral) C2 range in de novo heart transplant patients remains to be determined. PURPOSE:The purpose of this stu...

journal_title：Transplantation

authors： Cantarovich M,Ross H,Arizón JM,Gómez MA,Straatman L,Orús J,Alonso-Pulpón L,Molina BD,Wang S,Lage E,Crespo MG,Manito N,Howlett J,Haddad H,Motown Study Group.

更新日期：2008-04-15 00:00:00

abstract：:Pre- and post transplant sera from 51 cases of bone marrow transplants performed for severe aplastic anemia were tested on monocytes (M) and corresponding B cells (B) from a panel of unrelated donors. One-third of the sera were cytotoxic for B and M either from different or from the same individuals, while 45% reacted...

journal_title：Transplantation

authors： Gluckman JC,Gluckman E,Azogui O,Guillet J,Baldwin WM,Devergie A,Chapuis F,Brisson E,Andersen E,Dausset J

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Based on the excellent correlation between cyclosporine A 2-hr postdose blood levels (C2) and the area under the concentration versus time curve, we evaluated the clinical benefit of Neoral dose monitoring with C2 compared trough levels (C0) in stable heart transplant patients. METHODS:We studied 114 stable...

journal_title：Transplantation

authors： Cantarovich M,Elstein E,de Varennes B,Barkun JS

更新日期：1999-12-27 00:00:00

abstract：:We studied the reactivity of cardiac graft-infiltrating cells, cultured from endomyocardial biopsy specimens, toward heart endothelial cells (Hec). In two cases, Hec derived from the specific donor heart or Hec compatible with the donor were lysed, but not the syngeneic B cell line. A vessel-derived endothelial cell l...

journal_title：Transplantation

authors： Jutte NH,Knoop CJ,Heijse P,Balk AH,Mochtar B,Claas FH,Weimar W

更新日期：1996-08-15 00:00:00

abstract：BACKGROUND:The urinary CXC chemokine ligand (CXCL)10 detects renal transplant inflammation noninvasively, but has limited sensitivity and specificity. In this study, we performed urinary proteomic analysis to identify novel biomarkers that may improve the diagnostic performance of urinary CXCL10 for detecting alloimmun...

journal_title：Transplantation

authors： Ho J,Rush DN,Krokhin O,Antonovici M,Gao A,Bestland J,Wiebe C,Hiebert B,Rigatto C,Gibson IW,Wilkins JA,Nickerson PW

更新日期：2016-03-01 00:00:00

abstract：:T cells must be activated before they can elicit damage to allografts, through interaction of their T cell receptor (TCR) with peptide-MHC complex and through accessory molecules. Signaling through accessory molecules or costimulatory molecules is a critical way for the immune system to fine tune T cell activation. An...

journal_title：Transplantation

authors： Kinnear G,Jones ND,Wood KJ

更新日期：2013-02-27 00:00:00